dbPTM

RREB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RREB1_HUMAN
UniProt AC	Q92766
Protein Name	Ras-responsive element-binding protein 1
Gene Name	RREB1
Organism	Homo sapiens (Human).
Sequence Length	1687
Subcellular Localization	Nucleus speckle .
Protein Description	Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1..
Protein Sequence	MTSSSPAGLEGSDLSSINTMMSAVMSVGKVTENGGSPQGIKSPSKPPGPNRIGRRNQETKEEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHSCSICGKSLSSASSLDRHMLVHSGERPYKCTVCGQSFTTNGNMHRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKKADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRKFPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEPLPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQILKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLLQSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFAFSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAELVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGPAEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPSSLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQLAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDSLGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKFSPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQVAGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGEAGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQRIHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPILATADGASQLVGME

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSSSPAGL ------CCCCCCCCC	48.93	20068231
3	Phosphorylation	-----MTSSSPAGLE -----CCCCCCCCCC	40.45	24719451
4	Phosphorylation	----MTSSSPAGLEG ----CCCCCCCCCCC	48.01	28857561
4 (in isoform 2)	Phosphorylation	-	48.01	27251275
5	Phosphorylation	---MTSSSPAGLEGS ---CCCCCCCCCCCC	20.66	29759185
12	Phosphorylation	SPAGLEGSDLSSINT CCCCCCCCCHHHHHH	26.46	28348404
15	Phosphorylation	GLEGSDLSSINTMMS CCCCCCHHHHHHHHH	33.88	28348404
16	Phosphorylation	LEGSDLSSINTMMSA CCCCCHHHHHHHHHH	27.44	28348404
19	Phosphorylation	SDLSSINTMMSAVMS CCHHHHHHHHHHHHH	16.75	20068231
22	Phosphorylation	SSINTMMSAVMSVGK HHHHHHHHHHHHHCE	13.59	20068231
26	Phosphorylation	TMMSAVMSVGKVTEN HHHHHHHHHCEECCC	22.56	20068231
31	Phosphorylation	VMSVGKVTENGGSPQ HHHHCEECCCCCCCC	27.50	23927012
31 (in isoform 2)	Phosphorylation	-	27.50	-
36	Phosphorylation	KVTENGGSPQGIKSP EECCCCCCCCCCCCC	18.56	29255136
36 (in isoform 2)	Phosphorylation	-	18.56	27251275
36 (in isoform 3)	Phosphorylation	-	18.56	21406692
36 (in isoform 4)	Phosphorylation	-	18.56	-
37 (in isoform 4)	Phosphorylation	-	39.43	-
39 (in isoform 4)	Phosphorylation	-	32.45	-
42	Phosphorylation	GSPQGIKSPSKPPGP CCCCCCCCCCCCCCC	32.27	25159151
