dbPTM

FLNA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FLNA_HUMAN
UniProt AC	P21333
Protein Name	Filamin-A
Gene Name	FLNA
Organism	Homo sapiens (Human).
Sequence Length	2647
Subcellular Localization	Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Protein Description	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity)..
Protein Sequence	MSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSSHSRAG ------CCCCCCCCC	52.42	25944712
2	Phosphorylation	------MSSSHSRAG ------CCCCCCCCC	52.42	20068231
3	Phosphorylation	-----MSSSHSRAGQ -----CCCCCCCCCC	43.88	20068231
4	Phosphorylation	----MSSSHSRAGQS ----CCCCCCCCCCC	34.47	20068231
6	Phosphorylation	--MSSSHSRAGQSAA --CCCCCCCCCCCCC	26.27	20068231
7	Methylation	-MSSSHSRAGQSAAG -CCCCCCCCCCCCCC	37.00	-
11	Phosphorylation	SHSRAGQSAAGAAPG CCCCCCCCCCCCCCC	21.11	21712546
23	Phosphorylation	APGGGVDTRDAEMPA CCCCCCCCCCCCCCC	28.21	25849741
28	Sulfoxidation	VDTRDAEMPATEKDL CCCCCCCCCCCHHHH	2.68	30846556
31	Phosphorylation	RDAEMPATEKDLAED CCCCCCCCHHHHHHC	37.38	20068231
33	Succinylation	AEMPATEKDLAEDAP CCCCCCHHHHHHCCC	54.40	23954790
33	Ubiquitination	AEMPATEKDLAEDAP CCCCCCHHHHHHCCC	54.40	-
42	2-Hydroxyisobutyrylation	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	-
42	Acetylation	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	25953088
42	Methylation	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	-
42	Ubiquitination	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	24052262
43	Malonylation	AEDAPWKKIQQNTFT HHCCCHHHHHHHHHH	41.71	26320211
43	Ubiquitination	AEDAPWKKIQQNTFT HHCCCHHHHHHHHHH	41.71	-
48	Phosphorylation	WKKIQQNTFTRWCNE HHHHHHHHHHHHHHH	23.26	23403867
50	Phosphorylation	KIQQNTFTRWCNEHL HHHHHHHHHHHHHHH	22.63	23186163
58	2-Hydroxyisobutyrylation	RWCNEHLKCVSKRIA HHHHHHHHHHHHHHH	34.20	-
58	Acetylation	RWCNEHLKCVSKRIA HHHHHHHHHHHHHHH	34.20	25953088
58	Ubiquitination	RWCNEHLKCVSKRIA HHHHHHHHHHHHHHH	34.20	-
69	Phosphorylation	KRIANLQTDLSDGLR HHHHCCCCCCHHHHH	41.91	20068231
72	Phosphorylation	ANLQTDLSDGLRLIA HCCCCCCHHHHHHHH	32.23	20068231
85	Phosphorylation	IALLEVLSQKKMHRK HHHHHHHHHHHHHHH	45.16	21712546
87	2-Hydroxyisobutyrylation	LLEVLSQKKMHRKHN HHHHHHHHHHHHHHC	49.00	-
87	Acetylation	LLEVLSQKKMHRKHN HHHHHHHHHHHHHHC	49.00	26051181
87	Ubiquitination	LLEVLSQKKMHRKHN HHHHHHHHHHHHHHC	49.00	-
87 (in isoform 2)	Ubiquitination	-	49.00	-
88	Ubiquitination	LEVLSQKKMHRKHNQ HHHHHHHHHHHHHCC	32.09	-
92	Acetylation	SQKKMHRKHNQRPTF HHHHHHHHHCCCCCH	32.03	26210075
92	Ubiquitination	SQKKMHRKHNQRPTF HHHHHHHHHCCCCCH	32.03	-
102	Sulfoxidation	QRPTFRQMQLENVSV CCCCHHHHHHHCHHH	4.24	30846556
118	Phosphorylation	LEFLDRESIKLVSID HHHCCHHCCEEEEEC	26.39	28060719
120	Malonylation	FLDRESIKLVSIDSK HCCHHCCEEEEECCC	52.71	26320211
120	Ubiquitination	FLDRESIKLVSIDSK HCCHHCCEEEEECCC	52.71	-
123	Phosphorylation	RESIKLVSIDSKAIV HHCCEEEEECCCHHC	30.99	27499020
127	2-Hydroxyisobutyrylation	KLVSIDSKAIVDGNL EEEEECCCHHCCCCH	38.08	-
127	Malonylation	KLVSIDSKAIVDGNL EEEEECCCHHCCCCH	38.08	26320211
135	Ubiquitination	AIVDGNLKLILGLIW HHCCCCHHHHHHHHH	37.16	24052262
169	Acetylation	EAKKQTPKQRLLGWI HHHHHCHHHHHHHHH	51.98	7427289
186	Phosphorylation	KLPQLPITNFSRDWQ HCCCCCCCCCCCCCC	28.42	26657352
189	Phosphorylation	QLPITNFSRDWQSGR CCCCCCCCCCCCCCH	31.25	25850435
204	Phosphorylation	ALGALVDSCAPGLCP HHHHHHHHCCCCCCC	12.52	28857561
215	Phosphorylation	GLCPDWDSWDASKPV CCCCCHHHCCCCCCC	23.70	26657352
219	Phosphorylation	DWDSWDASKPVTNAR CHHHCCCCCCCCCHH	34.71	28857561
220	Acetylation	WDSWDASKPVTNARE HHHCCCCCCCCCHHH	45.27	26051181
220	Ubiquitination	WDSWDASKPVTNARE HHHCCCCCCCCCHHH	45.27	-
223	Phosphorylation	WDASKPVTNAREAMQ CCCCCCCCCHHHHHH	31.52	28857561
270	Ubiquitination	QFPKAKLKPGAPLRP HCCCCCCCCCCCCCC	40.47	-
287	Phosphorylation	NPKKARAYGPGIEPT CHHHHHHCCCCCCCC	20.49	27470641
294	Phosphorylation	YGPGIEPTGNMVKKR CCCCCCCCCCCCEEE	28.53	27470641
297	Sulfoxidation	GIEPTGNMVKKRAEF CCCCCCCCCEEEEEE	5.03	21406390
299	Sumoylation	EPTGNMVKKRAEFTV CCCCCCCEEEEEEEE	26.27	-
299	2-Hydroxyisobutyrylation	EPTGNMVKKRAEFTV CCCCCCCEEEEEEEE	26.27	-
299	Acetylation	EPTGNMVKKRAEFTV CCCCCCCEEEEEEEE	26.27	23236377
299	Malonylation	EPTGNMVKKRAEFTV CCCCCCCEEEEEEEE	26.27	26320211
299	Sumoylation	EPTGNMVKKRAEFTV CCCCCCCEEEEEEEE	26.27	25114211
299	Ubiquitination	EPTGNMVKKRAEFTV CCCCCCCEEEEEEEE	26.27	21906983
299 (in isoform 1)	Ubiquitination	-	26.27	21890473
299 (in isoform 2)	Ubiquitination	-	26.27	21890473
310	Phosphorylation	EFTVETRSAGQGEVL EEEEEECCCCCCEEE	44.14	26657352
319	Phosphorylation	GQGEVLVYVEDPAGH CCCEEEEEEECCCCC	8.25	28060719
333	Phosphorylation	HQEEAKVTANNDKNR CCEEEEEEECCCCCC	23.98	-
338	2-Hydroxyisobutyrylation	KVTANNDKNRTFSVW EEEECCCCCCEEEEE	50.91	-
341	Phosphorylation	ANNDKNRTFSVWYVP ECCCCCCEEEEEEEC	29.65	27080861
343	Phosphorylation	NDKNRTFSVWYVPEV CCCCCEEEEEEECCC	15.89	26657352
351	Phosphorylation	VWYVPEVTGTHKVTV EEEECCCCCCEEEEE	34.40	27080861
353	Phosphorylation	YVPEVTGTHKVTVLF EECCCCCCEEEEEEE	14.79	27080861
