AUHM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AUHM_HUMAN
• UniProt AC: Q13825
• Protein Name: Methylglutaconyl-CoA hydratase, mitochondrial
• Gene Name: AUH
• Organism: Homo sapiens (Human).
• Sequence Length: 339
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA. [PubMed: 11738050]
• Protein Sequence: MAAAVAAAPGALGSLHAGGARLVAACSAWLCPGLRLPGSLAGRRAGPAIWAQGWVPAAGGPAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	AAPGALGSLHAGGAR CCCCHHHCCCCCHHH	20.17	23612710
100	Succinylation	GINRAYGKNSLSKNL EECHHHCCCCCCHHH	30.59	-
100	Acetylation	GINRAYGKNSLSKNL EECHHHCCCCCCHHH	30.59	26210075
100	Succinylation	GINRAYGKNSLSKNL EECHHHCCCCCCHHH	30.59	-
105	Acetylation	YGKNSLSKNLIKMLS HCCCCCCHHHHHHHH	62.15	6568099
105	Malonylation	YGKNSLSKNLIKMLS HCCCCCCHHHHHHHH	62.15	26320211
109	Acetylation	SLSKNLIKMLSKAVD CCCHHHHHHHHHHHH	36.63	25953088
109	Succinylation	SLSKNLIKMLSKAVD CCCHHHHHHHHHHHH	36.63	-
109	Malonylation	SLSKNLIKMLSKAVD CCCHHHHHHHHHHHH	36.63	26320211
109	Succinylation	SLSKNLIKMLSKAVD CCCHHHHHHHHHHHH	36.63	-
113	Succinylation	NLIKMLSKAVDALKS HHHHHHHHHHHHHHC	48.76	-
113	Acetylation	NLIKMLSKAVDALKS HHHHHHHHHHHHHHC	48.76	-
113	Succinylation	NLIKMLSKAVDALKS HHHHHHHHHHHHHHC	48.76	-
122	Acetylation	VDALKSDKKVRTIII HHHHHCCCCEEEEEE	61.33	18603021
123	Acetylation	DALKSDKKVRTIIIR HHHHCCCCEEEEEEC	41.77	2402027
144	Succinylation	FCAGADLKERAKMSS EECCCCHHHHHCCCC	45.78	-
144	Succinylation	FCAGADLKERAKMSS EECCCCHHHHHCCCC	45.78	27452117
144	Acetylation	FCAGADLKERAKMSS EECCCCHHHHHCCCC	45.78	25038526
148	Succinylation	ADLKERAKMSSSEVG CCHHHHHCCCCCHHH	45.60	-
148	Succinylation	ADLKERAKMSSSEVG CCHHHHHCCCCCHHH	45.60	-
150	Phosphorylation	LKERAKMSSSEVGPF HHHHHCCCCCHHHHH	29.97	28857561
151	Phosphorylation	KERAKMSSSEVGPFV HHHHCCCCCHHHHHH	27.33	28857561
152	Phosphorylation	ERAKMSSSEVGPFVS HHHCCCCCHHHHHHH	29.06	28857561
159	Phosphorylation	SEVGPFVSKIRAVIN CHHHHHHHHHHHHHH	23.81	-
160	Succinylation	EVGPFVSKIRAVIND HHHHHHHHHHHHHHH	30.80	-
160	Succinylation	EVGPFVSKIRAVIND HHHHHHHHHHHHHHH	30.80	-
204	Succinylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	27452117
204	Malonylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	26320211
204	Acetylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	25953088
204	Succinylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	-
211	Acetylation	KMGLVETKLAIIPGG CCCCEEEEEEEECCC	23.55	25953088
211	Succinylation	KMGLVETKLAIIPGG CCCCEEEEEEEECCC	23.55	-
211	Succinylation	KMGLVETKLAIIPGG CCCCEEEEEEEECCC	23.55	-
231	Phosphorylation	LPRAIGMSLAKELIF HHHHHCHHHHHHHHH	21.69	21406692
239	Phosphorylation	LAKELIFSARVLDGK HHHHHHHHCEECCCH	14.26	21406692
246	2-Hydroxyisobutyrylation	SARVLDGKEAKAVGL HCEECCCHHHHHHHH	54.91	-
329	Succinylation	LEGLLAFKEKRPPRY HHHHHHHHCCCCCCC	57.63	-
329	Succinylation	LEGLLAFKEKRPPRY HHHHHHHHCCCCCCC	57.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AUHM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AUHM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AUHM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AUHM_HUMAN	AUH	physical	11738050

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 250950: 3-methylglutaconic aciduria 1 (MGA1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.