TRUB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRUB2_HUMAN
• UniProt AC: O95900
• Protein Name: Mitochondrial mRNA pseudouridine synthase TRUB2
• Gene Name: TRUB2
• Organism: Homo sapiens (Human).
• Sequence Length: 331
• Subcellular Localization: Mitochondrion matrix . Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly.
• Protein Description: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. [PubMed: 27974379 As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation]
• Protein Sequence: MGSAGLSRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLGPMEGSEEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERGAGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	TVELQLLKGLNARKP HHHHHHHHCCCCCCC	70.69	21890473
36	Ubiquitination	TVELQLLKGLNARKP HHHHHHHHCCCCCCC	70.69	21890473
80	Ubiquitination	PSFINHPLVCGPAFA CHHHCCCCCCCCCEE	3.76	-
136	Ubiquitination	TVRGLLGKATDDFRE CHHHHHCCCCCCCHH	48.35	-
150	Ubiquitination	EDGRLVEKTTYDHVT HCCCEEECCCCCHHH	38.39	-
180	Phosphorylation	QKALVMYSNLDLKTQ HHEEEEEECCCCCHH	16.90	20068231
186	Phosphorylation	YSNLDLKTQEAYEMA EECCCCCHHHHHHHH	38.65	24043423
190	Phosphorylation	DLKTQEAYEMAVRGL CCCHHHHHHHHHHHH	12.89	29496907
209	Phosphorylation	NKSPMLITGIRCLYF CCCCCEEECEEEEEE	23.69	24719451
240	Ubiquitination	KELRKLVHEIGLELK HHHHHHHHHHCCEEE	31.24	-
249	Ubiquitination	IGLELKTTAVCTQVR HCCEEECCEEECCCE	18.59	-
296	Ubiquitination	QVAAELEKSLSPGLD HHHHHHHHHCCCCCC	70.13	-
297	Phosphorylation	VAAELEKSLSPGLDT HHHHHHHHCCCCCCC	25.38	24961811
299	Phosphorylation	AELEKSLSPGLDTKQ HHHHHHCCCCCCCCC	24.82	25159151
305	Ubiquitination	LSPGLDTKQLPSPGW CCCCCCCCCCCCCCC	49.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRUB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRUB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRUB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FYCO1_HUMAN	FYCO1	physical	26186194
SYYM_HUMAN	YARS2	physical	26186194
ACAD8_HUMAN	ACAD8	physical	26186194
DCA10_HUMAN	DCAF10	physical	26186194
RM39_HUMAN	MRPL39	physical	26186194
TRUB2_HUMAN	TRUB2	physical	27499296
SPT20_HUMAN	SPATA20	physical	27499296
RCC1L_HUMAN	WBSCR16	physical	27499296
BOLA1_HUMAN	BOLA1	physical	27499296
UQCC1_HUMAN	UQCC1	physical	27499296
UQCC2_HUMAN	UQCC2	physical	27499296
NDK6_HUMAN	NME6	physical	27499296
FRIH_HUMAN	FTH1	physical	27499296
MTEF3_HUMAN	MTERF3	physical	27499296
CLPX_HUMAN	CLPX	physical	27499296
CLPB_HUMAN	CLPB	physical	27499296
RT35_HUMAN	MRPS35	physical	27499296
PREP_HUMAN	PITRM1	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
CYC_HUMAN	CYCS	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
NRDC_HUMAN	NRD1	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
TIM50_HUMAN	TIMM50	physical	27499296
FYCO1_HUMAN	FYCO1	physical	28514442
LAMP2_HUMAN	LAMP2	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
SYYM_HUMAN	YARS2	physical	28514442
DCA10_HUMAN	DCAF10	physical	28514442
RM39_HUMAN	MRPL39	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.