355	Acetylation	PEVTGTHKVTVLFAG CCCCCCEEEEEEECC	39.16	21466224
367	Acetylation	FAGQHIAKSPFEVYV ECCCEECCCCEEEEE	59.04	25953088
367	Ubiquitination	FAGQHIAKSPFEVYV ECCCEECCCCEEEEE	59.04	21890473
367 (in isoform 1)	Ubiquitination	-	59.04	21890473
367 (in isoform 2)	Ubiquitination	-	59.04	21890473
367	Ubiquitination	FAGQHIAKSPFEVYV ECCCEECCCCEEEEE	59.04	21890473
367	Ubiquitination	FAGQHIAKSPFEVYV ECCCEECCCCEEEEE	59.04	21890473
368	Phosphorylation	AGQHIAKSPFEVYVD CCCEECCCCEEEEEE	26.29	28857561
373	Nitration	AKSPFEVYVDKSQGD CCCCEEEEEECCCCC	8.85	-
373	Phosphorylation	AKSPFEVYVDKSQGD CCCCEEEEEECCCCC	8.85	21815630
376	Acetylation	PFEVYVDKSQGDASK CEEEEEECCCCCHHH	34.33	23236377
376	Malonylation	PFEVYVDKSQGDASK CEEEEEECCCCCHHH	34.33	26320211
376	Ubiquitination	PFEVYVDKSQGDASK CEEEEEECCCCCHHH	34.33	-
377	Phosphorylation	FEVYVDKSQGDASKV EEEEEECCCCCHHHC	34.63	26657352
382	Phosphorylation	DKSQGDASKVTAQGP ECCCCCHHHCEEECC	32.19	-
383	Acetylation	KSQGDASKVTAQGPG CCCCCHHHCEEECCC	45.38	26051181
383	Malonylation	KSQGDASKVTAQGPG CCCCCHHHCEEECCC	45.38	32601280
383	Ubiquitination	KSQGDASKVTAQGPG CCCCCHHHCEEECCC	45.38	-
385	Phosphorylation	QGDASKVTAQGPGLE CCCHHHCEEECCCCC	19.59	23911959
394	Phosphorylation	QGPGLEPSGNIANKT ECCCCCCCCCCCCCC	34.79	26657352
403	Phosphorylation	NIANKTTYFEIFTAG CCCCCCEEEEEEECC	12.40	-
440	Phosphorylation	QLEARGDSTYRCSYQ CEEECCCCCEECCCC	30.11	28102081
441	Phosphorylation	LEARGDSTYRCSYQP EEECCCCCEECCCCC	21.52	28102081
442	Phosphorylation	EARGDSTYRCSYQPT EECCCCCEECCCCCC	17.36	23312004
444	S-nitrosocysteine	RGDSTYRCSYQPTME CCCCCEECCCCCCCC	2.90	-
444	S-nitrosylation	RGDSTYRCSYQPTME CCCCCEECCCCCCCC	2.90	20140087
450	Sulfoxidation	RCSYQPTMEGVHTVH ECCCCCCCCCEEEEE	5.55	30846556
468	Phosphorylation	AGVPIPRSPYTVTVG ECEECCCCCCEEEEE	19.53	26657352
470	Phosphorylation	VPIPRSPYTVTVGQA EECCCCCCEEEEECC	18.32	26657352
471	Phosphorylation	PIPRSPYTVTVGQAC ECCCCCCEEEEECCC	17.06	-
473	Phosphorylation	PRSPYTVTVGQACNP CCCCCEEEEECCCCH	15.89	27080861
478	Glutathionylation	TVTVGQACNPSACRA EEEEECCCCHHHHHH	6.22	22555962
478	S-nitrosylation	TVTVGQACNPSACRA EEEEECCCCHHHHHH	6.22	22126794
481	Phosphorylation	VGQACNPSACRAVGR EECCCCHHHHHHCCC	26.47	21712546
483	S-nitrosylation	QACNPSACRAVGRGL CCCCHHHHHHCCCCC	3.17	22126794
498	2-Hydroxyisobutyrylation	QPKGVRVKETADFKV CCCCCEEEEECCEEE	38.49	-
498	Malonylation	QPKGVRVKETADFKV CCCCCEEEEECCEEE	38.49	26320211
500	Phosphorylation	KGVRVKETADFKVYT CCCEEEEECCEEEEE	26.30	21601212
504	Acetylation	VKETADFKVYTKGAG EEEECCEEEEECCCC	34.57	23236377
504	Ubiquitination	VKETADFKVYTKGAG EEEECCEEEEECCCC	34.57	21890473
504 (in isoform 1)	Ubiquitination	-	34.57	21890473
504 (in isoform 2)	Ubiquitination	-	34.57	21890473
504	Ubiquitination	VKETADFKVYTKGAG EEEECCEEEEECCCC	34.57	21890473
504	Ubiquitination	VKETADFKVYTKGAG EEEECCEEEEECCCC	34.57	21890473
506	Phosphorylation	ETADFKVYTKGAGSG EECCEEEEECCCCCC	11.88	28152594
507	Phosphorylation	TADFKVYTKGAGSGE ECCEEEEECCCCCCE	26.45	28152594
508	2-Hydroxyisobutyrylation	ADFKVYTKGAGSGEL CCEEEEECCCCCCEE	29.13	-
508	Acetylation	ADFKVYTKGAGSGEL CCEEEEECCCCCCEE	29.13	19608861
508	Ubiquitination	ADFKVYTKGAGSGEL CCEEEEECCCCCCEE	29.13	-
512	Phosphorylation	VYTKGAGSGELKVTV EEECCCCCCEEEEEE	28.67	23403867
516	Malonylation	GAGSGELKVTVKGPK CCCCCEEEEEEECCC	31.40	26320211
518	Phosphorylation	GSGELKVTVKGPKGE CCCEEEEEEECCCCC	18.21	26437602
538	Phosphorylation	KDLGDGVYGFEYYPM CCCCCCCCEEEEEEC	22.94	-
564	Phosphorylation	GGQNIGRSPFEVKVG CCEECCCCCCEEEEE	28.82	20068231
569	2-Hydroxyisobutyrylation	GRSPFEVKVGTECGN CCCCCEEEEECCCCC	27.96	-
569	Acetylation	GRSPFEVKVGTECGN CCCCCEEEEECCCCC	27.96	23236377
569	Malonylation	GRSPFEVKVGTECGN CCCCCEEEEECCCCC	27.96	26320211
572	Phosphorylation	PFEVKVGTECGNQKV CCEEEEECCCCCCEE	30.96	26657352
578	2-Hydroxyisobutyrylation	GTECGNQKVRAWGPG ECCCCCCEEEEECCC	37.37	-
578	Acetylation	GTECGNQKVRAWGPG ECCCCCCEEEEECCC	37.37	25953088
578	Malonylation	GTECGNQKVRAWGPG ECCCCCCEEEEECCC	37.37	26320211
578	Ubiquitination	GTECGNQKVRAWGPG ECCCCCCEEEEECCC	37.37	-
580	Methylation	ECGNQKVRAWGPGLE CCCCCEEEEECCCCC	31.49	-
626	Acetylation	AKIECDDKGDGSCDV CEEEECCCCCCCCEE	45.72	23749302
630	Phosphorylation	CDDKGDGSCDVRYWP ECCCCCCCCEEEEEC	16.34	28270605
643	Phosphorylation	WPQEAGEYAVHVLCN ECCCCCCEEEEEEEC	17.01	26657352
651	Phosphorylation	AVHVLCNSEDIRLSP EEEEEECCCCCCCCC	35.33	28060719
657	Phosphorylation	NSEDIRLSPFMADIR CCCCCCCCCHHCCCC	13.27	21712546
660	Sulfoxidation	DIRLSPFMADIRDAP CCCCCCHHCCCCCCC	3.58	21406390
674	Methylation	PQDFHPDRVKARGPG CCCCCHHHHCCCCCC	35.97	-
684	2-Hydroxyisobutyrylation	ARGPGLEKTGVAVNK CCCCCCCCCCEECCC	56.47	-
684	Acetylation	ARGPGLEKTGVAVNK CCCCCCCCCCEECCC	56.47	25953088
684	Malonylation	ARGPGLEKTGVAVNK CCCCCCCCCCEECCC	56.47	26320211
684	Ubiquitination	ARGPGLEKTGVAVNK CCCCCCCCCCEECCC	56.47	-
684 (in isoform 2)	Ubiquitination	-	56.47	-
685	Phosphorylation	RGPGLEKTGVAVNKP CCCCCCCCCEECCCC	27.75	23911959
691	Acetylation	KTGVAVNKPAEFTVD CCCEECCCCEEEEEE	38.72	26051181