42 (in isoform 2)	Phosphorylation	-	32.27	27251275
42 (in isoform 3)	Phosphorylation	-	32.27	21406692
44	Phosphorylation	PQGIKSPSKPPGPNR CCCCCCCCCCCCCCC	65.96	30266825
49 (in isoform 4)	Phosphorylation	-	32.47	-
52 (in isoform 4)	Phosphorylation	-	6.81	22210691
56 (in isoform 4)	Phosphorylation	-	42.55	22210691
107	Phosphorylation	SICGKSLSSASSLDR CCCCCCCCCCHHHCC	30.83	25159151
108	Phosphorylation	ICGKSLSSASSLDRH CCCCCCCCCHHHCCC	37.15	21815630
110	Phosphorylation	GKSLSSASSLDRHML CCCCCCCHHHCCCCE	33.12	28450419
111	Phosphorylation	KSLSSASSLDRHMLV CCCCCCHHHCCCCEE	33.72	21815630
120	O-linked_Glycosylation	DRHMLVHSGERPYKC CCCCEECCCCCCEEE	34.56	30379171
120	Phosphorylation	DRHMLVHSGERPYKC CCCCEECCCCCCEEE	34.56	20068231
120 (in isoform 2)	Phosphorylation	-	34.56	-
125	Phosphorylation	VHSGERPYKCTVCGQ ECCCCCCEEEEECCC	25.56	28985074
128	Phosphorylation	GERPYKCTVCGQSFT CCCCEEEEECCCEEE	18.06	20068231
133	Phosphorylation	KCTVCGQSFTTNGNM EEEECCCEEECCCCC	15.16	20068231
135	Phosphorylation	TVCGQSFTTNGNMHR EECCCEEECCCCCCC	25.30	20068231
136	Phosphorylation	VCGQSFTTNGNMHRH ECCCEEECCCCCCCE	38.83	20068231
153	Phosphorylation	IHEKDPNSATATAPP EECCCCCCCCCCCCC	32.17	23403867
155	Phosphorylation	EKDPNSATATAPPSP CCCCCCCCCCCCCCH	25.10	23927012
157	Phosphorylation	DPNSATATAPPSPLK CCCCCCCCCCCCHHH	35.03	23927012
161	Phosphorylation	ATATAPPSPLKRRRL CCCCCCCCHHHHHHH	41.63	29255136
161 (in isoform 2)	Phosphorylation	-	41.63	27251275
161 (in isoform 3)	Phosphorylation	-	41.63	21406692
175	Phosphorylation	LSSKRKLSHDAESER HHCCCCCCCCCHHCC	23.50	23401153
175 (in isoform 2)	Phosphorylation	-	23.50	27251275
180	Phosphorylation	KLSHDAESEREDPAP CCCCCCHHCCCCCCC	43.61	29255136
180 (in isoform 2)	Phosphorylation	-	43.61	27251275
203	Sumoylation	QSGDLEKKADEVFHC CCCCHHHHHHHEECC	52.25	28112733
225	Phosphorylation	VCKYGLETHMETHSD HHHHCHHHHHHHCCC	31.40	23663014
229	Phosphorylation	GLETHMETHSDNPLR CHHHHHHHCCCCCCC	21.07	30266825
229 (in isoform 2)	Phosphorylation	-	21.07	27251275
231	Phosphorylation	ETHMETHSDNPLRCD HHHHHHCCCCCCCCC	46.64	23401153
231 (in isoform 2)	Phosphorylation	-	46.64	-
347	Ubiquitination	AADQGQEKPQATPLP CCCCCCCCCCCCCCC	34.24	-
351	Phosphorylation	GQEKPQATPLPGDAL CCCCCCCCCCCCCCC	21.80	25159151
411	Phosphorylation	PGCTNLLSLSPFEAA CCCCCCCEECHHHHH	29.93	28348404
413	Phosphorylation	CTNLLSLSPFEAASL CCCCCEECHHHHHHC	24.94	28348404
413 (in isoform 2)	Phosphorylation	-	24.94	27251275
419	Phosphorylation	LSPFEAASLGGSLTV ECHHHHHHCCCCEEE	34.30	28348404
423	Phosphorylation	EAASLGGSLTVLPAT HHHHCCCCEEEEECC	21.04	28348404
435	Sumoylation	PATKDSIKHLSLQPF ECCHHHHHHCCCCCC	42.31	28112733
435	Ubiquitination	PATKDSIKHLSLQPF ECCHHHHHHCCCCCC	42.31	2189047
