PMVK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMVK_HUMAN
• UniProt AC: Q15126
• Protein Name: Phosphomevalonate kinase
• Gene Name: PMVK
• Organism: Homo sapiens (Human).
• Sequence Length: 192
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Sequence: MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PRLVLLFSGKRKSGK CEEEEEEECCCCCCH	43.29	30108239
17	Acetylation	LVLLFSGKRKSGKDF EEEEEECCCCCCHHH	56.29	25953088
17	Ubiquitination	LVLLFSGKRKSGKDF EEEEEECCCCCCHHH	56.29	21906983
19	Malonylation	LLFSGKRKSGKDFVT EEEECCCCCCHHHHH	68.02	32601280
19	Ubiquitination	LLFSGKRKSGKDFVT EEEECCCCCCHHHHH	68.02	-
20	Phosphorylation	LFSGKRKSGKDFVTE EEECCCCCCHHHHHH	55.92	29214152
22	Ubiquitination	SGKRKSGKDFVTEAL ECCCCCCHHHHHHHH	55.90	21890473
31	Phosphorylation	FVTEALQSRLGADVC HHHHHHHHHHCCCHH	30.26	20873877
38	Glutathionylation	SRLGADVCAVLRLSG HHHCCCHHHHHHHCC	1.92	22555962
44	Phosphorylation	VCAVLRLSGPLKEQY HHHHHHHCCCHHHHH	31.75	27251275
48	Acetylation	LRLSGPLKEQYAQEH HHHCCCHHHHHHHHC	46.00	23236377
48	Malonylation	LRLSGPLKEQYAQEH HHHCCCHHHHHHHHC	46.00	26320211
48	Ubiquitination	LRLSGPLKEQYAQEH HHHCCCHHHHHHHHC	46.00	21890473
65	Phosphorylation	NFQRLLDTSTYKEAF CHHHHHCCHHHHHHH	23.96	20068231
66	Phosphorylation	FQRLLDTSTYKEAFR HHHHHCCHHHHHHHH	29.43	25159151
67	Phosphorylation	QRLLDTSTYKEAFRK HHHHCCHHHHHHHHH	40.48	20068231
68	Phosphorylation	RLLDTSTYKEAFRKD HHHCCHHHHHHHHHH	13.44	20068231
69	Ubiquitination	LLDTSTYKEAFRKDM HHCCHHHHHHHHHHH	42.53	21890473
74	Ubiquitination	TYKEAFRKDMIRWGE HHHHHHHHHHHHHHH	45.23	-
83	Ubiquitination	MIRWGEEKRQADPGF HHHHHHHHHHCCCCC	45.57	-
94	Ubiquitination	DPGFFCRKIVEGISQ CCCCHHHHHHCCCCC	52.89	-
113	Phosphorylation	VSDTRRVSDIQWFRE EECCCCHHHHHHHHH	27.47	28450419
154	Phosphorylation	PGVDDAESECGLDNF CCCCCCHHHCCCCCC	39.65	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMVK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMVK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMVK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LA_HUMAN	SSB	physical	17353931
WDR92_HUMAN	WDR92	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.