GLUCM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLUCM_HUMAN
• UniProt AC: Q7Z3D6
• Protein Name: D-glutamate cyclase, mitochondrial {ECO:0000305}
• Gene Name: DGLUCY {ECO:0000312|HGNC:HGNC:20498}
• Organism: Homo sapiens (Human).
• Sequence Length: 616
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline..
• Protein Sequence: MPFTLHLRSRLPSAIRSLILQKKPNIRNTSSMAGELRPASLVVLPRSLAPAFERFCQVNTGPLPLLGQSEPEKWMLPPQGAISETRMGHPQFWKYEFGACTGSLASLEQYSEQLKDMVAFFLGCSFSLEEALEKAGLPRRDPAGHSQTTVPCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLGGEQGQPVHMGDPELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTDLKDAKAPPGCLTPERIPEVHHISQDPLHYSIASVSASQKIRELESMIGIDPGNRGIGHLLCKDELLKASLSLSHARSVLITTGFPTHFNHEPPEETDGPPGAVALVAFLQALEKEVAIIVDQRAWNLHQKIVEDAVEQGVLKTQIPILTYQGGSVEAAQAFLCKNGDPQTPRFDHLVAIERAGRAADGNYYNARKMNIKHLVDPIDDLFLAAKKIPGISSTGVGDGGNELGMGKVKEAVRRHIRHGDVIACDVEADFAVIAGVSNWGGYALACALYILYSCAVHSQYLRKAVGPSRAPGDQAWTQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHNTHAEMIQKLVDVTTAQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	PFTLHLRSRLPSAIR CCEEHHHHCCHHHHH		28674151
13	Phosphorylation	HLRSRLPSAIRSLIL HHHHCCHHHHHHHHH		28674151
17	Phosphorylation	RLPSAIRSLILQKKP CCHHHHHHHHHHCCC		22673903
29	Phosphorylation	KKPNIRNTSSMAGEL CCCCCCCCCCCCCCC		-
30	Phosphorylation	KPNIRNTSSMAGELR CCCCCCCCCCCCCCC		24719451
40	Phosphorylation	AGELRPASLVVLPRS CCCCCCCEEEEEEHH		24719451
97 (in isoform 6)	Phosphorylation	-		24043423
98 (in isoform 6)	Phosphorylation	-		24043423
101 (in isoform 6)	Phosphorylation	-		24043423
111 (in isoform 6)	Phosphorylation	-		24043423
114 (in isoform 6)	Phosphorylation	-		24043423
116 (in isoform 6)	Phosphorylation	-		24043423
119 (in isoform 6)	Phosphorylation	-		24043423
123 (in isoform 6)	Phosphorylation	-		24043423
125	Phosphorylation	VAFFLGCSFSLEEAL HHHHHHCCCCHHHHH		25850435
127	Phosphorylation	FFLGCSFSLEEALEK HHHHCCCCHHHHHHH		25850435
203	Acetylation	DPELLGIKELSKPAY CHHHCCCCCCCCCCC		21339330
324	Phosphorylation	KDELLKASLSLSHAR HHHHHHHHHCHHHHH		-
326	Phosphorylation	ELLKASLSLSHARSV HHHHHHHCHHHHHHH		-
328	O-linked_Glycosylation	LKASLSLSHARSVLI HHHHHCHHHHHHHEE		29351928
473 (in isoform 2)	Ubiquitination	-		-
474 (in isoform 2)	Ubiquitination	-		-
475	Phosphorylation	KKIPGISSTGVGDGG HCCCCCCCCCCCCCC		24850871

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLUCM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLUCM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLUCM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
GLUCM_HUMAN	C14orf159	physical	27499296
MSRB2_HUMAN	MSRB2	physical	27499296
BOLA3_HUMAN	BOLA3	physical	27499296
ADT3_HUMAN	SLC25A6	physical	27499296

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.