SPT20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPT20_HUMAN
• UniProt AC: Q8TB22
• Protein Name: Spermatogenesis-associated protein 20
• Gene Name: SPATA20
• Organism: Homo sapiens (Human).
• Sequence Length: 786
• Subcellular Localization: Secreted .
• Protein Description: May play a role in fertility regulation..
• Protein Sequence: MLGARAWLGRVLLLPRAGAGLAASRRGSSSRDKDRSATVSSSVPMPAGGKGSHPSSTPQRVPNRLIHEKSPYLLQHAYNPVDWYPWGQEAFDKARKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLSEDFVSVKVDREERPDVDKVYMTFVQATSSGGGWPMNVWLTPNLQPFVGGTYFPPEDGLTRVGFRTVLLRIREQWKQNKNTLLENSQRVTTALLARSEISVGDRQLPPSAATVNNRCFQQLDEGYDEEYGGFAEAPKFPTPVILSFLFSYWLSHRLTQDGSRAQQMALHTLKMMANGGIRDHVGQGFHRYSTDRQWHVPHFEKMLYDQAQLAVAYSQAFQLSGDEFYSDVAKGILQYVARSLSHRSGGFYSAEDADSPPERGQRPKEGAYYVWTVKEVQQLLPEPVLGATEPLTSGQLLMKHYGLTEAGNISPSQDPKGELQGQNVLTVRYSLELTAARFGLDVEAVRTLLNSGLEKLFQARKHRPKPHLDSKMLAAWNGLMVSGYAVTGAVLGQDRLINYATNGAKFLKRHMFDVASGRLMRTCYTGPGGTVEHSNPPCWGFLEDYAFVVRGLLDLYEASQESAWLEWALRLQDTQDKLFWDSQGGGYFCSEAELGAGLPLRLKDDQDGAEPSANSVSAHNLLRLHGFTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRALSAQQQTLKQIVICGDRQAKDTKALVQCVHSVYIPNKVLILADGDPSSFLSRQLPFLSTLRRLEDQATAYVCENQACSVPITDPCELRKLLHP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	AGAGLAASRRGSSSR CCCCCHHHCCCCCCC	19.53	24670416
39	Phosphorylation	DKDRSATVSSSVPMP CCCCCCCEECCCCCC	5.37	27251275
39 (in isoform 2)	Phosphorylation	-	5.37	28842319
52	Phosphorylation	MPAGGKGSHPSSTPQ CCCCCCCCCCCCCCC	35.39	29052541
55	Phosphorylation	GGKGSHPSSTPQRVP CCCCCCCCCCCCCCC	41.23	29052541
56	Phosphorylation	GKGSHPSSTPQRVPN CCCCCCCCCCCCCCC	48.86	29052541
57	Phosphorylation	KGSHPSSTPQRVPNR CCCCCCCCCCCCCCC	27.98	29052541
131	Phosphorylation	EEIGRLLSEDFVSVK HHHHHHHCCCEEEEE	39.45	30622161
537	Malonylation	NYATNGAKFLKRHMF HHHHHHHHHHHHHCC	53.26	26320211
619	Phosphorylation	WDSQGGGYFCSEAEL EECCCCCEECCHHHC	12.51	-
649	Phosphorylation	EPSANSVSAHNLLRL CCCCCCCCHHHHHHH	24.51	-
744	Phosphorylation	GDPSSFLSRQLPFLS CCHHHHHHHHCHHHH	18.90	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPT20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPT20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPT20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIA7D_HUMAN	ST6GALNAC4	physical	21988832
GDE_HUMAN	AGL	physical	26344197
SPT20_HUMAN	SPATA20	physical	27499296
NUDT8_HUMAN	NUDT8	physical	27499296
LYRM7_HUMAN	LYRM7	physical	27499296
GLSK_HUMAN	GLS	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
NDUAA_HUMAN	NDUFA10	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
CYC_HUMAN	CYCS	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
SYSM_HUMAN	SARS2	physical	27499296
GLRX5_HUMAN	GLRX5	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
ACPM_HUMAN	NDUFAB1	physical	27499296
RAVR2_HUMAN	RAVER2	physical	28514442
ZBT10_HUMAN	ZBTB10	physical	28514442
ZN566_HUMAN	ZNF566	physical	28514442
UBP47_HUMAN	USP47	physical	28514442
SCRN3_HUMAN	SCRN3	physical	28514442
FBW1A_HUMAN	BTRC	physical	28514442
RREB1_HUMAN	RREB1	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.