691	Malonylation	KTGVAVNKPAEFTVD CCCEECCCCEEEEEE	38.72	26320211
691	Methylation	KTGVAVNKPAEFTVD CCCEECCCCEEEEEE	38.72	-
691	Ubiquitination	KTGVAVNKPAEFTVD CCCEECCCCEEEEEE	38.72	-
696	Phosphorylation	VNKPAEFTVDAKHGG CCCCEEEEEECCCCC	14.69	26657352
700	2-Hydroxyisobutyrylation	AEFTVDAKHGGKAPL EEEEEECCCCCCCCE	38.02	-
700	Acetylation	AEFTVDAKHGGKAPL EEEEEECCCCCCCCE	38.02	19608861
700	Malonylation	AEFTVDAKHGGKAPL EEEEEECCCCCCCCE	38.02	26320211
700	Ubiquitination	AEFTVDAKHGGKAPL EEEEEECCCCCCCCE	38.02	-
704	2-Hydroxyisobutyrylation	VDAKHGGKAPLRVQV EECCCCCCCCEEEEE	51.96	-
704	Acetylation	VDAKHGGKAPLRVQV EECCCCCCCCEEEEE	51.96	21466224
704	Ubiquitination	VDAKHGGKAPLRVQV EECCCCCCCCEEEEE	51.96	-
717	S-nitrosocysteine	QVQDNEGCPVEALVK EEECCCCCCEEEEEE	2.52	-
717	Glutathionylation	QVQDNEGCPVEALVK EEECCCCCCEEEEEE	2.52	22555962
717	S-nitrosylation	QVQDNEGCPVEALVK EEECCCCCCEEEEEE	2.52	25040305
724	Acetylation	CPVEALVKDNGNGTY CCEEEEEEECCCCEE	46.45	26051181
724	Malonylation	CPVEALVKDNGNGTY CCEEEEEEECCCCEE	46.45	32601280
730	Phosphorylation	VKDNGNGTYSCSYVP EEECCCCEEEEEEEC	19.09	26356563
731	Phosphorylation	KDNGNGTYSCSYVPR EECCCCEEEEEEECC	14.74	25884760
732	Phosphorylation	DNGNGTYSCSYVPRK ECCCCEEEEEEECCC	9.09	26356563
733	S-nitrosylation	NGNGTYSCSYVPRKP CCCCEEEEEEECCCC	2.10	2212679
734	Phosphorylation	GNGTYSCSYVPRKPV CCCEEEEEEECCCCC	24.19	-
735	Phosphorylation	NGTYSCSYVPRKPVK CCEEEEEEECCCCCC	20.85	27762562
746	Sulfoxidation	KPVKHTAMVSWGGVS CCCCCEEEEEECCEE	2.29	30846556
748	Phosphorylation	VKHTAMVSWGGVSIP CCCEEEEEECCEECC	13.61	28857561
753	Phosphorylation	MVSWGGVSIPNSPFR EEEECCEECCCCCCE	35.29	27251275
757	Phosphorylation	GGVSIPNSPFRVNVG CCEECCCCCCEEEEC	21.77	26657352
767	Phosphorylation	RVNVGAGSHPNKVKV EEEECCCCCCCCEEE	34.93	28060719
771	2-Hydroxyisobutyrylation	GAGSHPNKVKVYGPG CCCCCCCCEEEECCC	48.13	-
771	Acetylation	GAGSHPNKVKVYGPG CCCCCCCCEEEECCC	48.13	25953088
771	Ubiquitination	GAGSHPNKVKVYGPG CCCCCCCCEEEECCC	48.13	-
773	2-Hydroxyisobutyrylation	GSHPNKVKVYGPGVA CCCCCCEEEECCCCC	31.20	-
773	Malonylation	GSHPNKVKVYGPGVA CCCCCCEEEECCCCC	31.20	26320211
773	Ubiquitination	GSHPNKVKVYGPGVA CCCCCCEEEECCCCC	31.20	-
775	Phosphorylation	HPNKVKVYGPGVAKT CCCCEEEECCCCCCC	16.34	28152594
781	2-Hydroxyisobutyrylation	VYGPGVAKTGLKAHE EECCCCCCCCCCCCC	40.49	-
781	Acetylation	VYGPGVAKTGLKAHE EECCCCCCCCCCCCC	40.49	19608861
781	Malonylation	VYGPGVAKTGLKAHE EECCCCCCCCCCCCC	40.49	26320211
781	Succinylation	VYGPGVAKTGLKAHE EECCCCCCCCCCCCC	40.49	23954790
781	Ubiquitination	VYGPGVAKTGLKAHE EECCCCCCCCCCCCC	40.49	-
782	Phosphorylation	YGPGVAKTGLKAHEP ECCCCCCCCCCCCCC	37.70	-
790	Phosphorylation	GLKAHEPTYFTVDCA CCCCCCCCEEEEEHH	28.43	28152594
791	Phosphorylation	LKAHEPTYFTVDCAE CCCCCCCEEEEEHHH	14.15	28152594
793	Phosphorylation	AHEPTYFTVDCAEAG CCCCCEEEEEHHHCC	12.67	28152594
796	Glutathionylation	PTYFTVDCAEAGQGD CCEEEEEHHHCCCCC	2.99	22555962
810	S-nitrosocysteine	DVSIGIKCAPGVVGP CEEEEEEECCCCCCC	5.37	-
810	Glutathionylation	DVSIGIKCAPGVVGP CEEEEEEECCCCCCC	5.37	22555962
810	S-nitrosylation	DVSIGIKCAPGVVGP CEEEEEEECCCCCCC	5.37	20140087
810	S-palmitoylation	DVSIGIKCAPGVVGP CEEEEEEECCCCCCC	5.37	29575903
833	Phosphorylation	IIRNDNDTFTVKYTP EEECCCCCEEEEEEC	27.71	26657352
837	2-Hydroxyisobutyrylation	DNDTFTVKYTPRGAG CCCCEEEEEECCCCC	40.11	-
837	Acetylation	DNDTFTVKYTPRGAG CCCCEEEEEECCCCC	40.11	19608861
837	Malonylation	DNDTFTVKYTPRGAG CCCCEEEEEECCCCC	40.11	26320211
837	Ubiquitination	DNDTFTVKYTPRGAG CCCCEEEEEECCCCC	40.11	21890473
837 (in isoform 1)	Ubiquitination	-	40.11	21890473
837 (in isoform 2)	Ubiquitination	-	40.11	21890473
837	Ubiquitination	DNDTFTVKYTPRGAG CCCCEEEEEECCCCC	40.11	21890473
837	Ubiquitination	DNDTFTVKYTPRGAG CCCCEEEEEECCCCC	40.11	21890473
845	Phosphorylation	YTPRGAGSYTIMVLF EECCCCCEEEEEEEE	20.69	28060719
846	Phosphorylation	TPRGAGSYTIMVLFA ECCCCCEEEEEEEEE	10.20	27080861
847	Phosphorylation	PRGAGSYTIMVLFAD CCCCCEEEEEEEEEC	12.32	28060719
849	Sulfoxidation	GAGSYTIMVLFADQA CCCEEEEEEEEECCC	1.33	30846556
857	Phosphorylation	VLFADQATPTSPIRV EEEECCCCCCCCEEE	22.82	26657352
859	Phosphorylation	FADQATPTSPIRVKV EECCCCCCCCEEEEE	42.66	26657352
860	Phosphorylation	ADQATPTSPIRVKVE ECCCCCCCCEEEEEE	21.38	26657352
865	Acetylation	PTSPIRVKVEPSHDA CCCCEEEEEECCCCH	30.91	23749302
865	Ubiquitination	PTSPIRVKVEPSHDA CCCCEEEEEECCCCH	30.91	-
869	Phosphorylation	IRVKVEPSHDASKVK EEEEEECCCCHHHCC	22.09	28060719
874	2-Hydroxyisobutyrylation	EPSHDASKVKAEGPG ECCCCHHHCCCCCCC	49.85	-
874	Acetylation	EPSHDASKVKAEGPG ECCCCHHHCCCCCCC	49.85	23749302
876	Malonylation	SHDASKVKAEGPGLS CCCHHHCCCCCCCCC	44.44	26320211
876	Ubiquitination	SHDASKVKAEGPGLS CCCHHHCCCCCCCCC	44.44	-
883	Phosphorylation	KAEGPGLSRTGVELG CCCCCCCCCCCCCCC	33.44	29514088
885	Phosphorylation	EGPGLSRTGVELGKP CCCCCCCCCCCCCCC	42.05	29514088
891	Acetylation	RTGVELGKPTHFTVN CCCCCCCCCCEEEEE	60.41	26051181
891	Malonylation	RTGVELGKPTHFTVN CCCCCCCCCCEEEEE	60.41	26320211
891	Ubiquitination	RTGVELGKPTHFTVN CCCCCCCCCCEEEEE	60.41	-
