RM21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM21_HUMAN
• UniProt AC: Q7Z2W9
• Protein Name: 39S ribosomal protein L21, mitochondrial
• Gene Name: MRPL21
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MAASSLTVTLGRLASACSHSILRPSGPGAASLWSASRRFNSQSTSYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTGQYGRLFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKVLLVGADNFTLLGKPLLGKDLVRVEATVIEKTESWPRIIMRFRKRKNFKKKRIVTTPQTVLRINSIEIAPCLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAASSLTVTLG ----CCCCCCEEHHH	19.15	21406692
5	Phosphorylation	---MAASSLTVTLGR ---CCCCCCEEHHHH	24.27	21406692
7	Phosphorylation	-MAASSLTVTLGRLA -CCCCCCEEHHHHHH	17.25	21406692
9	Phosphorylation	AASSLTVTLGRLASA CCCCCEEHHHHHHHH	20.47	21406692
25	Phosphorylation	SHSILRPSGPGAASL CCCCCCCCCCCHHHH	51.70	23663014
31	Phosphorylation	PSGPGAASLWSASRR CCCCCHHHHHHHHHH	29.82	23663014
34	Phosphorylation	PGAASLWSASRRFNS CCHHHHHHHHHHCCC	22.97	23663014
36	Phosphorylation	AASLWSASRRFNSQS HHHHHHHHHHCCCCC	20.62	23663014
66	Ubiquitination	PPWPEVVLPDPVEET CCCCCCCCCCCHHHH	4.87	21890473
81	Ubiquitination	RHHAEVVKKVNEMIV HHHHHHHHHHHHHEE	57.06	-
81	2-Hydroxyisobutyrylation	RHHAEVVKKVNEMIV HHHHHHHHHHHHHEE	57.06	-
89	Phosphorylation	KVNEMIVTGQYGRLF HHHHHEEEECCHHHE	13.98	-
146	Ubiquitination	DNFTLLGKPLLGKDL CCCEECCCCCCCCCE	32.25	-
151	Succinylation	LGKPLLGKDLVRVEA CCCCCCCCCEEEEEE	48.10	23954790
151	Ubiquitination	LGKPLLGKDLVRVEA CCCCCCCCCEEEEEE	48.10	-
155	Ubiquitination	LLGKDLVRVEATVIE CCCCCEEEEEEEEEE	28.05	21890473
163	Ubiquitination	VEATVIEKTESWPRI EEEEEEECCCCCHHH	46.60	2190698
166	Phosphorylation	TVIEKTESWPRIIMR EEEECCCCCHHHHHH	47.84	24719451
167	Ubiquitination	VIEKTESWPRIIMRF EEECCCCCHHHHHHH	4.67	21890473
187	Phosphorylation	FKKKRIVTTPQTVLR CCCCCEEECCCCEEE	30.32	23312004
188	Phosphorylation	KKKRIVTTPQTVLRI CCCCEEECCCCEEEE	11.51	20860994
191	Phosphorylation	RIVTTPQTVLRINSI CEEECCCCEEEEECE	23.78	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RM40_HUMAN	MRPL40	physical	22939629
RM51_HUMAN	MRPL51	physical	22939629
RM32_HUMAN	MRPL32	physical	22939629
RT09_HUMAN	MRPS9	physical	22939629
RM24_HUMAN	MRPL24	physical	22939629
RM38_HUMAN	MRPL38	physical	22939629
NBEA_HUMAN	NBEA	physical	28514442
RT30_HUMAN	MRPS30	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
RM47_HUMAN	MRPL47	physical	28514442
GTPB8_HUMAN	GTPBP8	physical	28514442
AUHM_HUMAN	AUH	physical	28514442
RM20_HUMAN	MRPL20	physical	28514442
SYHM_HUMAN	HARS2	physical	28514442
NDUF7_HUMAN	NDUFAF7	physical	28514442
RM04_HUMAN	MRPL4	physical	28514442
RM10_HUMAN	MRPL10	physical	28514442
ADRO_HUMAN	FDXR	physical	28514442
SYLM_HUMAN	LARS2	physical	28514442
RNZ2_HUMAN	ELAC2	physical	28514442
TOP3A_HUMAN	TOP3A	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28514442
SYIM_HUMAN	IARS2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.