| UniProt ID | ACD10_HUMAN | |
|---|---|---|
| UniProt AC | Q6JQN1 | |
| Protein Name | Acyl-CoA dehydrogenase family member 10 | |
| Gene Name | ACAD10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1059 | |
| Subcellular Localization | ||
| Protein Description | Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.. | |
| Protein Sequence | MCVRSCFQSPRLQWVWRTAFLKHTQRRHQGSHRWTHLGGSTYRAVIFDMGGVLIPSPGRVAAEWEVQNRIPSGTILKALMEGGENGPWMRFMRAEITAEGFLREFGRLCSEMLKTSVPVDSFFSLLTSERVAKQFPVMTEAITQIRAKGLQTAVLSNNFYLPNQKSFLPLDRKQFDVIVESCMEGICKPDPRIYKLCLEQLGLQPSESIFLDDLGTNLKEAARLGIHTIKVNDPETAVKELEALLGFTLRVGVPNTRPVKKTMEIPKDSLQKYLKDLLGIQTTGPLELLQFDHGQSNPTYYIRLANRDLVLRKKPPGTLLPSAHAIEREFRIMKALANAGVPVPNVLDLCEDSSVIGTPFYVMEYCPGLIYKDPSLPGLEPSHRRAIYTAMNTVLCKIHSVDLQAVGLEDYGKQGDYIPRQVRTWVKQYRASETSTIPAMERLIEWLPLHLPRQQRTTVVHGDFRLDNLVFHPEEPEVLAVLDWELSTLGDPLADVAYSCLAHYLPSSFPVLRGINDCDLTQLGIPAAEEYFRMYCLQMGLPPTENWNFYMAFSFFRVAAILQGVYKRSLTGQASSTYAEQTGKLTEFVSNLAWDFAVKEGFRVFKEMPFTNPLTRSYHTWARPQSQWCPTGSRSYSSVPEASPAHTSRGGLVISPESLSPPVRELYHRLKHFMEQRVYPAEPELQSHQASAARWSPSPLIEDLKEKAKAEGLWNLFLPLEADPEKKYGAGLTNVEYAHLCELMGTSLYAPEVCNCSAPDTGNMELLVRYGTEAQKARWLIPLLEGKARSCFAMTEPQVASSDATNIEASIREEDSFYVINGHKWWITGILDPRCQLCVFMGKTDPHAPRHRQQSVLLVPMDTPGIKIIRPLTVYGLEDAPGGHGEVRFEHVRVPKENMVLGPGRGFEIAQGRLGPGRIHHCMRLIGFSERALALMKARVKSRLAFGKPLVEQGTVLADIAQSRVEIEQARLLVLRAAHLMDLAGNKAAALDIAMIKMVAPSMASRVIDRAIQAFGAAGLSSDYPLAQFFTWARALRFADGPDEVHRATVAKLELKHRI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 72 | Phosphorylation | EVQNRIPSGTILKAL EEECCCCCCHHHHHH | 46.31 | 24425749 | |
| 74 | Phosphorylation | QNRIPSGTILKALME ECCCCCCHHHHHHHH | 27.72 | 24425749 | |
| 109 | S-nitrosylation | LREFGRLCSEMLKTS HHHHHHHHHHHHCCC | 2.89 | 24105792 | |
| 248 | Phosphorylation | LEALLGFTLRVGVPN HHHHHCCEEECCCCC | 16.32 | 24719451 | |
| 389 (in isoform 3) | Ubiquitination | - | 17.20 | 21906983 | |
| 413 | Succinylation | VGLEDYGKQGDYIPR ECCCCCCCCCCCHHH | 44.90 | - | |
| 413 | Succinylation | VGLEDYGKQGDYIPR ECCCCCCCCCCCHHH | 44.90 | - | |
| 427 | Acetylation | RQVRTWVKQYRASET HHHHHHHHHHHCCCC | 32.92 | - | |
| 427 | Succinylation | RQVRTWVKQYRASET HHHHHHHHHHHCCCC | 32.92 | - | |
| 427 | Ubiquitination | RQVRTWVKQYRASET HHHHHHHHHHHCCCC | 32.92 | - | |
| 427 | Succinylation | RQVRTWVKQYRASET HHHHHHHHHHHCCCC | 32.92 | - | |
| 554 | Phosphorylation | WNFYMAFSFFRVAAI CCHHHHHHHHHHHHH | 17.59 | 24719451 | |
| 566 | Phosphorylation | AAILQGVYKRSLTGQ HHHHHHHHHHHHCCC | 13.91 | 7105785 | |
| 611 | Phosphorylation | VFKEMPFTNPLTRSY ECCCCCCCCCCCCCE | 30.01 | 22210691 | |
| 626 | Phosphorylation | HTWARPQSQWCPTGS ECCCCCCHHCCCCCC | 28.47 | 22210691 | |
| 647 | Phosphorylation | PEASPAHTSRGGLVI CCCCCCCCCCCCEEE | 23.40 | 22210691 | |
| 709 | Ubiquitination | EDLKEKAKAEGLWNL HHHHHHHHHCCCCHH | 59.02 | 29967540 | |
| 740 | Ubiquitination | TNVEYAHLCELMGTS CCHHHHHHHHHHCCC | 1.52 | 29967540 | |
| 776 | Ubiquitination | RYGTEAQKARWLIPL ECCCHHHHHHHHHHH | 47.14 | 29967540 | |
| 787 | Ubiquitination | LIPLLEGKARSCFAM HHHHHCCCCCCCEEE | 31.11 | 22817900 | |
| 787 (in isoform 1) | Ubiquitination | - | 31.11 | 21906983 | |
| 787 (in isoform 2) | Ubiquitination | - | 31.11 | 21906983 | |
| 807 | Ubiquitination | ASSDATNIEASIREE ECCCCCCCEEEECCC | 3.98 | 29967540 | |
| 818 | Ubiquitination | IREEDSFYVINGHKW ECCCCCEEEEECEEE | 12.36 | 22817900 | |
| 1002 | Phosphorylation | MIKMVAPSMASRVID HHHHHCHHHHHHHHH | 19.76 | 50563007 | |
| 1005 | Phosphorylation | MVAPSMASRVIDRAI HHCHHHHHHHHHHHH | 20.59 | 50563013 | |
| 1052 | Acetylation | VHRATVAKLELKHRI HHHHHHHHHHHHCCC | 37.85 | 25953088 | |
| 1052 | Succinylation | VHRATVAKLELKHRI HHHHHHHHHHHHCCC | 37.85 | - | |
| 1052 | Succinylation | VHRATVAKLELKHRI HHHHHHHHHHHHCCC | 37.85 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACD10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACD10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACD10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| EKI1_HUMAN | ETNK1 | physical | 26344197 | |
| FLNA_HUMAN | FLNA | physical | 26344197 | |
| GARS_HUMAN | GARS | physical | 26344197 | |
| OXSR1_HUMAN | OXSR1 | physical | 26344197 | |
| PLSI_HUMAN | PLS1 | physical | 26344197 | |
| TIPRL_HUMAN | TIPRL | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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