| UniProt ID | KLH42_HUMAN | |
|---|---|---|
| UniProt AC | Q9P2K6 | |
| Protein Name | Kelch-like protein 42 | |
| Gene Name | KLHL42 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 505 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton, spindle . Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase | |
| Protein Description | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.. | |
| Protein Sequence | MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWEAFRRFPAFGHNLLVSSLYLPNKAET | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Ubiquitination | DRCYPVSKRKLIEQS HCCEECCHHHHHHHH | - | ||
| 22 | Ubiquitination | CYPVSKRKLIEQSDY CEECCHHHHHHHHHH | 21890473 | ||
| 43 | Phosphorylation | SGMREALSQEAGGPE HHHHHHHHHHCCCHH | 17525332 | ||
| 171 | Phosphorylation | PQFHLLGSPPQAPGD CEEEECCCCCCCCCC | 30576142 | ||
| 290 | Ubiquitination | QVASMNQKRSNFKLV HHHHHCCCCCCCEEE | 21890473 | ||
| 364 | Phosphorylation | RNMNILQYCPSSDMW CCCCHHHHCCCCCHH | - | ||
| 376 | Phosphorylation | DMWTLFETCDVHIRK CHHHHHHHCCEEEEH | - | ||
| 410 | Phosphorylation | LGPNRRSSQSEDMLT CCCCCCCCCCCCCEE | 17525332 | ||
| 476 | Phosphorylation | FLKYNIFSDSWEAFR EEEECCCCCCHHHHH | 30243723 | ||
| 478 | Phosphorylation | KYNIFSDSWEAFRRF EECCCCCCHHHHHCC | 30243723 | ||
| 496 | O-linked_Glycosylation | GHNLLVSSLYLPNKA CCCEEEEEEECCCCC | 29351928 | ||
| 502 | Ubiquitination | SSLYLPNKAET---- EEEECCCCCCC---- | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KLH42_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KLH42_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KLH42_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| USBP1_HUMAN | USHBP1 | physical | 16189514 | |
| KTNA1_HUMAN | KATNA1 | physical | 19261606 | |
| ADIP_HUMAN | SSX2IP | physical | 25416956 | |
| STXB4_HUMAN | STXBP4 | physical | 25416956 | |
| DDI1_HUMAN | DDI1 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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