NDUF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUF5_HUMAN
• UniProt AC: Q5TEU4
• Protein Name: Arginine-hydroxylase NDUFAF5, mitochondrial {ECO:0000305}
• Gene Name: NDUFAF5 {ECO:0000312|HGNC:HGNC:15899}
• Organism: Homo sapiens (Human).
• Sequence Length: 345
• Subcellular Localization: Mitochondrion inner membrane . Peripherally localized on the matrix face of the mitochondrial inner membrane.
• Protein Description: Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. [PubMed: 18940309]
• Protein Sequence: MLRPAGLWRLCRRPWAARVPAENLGRREVTSGVSPRGSTSPRTLNIFDRDLKRKQKNWAARQPEPTKFDYLKEEVGSRIADRVYDIPRNFPLALDLGCGRGYIAQYLNKETIGKFFQADIAENALKNSSETEIPTVSVLADEEFLPFKENTFDLVVSSLSLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLQGMGESNCAWNRKALLHRDTMLAAAAVYREMYRNEDGSVPATYQIYYMIGWKYHESQARPAERGSATVSFGELGKINNLMPPGKKSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	NLGRREVTSGVSPRG HCCCCCCCCCCCCCC	18.27	-
31	Phosphorylation	LGRREVTSGVSPRGS CCCCCCCCCCCCCCC	42.23	22817900
34	Phosphorylation	REVTSGVSPRGSTSP CCCCCCCCCCCCCCC	16.65	22817900
67	Acetylation	ARQPEPTKFDYLKEE HCCCCCCCHHHHHHH	47.13	7683747
72	Ubiquitination	PTKFDYLKEEVGSRI CCCHHHHHHHHHHHH	45.67	24816145
77	Phosphorylation	YLKEEVGSRIADRVY HHHHHHHHHHHHHHC	26.20	-
84	Phosphorylation	SRIADRVYDIPRNFP HHHHHHHCCCCCCCC	14.73	25839225
109	Ubiquitination	YIAQYLNKETIGKFF HHHHHCCHHHHHHHH	54.35	22817900
109 (in isoform 1)	Ubiquitination	-	54.35	21890473
114	Ubiquitination	LNKETIGKFFQADIA CCHHHHHHHHHHHHH	38.87	22817900
286	Phosphorylation	MLAAAAVYREMYRNE HHHHHHHHHHHHHCC	8.98	-
290	Phosphorylation	AAVYREMYRNEDGSV HHHHHHHHHCCCCCC	12.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPM1E_HUMAN	PPM1E	physical	26186194
XRCC2_HUMAN	XRCC2	physical	26186194
RA51D_HUMAN	RAD51D	physical	26186194
HBB_HUMAN	HBB	physical	26186194
NDUF5_HUMAN	NDUFAF5	physical	27499296
BOLA3_HUMAN	BOLA3	physical	27499296
NDUF8_HUMAN	C17orf89	physical	27499296
STAR7_HUMAN	STARD7	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
ATP5E_HUMAN	ATP5E	physical	27499296
ACPM_HUMAN	NDUFAB1	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
XRCC2_HUMAN	XRCC2	physical	28514442
HBB_HUMAN	HBB	physical	28514442
RA51D_HUMAN	RAD51D	physical	28514442
PPM1E_HUMAN	PPM1E	physical	28514442
FPPS_HUMAN	FDPS	physical	28514442
CGL_HUMAN	CTH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• OMIM Disease
• 252010: Mitochondrial complex I deficiency (MT-C1D)
• 256000: Leigh syndrome (LS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.