dbPTM

SC61B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SC61B_HUMAN
UniProt AC	P60468
Protein Name	Protein transport protein Sec61 subunit beta
Gene Name	SEC61B
Organism	Homo sapiens (Human).
Sequence Length	96
Subcellular Localization	Endoplasmic reticulum membrane Single-pass membrane protein.
Protein Description	Necessary for protein translocation in the endoplasmic reticulum..
Protein Sequence	MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MPGPTPSGT ------CCCCCCCCC	58.43	21406692
5	Phosphorylation	---MPGPTPSGTNVG ---CCCCCCCCCCCC	35.68	29255136
7	Phosphorylation	-MPGPTPSGTNVGSS -CCCCCCCCCCCCCC	61.81	29255136
9	Phosphorylation	PGPTPSGTNVGSSGR CCCCCCCCCCCCCCC	30.94	29255136
13	Phosphorylation	PSGTNVGSSGRSPSK CCCCCCCCCCCCHHH	25.90	29255136
13	O-linked_Glycosylation	PSGTNVGSSGRSPSK CCCCCCCCCCCCHHH	25.90	28510447
14	Phosphorylation	SGTNVGSSGRSPSKA CCCCCCCCCCCHHHH	32.09	29255136
14	O-linked_Glycosylation	SGTNVGSSGRSPSKA CCCCCCCCCCCHHHH	32.09	28510447
17	Phosphorylation	NVGSSGRSPSKAVAA CCCCCCCCHHHHHHH	36.73	29255136
19	Phosphorylation	GSSGRSPSKAVAARA CCCCCCHHHHHHHHH	34.20	22167270
20	Ubiquitination	SSGRSPSKAVAARAA CCCCCHHHHHHHHHC	50.71	24816145
29	Phosphorylation	VAARAAGSTVRQRKN HHHHHCCCCHHHHCC	21.00	29900121
30	Phosphorylation	AARAAGSTVRQRKNA HHHHCCCCHHHHCCC	20.84	23403867
38	Phosphorylation	VRQRKNASCGTRSAG HHHHCCCCCCCCCCC	23.60	24719451
39	S-palmitoylation	RQRKNASCGTRSAGR HHHCCCCCCCCCCCC	6.32	21044946
43	Phosphorylation	NASCGTRSAGRTTSA CCCCCCCCCCCCCCC	34.61	22199227
47	Phosphorylation	GTRSAGRTTSAGTGG CCCCCCCCCCCCCCC	24.96	23403867
48	Phosphorylation	TRSAGRTTSAGTGGM CCCCCCCCCCCCCCC	18.41	23403867
49	Phosphorylation	RSAGRTTSAGTGGMW CCCCCCCCCCCCCCE	24.88	26846344
52	Phosphorylation	GRTTSAGTGGMWRFY CCCCCCCCCCCEEEE	30.22	23403867
59	Phosphorylation	TGGMWRFYTEDSPGL CCCCEEEEECCCCCC	10.72	28152594
59	Nitration	TGGMWRFYTEDSPGL CCCCEEEEECCCCCC	10.72	-
60	Phosphorylation	GGMWRFYTEDSPGLK CCCEEEEECCCCCCC	30.51	28152594
63	Phosphorylation	WRFYTEDSPGLKVGP EEEEECCCCCCCCCC	18.03	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SC61B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SC61B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SC61B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APOB_HUMAN	APOB	physical	9565615
BAG6_HUMAN	BAG6	physical	20676083
GET4_HUMAN	GET4	physical	20676083
UBL4A_HUMAN	UBL4A	physical	20676083
ASNA_HUMAN	ASNA1	physical	20676083
BAP31_HUMAN	BCAP31	physical	18555783
EGFR_HUMAN	EGFR	physical	19602593
S61A1_HUMAN	SEC61A1	physical	9585408
SPC25_HUMAN	SPC25	physical	9585408
SC61B_HUMAN	SEC61B	physical	9585408
RAGE_HUMAN	AGER	physical	10601334
SGTA_HUMAN	SGTA	physical	23533635
SGTA_HUMAN	SGTA	physical	20516149
CALX_HUMAN	CANX	physical	26344197
LTN1_HUMAN	LTN1	physical	25877867
SSRA_HUMAN	SSR1	physical	25877867
RL6_HUMAN	RPL6	physical	25877867
RS9_HUMAN	RPS9	physical	25877867
S61A1_HUMAN	SEC61A1	physical	26085089

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SC61B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5; SER-7; SER-14 ANDSER-17, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5; SER-14; SER-17 ANDSER-19, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-14 AND SER-17,AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-19; SER-29 ANDTHR-30, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.	16083285 [Abstract]