435 (in isoform 1)	Ubiquitination	-	42.31	21890473
435 (in isoform 2)	Ubiquitination	-	42.31	21890473
435 (in isoform 3)	Ubiquitination	-	42.31	21890473
438	Phosphorylation	KDSIKHLSLQPFQKG HHHHHHCCCCCCCCC	25.36	28555341
502	Sumoylation	APLQAIFKHMPPLKP HHHHHHHHCCCCCCC	32.64	28112733
508	Ubiquitination	FKHMPPLKPKPLVTP HHCCCCCCCCCCCCC	57.69	-
514	Phosphorylation	LKPKPLVTPRTVVAT CCCCCCCCCCEEEEE	18.09	24719451
517	Phosphorylation	KPLVTPRTVVATSTP CCCCCCCEEEEECCC	22.12	22210691
522	Phosphorylation	PRTVVATSTPPPLIN CCEEEEECCCCCCCC	29.22	27251275
523	Phosphorylation	RTVVATSTPPPLINA CEEEEECCCCCCCCC	35.14	24719451
523 (in isoform 2)	Phosphorylation	-	35.14	27251275
534	Phosphorylation	LINAQQASPGCISPS CCCCHHCCCCCCCCC	19.93	26657352
534 (in isoform 2)	Phosphorylation	-	19.93	27251275
539	Phosphorylation	QASPGCISPSLPPPP HCCCCCCCCCCCCCC	16.71	22210691
539 (in isoform 2)	Phosphorylation	-	16.71	27251275
541	Phosphorylation	SPGCISPSLPPPPLK CCCCCCCCCCCCCHH	46.87	22210691
551	Sumoylation	PPPLKLLKGSVEAAS CCCHHHCCCCHHHHH	60.62	-
551	Sumoylation	PPPLKLLKGSVEAAS CCCHHHCCCCHHHHH	60.62	28112733
566	Sumoylation	NAHLLQSKSGTQPHA HHHHHHCCCCCCCCH	39.69	28112733
566	Ubiquitination	NAHLLQSKSGTQPHA HHHHHHCCCCCCCCH	39.69	-
578	Phosphorylation	PHAATRLSLQQPRAE CCHHHCCCCCCCCCC	22.35	28555341
593	Sumoylation	LPGQPEMKTQLEQDS CCCCCCHHHHHCHHH	31.30	28112733
600	Phosphorylation	KTQLEQDSIIEALLP HHHHCHHHHHHHHHH	25.76	27251275
600 (in isoform 2)	Phosphorylation	-	25.76	27251275
613	Sumoylation	LPLSMEAKIKQEITE HHHCHHHHHHHHCCH	36.81	28112733
613	Ubiquitination	LPLSMEAKIKQEITE HHHCHHHHHHHHCCH	36.81	-
615	Sumoylation	LSMEAKIKQEITEGE HCHHHHHHHHCCHHH	40.97	-
615	Sumoylation	LSMEAKIKQEITEGE HCHHHHHHHHCCHHH	40.97	17000644
615	Ubiquitination	LSMEAKIKQEITEGE HCHHHHHHHHCCHHH	40.97	-
615 (in isoform 2)	Sumoylation	-	40.97	-
615 (in isoform 2)	Ubiquitination	-	40.97	-
624	Sumoylation	EITEGELKAFMTAPG HCCHHHHHHHEECCC	34.96	28112733
624	Ubiquitination	EITEGELKAFMTAPG HCCHHHHHHHEECCC	34.96	-
628	Phosphorylation	GELKAFMTAPGGKKT HHHHHHEECCCCCCC	24.21	20068231
628 (in isoform 2)	Phosphorylation	-	24.21	-
633	Acetylation	FMTAPGGKKTPAMRK HEECCCCCCCHHHHH	60.43	18585299
640	Ubiquitination	KKTPAMRKVLYPCRF CCCHHHHHHHHHHHH	24.41	-
640 (in isoform 2)	Ubiquitination	-	24.41	-
669	Phosphorylation	VRSHLGISPYQCNIC HHHHCCCCCCCCCHH	18.76	23898821
692	Phosphorylation	ALIRHLRTHSGERPY HHHHHHHHCCCCCCE	27.10	23312004
694	Phosphorylation	IRHLRTHSGERPYIC HHHHHHCCCCCCEEE	41.56	30576142
694 (in isoform 2)	Phosphorylation	-	41.56	27251275
699	Phosphorylation	THSGERPYICKICHY HCCCCCCEEEEECCC	25.77	23312004
706	Phosphorylation	YICKICHYPFTVKAN EEEEECCCCEEHHHH	8.81	25159151