893	Phosphorylation	GVELGKPTHFTVNAK CCCCCCCCEEEEEHH	32.86	29514088
896	Phosphorylation	LGKPTHFTVNAKAAG CCCCCEEEEEHHCCC	12.78	21406692
900	Acetylation	THFTVNAKAAGKGKL CEEEEEHHCCCCCCC	33.30	25953088
900	Malonylation	THFTVNAKAAGKGKL CEEEEEHHCCCCCCC	33.30	26320211
906	2-Hydroxyisobutyrylation	AKAAGKGKLDVQFSG HHCCCCCCCEEEECC	45.03	-
906	Acetylation	AKAAGKGKLDVQFSG HHCCCCCCCEEEECC	45.03	23954790
906	Malonylation	AKAAGKGKLDVQFSG HHCCCCCCCEEEECC	45.03	26320211
906	Ubiquitination	AKAAGKGKLDVQFSG HHCCCCCCCEEEECC	45.03	21890473
906 (in isoform 1)	Ubiquitination	-	45.03	21890473
906 (in isoform 2)	Ubiquitination	-	45.03	21890473
906	Ubiquitination	AKAAGKGKLDVQFSG HHCCCCCCCEEEECC	45.03	21890473
906	Ubiquitination	AKAAGKGKLDVQFSG HHCCCCCCCEEEECC	45.03	21890473
912	Phosphorylation	GKLDVQFSGLTKGDA CCCEEEECCCCCCCC	18.79	26657352
915	Phosphorylation	DVQFSGLTKGDAVRD EEEECCCCCCCCEEE	36.18	21406692
916	2-Hydroxyisobutyrylation	VQFSGLTKGDAVRDV EEECCCCCCCCEEEE	60.89	-
916	Malonylation	VQFSGLTKGDAVRDV EEECCCCCCCCEEEE	60.89	26320211
916	Ubiquitination	VQFSGLTKGDAVRDV EEECCCCCCCCEEEE	60.89	21890473
916 (in isoform 1)	Ubiquitination	-	60.89	21890473
916 (in isoform 2)	Ubiquitination	-	60.89	21890473
916	Ubiquitination	VQFSGLTKGDAVRDV EEECCCCCCCCEEEE	60.89	21890473
916	Ubiquitination	VQFSGLTKGDAVRDV EEECCCCCCCCEEEE	60.89	21890473
932	Phosphorylation	IIDHHDNTYTVKYTP EEECCCCEEEEEEEE	26.99	23312004
933	Phosphorylation	IDHHDNTYTVKYTPV EECCCCEEEEEEEEC	18.78	23312004
934	Phosphorylation	DHHDNTYTVKYTPVQ ECCCCEEEEEEEECC	14.42	23312004
936	2-Hydroxyisobutyrylation	HDNTYTVKYTPVQQG CCCEEEEEEEECCCC	35.29	-
936	Acetylation	HDNTYTVKYTPVQQG CCCEEEEEEEECCCC	35.29	23236377
936	Malonylation	HDNTYTVKYTPVQQG CCCEEEEEEEECCCC	35.29	26320211
937	Phosphorylation	DNTYTVKYTPVQQGP CCEEEEEEEECCCCC	16.37	28152594
938	Phosphorylation	NTYTVKYTPVQQGPV CEEEEEEEECCCCCC	15.97	28152594
950	Phosphorylation	GPVGVNVTYGGDPIP CCCEEEEEECCCCCC	15.96	28152594
951	Phosphorylation	PVGVNVTYGGDPIPK CCEEEEEECCCCCCC	18.15	28152594
958	Acetylation	YGGDPIPKSPFSVAV ECCCCCCCCCCEEEE	72.05	23236377
958	Ubiquitination	YGGDPIPKSPFSVAV ECCCCCCCCCCEEEE	72.05	-
959	Phosphorylation	GGDPIPKSPFSVAVS CCCCCCCCCCEEEEC	26.31	29255136
962	Phosphorylation	PIPKSPFSVAVSPSL CCCCCCCEEEECCCC	16.73	29255136
966	Phosphorylation	SPFSVAVSPSLDLSK CCCEEEECCCCCHHH	10.07	30266825
968	Phosphorylation	FSVAVSPSLDLSKIK CEEEECCCCCHHHCE	27.32	30266825
972	Phosphorylation	VSPSLDLSKIKVSGL ECCCCCHHHCEECCC	31.81	30266825
973	2-Hydroxyisobutyrylation	SPSLDLSKIKVSGLG CCCCCHHHCEECCCC	54.57	-
973	Acetylation	SPSLDLSKIKVSGLG CCCCCHHHCEECCCC	54.57	23954790
973	Ubiquitination	SPSLDLSKIKVSGLG CCCCCHHHCEECCCC	54.57	-
975	Malonylation	SLDLSKIKVSGLGEK CCCHHHCEECCCCCE	33.80	26320211
975	Ubiquitination	SLDLSKIKVSGLGEK CCCHHHCEECCCCCE	33.80	-
977	Phosphorylation	DLSKIKVSGLGEKVD CHHHCEECCCCCEEC	24.25	25159151
982	Acetylation	KVSGLGEKVDVGKDQ EECCCCCEECCCCCC	41.77	23236377
982	Malonylation	KVSGLGEKVDVGKDQ EECCCCCEECCCCCC	41.77	26320211
982	Ubiquitination	KVSGLGEKVDVGKDQ EECCCCCEECCCCCC	41.77	-
987	2-Hydroxyisobutyrylation	GEKVDVGKDQEFTVK CCEECCCCCCEEEEE	56.96	-
987	Acetylation	GEKVDVGKDQEFTVK CCEECCCCCCEEEEE	56.96	23749302
987	Malonylation	GEKVDVGKDQEFTVK CCEECCCCCCEEEEE	56.96	26320211
987	Succinylation	GEKVDVGKDQEFTVK CCEECCCCCCEEEEE	56.96	23954790
987	Ubiquitination	GEKVDVGKDQEFTVK CCEECCCCCCEEEEE	56.96	-
992	Phosphorylation	VGKDQEFTVKSKGAG CCCCCEEEEEECCCC	26.69	21601212
994	Acetylation	KDQEFTVKSKGAGGQ CCCEEEEEECCCCCC	43.31	23749302
994	Malonylation	KDQEFTVKSKGAGGQ CCCEEEEEECCCCCC	43.31	26320211
995	Phosphorylation	DQEFTVKSKGAGGQG CCEEEEEECCCCCCC	31.80	21601212
1003	Ubiquitination	KGAGGQGKVASKIVG CCCCCCCCEEEEEEC	27.09	-
1007	Malonylation	GQGKVASKIVGPSGA CCCCEEEEEECCCCC	31.50	26320211
1007	Ubiquitination	GQGKVASKIVGPSGA CCCCEEEEEECCCCC	31.50	-
1019	Acetylation	SGAAVPCKVEPGLGA CCCCCCCEECCCCCC	43.49	23749302
1019	Malonylation	SGAAVPCKVEPGLGA CCCCCCCEECCCCCC	43.49	26320211
1019	Ubiquitination	SGAAVPCKVEPGLGA CCCCCCCEECCCCCC	43.49	21890473
1019 (in isoform 1)	Ubiquitination	-	43.49	21890473
1019 (in isoform 2)	Ubiquitination	-	43.49	21890473
1019	Ubiquitination	SGAAVPCKVEPGLGA CCCCCCCEECCCCCC	43.49	21890473
1019	Ubiquitination	SGAAVPCKVEPGLGA CCCCCCCEECCCCCC	43.49	21890473
1029	Phosphorylation	PGLGADNSVVRFLPR CCCCCCCCEEEEECC	23.65	21712546
1041	Phosphorylation	LPREEGPYEVEVTYD ECCCCCCEEEEEEEC	43.39	27642862
1046	Phosphorylation	GPYEVEVTYDGVPVP CCEEEEEEECCEECC	11.46	28796482
1047	Phosphorylation	PYEVEVTYDGVPVPG CEEEEEEECCEECCC	18.84	28796482
1055	O-linked_Glycosylation	DGVPVPGSPFPLEAV CCEECCCCCCCHHEE	19.80	23301498
1055	Phosphorylation	DGVPVPGSPFPLEAV CCEECCCCCCCHHEE	19.80	26657352
1065	Phosphorylation	PLEAVAPTKPSKVKA CHHEECCCCCCCCEE	45.94	27642862
1069	Malonylation	VAPTKPSKVKAFGPG ECCCCCCCCEEECCC	57.17	26320211
1071	Acetylation	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	26051181
1071	Malonylation	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	26320211
