dbPTM

NDUAA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUAA_HUMAN
UniProt AC	O95299
Protein Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Gene Name	NDUFA10
Organism	Homo sapiens (Human).
Sequence Length	355
Subcellular Localization	Mitochondrion matrix .
Protein Description	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
Protein Sequence	MALRLLKLAATSASARVVAAGAQRVRGIHSSVQCKLRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGDPHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYLKFDKGPWLKQDNRTLYHLRLLVQDKFEVLNYTSIPIFLPEVTIGAHQTDRVLHQFRELPGRKYSPGYNTEVGDKWIWLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	SVQCKLRYGMWHFLL CCHHHHHHCCHHHHH	23.05	24719451
48	Ubiquitination	WHFLLGDKASKRLTE HHHHHCCHHHHHHHC	53.41	21890473
48	Ubiquitination	WHFLLGDKASKRLTE HHHHHCCHHHHHHHC	53.41	21890473
50	Phosphorylation	FLLGDKASKRLTERS HHHCCHHHHHHHCCC	24.85	24719451
57	Phosphorylation	SKRLTERSRVITVDG HHHHHCCCCEEEEEC	25.35	-
61	Phosphorylation	TERSRVITVDGNICT HCCCCEEEEECCCCC	15.08	-
70	Ubiquitination	DGNICTGKGKLAKEI ECCCCCCCCHHHHHH	34.42	33845483
75	Succinylation	TGKGKLAKEIAEKLG CCCCHHHHHHHHHHC	61.15	23954790
75	Acetylation	TGKGKLAKEIAEKLG CCCCHHHHHHHHHHC	61.15	23236377
75	Malonylation	TGKGKLAKEIAEKLG CCCCHHHHHHHHHHC	61.15	26320211
80	Acetylation	LAKEIAEKLGFKHFP HHHHHHHHHCCCCCC	44.91	25825284
80	Malonylation	LAKEIAEKLGFKHFP HHHHHHHHHCCCCCC	44.91	26320211
80	2-Hydroxyisobutyrylation	LAKEIAEKLGFKHFP HHHHHHHHHCCCCCC	44.91	-
80	Ubiquitination	LAKEIAEKLGFKHFP HHHHHHHHHCCCCCC	44.91	29967540
84	Ubiquitination	IAEKLGFKHFPEAGI HHHHHCCCCCCCCCC	42.40	29967540
102	Ubiquitination	DSTTGDGKPLATDYN CCCCCCCCCCCCCCC	41.41	21890473
102	Ubiquitination	DSTTGDGKPLATDYN CCCCCCCCCCCCCCC	41.41	21906983
116	Acetylation	NGNCSLEKFYDDPRS CCCEEEEEECCCCCC	55.29	26051181
181	Ubiquitination	YNQGFIRKQCVDHYN HHCCCCHHHHHHCCC	43.14	-
221	Acetylation	VQRRIQKKGDPHEMK HHHHHHHCCCHHHHH	52.77	12438973
228	Acetylation	KGDPHEMKITSAYLQ CCCHHHHHCCHHHHH	39.59	25038526
230	Phosphorylation	DPHEMKITSAYLQDI CHHHHHCCHHHHHHH	11.20	24641631
231	Phosphorylation	PHEMKITSAYLQDIE HHHHHCCHHHHHHHH	20.56	28857561
233	Phosphorylation	EMKITSAYLQDIENA HHHCCHHHHHHHHHH	12.50	24641631
241	Phosphorylation	LQDIENAYKKTFLPE HHHHHHHHHHHCCHH	25.30	24641631
242	Ubiquitination	QDIENAYKKTFLPEM HHHHHHHHHHCCHHH	42.82	23503661
242	Acetylation	QDIENAYKKTFLPEM HHHHHHHHHHCCHHH	42.82	26051181
243	Ubiquitination	DIENAYKKTFLPEMS HHHHHHHHHCCHHHH	31.65	21906983
243	Acetylation	DIENAYKKTFLPEMS HHHHHHHHHCCHHHH	31.65	130451
243	2-Hydroxyisobutyrylation	DIENAYKKTFLPEMS HHHHHHHHHCCHHHH	31.65	-
250	Phosphorylation	KTFLPEMSEKCEVLQ HHCCHHHHHHHHHHH	32.04	-
252	Ubiquitination	FLPEMSEKCEVLQYS CCHHHHHHHHHHHHH	28.52	29967540
267	Acetylation	AREAQDSKKVVEDIE HHHHHHHCHHHHHHH	58.85	30584079