763	Ubiquitination	RLCGEDLKHYRALRI HHHCCCCHHHHHHHH	51.41	-
763 (in isoform 2)	Ubiquitination	-	51.41	-
802	Ubiquitination	CSAAFAAKRNCIHHI HHHHHHHHHHHHHHH	40.49	-
802 (in isoform 2)	Ubiquitination	-	40.49	-
848	Phosphorylation	ASGRGEDSGCAALGD HCCCCCCCCCCCCCC	31.31	25159151
857	Sumoylation	CAALGDCKPLTAFLE CCCCCCCCCCCEEEC	48.04	28112733
885	Sumoylation	PPPHVSIKLEPASSF CCCCEEEEEEECCEE	39.01	-
885	Sumoylation	PPPHVSIKLEPASSF CCCCEEEEEEECCEE	39.01	17000644
885 (in isoform 2)	Sumoylation	-	39.01	-
913	Sumoylation	GLALVQVKQENISFL CEEEEEEEECCCEEC	34.50	-
913	Sumoylation	GLALVQVKQENISFL CEEEEEEEECCCEEC	34.50	17000644
913 (in isoform 2)	Sumoylation	-	34.50	-
918	Phosphorylation	QVKQENISFLSPSSL EEEECCCEECCHHHC	31.55	28348404
921	Phosphorylation	QENISFLSPSSLVPY ECCCEECCHHHCCCC	22.26	28348404
923	Phosphorylation	NISFLSPSSLVPYDC CCEECCHHHCCCCCC	32.69	28348404
924	Phosphorylation	ISFLSPSSLVPYDCS CEECCHHHCCCCCCC	36.45	28348404
928	Phosphorylation	SPSSLVPYDCSMEPI CHHHCCCCCCCCCCC	23.31	27251275
931	Phosphorylation	SLVPYDCSMEPIDLS HCCCCCCCCCCCCCC	24.23	28348404
931 (in isoform 2)	Phosphorylation	-	24.23	27251275
938	Phosphorylation	SMEPIDLSIPKNFRK CCCCCCCCCCCCCCC	32.85	24719451
948	Acetylation	KNFRKGDKDLATPSE CCCCCCCCCCCCHHH	64.41	25953088
952	Phosphorylation	KGDKDLATPSEAKKP CCCCCCCCHHHCCCH	34.34	21815630
965	Phosphorylation	KPEEEAGSSEQPSPC CHHHHCCCCCCCCCC	37.44	26074081
966	Phosphorylation	PEEEAGSSEQPSPCP HHHHCCCCCCCCCCC	39.06	26074081
970	Phosphorylation	AGSSEQPSPCPAPGP CCCCCCCCCCCCCCC	38.54	26074081
1025	Phosphorylation	IYSSALVSSPPLVGS ECCHHHCCCCCCCCC	37.67	26074081
1026	Phosphorylation	YSSALVSSPPLVGSS CCHHHCCCCCCCCCH	24.06	26074081
1085	Acetylation	APTLLKTKVADPGPA CCCCCCCCCCCCCCC	33.56	26051181
1085	Ubiquitination	APTLLKTKVADPGPA CCCCCCCCCCCCCCC	33.56	-
1094	O-linked_Glycosylation	ADPGPASTGSNTTAS CCCCCCCCCCCCCCC	46.89	30379171
1094	Phosphorylation	ADPGPASTGSNTTAS CCCCCCCCCCCCCCC	46.89	27251275
1096	Phosphorylation	PGPASTGSNTTASDS CCCCCCCCCCCCCHH	30.96	27251275
1098	Phosphorylation	PASTGSNTTASDSLG CCCCCCCCCCCHHCC	25.99	28555341
1099	Phosphorylation	ASTGSNTTASDSLGG CCCCCCCCCCHHCCC	28.54	27251275
1101	Phosphorylation	TGSNTTASDSLGGSV CCCCCCCCHHCCCCC	26.16	27251275
1101 (in isoform 2)	Phosphorylation	-	26.16	27251275
1103	Phosphorylation	SNTTASDSLGGSVPK CCCCCCHHCCCCCCC	26.81	25159151
1103 (in isoform 2)	Phosphorylation	-	26.81	-
1107	Phosphorylation	ASDSLGGSVPKAATT CCHHCCCCCCCCCCC	33.19	25159151
1113	Phosphorylation	GSVPKAATTATPAAT CCCCCCCCCCCCCCC	23.09	23403867
1114	Phosphorylation	SVPKAATTATPAATT CCCCCCCCCCCCCCC	24.65	23403867
1116	Phosphorylation	PKAATTATPAATTSP CCCCCCCCCCCCCCC	16.03	28176443
1120	Phosphorylation	TTATPAATTSPKESS CCCCCCCCCCCCCCC	29.88	23401153