1071	Succinylation	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	-
1071	Succinylation	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	-
1071	Ubiquitination	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	-
1081	Phosphorylation	GPGLQGGSAGSPARF CCCCCCCCCCCCEEE	35.96	22167270
1084	Phosphorylation	LQGGSAGSPARFTID CCCCCCCCCEEEEEE	18.33	19664994
1087	Methylation	GSAGSPARFTIDTKG CCCCCCEEEEEECCC	32.40	-
1089	Phosphorylation	AGSPARFTIDTKGAG CCCCEEEEEECCCCC	16.64	22617229
1092	Phosphorylation	PARFTIDTKGAGTGG CEEEEEECCCCCCCC	27.77	24732914
1157	Glutathionylation	FKAHVVPCFDASKVK CEEEEEECCCHHHCC	3.05	22555962
1157	S-palmitoylation	FKAHVVPCFDASKVK CEEEEEECCCHHHCC	3.05	26865113
1161	Phosphorylation	VVPCFDASKVKCSGP EEECCCHHHCCCCCC	39.56	23312004
1162	2-Hydroxyisobutyrylation	VPCFDASKVKCSGPG EECCCHHHCCCCCCC	47.65	-
1162	Acetylation	VPCFDASKVKCSGPG EECCCHHHCCCCCCC	47.65	23749302
1162	Ubiquitination	VPCFDASKVKCSGPG EECCCHHHCCCCCCC	47.65	-
1164	2-Hydroxyisobutyrylation	CFDASKVKCSGPGLE CCCHHHCCCCCCCCC	26.81	-
1164	Ubiquitination	CFDASKVKCSGPGLE CCCHHHCCCCCCCCC	26.81	-
1246	Acetylation	PVPNFPSKLQVEPAV ECCCCCCCCCCCCCC	43.08	26051181
1246	Ubiquitination	PVPNFPSKLQVEPAV ECCCCCCCCCCCCCC	43.08	-
1246 (in isoform 2)	Ubiquitination	-	43.08	-
1255	Phosphorylation	QVEPAVDTSGVQCYG CCCCCCCCCCCEEEC	22.30	21945579
1256	Phosphorylation	VEPAVDTSGVQCYGP CCCCCCCCCCEEECC	32.29	21945579
1260	S-nitrosocysteine	VDTSGVQCYGPGIEG CCCCCCEEECCCCCC	3.84	-
1260	Glutathionylation	VDTSGVQCYGPGIEG CCCCCCEEECCCCCC	3.84	22555962
1260	S-nitrosylation	VDTSGVQCYGPGIEG CCCCCCEEECCCCCC	3.84	20140087
1261	Phosphorylation	DTSGVQCYGPGIEGQ CCCCCEEECCCCCCC	14.84	21945579
1275	Phosphorylation	QGVFREATTEFSVDA CCCCEECEEEEEEEH	23.31	21815630
1279	Phosphorylation	REATTEFSVDARALT EECEEEEEEEHHHHH	16.92	21712546
1286	Phosphorylation	SVDARALTQTGGPHV EEEHHHHHCCCCCCC	24.09	26657352
1288	Phosphorylation	DARALTQTGGPHVKA EHHHHHCCCCCCCEE	38.58	20068231
1294	2-Hydroxyisobutyrylation	QTGGPHVKARVANPS CCCCCCCEEEEECCC	27.69	-
1294	Acetylation	QTGGPHVKARVANPS CCCCCCCEEEEECCC	27.69	25953088
1294	Ubiquitination	QTGGPHVKARVANPS CCCCCCCEEEEECCC	27.69	-
1301	Phosphorylation	KARVANPSGNLTETY EEEEECCCCCCEEEE	39.87	25159151
1305	Phosphorylation	ANPSGNLTETYVQDR ECCCCCCEEEEEEEC	30.22	21712546
1307	Phosphorylation	PSGNLTETYVQDRGD CCCCCEEEEEEECCC	24.61	28796482
1308	Nitration	SGNLTETYVQDRGDG CCCCEEEEEEECCCC	7.00	-
1308	Phosphorylation	SGNLTETYVQDRGDG CCCCEEEEEEECCCC	7.00	24927040
1312	Methylation	TETYVQDRGDGMYKV EEEEEEECCCCCEEE	28.19	-
1321	Phosphorylation	DGMYKVEYTPYEEGL CCCEEEEEECCCCCC	18.92	23663014
1322	Phosphorylation	GMYKVEYTPYEEGLH CCEEEEEECCCCCCC	13.09	23663014
1324	Phosphorylation	YKVEYTPYEEGLHSV EEEEEECCCCCCCEE	20.86	23663014
1330	Phosphorylation	PYEEGLHSVDVTYDG CCCCCCCEEEEEECC	25.67	23663014
1334	Phosphorylation	GLHSVDVTYDGSPVP CCCEEEEEECCCCCC	16.07	25159151
1335	Phosphorylation	LHSVDVTYDGSPVPS CCEEEEEECCCCCCC	20.39	23663014
1338	Phosphorylation	VDVTYDGSPVPSSPF EEEEECCCCCCCCCC	21.59	25159151
1342	Phosphorylation	YDGSPVPSSPFQVPV ECCCCCCCCCCCCCC	51.37	25159151
1343	Phosphorylation	DGSPVPSSPFQVPVT CCCCCCCCCCCCCCC	24.54	25159151
1350	Phosphorylation	SPFQVPVTEGCDPSR CCCCCCCCCCCCHHC	22.16	24732914
1356	Phosphorylation	VTEGCDPSRVRVHGP CCCCCCHHCEEEECC	30.11	27080861
1367	Phosphorylation	VHGPGIQSGTTNKPN EECCCCCCCCCCCCC	35.87	25159151
1369	Phosphorylation	GPGIQSGTTNKPNKF CCCCCCCCCCCCCCE	32.23	29116813
1370	Phosphorylation	PGIQSGTTNKPNKFT CCCCCCCCCCCCCEE	44.78	28060719
1372	Acetylation	IQSGTTNKPNKFTVE CCCCCCCCCCCEEEE	48.12	26051181
1372	Ubiquitination	IQSGTTNKPNKFTVE CCCCCCCCCCCEEEE	48.12	21890473
1372 (in isoform 1)	Ubiquitination	-	48.12	21890473
1372 (in isoform 2)	Ubiquitination	-	48.12	21890473
1372	Ubiquitination	IQSGTTNKPNKFTVE CCCCCCCCCCCEEEE	48.12	21890473
1372	Ubiquitination	IQSGTTNKPNKFTVE CCCCCCCCCCCEEEE	48.12	21890473
1375	Acetylation	GTTNKPNKFTVETRG CCCCCCCCEEEEECC	51.44	25953088
1375	Malonylation	GTTNKPNKFTVETRG CCCCCCCCEEEEECC	51.44	26320211
1375	Ubiquitination	GTTNKPNKFTVETRG CCCCCCCCEEEEECC	51.44	21890473
1375 (in isoform 1)	Ubiquitination	-	51.44	21890473
1375 (in isoform 2)	Ubiquitination	-	51.44	21890473
1375	Ubiquitination	GTTNKPNKFTVETRG CCCCCCCCEEEEECC	51.44	21890473
1375	Ubiquitination	GTTNKPNKFTVETRG CCCCCCCCEEEEECC	51.44	21890473
1377	Phosphorylation	TNKPNKFTVETRGAG CCCCCCEEEEECCCC	21.02	28555341
1385	Phosphorylation	VETRGAGTGGLGLAV EEECCCCCCCCEEEE	27.78	21815630
1396	Phosphorylation	GLAVEGPSEAKMSCM EEEEECCCCCCEECC	62.13	23911959
1399	Acetylation	VEGPSEAKMSCMDNK EECCCCCCEECCCCC	27.56	25953088
1399	Ubiquitination	VEGPSEAKMSCMDNK EECCCCCCEECCCCC	27.56	-
1406	Acetylation	KMSCMDNKDGSCSVE CEECCCCCCCCEEEE	60.24	26051181
1409	Phosphorylation	CMDNKDGSCSVEYIP CCCCCCCCEEEEEEE	17.22	28270605
1411	Phosphorylation	DNKDGSCSVEYIPYE CCCCCCEEEEEEECC	21.49	28270605
1414	Phosphorylation	DGSCSVEYIPYEAGT CCCEEEEEEECCCEE	12.68	28270605
