dbPTM

AR6P6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AR6P6_HUMAN
UniProt AC	Q8N6S5
Protein Name	ADP-ribosylation factor-like protein 6-interacting protein 6
Gene Name	ARL6IP6
Organism	Homo sapiens (Human).
Sequence Length	226
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MSFAESGWRSALRRRGPGTPGPVARPSYSSFTQGDSWGEGEVDEEEGCDQVARDLRAEFSAGAWSEPRKRSVLPPDGNGSPVLPDKRNGIFPAAAGSRAQPRRWPVQVLSILCSLLFAILLAFLLAIAYLIVKELHAENLKNEDDVDTGLLGFWTLLIISLTAGFSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKKLTGHSFHMGYSMAILNGIVAALTVAWCLM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFAESGWR ------CCHHHHHHH	32.91	23401153
6	Phosphorylation	--MSFAESGWRSALR --CCHHHHHHHHHHH	39.98	22199227
10	Phosphorylation	FAESGWRSALRRRGP HHHHHHHHHHHHHCC	25.75	22199227
19	Phosphorylation	LRRRGPGTPGPVARP HHHHCCCCCCCCCCC	28.36	23401153
27	Phosphorylation	PGPVARPSYSSFTQG CCCCCCCCCCCCCCC	31.90	28450419
28	Phosphorylation	GPVARPSYSSFTQGD CCCCCCCCCCCCCCC	15.83	28450419
29	Phosphorylation	PVARPSYSSFTQGDS CCCCCCCCCCCCCCC	24.26	28450419
30	Phosphorylation	VARPSYSSFTQGDSW CCCCCCCCCCCCCCC	24.87	28450419
32	Phosphorylation	RPSYSSFTQGDSWGE CCCCCCCCCCCCCCC	33.32	28450419
36	Phosphorylation	SSFTQGDSWGEGEVD CCCCCCCCCCCCCCC	43.75	23927012
48	S-palmitoylation	EVDEEEGCDQVARDL CCCCCCCHHHHHHHH	3.60	29575903
60	Phosphorylation	RDLRAEFSAGAWSEP HHHHHHHHCCCCCCC	19.80	30266825
65	Phosphorylation	EFSAGAWSEPRKRSV HHHCCCCCCCCCCCC	36.87	30266825
71	Phosphorylation	WSEPRKRSVLPPDGN CCCCCCCCCCCCCCC	30.92	30266825
80	Phosphorylation	LPPDGNGSPVLPDKR CCCCCCCCCCCCCCC	18.81	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AR6P6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AR6P6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AR6P6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
YKT6_HUMAN	YKT6	physical	26186194
DUS3_HUMAN	DUSP3	physical	26186194
PNPO_HUMAN	PNPO	physical	26186194
BLVRB_HUMAN	BLVRB	physical	26186194
GSTM1_HUMAN	GSTM1	physical	26186194
PEBB_HUMAN	CBFB	physical	26186194
PMVK_HUMAN	PMVK	physical	26186194
NAA50_HUMAN	NAA50	physical	26186194
UB2D2_HUMAN	UBE2D2	physical	26186194
PYGB_HUMAN	PYGB	physical	26186194
SNX3_HUMAN	SNX3	physical	26186194
PNPO_HUMAN	PNPO	physical	28514442
DUS3_HUMAN	DUSP3	physical	28514442
PMVK_HUMAN	PMVK	physical	28514442
SNX3_HUMAN	SNX3	physical	28514442
GSTM1_HUMAN	GSTM1	physical	28514442
NAA50_HUMAN	NAA50	physical	28514442
CHM4A_HUMAN	CHMP4A	physical	28514442
PEBB_HUMAN	CBFB	physical	28514442
YKT6_HUMAN	YKT6	physical	28514442
BLVRB_HUMAN	BLVRB	physical	28514442
BID_HUMAN	BID	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AR6P6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-65, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-36; SER-65 ANDSER-80, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19, AND MASSSPECTROMETRY.	19007248 [Abstract]