1120 (in isoform 2)	Phosphorylation	-	29.88	-
1120 (in isoform 3)	Phosphorylation	-	29.88	21406692
1121	Phosphorylation	TATPAATTSPKESSE CCCCCCCCCCCCCCC	38.00	30266825
1121 (in isoform 2)	Phosphorylation	-	38.00	27251275
1121 (in isoform 3)	Phosphorylation	-	38.00	21406692
1122	Phosphorylation	ATPAATTSPKESSEP CCCCCCCCCCCCCCC	29.62	30266825
1122 (in isoform 2)	Phosphorylation	-	29.62	-
1122 (in isoform 3)	Phosphorylation	-	29.62	21406692
1126	Phosphorylation	ATTSPKESSEPPAPA CCCCCCCCCCCCCCC	46.24	28450419
1127	Phosphorylation	TTSPKESSEPPAPAS CCCCCCCCCCCCCCC	56.04	28450419
1134	Phosphorylation	SEPPAPASSPEAASP CCCCCCCCCCCCCCC	45.42	25159151
1134 (in isoform 2)	Phosphorylation	-	45.42	27251275
1135	Phosphorylation	EPPAPASSPEAASPT CCCCCCCCCCCCCCC	28.94	25159151
1135 (in isoform 2)	Phosphorylation	-	28.94	27251275
1140	Phosphorylation	ASSPEAASPTEQGPA CCCCCCCCCCCCCCC	39.13	25159151
1140 (in isoform 2)	Phosphorylation	-	39.13	27251275
1142	Phosphorylation	SPEAASPTEQGPAGT CCCCCCCCCCCCCCC	38.14	23663014
1149	Phosphorylation	TEQGPAGTSKKRGRK CCCCCCCCCCCCCCC	39.21	23663014
1150	Phosphorylation	EQGPAGTSKKRGRKR CCCCCCCCCCCCCCC	34.95	23663014
1161	Phosphorylation	GRKRGMRSRPRANSG CCCCCCCCCCCCCCC	37.43	-
1167	Phosphorylation	RSRPRANSGGVDLDS CCCCCCCCCCCCCCC	35.62	19664994
1167 (in isoform 2)	Phosphorylation	-	35.62	27251275
1167 (in isoform 3)	Phosphorylation	-	35.62	21406692
1174	Phosphorylation	SGGVDLDSSGEFASI CCCCCCCCCCCCCHH	47.76	23927012
1174 (in isoform 2)	Phosphorylation	-	47.76	27251275
1175	Phosphorylation	GGVDLDSSGEFASIE CCCCCCCCCCCCHHH	41.85	23927012
1175 (in isoform 2)	Phosphorylation	-	41.85	27251275
1180	Phosphorylation	DSSGEFASIEKMLAT CCCCCCCHHHHHHHC	36.28	23927012
1187	Phosphorylation	SIEKMLATTDTNKFS HHHHHHHCCCCCCCC	22.65	22468782
1190	Phosphorylation	KMLATTDTNKFSPFL HHHHCCCCCCCCHHH	37.91	22468782
1194	Phosphorylation	TTDTNKFSPFLQTAE CCCCCCCCHHHHCCC	19.15	20873877
1199	Phosphorylation	KFSPFLQTAEDNTQD CCCHHHHCCCCCCCC	33.87	28450419
1204	Phosphorylation	LQTAEDNTQDEVAGA HHCCCCCCCCCCCCC	50.12	23927012
1219	Phosphorylation	PADHHGPSDEEQGSP CCCCCCCCCCCCCCC	63.35	23401153
1219 (in isoform 2)	Phosphorylation	-	63.35	27251275
1225	Phosphorylation	PSDEEQGSPPEDKLL CCCCCCCCCCHHHHH	36.66	23927012
1225 (in isoform 2)	Phosphorylation	-	36.66	27251275
1238	Phosphorylation	LLRAKRNSYTNCLQK HHHHHHHHHCCHHHH	37.05	25849741
1238 (in isoform 2)	Phosphorylation	-	37.05	27251275
1239	Phosphorylation	LRAKRNSYTNCLQKI HHHHHHHHCCHHHHC	12.91	28450419
1240	Phosphorylation	RAKRNSYTNCLQKIT HHHHHHHCCHHHHCC	21.19	30108239
1260	Phosphorylation	RVFPWASSLQRHMLT CCCCCHHHHHHHHHH	22.30	28555341
