SYHM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYHM_HUMAN
• UniProt AC: P49590
• Protein Name: Probable histidine--tRNA ligase, mitochondrial
• Gene Name: HARS2
• Organism: Homo sapiens (Human).
• Sequence Length: 506
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MPLLGLLPRRAWASLLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFCQCDFDIAGQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAAGGRYDGLVGMFDPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKNFLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRLSES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42 (in isoform 2)	Phosphorylation	-	5.00	29507054
52	Acetylation	QLKAHQEKPNFIIKT HHHHHHCCCCEEEEC	38.40	23236377
52	Malonylation	QLKAHQEKPNFIIKT HHHHHHCCCCEEEEC	38.40	26320211
52	Ubiquitination	QLKAHQEKPNFIIKT HHHHHHCCCCEEEEC	38.40	-
59	Phosphorylation	KPNFIIKTPKGTRDL CCCEEEECCCCCCCC	21.59	25599653
63	Phosphorylation	IIKTPKGTRDLSPQH EEECCCCCCCCCHHH	27.43	29514088
67	Phosphorylation	PKGTRDLSPQHMVVR CCCCCCCCHHHHHHH	27.14	29255136
76	Sumoylation	QHMVVREKILDLVIS HHHHHHHHHHHHHHH	37.70	-
91	Succinylation	CFKRHGAKGMDTPAF HHHHHCCCCCCCCCC	60.40	27452117
91	Malonylation	CFKRHGAKGMDTPAF HHHHHCCCCCCCCCC	60.40	26320211
93	Sulfoxidation	KRHGAKGMDTPAFEL HHHCCCCCCCCCCHH	5.23	21406390
94	Ubiquitination	RHGAKGMDTPAFELK HHCCCCCCCCCCHHH	59.20	-
116	Phosphorylation	GEDSGLMYDLKDQGG CCCCCCEEEEECCCC	24.14	24961811
119	Ubiquitination	SGLMYDLKDQGGELL CCCEEEEECCCCCEE	45.14	-
127	Phosphorylation	DQGGELLSLRYDLTV CCCCCEEEEEEEEHH	24.35	21712546
130	Phosphorylation	GELLSLRYDLTVPFA CCEEEEEEEEHHHHH	22.16	28152594
144	Acetylation	ARYLAMNKVKKMKRY HHHHHHHHHHHCHHH	42.20	25953088
151	Phosphorylation	KVKKMKRYHVGKVWR HHHHCHHHCCCCEEC	8.71	-
161	Phosphorylation	GKVWRRESPTIVQGR CCEECCCCCCEEECC	26.07	30266825
163	Phosphorylation	VWRRESPTIVQGRYR EECCCCCCEEECCCH	42.96	30266825
241	Acetylation	AICSSIDKLDKMAWK HHHHCHHHHHHHHHH	57.84	25953088
257	Succinylation	VRHEMVVKKGLAPEV HHHHHHHHCCCCHHH	29.70	27452117
257	Acetylation	VRHEMVVKKGLAPEV HHHHHHHHCCCCHHH	29.70	25953088
258	Ubiquitination	RHEMVVKKGLAPEVA HHHHHHHCCCCHHHH	47.77	-
294	Ubiquitination	DPRLSQNKQALEGLG CCCHHHCHHHHHCHH	29.34	21906983
364	Phosphorylation	SVAAGGRYDGLVGMF CCEECCCCCCEEECC	20.03	20068231
377	Ubiquitination	MFDPKGHKVPCVGLS CCCCCCCCCCEEEEE	57.45	-
392	Phosphorylation	IGVERIFYIVEQRMK ECHHHHHHHHHHHHC	11.16	28152594
394	Ubiquitination	VERIFYIVEQRMKTK HHHHHHHHHHHHCCC	3.32	-
407	Phosphorylation	TKGEKVRTTETQVFV CCCCCCCCCCCEEEE	31.78	21406692
408	Phosphorylation	KGEKVRTTETQVFVA CCCCCCCCCCEEEEE	26.86	21406692
410	Phosphorylation	EKVRTTETQVFVATP CCCCCCCCEEEEECC	28.13	21406692
416	Phosphorylation	ETQVFVATPQKNFLQ CCEEEEECCCCCHHH	22.43	21406692
419	Ubiquitination	VFVATPQKNFLQERL EEEECCCCCHHHHHH	51.36	-
419	Acetylation	VFVATPQKNFLQERL EEEECCCCCHHHHHH	51.36	-
419	Acetylation	VFVATPQKNFLQERL EEEECCCCCHHHHHH	51.36	132945
419	Succinylation	VFVATPQKNFLQERL EEEECCCCCHHHHHH	51.36	23954790
444	Malonylation	IKAEMLYKNNPKLLT HHHHHHHHCCHHHHH	46.41	26320211
444	Acetylation	IKAEMLYKNNPKLLT HHHHHHHHCCHHHHH	46.41	19608861
444	Succinylation	IKAEMLYKNNPKLLT HHHHHHHHCCHHHHH	46.41	27452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYHM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYHM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYHM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATRAP_HUMAN	AGTRAP	physical	25416956
GARS_HUMAN	GARS	physical	26344197
SYHC_HUMAN	HARS	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
SDHB_HUMAN	SDHB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614926: Perrault syndrome 2 (PRLTS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-444, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, AND MASSSPECTROMETRY.
PubMed: 17081983