GET4_HUMAN - dbPTM
GET4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GET4_HUMAN
UniProt AC Q7L5D6
Protein Name Golgi to ER traffic protein 4 homolog {ECO:0000305}
Gene Name GET4 {ECO:0000312|HGNC:HGNC:21690}
Organism Homo sapiens (Human).
Sequence Length 327
Subcellular Localization Cytoplasm, cytosol .
Protein Description As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. [PubMed: 20676083]
Protein Sequence MAAAAAMAEQESARNGGRNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHTEARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVEVADELLENLAKVFSLMDPNSPERVTFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSADGEGCANMLVEYSTSRGFRSEVDMFVAQAVLQFLCLKNKSSASVVFTTYTQKHPSIEDGPPFVEPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLTSLMGSSEQEDGEESPSDGSPIELD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAAAAMAE
------CHHHHHHHH		13.0522223895
12PhosphorylationAAMAEQESARNGGRN
HHHHHHHHHHCCCCC		32.0214702039
33PhosphorylationVEGKLRASVEKGDYY
EECEEEEHHCCCCHH		25.1124719451
36AcetylationKLRASVEKGDYYEAH
EEEEHHCCCCHHHHH		55.7323236377
36UbiquitinationKLRASVEKGDYYEAH
EEEEHHCCCCHHHHH		55.7324816145
39PhosphorylationASVEKGDYYEAHQMY
EHHCCCCHHHHHHHH		16.33-
58UbiquitinationFRYMSQSKHTEAREL
HHHHHCCCCHHHHHH		47.0830230243
115SulfoxidationLAKVFSLMDPNSPER
HHHHHHHCCCCCHHH		8.5721406390
131UbiquitinationTFVSRALKWSSGGSG
HEEEEEHHCCCCCCC		44.0029967540
139UbiquitinationWSSGGSGKLGHPRLH
CCCCCCCCCCCHHHH		53.6529967540
210PhosphorylationFLCLKNKSSASVVFT
HHHHCCCCCCEEEEE		40.30-
211PhosphorylationLCLKNKSSASVVFTT
HHHCCCCCCEEEEEE		26.60-
213PhosphorylationLKNKSSASVVFTTYT
HCCCCCCEEEEEEEC		22.29-
291PhosphorylationFGVPPKQTSSYGGLL
HCCCCCCCCCHHHHH		26.2621406692
292PhosphorylationGVPPKQTSSYGGLLG
CCCCCCCCCHHHHHH		21.0421406692
293PhosphorylationVPPKQTSSYGGLLGN
CCCCCCCCHHHHHHH		31.0521406692
294PhosphorylationPPKQTSSYGGLLGNL
CCCCCCCHHHHHHHH		18.2521406692
303PhosphorylationGLLGNLLTSLMGSSE
HHHHHHHHHHHCCCC		23.9921406692
304PhosphorylationLLGNLLTSLMGSSEQ
HHHHHHHHHHCCCCC		19.1421406692
308PhosphorylationLLTSLMGSSEQEDGE
HHHHHHCCCCCCCCC		19.4121406692
309PhosphorylationLTSLMGSSEQEDGEE
HHHHHCCCCCCCCCC		37.2521406692
317PhosphorylationEQEDGEESPSDGSPI
CCCCCCCCCCCCCCC		25.9625159151
319PhosphorylationEDGEESPSDGSPIEL
CCCCCCCCCCCCCCC		64.9821406692
322PhosphorylationEESPSDGSPIELD--
CCCCCCCCCCCCC--		27.9125159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GET4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GET4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GET4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDN1A_HUMANCDKN1Aphysical
16169070
GLU2B_HUMANPRKCSHphysical
16169070
CPNS1_HUMANCAPNS1physical
16169070
PLK1_HUMANPLK1physical
16169070
TTHY_HUMANTTRphysical
16169070
KAT5_HUMANKAT5physical
16169070
EF1G_HUMANEEF1Gphysical
16169070
CE126_HUMANKIAA1377physical
16169070
EXOC2_HUMANEXOC2physical
22939629
FAF2_HUMANFAF2physical
23665563
BAG6_HUMANBAG6physical
23665563
MTA2_HUMANMTA2physical
22863883
LSM8_HUMANLSM8physical
22863883
RABE2_HUMANRABEP2physical
22863883
BAG6_HUMANBAG6physical
25535373
UBL4A_HUMANUBL4Aphysical
26186194
BAG6_HUMANBAG6physical
26186194
ASNA_HUMANASNA1physical
26186194
AAKB2_HUMANPRKAB2physical
21516116
UBL4A_HUMANUBL4Aphysical
28514442
BAG6_HUMANBAG6physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GET4_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.

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