1267	Phosphorylation	SLQRHMLTHTDSQSD HHHHHHHHCCCCHHH	18.36	30576142
1269	Phosphorylation	QRHMLTHTDSQSDAE HHHHHHCCCCHHHHH	31.91	30576142
1271	Phosphorylation	HMLTHTDSQSDAETA HHHHCCCCHHHHHHH	32.51	30576142
1273	Phosphorylation	LTHTDSQSDAETAAA HHCCCCHHHHHHHHH	42.62	30108239
1277	Phosphorylation	DSQSDAETAAAAGEV CCHHHHHHHHHHHHH	24.26	30576142
1300 (in isoform 2)	Phosphorylation	-	46.54	-
1300 (in isoform 3)	Phosphorylation	-	46.54	-
1301 (in isoform 2)	Phosphorylation	-	41.23	-
1301 (in isoform 3)	Phosphorylation	-	41.23	-
1303 (in isoform 2)	Phosphorylation	-	23.77	-
1303 (in isoform 3)	Phosphorylation	-	23.77	-
1313 (in isoform 2)	Phosphorylation	-	44.22	-
1313 (in isoform 3)	Phosphorylation	-	44.22	-
1315	Phosphorylation	DAPVEQATAETASPV CCCHHHHHCCCCCCC	25.40	29255136
1316 (in isoform 2)	Phosphorylation	-	18.37	22210691
1318	Phosphorylation	VEQATAETASPVHRE HHHHHCCCCCCCCHH	29.94	30266825
1320	Phosphorylation	QATAETASPVHREEH HHHCCCCCCCCHHHC	34.57	29255136
1320 (in isoform 2)	Phosphorylation	-	34.57	22210691
1370 (in isoform 2)	Phosphorylation	-	6.41	21406692
1373 (in isoform 2)	Phosphorylation	-	42.39	21406692
1374 (in isoform 3)	Phosphorylation	-	5.46	21406692
1375 (in isoform 2)	Phosphorylation	-	21.22	21406692
1381 (in isoform 3)	Phosphorylation	-	20.75	21406692
1387 (in isoform 3)	Phosphorylation	-	18.28	21406692
1388	Phosphorylation	AGAGGAASQEQKLAC CCCCCCCCHHHHHHC	33.44	17525332
1397	Phosphorylation	EQKLACDTCGKSFKF HHHHHCCCCCCHHHH	24.04	23312004
1398 (in isoform 3)	Phosphorylation	-	4.05	21406692
1400	Acetylation	LACDTCGKSFKFLGT HHCCCCCCHHHHHHH	55.66	25953088
1401	Phosphorylation	ACDTCGKSFKFLGTL HCCCCCCHHHHHHHH	20.96	23312004
1404 (in isoform 3)	Phosphorylation	-	7.78	21406692
1407	Phosphorylation	KSFKFLGTLSRHRKA CHHHHHHHHHHHHHH	24.57	-
1409	Phosphorylation	FKFLGTLSRHRKAHG HHHHHHHHHHHHHHC	26.36	23186163
1443 (in isoform 2)	Phosphorylation	-	71.24	-
1455	Phosphorylation	TPAEVVESAPGAGEA CCHHHHHCCCCCCCC	28.31	22798277
1471	Phosphorylation	AEKLAEETEGPSDGE HHHHHHHCCCCCCCH	37.43	23927012
1475	Phosphorylation	AEETEGPSDGESAAE HHHCCCCCCCHHHHH	69.93	23401153
1479	Phosphorylation	EGPSDGESAAEKRSS CCCCCCHHHHHHHHC	38.00	23927012
1486	Phosphorylation	SAAEKRSSEKSDDDK HHHHHHHCCCCCCCC	53.74	28985074
1489	Phosphorylation	EKRSSEKSDDDKKPK HHHHCCCCCCCCCCC	42.07	19664994
1497	Phosphorylation	DDDKKPKTDSPKSVA CCCCCCCCCCHHHHH	50.68	25262027
1499	Phosphorylation	DKKPKTDSPKSVASK CCCCCCCCHHHHHHH	39.19	26055452
1502	Phosphorylation	PKTDSPKSVASKADK CCCCCHHHHHHHHHH	26.71	26055452
1505	Phosphorylation	DSPKSVASKADKRKK CCHHHHHHHHHHHHC	26.65	25262027
1526 (in isoform 2)	Phosphorylation	-	56.13	21406692
1528	O-linked_Glycosylation	FWSLQDLTRHMRSHT HHCHHHHHHHHHHHC	27.15	30379171
