NDUF7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUF7_HUMAN
• UniProt AC: Q7L592
• Protein Name: Protein arginine methyltransferase NDUFAF7, mitochondrial {ECO:0000305}
• Gene Name: NDUFAF7 {ECO:0000312|HGNC:HGNC:28816}
• Organism: Homo sapiens (Human).
• Sequence Length: 441
• Subcellular Localization: Mitochondrion .
• Protein Description: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). [PubMed: 20406883]
• Protein Sequence: MSVLLRSGLGPLCAVARAAIPFIWRGKYFSSGNEPAENPVTPMLRHLMYKIKSTGPITVAEYMKEVLTNPAKGYYVYRDMLGEKGDFITSPEISQIFGELLGIWFISEWMATGKSTAFQLVELGPGRGTLVGDILRVFTQLGSVLKNCDISVHLVEVSQKLSEIQALTLTKEKVPLERNAGSPVYMKGVTKSGIPISWYRDLHDVPKGYSFYLAHEFFDVLPVHKFQKTPQGWREVFVDIDPQVSDKLRFVLAPSATPAEAFIQHDETRDHVEVCPDAGVIIEELSQRIALTGGAALVADYGHDGTKTDTFRGFCDHKLHDVLIAPGTADLTADVDFSYLRRMAQGKVASLGPIKQHTFLKNMGIDVRLKVLLDKSNEPSVRQQLLQGYDMLMNPKKMGERFNFFALLPHQRLQGGRYQRNARQSKPFASVVAGFSELAWQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MSVLLRSGL ------CCCCCCCCC		22817900
6	Ubiquitination	--MSVLLRSGLGPLC --CCCCCCCCCHHHH		21890473
28	Phosphorylation	PFIWRGKYFSSGNEP CCHHCCCCCCCCCCC		-
53	Phosphorylation	HLMYKIKSTGPITVA HHHHHHHCCCCEEHH		29396449
54	Phosphorylation	LMYKIKSTGPITVAE HHHHHHCCCCEEHHH		29396449
62	Phosphorylation	GPITVAEYMKEVLTN CCEEHHHHHHHHHHC		-
75	Phosphorylation	TNPAKGYYVYRDMLG HCCCCCCEEEEHHCC		-
77	Phosphorylation	PAKGYYVYRDMLGEK CCCCCEEEEHHCCCC		-
145	Ubiquitination	FTQLGSVLKNCDISV HHHHHHHHHCCCEEE		22817900
149	Ubiquitination	GSVLKNCDISVHLVE HHHHHCCCEEEEEEH		21890473
171	Ubiquitination	IQALTLTKEKVPLER HHHHHCCCCCCCCCC		-
187	Ubiquitination	AGSPVYMKGVTKSGI CCCCEEEECCCCCCC		22817900
191	Ubiquitination	VYMKGVTKSGIPISW EEEECCCCCCCEEEE		22817900
191 (in isoform 1)	Ubiquitination	-		21890473
192	Phosphorylation	YMKGVTKSGIPISWY EEECCCCCCCEEEEE		28509920
197	Phosphorylation	TKSGIPISWYRDLHD CCCCCEEEEEECHHC		28509920
199	Phosphorylation	SGIPISWYRDLHDVP CCCEEEEEECHHCCC		28509920
247	Ubiquitination	IDPQVSDKLRFVLAP CCHHHCCCEEEEECC		29967540
301	Phosphorylation	GAALVADYGHDGTKT CEEEEEECCCCCCCC		23401153
306	Phosphorylation	ADYGHDGTKTDTFRG EECCCCCCCCCCCCC		23401153
308	Phosphorylation	YGHDGTKTDTFRGFC CCCCCCCCCCCCCCC		23401153
347	Acetylation	LRRMAQGKVASLGPI HHHHHCCCCCCCCCC		12650443
350	Phosphorylation	MAQGKVASLGPIKQH HHCCCCCCCCCCCHH		-
355	Acetylation	VASLGPIKQHTFLKN CCCCCCCCHHHHHHH		12650453

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUF7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUF7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUF7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.