MSRB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSRB2_HUMAN
• UniProt AC: Q9Y3D2
• Protein Name: Methionine-R-sulfoxide reductase B2, mitochondrial
• Gene Name: MSRB2
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Subcellular Localization: Mitochondrion .
• Protein Description: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance..
• Protein Sequence: MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLAKSEWQKKLTPEQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTSGSDESHTGILRRLDTSLGSARTEVVCKQCEAHLGHVFPDGPGPNGQRFCINSVALKFKPRKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	PGLGEAGSLATCELP CCCCCCCCEEECCCC	23.14	24275569
64	Phosphorylation	KLTPEQFYVTREKGT CCCHHHEEEECCCCC	10.70	27642862
71	Phosphorylation	YVTREKGTEPPFSGI EEECCCCCCCCCCCE	57.28	30206219
79	Phosphorylation	EPPFSGIYLNNKEAG CCCCCCEEECCCCCC	13.60	30206219
83	Acetylation	SGIYLNNKEAGMYHC CCEEECCCCCCEEEE	48.11	11922981
88	Phosphorylation	NNKEAGMYHCVCCDS CCCCCCEEEEEECCC	7.37	-
95	Phosphorylation	YHCVCCDSPLFSSEK EEEEECCCCCCCCCC	15.02	-
100	Phosphorylation	CDSPLFSSEKKYCSG CCCCCCCCCCCCCCC	46.21	-
120	Phosphorylation	FSEAHGTSGSDESHT HHHHHCCCCCCHHHH	40.67	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSRB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSRB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSRB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD8_HUMAN	NEDD8	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.