1530 (in isoform 2)	Phosphorylation	-	15.69	21406692
1533	Phosphorylation	DLTRHMRSHTGERPY HHHHHHHHHCCCCCC	20.16	24719451
1534 (in isoform 2)	Phosphorylation	-	27.76	27251275
1535	Phosphorylation	TRHMRSHTGERPYKC HHHHHHHCCCCCCCC	41.82	28985074
1544	Phosphorylation	ERPYKCQTCERTFTL CCCCCCCCCCCEEEE	26.29	-
1544 (in isoform 2)	Phosphorylation	-	26.29	-
1548	Phosphorylation	KCQTCERTFTLKHSL CCCCCCCEEEECHHH	9.93	-
1550	Phosphorylation	QTCERTFTLKHSLVR CCCCCEEEECHHHHH	33.99	-
1554	Phosphorylation	RTFTLKHSLVRHQRI CEEEECHHHHHHHHH	27.29	-
1575	Phosphorylation	AKHHGKDSDKEERGE HHHCCCCCCHHHCCC	54.81	23186163
1585	Phosphorylation	EERGEEDSENESTHS HHCCCCCCCCCCCCC	45.67	20873877
1589	Phosphorylation	EEDSENESTHSGNNA CCCCCCCCCCCCCCC	42.90	20873877
1590	Phosphorylation	EDSENESTHSGNNAV CCCCCCCCCCCCCCC	17.55	30278072
1590 (in isoform 2)	Phosphorylation	-	17.55	27251275
1592	Phosphorylation	SENESTHSGNNAVSE CCCCCCCCCCCCCCC	43.22	30278072
1598	Phosphorylation	HSGNNAVSENEAELA CCCCCCCCCCHHHHC	32.09	30278072
1609	Phosphorylation	AELAPNASNHMAVTR HHHCCCCCCCCEECC	33.63	30278072
1615	Phosphorylation	ASNHMAVTRSRKEGL CCCCCEECCHHHHHH	17.25	20873877
1624	Phosphorylation	SRKEGLASATKDCSH HHHHHHHHCCCCCCC	41.32	25159151
1637	Phosphorylation	SHREEKVTAGWPSEP CCCCCCCCCCCCCCC	30.44	28176443
1640 (in isoform 2)	Phosphorylation	-	7.26	-
1642	Phosphorylation	KVTAGWPSEPGQGDL CCCCCCCCCCCCCCC	50.33	28176443
1653	Phosphorylation	QGDLNPESPAALGQD CCCCCCCCHHHHCCC	22.54	15067362
1666	Phosphorylation	QDLLEPRSKRPAHPI CCCCCCCCCCCCCCE	43.67	20860994
1676	Phosphorylation	PAHPILATADGASQL CCCCEEEECCCHHHH	23.10	23312004
1681	Phosphorylation	LATADGASQLVGME- EEECCCHHHHCCCC-	29.58	23312004
1708 (in isoform 2)	Phosphorylation	-		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RREB1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RREB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RREB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANDR_HUMAN	AR	physical	17550981
H31T_HUMAN	HIST3H3	physical	12700765
HDAC3_HUMAN	HDAC3	physical	23752268
ARL6_HUMAN	ARL6	physical	27173435
NEK7_HUMAN	NEK7	physical	27173435
TOIP2_HUMAN	TOR1AIP2	physical	27173435
IFG15_HUMAN	TOR1AIP2	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RREB1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1167; SER-1174 ANDSER-1175, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1122, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-42; SER-231;SER-1167; SER-1174; SER-1175; SER-1219; SER-1225; THR-1315 ANDSER-1653, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1388, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1167, AND MASSSPECTROMETRY.	15302935 [Abstract]