268	Ubiquitination	REAQDSKKVVEDIEY HHHHHHCHHHHHHHH	56.30	29967540
273	Ubiquitination	SKKVVEDIEYLKFDK HCHHHHHHHHHEECC	2.07	21890473
275	Phosphorylation	KVVEDIEYLKFDKGP HHHHHHHHHEECCCC	18.61	-
277	Ubiquitination	VEDIEYLKFDKGPWL HHHHHHHEECCCCCC	51.09	21906983
280	Ubiquitination	IEYLKFDKGPWLKQD HHHHEECCCCCCCCC	70.75	21906983
285	Succinylation	FDKGPWLKQDNRTLY ECCCCCCCCCCCEEE	52.30	21890473
285	Ubiquitination	FDKGPWLKQDNRTLY ECCCCCCCCCCCEEE	52.30	21890473
285	Succinylation	FDKGPWLKQDNRTLY ECCCCCCCCCCCEEE	52.30	-
292	Phosphorylation	KQDNRTLYHLRLLVQ CCCCCEEEEHHHHHH	9.74	23532336
307	Ubiquitination	DKFEVLNYTSIPIFL CCCHHHCCCCCCEEC	9.56	21890473
310	Ubiquitination	EVLNYTSIPIFLPEV HHHCCCCCCEECCEE	2.03	21890473
315	Ubiquitination	TSIPIFLPEVTIGAH CCCCEECCEEEECHH	24.22	21890473
338	Ubiquitination	FRELPGRKYSPGYNT HHCCCCCCCCCCCCC	56.87	21906983
345	Phosphorylation	KYSPGYNTEVGDKWI CCCCCCCCCCCCEEE	24.46	-
350	Ubiquitination	YNTEVGDKWIWLK-- CCCCCCCEEEEEC--	34.35	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
250	S	Phosphorylation	Kinase	PINK1	Q9BXM7	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
250	S	Phosphorylation		-
Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUAA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUV2_HUMAN	NDUFV2	physical	22939629
IF2M_HUMAN	MTIF2	physical	26186194
ACD10_HUMAN	ACAD10	physical	26186194
CLU_HUMAN	CLUH	physical	26186194
KDM1B_HUMAN	KDM1B	physical	26186194
DECR_HUMAN	DECR1	physical	26186194
RN123_HUMAN	RNF123	physical	26186194
PXDC2_HUMAN	PLXDC2	physical	26186194
SIR3_HUMAN	SIRT3	physical	26186194
CLPP_HUMAN	CLPP	physical	26186194
NDUF5_HUMAN	NDUFAF5	physical	26186194
SPT20_HUMAN	SPATA20	physical	26186194
RSPRY_HUMAN	RSPRY1	physical	26186194
NDUF7_HUMAN	NDUFAF7	physical	26186194
DHRS4_HUMAN	DHRS4	physical	26186194
BCKD_HUMAN	BCKDK	physical	26186194
PPOX_HUMAN	PPOX	physical	26186194
COX41_HUMAN	COX4I1	physical	26344197
COX5B_HUMAN	COX5B	physical	26344197
MIC60_HUMAN	IMMT	physical	26344197
NDUAC_HUMAN	NDUFA12	physical	26344197
NDUS2_HUMAN	NDUFS2	physical	26344197
NDUV1_HUMAN	NDUFV1	physical	26344197
QCR7_HUMAN	UQCRB	physical	26344197
QCR8_HUMAN	UQCRQ	physical	26344197
KDM1B_HUMAN	KDM1B	physical	28514442
ACD10_HUMAN	ACAD10	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
SPT20_HUMAN	SPATA20	physical	28514442
DCX_HUMAN	DCX	physical	28514442
NDUF7_HUMAN	NDUFAF7	physical	28514442
DHRS4_HUMAN	DHRS4	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28514442
DECR_HUMAN	DECR1	physical	28514442
RSPRY_HUMAN	RSPRY1	physical	28514442
CLU_HUMAN	CLUH	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
SIR3_HUMAN	SIRT3	physical	28514442
RAB8A_HUMAN	RAB8A	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDUAA_HUMAN

Related Literatures of Post-Translational Modification

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