BLVRB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BLVRB_HUMAN
• UniProt AC: P30043
• Protein Name: Flavin reductase (NADPH)
• Gene Name: BLVRB
• Organism: Homo sapiens (Human).
• Sequence Length: 206
• Subcellular Localization: Cytoplasm .
• Protein Description: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin..
• Protein Sequence: MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	VTVLVRDSSRLPSEG EEEEEECCCCCCCCC	13.54	28787133
38	Phosphorylation	TVLVRDSSRLPSEGP EEEEECCCCCCCCCC	41.97	20873877
42	Phosphorylation	RDSSRLPSEGPRPAH ECCCCCCCCCCCCCE	60.83	29496963
64	Phosphorylation	QAADVDKTVAGQDAV HHCCCCCCCCCCCEE	15.89	20068231
77	Phosphorylation	AVIVLLGTRNDLSPT EEEEEECCCCCCCCC	26.69	20068231
82	Phosphorylation	LGTRNDLSPTTVMSE ECCCCCCCCCCCCCH	24.06	23401153
84	Phosphorylation	TRNDLSPTTVMSEGA CCCCCCCCCCCCHHH	28.75	21406692
85	Phosphorylation	RNDLSPTTVMSEGAR CCCCCCCCCCCHHHH	20.00	21406692
87	Sulfoxidation	DLSPTTVMSEGARNI CCCCCCCCCHHHHHH	2.57	30846556
88	Phosphorylation	LSPTTVMSEGARNIV CCCCCCCCHHHHHHH	28.66	21406692
98	Sulfoxidation	ARNIVAAMKAHGVDK HHHHHHHHHHCCCCC	2.58	30846556
99	2-Hydroxyisobutyrylation	RNIVAAMKAHGVDKV HHHHHHHHHCCCCCE	32.29	-
99	Ubiquitination	RNIVAAMKAHGVDKV HHHHHHHHHCCCCCE	32.29	21906983
105	Ubiquitination	MKAHGVDKVVACTSA HHHCCCCCEEEECCC	35.88	-
120	Ubiquitination	FLLWDPTKVPPRLQA HHHCCCCCCCCCCEE	59.12	-
129	Phosphorylation	PPRLQAVTDDHIRMH CCCCEECCCCHHHHH	38.43	28857561
134	Methylation	AVTDDHIRMHKVLRE ECCCCHHHHHHHHHH	20.10	-
137	Ubiquitination	DDHIRMHKVLRESGL CCHHHHHHHHHHCCC	33.35	-
142	Phosphorylation	MHKVLRESGLKYVAV HHHHHHHCCCEEEEE	42.88	27251275
146	Phosphorylation	LRESGLKYVAVMPPH HHHCCCEEEEECCCC	9.93	-
150	Sulfoxidation	GLKYVAVMPPHIGDQ CCEEEEECCCCCCCC	2.85	30846556
160	Phosphorylation	HIGDQPLTGAYTVTL CCCCCCCCEEEEEEE	26.84	-
164	Phosphorylation	QPLTGAYTVTLDGRG CCCCEEEEEEECCCC	13.38	-
173	Phosphorylation	TLDGRGPSRVISKHD EECCCCCCCEEEHHH	41.84	26437602
177	Phosphorylation	RGPSRVISKHDLGHF CCCCCEEEHHHHHCH	22.53	24719451
178	Ubiquitination	GPSRVISKHDLGHFM CCCCEEEHHHHHCHH	29.98	21890473
178	Acetylation	GPSRVISKHDLGHFM CCCCEEEHHHHHCHH	29.98	25825284
187	Methylation	DLGHFMLRCLTTDEY HHHCHHHHHCCCCCC	11.12	-
190	Phosphorylation	HFMLRCLTTDEYDGH CHHHHHCCCCCCCCC	35.51	30576142
191	Phosphorylation	FMLRCLTTDEYDGHS HHHHHCCCCCCCCCC	17.56	30576142
194	Phosphorylation	RCLTTDEYDGHSTYP HHCCCCCCCCCCCCC	29.99	21253578
202	Phosphorylation	DGHSTYPSHQYQ--- CCCCCCCCCCCC---	16.89	-
205	Phosphorylation	STYPSHQYQ------ CCCCCCCCC------	15.69	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BLVRB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BLVRB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BLVRB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMDS_HUMAN	GMDS	physical	22939629
A1AG1_HUMAN	ORM1	physical	21988832
RL31_HUMAN	RPL31	physical	21988832
UFM1_HUMAN	UFM1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00140: Riboflavin