NDUF8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUF8_HUMAN
• UniProt AC: A1L188
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 {ECO:0000312|HGNC:HGNC:33551}
• Gene Name: NDUFAF8 {ECO:0000312|HGNC:HGNC:33551}
• Organism: Homo sapiens (Human).
• Sequence Length: 74
• Subcellular Localization: Mitochondrion .
• Protein Description: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). [PubMed: 27499296 Required to stabilize NDUFAF5]
• Protein Sequence: MSANGAVWGRVRSRLRAFPERLAACGAEAAAYGRCVQASTAPGGRLSKDFCAREFEALRSCFAAAAKKTLEGGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Methylation	ANGAVWGRVRSRLRA CCCHHHHHHHHHHHH		115482203
13	Phosphorylation	AVWGRVRSRLRAFPE HHHHHHHHHHHHCHH		24719451
32	Phosphorylation	CGAEAAAYGRCVQAS HCHHHHHHCHHHHCC		24719451
39	Phosphorylation	YGRCVQASTAPGGRL HCHHHHCCCCCCCCC		23927012
40	Phosphorylation	GRCVQASTAPGGRLS CHHHHCCCCCCCCCC		23927012
47	Phosphorylation	TAPGGRLSKDFCARE CCCCCCCCHHHHHHH		23927012
48	Ubiquitination	APGGRLSKDFCAREF CCCCCCCHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUF8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUF8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUF8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUF5_HUMAN	NDUFAF5	physical	27499296
NDUF8_HUMAN	C17orf89	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
ATP5H_HUMAN	ATP5H	physical	27499296
GLUCM_HUMAN	C14orf159	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
MOT1_HUMAN	SLC16A1	physical	27499296
NDUS3_HUMAN	NDUFS3	physical	27499296
TRUB2_HUMAN	TRUB2	physical	27499296
ATPO_HUMAN	ATP5O	physical	27499296
RT35_HUMAN	MRPS35	physical	27499296
AT5F1_HUMAN	ATP5F1	physical	27499296
CX6A1_HUMAN	COX6A1	physical	27499296
TIM50_HUMAN	TIMM50	physical	27499296
NFS1_HUMAN	NFS1	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
CPT2_HUMAN	CPT2	physical	27499296
NDUA5_HUMAN	NDUFA5	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
CLPB_HUMAN	CLPB	physical	27499296
RM54_HUMAN	MRPL54	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
STAR7_HUMAN	STARD7	physical	27499296
ATP5E_HUMAN	ATP5E	physical	27499296
NDUF5_HUMAN	NDUFAF5	physical	28514442
TTC19_HUMAN	TTC19	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28162770
ACTG_HUMAN	ACTG1	physical	28162770
TBA1B_HUMAN	TUBA1B	physical	28162770
MEP50_HUMAN	WDR77	physical	28162770
SPIN1_HUMAN	SPIN1	physical	28162770
ROA1_HUMAN	HNRNPA1	physical	28162770
RL6_HUMAN	RPL6	physical	28162770
ROA2_HUMAN	HNRNPA2B1	physical	28162770
CK084_HUMAN	C11orf84	physical	28162770
TBB5_HUMAN	TUBB	physical	28162770

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.