1417	Phosphorylation	CSVEYIPYEAGTYSL EEEEEEECCCEEEEE	14.62	28270605
1421	Phosphorylation	YIPYEAGTYSLNVTY EEECCCEEEEEEEEE	19.58	28270605
1422	Phosphorylation	IPYEAGTYSLNVTYG EECCCEEEEEEEEEC	15.39	28270605
1423	Phosphorylation	PYEAGTYSLNVTYGG ECCCEEEEEEEEECC	17.19	28270605
1427	Phosphorylation	GTYSLNVTYGGHQVP EEEEEEEEECCEECC	18.51	28270605
1428	Phosphorylation	TYSLNVTYGGHQVPG EEEEEEEECCEECCC	19.48	28270605
1436	Phosphorylation	GGHQVPGSPFKVPVH CCEECCCCCEECCCC	22.54	17408621
1439	Acetylation	QVPGSPFKVPVHDVT ECCCCCEECCCCCCC	49.35	26051181
1446	Phosphorylation	KVPVHDVTDASKVKC ECCCCCCCCHHHCCC	31.72	-
1449	Phosphorylation	VHDVTDASKVKCSGP CCCCCCHHHCCCCCC	40.57	26074081
1450	2-Hydroxyisobutyrylation	HDVTDASKVKCSGPG CCCCCHHHCCCCCCC	47.65	-
1450	Acetylation	HDVTDASKVKCSGPG CCCCCHHHCCCCCCC	47.65	26051181
1452	2-Hydroxyisobutyrylation	VTDASKVKCSGPGLS CCCHHHCCCCCCCCC	26.81	-
1452	Malonylation	VTDASKVKCSGPGLS CCCHHHCCCCCCCCC	26.81	26320211
1452	Ubiquitination	VTDASKVKCSGPGLS CCCHHHCCCCCCCCC	26.81	-
1453	S-nitrosylation	TDASKVKCSGPGLSP CCHHHCCCCCCCCCC	6.78	2212679
1454	Phosphorylation	DASKVKCSGPGLSPG CHHHCCCCCCCCCCC	42.16	23927012
1459	Phosphorylation	KCSGPGLSPGMVRAN CCCCCCCCCCCEECC	25.89	19664994
1470	Phosphorylation	VRANLPQSFQVDTSK EECCCCCCEECCCCC	18.73	26074081
1475	Phosphorylation	PQSFQVDTSKAGVAP CCCEECCCCCCCEEC	33.02	26074081
1476	Phosphorylation	QSFQVDTSKAGVAPL CCEECCCCCCCEECE	18.95	26074081
1477	2-Hydroxyisobutyrylation	SFQVDTSKAGVAPLQ CEECCCCCCCEECEE	51.78	-
1477	Acetylation	SFQVDTSKAGVAPLQ CEECCCCCCCEECEE	51.78	23236377
1477	Malonylation	SFQVDTSKAGVAPLQ CEECCCCCCCEECEE	51.78	26320211
1477	Ubiquitination	SFQVDTSKAGVAPLQ CEECCCCCCCEECEE	51.78	-
1477 (in isoform 2)	Ubiquitination	-	51.78	-
1486	2-Hydroxyisobutyrylation	GVAPLQVKVQGPKGL CEECEEEEEECCCCC	18.84	-
1486	Acetylation	GVAPLQVKVQGPKGL CEECEEEEEECCCCC	18.84	25953088
1486	Malonylation	GVAPLQVKVQGPKGL CEECEEEEEECCCCC	18.84	26320211
1486	Ubiquitination	GVAPLQVKVQGPKGL CEECEEEEEECCCCC	18.84	-
1491	2-Hydroxyisobutyrylation	QVKVQGPKGLVEPVD EEEEECCCCCEEEEE	72.24	-
1491	Acetylation	QVKVQGPKGLVEPVD EEEEECCCCCEEEEE	72.24	26051181
1491	Malonylation	QVKVQGPKGLVEPVD EEEEECCCCCEEEEE	72.24	26320211
1491	Ubiquitination	QVKVQGPKGLVEPVD EEEEECCCCCEEEEE	72.24	21906983
1491 (in isoform 1)	Ubiquitination	-	72.24	21890473
1491 (in isoform 2)	Ubiquitination	-	72.24	21890473
1506	Phosphorylation	VVDNADGTQTVNYVP EEECCCCCEEEEECC	22.93	21712546
1508	Phosphorylation	DNADGTQTVNYVPSR ECCCCCEEEEECCCC	15.57	28555341
1511	Phosphorylation	DGTQTVNYVPSREGP CCCEEEEECCCCCCC	14.92	-
1514	Phosphorylation	QTVNYVPSREGPYSI EEEEECCCCCCCEEE	32.68	21712546
1519	Phosphorylation	VPSREGPYSISVLYG CCCCCCCEEEEEEEC	29.50	28796482
1520	Phosphorylation	PSREGPYSISVLYGD CCCCCCEEEEEEECC	16.12	26657352
1522	Phosphorylation	REGPYSISVLYGDEE CCCCEEEEEEECCCC	10.50	26657352
1525	Phosphorylation	PYSISVLYGDEEVPR CEEEEEEECCCCCCC	22.00	28176443
1533	Phosphorylation	GDEEVPRSPFKVKVL CCCCCCCCCCEEEEE	28.72	22167270
1536	Acetylation	EVPRSPFKVKVLPTH CCCCCCCEEEEEECC	44.52	26051181
1538	2-Hydroxyisobutyrylation	PRSPFKVKVLPTHDA CCCCCEEEEEECCCH	38.35	-
1538	Acetylation	PRSPFKVKVLPTHDA CCCCCEEEEEECCCH	38.35	26051181
1538	Malonylation	PRSPFKVKVLPTHDA CCCCCEEEEEECCCH	38.35	26320211
1538	Ubiquitination	PRSPFKVKVLPTHDA CCCCCEEEEEECCCH	38.35	-
1547	2-Hydroxyisobutyrylation	LPTHDASKVKASGPG EECCCHHHCCCCCCC	49.85	-
1547	Acetylation	LPTHDASKVKASGPG EECCCHHHCCCCCCC	49.85	25953088
1547	Ubiquitination	LPTHDASKVKASGPG EECCCHHHCCCCCCC	49.85	-
1551	Phosphorylation	DASKVKASGPGLNTT CHHHCCCCCCCCCCC	39.54	26657352
1557	O-linked_Glycosylation	ASGPGLNTTGVPASL CCCCCCCCCCCCCCC	29.94	23301498
1557	Phosphorylation	ASGPGLNTTGVPASL CCCCCCCCCCCCCCC	29.94	21406692
1558	O-linked_Glycosylation	SGPGLNTTGVPASLP CCCCCCCCCCCCCCC	34.80	23301498
1558	Phosphorylation	SGPGLNTTGVPASLP CCCCCCCCCCCCCCC	34.80	21406692
1563	Phosphorylation	NTTGVPASLPVEFTI CCCCCCCCCCEEEEE	27.43	21406692
1569	Phosphorylation	ASLPVEFTIDAKDAG CCCCEEEEEECCCCC	12.39	21406692
1585	Phosphorylation	GLLAVQITDPEGKPK CEEEEEEECCCCCCC	28.54	21712546
1590	Acetylation	QITDPEGKPKKTHIQ EEECCCCCCCCCCEE	52.59	26051181
1590	Ubiquitination	QITDPEGKPKKTHIQ EEECCCCCCCCCCEE	52.59	-
1593	Malonylation	DPEGKPKKTHIQDNH CCCCCCCCCCEEECC	54.59	26320211
1594	Phosphorylation	PEGKPKKTHIQDNHD CCCCCCCCCEEECCC	30.27	28152594
1603	Phosphorylation	IQDNHDGTYTVAYVP EEECCCCEEEEEECC	23.29	28152594
1604	Phosphorylation	QDNHDGTYTVAYVPD EECCCCEEEEEECCC	12.54	21082442
1605	Phosphorylation	DNHDGTYTVAYVPDV ECCCCEEEEEECCCC	9.86	28152594
1608	Phosphorylation	DGTYTVAYVPDVTGR CCEEEEEECCCCCCE	14.26	23312004
1613	Phosphorylation	VAYVPDVTGRYTILI EEECCCCCCEEEEEE	24.26	23312004
1617	Phosphorylation	PDVTGRYTILIKYGG CCCCCEEEEEEEECC	14.14	23312004
1621	Ubiquitination	GRYTILIKYGGDEIP CEEEEEEEECCCCCC	34.10	-
1622	Phosphorylation	RYTILIKYGGDEIPF EEEEEEEECCCCCCC	21.24	28152594
1630	Phosphorylation	GGDEIPFSPYRVRAV CCCCCCCCCEEEEEE	18.70	19664994
1632	Phosphorylation	DEIPFSPYRVRAVPT CCCCCCCEEEEEEEC	22.12	22617229
