ARL6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL6_HUMAN
• UniProt AC: Q9H0F7
• Protein Name: ADP-ribosylation factor-like protein 6
• Gene Name: ARL6
• Organism: Homo sapiens (Human).
• Sequence Length: 186
• Subcellular Localization: Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Appears in a pattern of punctae flanking the microtubule axoneme that likely corresp
• Protein Description: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. [PubMed: 20603001 Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation]
• Protein Sequence: MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKHRRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQIQTVKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGLLDRLSV ------CCHHHHHHH	34.64	-
14	Acetylation	LSVLLGLKKKEVHVL HHHHHCCCCCEEEEE	61.06	25953088
28	Phosphorylation	LCLGLDNSGKTTIIN EEEEECCCCCEEEEE	41.14	30243723
44	Phosphorylation	LKPSNAQSQNILPTI CCCCCCCCCCCCCCC	23.84	28348404
76	Phosphorylation	DMSGQGRYRNLWEHY ECCCCCCCHHHHHHH	15.63	30622161
83	Phosphorylation	YRNLWEHYYKEGQAI CHHHHHHHHHCCCEE	12.52	30622161
84	Phosphorylation	RNLWEHYYKEGQAII HHHHHHHHHCCCEEE	12.41	30622161
106	Acetylation	RLRMVVAKEELDTLL CEEEEEEHHHHHHHH	39.86	26822725
119	Acetylation	LLNHPDIKHRRIPIL HHCCCCCCCCCCCEE	38.14	25953088
142	Ubiquitination	RDAVTSVKVSQLLCL HHHHHHCCHHHHHHH	35.62	-
148	S-nitrosocysteine	VKVSQLLCLENIKDK CCHHHHHHHHCCCCC	6.44	-
148	S-nitrosylation	VKVSQLLCLENIKDK CCHHHHHHHHCCCCC	6.44	19483679
185	Ubiquitination	QDQIQTVKT------ HHHHHHCCC------	52.48	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRAF3_HUMAN	ARL6IP5	physical	10508919
AR6P4_HUMAN	ARL6IP4	physical	10508919
AR6P1_HUMAN	ARL6IP1	physical	10508919
ATLA2_HUMAN	ATL2	physical	10508919
AR6P6_HUMAN	ARL6IP6	physical	10508919
SC61B_HUMAN	SEC61B	physical	10508919
SNUT1_HUMAN	SART1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• H00418: Bardet-Biedl syndrome (BBS)
• H00527: Retinitis pigmentosa (RP)
• OMIM Disease
• 600151: Bardet-Biedl syndrome 3 (BBS3)
• 613575: Retinitis pigmentosa 55 (RP55)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.