| UniProt ID | MRM3_HUMAN | |
|---|---|---|
| UniProt AC | Q9HC36 | |
| Protein Name | rRNA methyltransferase 3, mitochondrial {ECO:0000303|PubMed:25009282} | |
| Gene Name | MRM3 {ECO:0000303|PubMed:25009282, ECO:0000312|HGNC:HGNC:18485} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 420 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.. | |
| Protein Sequence | MAALVRPARFVVRPLLQVVQAWDLDARRWVRALRRSPVKVVFPSGEVVEQKRAPGKQPRKAPSEASAQEQREKQPLEESASRAPSTWEESGLRYDKAYPGDRRLSSVMTIVKSRPFREKQGKILLEGRRLISDALKAGAVPKMFFFSRLEYLKELPVDKLKGVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDHVKMTYPKTQLQHSLPLLLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFRMPIINNLEWETVPNYLPPDTRVYVADNCGLYAQAEMSNKASDHGWVCDQRVMKFHKYEEEEDVETGASQDWLPHVEVQSYDSDWTEAPAAVVIGGETYGVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMAASILLFEGKRQLRGRAEDLSRDRSYH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 56 | Ubiquitination | EQKRAPGKQPRKAPS EECCCCCCCCCCCCC | 27667366 | ||
| 60 | Ubiquitination | APGKQPRKAPSEASA CCCCCCCCCCCHHHH | 24816145 | ||
| 66 | Phosphorylation | RKAPSEASAQEQREK CCCCCHHHHHHHHHH | 24719451 | ||
| 79 | Phosphorylation | EKQPLEESASRAPST HHCCHHHHHHCCCCC | 24719451 | ||
| 81 | Phosphorylation | QPLEESASRAPSTWE CCHHHHHHCCCCCHH | 28634298 | ||
| 86 | Phosphorylation | SASRAPSTWEESGLR HHHCCCCCHHHHCCC | 28152594 | ||
| 90 | Phosphorylation | APSTWEESGLRYDKA CCCCHHHHCCCCCCC | 28152594 | ||
| 94 | Phosphorylation | WEESGLRYDKAYPGD HHHHCCCCCCCCCCC | 28152594 | ||
| 96 | Ubiquitination | ESGLRYDKAYPGDRR HHCCCCCCCCCCCCC | 24816145 | ||
| 98 | Phosphorylation | GLRYDKAYPGDRRLS CCCCCCCCCCCCCHH | 28152594 | ||
| 105 | Phosphorylation | YPGDRRLSSVMTIVK CCCCCCHHHHHHHEE | 21406692 | ||
| 106 | Phosphorylation | PGDRRLSSVMTIVKS CCCCCHHHHHHHEEC | 21406692 | ||
| 109 | Phosphorylation | RRLSSVMTIVKSRPF CCHHHHHHHEECCCC | 21406692 | ||
| 113 | Phosphorylation | SVMTIVKSRPFREKQ HHHHHEECCCCHHHC | 21406692 | ||
| 119 | Ubiquitination | KSRPFREKQGKILLE ECCCCHHHCCCEEEE | 24816145 | ||
| 153 | 2-Hydroxyisobutyrylation | FSRLEYLKELPVDKL HHHHHHHHHCCCCCC | - | ||
| 153 | Acetylation | FSRLEYLKELPVDKL HHHHHHHHHCCCCCC | 23236377 | ||
| 153 | Succinylation | FSRLEYLKELPVDKL HHHHHHHHHCCCCCC | 27452117 | ||
| 159 | 2-Hydroxyisobutyrylation | LKELPVDKLKGVSLI HHHCCCCCCCCCEEE | - | ||
| 161 | Ubiquitination | ELPVDKLKGVSLIKV HCCCCCCCCCEEEEE | 27667366 | ||
| 164 | Phosphorylation | VDKLKGVSLIKVKFE CCCCCCCEEEEEEHH | 24719451 | ||
| 167 | Malonylation | LKGVSLIKVKFEDIK CCCCEEEEEEHHHCC | 26320211 | ||
| 181 | O-linked_Glycosylation | KDWSDLVTPQGIMGI CCHHHCCCCCCEEEE | 30379171 | ||
| 237 | Acetylation | AAGAGCSKVLLTKGC HCCCCCCEEEEECCC | 26051181 | ||
| 237 | Succinylation | AAGAGCSKVLLTKGC HCCCCCCEEEEECCC | 27452117 | ||
| 237 | Ubiquitination | AAGAGCSKVLLTKGC HCCCCCCEEEEECCC | 29967540 | ||
| 237 | 2-Hydroxyisobutyrylation | AAGAGCSKVLLTKGC HCCCCCCEEEEECCC | - | ||
| 242 | Ubiquitination | CSKVLLTKGCVDAWE CCEEEEECCCHHCCC | 29967540 | ||
| 251 | Acetylation | CVDAWEPKVLRAGMG CHHCCCHHHHHCCCC | 26051181 | ||
| 414 | Phosphorylation | RGRAEDLSRDRSYH- CCCHHHHHCCCCCC- | 27966365 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MRM3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MRM3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MRM3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| RT30_HUMAN | MRPS30 | physical | 22939629 | |
| RUSD4_HUMAN | RPUSD4 | physical | 22939629 | |
| RT07_HUMAN | MRPS7 | physical | 22939629 | |
| MPPB_HUMAN | PMPCB | physical | 26186194 | |
| SPT2_HUMAN | SPTY2D1 | physical | 26186194 | |
| ZN131_HUMAN | ZNF131 | physical | 28514442 | |
| UHRF1_HUMAN | UHRF1 | physical | 28514442 | |
| ATPF2_HUMAN | ATPAF2 | physical | 28514442 | |
| MPPA_HUMAN | PMPCA | physical | 28514442 | |
| NDUS6_HUMAN | NDUFS6 | physical | 28514442 | |
| MPPB_HUMAN | PMPCB | physical | 28514442 | |
| SC24B_HUMAN | SEC24B | physical | 28514442 | |
| CPT2_HUMAN | CPT2 | physical | 28514442 | |
| PTER_HUMAN | PTER | physical | 28514442 | |
| IF2M_HUMAN | MTIF2 | physical | 28514442 | |
| NDUF7_HUMAN | NDUFAF7 | physical | 28514442 | |
| KLH42_HUMAN | KLHL42 | physical | 28514442 | |
| RLA0_HUMAN | RPLP0 | physical | 28514442 | |
| MASU1_HUMAN | MALSU1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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