1639	Phosphorylation	YRVRAVPTGDASKCT EEEEEEECCCCCCCE	40.89	26657352
1643	Phosphorylation	AVPTGDASKCTVTVS EEECCCCCCCEEEEE	32.76	21406692
1720	Phosphorylation	TAPQPGKYVICVRFG ECCCCCEEEEEEEEC	10.85	-
1723	S-palmitoylation	QPGKYVICVRFGGEH CCCEEEEEEEECCEE	0.97	29575903
1734	Phosphorylation	GGEHVPNSPFQVTAL CCEECCCCCCEEEEE	22.48	29255136
1739	Phosphorylation	PNSPFQVTALAGDQP CCCCCEEEEECCCCC	12.74	29255136
1747	Phosphorylation	ALAGDQPSVQPPLRS EECCCCCCCCCCCCC	27.96	22199227
1761	Phosphorylation	SQQLAPQYTYAQGGQ CCCCCCCCEECCCCC	10.72	-
1762	Phosphorylation	QQLAPQYTYAQGGQQ CCCCCCCEECCCCCC	13.72	-
1763	Phosphorylation	QLAPQYTYAQGGQQT CCCCCCEECCCCCCC	7.62	-
1793 (in isoform 2)	Ubiquitination	-	3.73	21890473
1801	Malonylation	VIPFTIKKGEITGEV EEEEEEECCEEEEEE	58.90	26320211
1801	Ubiquitination	VIPFTIKKGEITGEV EEEEEEECCEEEEEE	58.90	21906983
1801 (in isoform 1)	Ubiquitination	-	58.90	21890473
1805	Phosphorylation	TIKKGEITGEVRMPS EEECCEEEEEEECCC	24.00	26437602
1812	Phosphorylation	TGEVRMPSGKVAQPT EEEEECCCCCEECCE	41.73	29759185
1814	Malonylation	EVRMPSGKVAQPTIT EEECCCCCEECCEEE	38.44	26320211
1814	Ubiquitination	EVRMPSGKVAQPTIT EEECCCCCEECCEEE	38.44	-
1816 (in isoform 2)	Ubiquitination	-	17.08	21890473
1816	Ubiquitination	RMPSGKVAQPTITDN ECCCCCEECCEEEEC	17.08	21890473
1821	Phosphorylation	KVAQPTITDNKDGTV CEECCEEEECCCCCE	35.68	29759185
1824	2-Hydroxyisobutyrylation	QPTITDNKDGTVTVR CCEEEECCCCCEEEE	61.41	-
1824	Acetylation	QPTITDNKDGTVTVR CCEEEECCCCCEEEE	61.41	23236377
1824	Malonylation	QPTITDNKDGTVTVR CCEEEECCCCCEEEE	61.41	26320211
1824	Ubiquitination	QPTITDNKDGTVTVR CCEEEECCCCCEEEE	61.41	21890473
1824 (in isoform 1)	Ubiquitination	-	61.41	21890473
1824	Ubiquitination	QPTITDNKDGTVTVR CCEEEECCCCCEEEE	61.41	21890473
1827	Phosphorylation	ITDNKDGTVTVRYAP EEECCCCCEEEEECC	24.12	22210691
1829	Phosphorylation	DNKDGTVTVRYAPSE ECCCCCEEEEECCCC	10.09	22210691
1832	Phosphorylation	DGTVTVRYAPSEAGL CCCEEEEECCCCCCC	20.66	23403867
1835	Phosphorylation	VTVRYAPSEAGLHEM EEEEECCCCCCCCEE	31.72	25850435
1842	Sulfoxidation	SEAGLHEMDIRYDNM CCCCCCEEEEEECCC	3.46	30846556
1854	Phosphorylation	DNMHIPGSPLQFYVD CCCCCCCCCEEEEEE	19.65	27251275
1862	Phosphorylation	PLQFYVDYVNCGHVT CEEEEEEECCCCCEE	5.41	-
1871	Phosphorylation	NCGHVTAYGPGLTHG CCCCEEEECCCCCCC	17.94	-
1899	Phosphorylation	DAGEGGLSLAIEGPS CCCCCCEEEEEECCC	21.01	25849741
1906	Phosphorylation	SLAIEGPSKAEISCT EEEEECCCCCEEEEE	56.19	20860994
1919	Phosphorylation	CTDNQDGTCSVSYLP EECCCCCEEEEEEEE	15.19	27251275
1920	Glutathionylation	TDNQDGTCSVSYLPV ECCCCCEEEEEEEEE	4.65	22555962
1921	Phosphorylation	DNQDGTCSVSYLPVL CCCCCEEEEEEEEEC	17.59	26657352
1923	Phosphorylation	QDGTCSVSYLPVLPG CCCEEEEEEEEECCC	12.50	27251275
1924	Phosphorylation	DGTCSVSYLPVLPGD CCEEEEEEEEECCCC	16.93	27251275
1932	Phosphorylation	LPVLPGDYSILVKYN EEECCCCEEEEEEEC	11.97	27251275
1937	Ubiquitination	GDYSILVKYNEQHVP CCEEEEEEECCCCCC	38.62	-
1938	Phosphorylation	DYSILVKYNEQHVPG CEEEEEEECCCCCCC	19.22	28152594
1946	Phosphorylation	NEQHVPGSPFTARVT CCCCCCCCCCEEEEE	15.69	25159151
1949	Phosphorylation	HVPGSPFTARVTGDD CCCCCCCEEEEECCC	19.55	22199227
1956 (in isoform 2)	Ubiquitination	-	45.75	21890473
1956	Ubiquitination	TARVTGDDSMRMSHL EEEEECCCCCCCCEE	45.75	21890473
1957	Phosphorylation	ARVTGDDSMRMSHLK EEEECCCCCCCCEEE	17.02	28555341
1961	Phosphorylation	GDDSMRMSHLKVGSA CCCCCCCCEEEECCC	18.46	28555341
1964	Malonylation	SMRMSHLKVGSAADI CCCCCEEEECCCCCC	38.84	26320211
1964	Ubiquitination	SMRMSHLKVGSAADI CCCCCEEEECCCCCC	38.84	21890473
1964 (in isoform 1)	Ubiquitination	-	38.84	21890473
1964	Ubiquitination	SMRMSHLKVGSAADI CCCCCEEEECCCCCC	38.84	21890473
1967	Phosphorylation	MSHLKVGSAADIPIN CCEEEECCCCCCCCC	24.22	26846344
1976	Phosphorylation	ADIPINISETDLSLL CCCCCCCCCCCCEEE	29.92	26846344
1978	Phosphorylation	IPINISETDLSLLTA CCCCCCCCCCEEEEE	35.13	26846344
1981	Phosphorylation	NISETDLSLLTATVV CCCCCCCEEEEEEEC	24.92	26657352
1984	Phosphorylation	ETDLSLLTATVVPPS CCCCEEEEEEECCCC	26.10	26846344
1986	Phosphorylation	DLSLLTATVVPPSGR CCEEEEEEECCCCCC	19.46	26846344
1991	Phosphorylation	TATVVPPSGREEPCL EEEECCCCCCCCCCH	44.40	28060719
2000	2-Hydroxyisobutyrylation	REEPCLLKRLRNGHV CCCCCHHHHHHCCCC	36.12	-
2000	Acetylation	REEPCLLKRLRNGHV CCCCCHHHHHHCCCC	36.12	25953088
2000	Malonylation	REEPCLLKRLRNGHV CCCCCHHHHHHCCCC	36.12	26320211
2000	Ubiquitination	REEPCLLKRLRNGHV CCCCCHHHHHHCCCC	36.12	21890473
2010	Phosphorylation	RNGHVGISFVPKETG HCCCCEEEEECCCCC	17.79	23312004
2016	Acetylation	ISFVPKETGEHLVHV EEEECCCCCCEEEEE	54.73	19608861
2016	Phosphorylation	ISFVPKETGEHLVHV EEEECCCCCCEEEEE	54.73	28674419
2024	2-Hydroxyisobutyrylation	GEHLVHVKKNGQHVA CCEEEEEEECCEEEE	26.16	-
2024	Acetylation	GEHLVHVKKNGQHVA CCEEEEEEECCEEEE	26.16	25953088
2024	Ubiquitination	GEHLVHVKKNGQHVA CCEEEEEEECCEEEE	26.16	-
2025	Malonylation	EHLVHVKKNGQHVAS CEEEEEEECCEEEEC	66.28	26320211
2032	Phosphorylation	KNGQHVASSPIPVVI ECCEEEECCCCCEEE	35.24	21712546
2033	Phosphorylation	NGQHVASSPIPVVIS CCEEEECCCCCEEEE	19.67	25159151
