RT35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RT35_HUMAN
• UniProt AC: P82673
• Protein Name: 28S ribosomal protein S35, mitochondrial
• Gene Name: MRPS35 {ECO:0000312|HGNC:HGNC:16635}
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGNERPPRRKALPPRTEKMAVDQDWPSVYPVAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLKIPNFLHLTPVAIKKHCEALKDFCTEWPAALDSDEKCEKHFPIEIDSTDYVSSGPSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKEIEEYKKSVVSLKNEEENENSISQYKESVKRLLNVT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	AALPAWLSLQSRART HHHHHHHHHHHHHHH	17.42	27251275
14	Phosphorylation	PAWLSLQSRARTLRA HHHHHHHHHHHHHHH	32.95	24719451
18	Phosphorylation	SLQSRARTLRAFSTA HHHHHHHHHHHHHHH	21.44	24719451
36	Phosphorylation	ATPVPTPSLPERTPG CCCCCCCCCCCCCCC	60.06	27251275
41	Phosphorylation	TPSLPERTPGNERPP CCCCCCCCCCCCCCC	33.61	27251275
68	Phosphorylation	AVDQDWPSVYPVAAP CCCCCCCCCCCCCCC	29.99	19835603
70	Phosphorylation	DQDWPSVYPVAAPFK CCCCCCCCCCCCCCC	9.05	19835603
79	Phosphorylation	VAAPFKPSAVPLPVR CCCCCCCCCCCCCEE	42.35	19835603
89	Phosphorylation	PLPVRMGYPVKKGVP CCCEECCCCCCCCCC	8.77	19835603
99	Ubiquitination	KKGVPMAKEGNLELL CCCCCCCCCCCEEEE	60.96	33845483
115	Phosphorylation	IPNFLHLTPVAIKKH CCCCHHCHHHHHHHH	12.64	24719451
120	Acetylation	HLTPVAIKKHCEALK HCHHHHHHHHHHHHH	27.08	25953088
127	Ubiquitination	KKHCEALKDFCTEWP HHHHHHHHHHHHHCC	56.67	29967540
127	Acetylation	KKHCEALKDFCTEWP HHHHHHHHHHHHHCC	56.67	26822725
142	Ubiquitination	AALDSDEKCEKHFPI CCCCCCCHHHHHCCE	53.32	29967540
156	Phosphorylation	IEIDSTDYVSSGPSV EEECCCCCCCCCCCC	11.43	-
176	2-Hydroxyisobutyrylation	RVVVLRVKLSSLNLD EEEEEEEEHHHCCCC	35.90	-
187	2-Hydroxyisobutyrylation	LNLDDHAKKKLIKLV CCCCHHHHHHHHHHH	47.20	-
206	Phosphorylation	CKTTDVLTIKTDRCP CCCCCEEEEECCCCC	21.92	-
207 (in isoform 2)	Ubiquitination	-	3.85	-
208	Acetylation	TTDVLTIKTDRCPLR CCCEEEEECCCCCCC	38.85	25953088
219	Phosphorylation	CPLRRQNYDYAVYLL CCCCCCCHHHHHHHH	11.29	-
230	Phosphorylation	VYLLTVLYHESWNTE HHHHHHHHHHCCCHH	10.13	-
234 (in isoform 2)	Ubiquitination	-	16.87	-
238 (in isoform 2)	Ubiquitination	-	59.92	-
241	Ubiquitination	WNTEEWEKSKTEADM CCHHHHHHHCCHHHH	59.32	23503661
242	Phosphorylation	NTEEWEKSKTEADME CHHHHHHHCCHHHHH	33.04	26503514
243	Ubiquitination	TEEWEKSKTEADMEE HHHHHHHCCHHHHHH	62.54	23503661
251	Phosphorylation	TEADMEEYIWENSSS CHHHHHHHHCCCCHH	9.68	26503514
256	Phosphorylation	EEYIWENSSSERNIL HHHHCCCCHHHHHHH	24.59	-
264 (in isoform 2)	Ubiquitination	-	33.34	-
265	Phosphorylation	SERNILETLLQMKAA HHHHHHHHHHHHHHH	29.35	26503514
270	Ubiquitination	LETLLQMKAAEKNME HHHHHHHHHHHHHCC	31.33	23503661
274	Ubiquitination	LQMKAAEKNMEINKE HHHHHHHHHCCCCHH	57.79	23503661
276	Sulfoxidation	MKAAEKNMEINKEEL HHHHHHHCCCCHHHH	8.95	21406390
277 (in isoform 2)	Ubiquitination	-	53.45	-
280	Ubiquitination	EKNMEINKEELLGTK HHHCCCCHHHHCCCH	59.22	23503661
294	Ubiquitination	KEIEEYKKSVVSLKN HHHHHHHHHHHCCCC	47.80	23503661
300	Ubiquitination	KKSVVSLKNEEENEN HHHHHCCCCHHHCCC	55.60	23503661
313	Ubiquitination	ENSISQYKESVKRLL CCHHHHHHHHHHHHH	35.56	23503661
317	Ubiquitination	SQYKESVKRLLNVT- HHHHHHHHHHHCCC-	46.75	23503661

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RT35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RT35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RT35_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATC1_HUMAN	ATP6V1C1	physical	22939629
AT1B1_HUMAN	ATP1B1	physical	26344197
RT29_HUMAN	DAP3	physical	26344197
RT18B_HUMAN	MRPS18B	physical	26344197
RT23_HUMAN	MRPS23	physical	26344197
RT31_HUMAN	MRPS31	physical	26344197
RT05_HUMAN	MRPS5	physical	26344197
RT07_HUMAN	MRPS7	physical	26344197
RT09_HUMAN	MRPS9	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.