2040	Phosphorylation	SPIPVVISQSEIGDA CCCCEEEEHHHCCCC	18.95	26699800
2042	Phosphorylation	IPVVISQSEIGDASR CCEEEEHHHCCCCCC	25.13	26699800
2048	Phosphorylation	QSEIGDASRVRVSGQ HHHCCCCCCEEECCC	35.73	23663014
2053	Phosphorylation	DASRVRVSGQGLHEG CCCCEEECCCCCCCC	18.16	26055452
2062	Phosphorylation	QGLHEGHTFEPAEFI CCCCCCCCCCCEEEE	40.32	28464451
2081	Phosphorylation	DAGYGGLSLSIEGPS CCCCCCEEEEEECCC	24.28	26657352
2083	Phosphorylation	GYGGLSLSIEGPSKV CCCCEEEEEECCCCE	18.41	27499020
2088	Phosphorylation	SLSIEGPSKVDINTE EEEEECCCCEECCCC	57.05	-
2107	Glutathionylation	GTCRVTYCPTEPGNY CEEEEEECCCCCCCE	2.16	22555962
2109	Phosphorylation	CRVTYCPTEPGNYII EEEEECCCCCCCEEE	51.77	26657352
2128	Phosphorylation	ADQHVPGSPFSVKVT CCCCCCCCCCEEEEE	19.39	30266825
2131	Phosphorylation	HVPGSPFSVKVTGEG CCCCCCCEEEEECCC	25.14	30266825
2133	2-Hydroxyisobutyrylation	PGSPFSVKVTGEGRV CCCCCEEEEECCCCC	32.64	-
2133	Acetylation	PGSPFSVKVTGEGRV CCCCCEEEEECCCCC	32.64	23236377
2133	Malonylation	PGSPFSVKVTGEGRV CCCCCEEEEECCCCC	32.64	26320211
2133	Ubiquitination	PGSPFSVKVTGEGRV CCCCCEEEEECCCCC	32.64	-
2135	Phosphorylation	SPFSVKVTGEGRVKE CCCEEEEECCCCCCC	24.65	-
2141	Ubiquitination	VTGEGRVKESITRRR EECCCCCCCCCCCCC	44.37	-
2143	Phosphorylation	GEGRVKESITRRRRA CCCCCCCCCCCCCCC	24.44	23401153
2145	Phosphorylation	GRVKESITRRRRAPS CCCCCCCCCCCCCCC	27.66	29691806
2152	Phosphorylation	TRRRRAPSVANVGSH CCCCCCCCCCCCCCC	32.64	29255136
2158	Phosphorylation	PSVANVGSHCDLSLK CCCCCCCCCCCEECC	19.36	22167270
2163	Phosphorylation	VGSHCDLSLKIPEIS CCCCCCEECCCCCCE	17.86	22167270
2170	Phosphorylation	SLKIPEISIQDMTAQ ECCCCCCEEEEEEEE	16.73	22167270
2174	Sulfoxidation	PEISIQDMTAQVTSP CCCEEEEEEEEEECC	1.59	30846556
2175	Phosphorylation	EISIQDMTAQVTSPS CCEEEEEEEEEECCC	23.40	22167270
2179	Phosphorylation	QDMTAQVTSPSGKTH EEEEEEEECCCCCCE	23.88	29255136
2180	Phosphorylation	DMTAQVTSPSGKTHE EEEEEEECCCCCCEE	20.43	29255136
2182	Phosphorylation	TAQVTSPSGKTHEAE EEEEECCCCCCEEEE	53.33	29255136
2184	2-Hydroxyisobutyrylation	QVTSPSGKTHEAEIV EEECCCCCCEEEEEE	51.55	-
2184	Ubiquitination	QVTSPSGKTHEAEIV EEECCCCCCEEEEEE	51.55	-
2185	Phosphorylation	VTSPSGKTHEAEIVE EECCCCCCEEEEEEE	28.59	23312004
2197	Phosphorylation	IVEGENHTYCIRFVP EEECCCCEEEEEEEE	31.50	28152594
2198	Phosphorylation	VEGENHTYCIRFVPA EECCCCEEEEEEEEC	4.37	28152594
2199	S-nitrosylation	EGENHTYCIRFVPAE ECCCCEEEEEEEECC	1.57	25040305
2207	Sulfoxidation	IRFVPAEMGTHTVSV EEEEECCCCEEEEEE	9.01	30846556
2207 (in isoform 2)	Ubiquitination	-	9.01	21890473
2207	Ubiquitination	IRFVPAEMGTHTVSV EEEEECCCCEEEEEE	9.01	21890473
2209	Phosphorylation	FVPAEMGTHTVSVKY EEECCCCEEEEEEEE	17.05	26657352
2209 (in isoform 2)	Ubiquitination	-	17.05	21890473
2209	Ubiquitination	FVPAEMGTHTVSVKY EEECCCCEEEEEEEE	17.05	21890473
2211	Phosphorylation	PAEMGTHTVSVKYKG ECCCCEEEEEEEECC	17.83	28060719
2213	Phosphorylation	EMGTHTVSVKYKGQH CCCEEEEEEEECCEE	17.66	28857561
2215	2-Hydroxyisobutyrylation	GTHTVSVKYKGQHVP CEEEEEEEECCEECC	33.47	-
2215	Acetylation	GTHTVSVKYKGQHVP CEEEEEEEECCEECC	33.47	23236377
2215	Ubiquitination	GTHTVSVKYKGQHVP CEEEEEEEECCEECC	33.47	21890473
2215 (in isoform 1)	Ubiquitination	-	33.47	21890473
2215	Ubiquitination	GTHTVSVKYKGQHVP CEEEEEEEECCEECC	33.47	21890473
2217	2-Hydroxyisobutyrylation	HTVSVKYKGQHVPGS EEEEEEECCEECCCC	46.51	-
2217	Acetylation	HTVSVKYKGQHVPGS EEEEEEECCEECCCC	46.51	26051181
2217	Malonylation	HTVSVKYKGQHVPGS EEEEEEECCEECCCC	46.51	26320211
2217	Methylation	HTVSVKYKGQHVPGS EEEEEEECCEECCCC	46.51	-
2217	Ubiquitination	HTVSVKYKGQHVPGS EEEEEEECCEECCCC	46.51	21890473
2217 (in isoform 1)	Ubiquitination	-	46.51	21890473
2217	Ubiquitination	HTVSVKYKGQHVPGS EEEEEEECCEECCCC	46.51	21890473
2224	Phosphorylation	KGQHVPGSPFQFTVG CCEECCCCCCEEEEE	19.23	26657352
2229	Phosphorylation	PGSPFQFTVGPLGEG CCCCCEEEEECCCCC	17.48	28857561
2240	Ubiquitination	LGEGGAHKVRAGGPG CCCCCCCEECCCCCC	32.65	-
2242	Methylation	EGGAHKVRAGGPGLE CCCCCEECCCCCCHH	32.11	-
2260	Phosphorylation	AGVPAEFSIWTREAG CCCCCEEEEEECCCC	14.55	21712546
2279	Phosphorylation	AIAVEGPSKAEISFE EEEEECCCCCEEEEC	56.19	27080861
2284	Phosphorylation	GPSKAEISFEDRKDG CCCCCEEEECCCCCC	17.68	29255136
2289	Acetylation	EISFEDRKDGSCGVA EEEECCCCCCCCEEE	77.94	26051181
2289	Malonylation	EISFEDRKDGSCGVA EEEECCCCCCCCEEE	77.94	26320211
2289	Ubiquitination	EISFEDRKDGSCGVA EEEECCCCCCCCEEE	77.94	-
2292	Phosphorylation	FEDRKDGSCGVAYVV ECCCCCCCCEEEEEE	20.17	26657352
2293	Glutathionylation	EDRKDGSCGVAYVVQ CCCCCCCCEEEEEEE	6.59	22555962
2305	Phosphorylation	VVQEPGDYEVSVKFN EEECCCCEEEEEEEC	24.93	21712546
2308	Phosphorylation	EPGDYEVSVKFNEEH CCCCEEEEEEECHHH	13.98	21712546
2319	Phosphorylation	NEEHIPDSPFVVPVA CHHHCCCCCEEEEEE	18.19	23927012
2327	Phosphorylation	PFVVPVASPSGDARR CEEEEEECCCCCHHE	21.60	29255136
2329	Phosphorylation	VVPVASPSGDARRLT EEEEECCCCCHHEEE	46.97	29255136
2336	Phosphorylation	SGDARRLTVSSLQES CCCHHEEEHHHHHHC	19.27	30266825
2338	Phosphorylation	DARRLTVSSLQESGL CHHEEEHHHHHHCCC	21.79	30266825
2339	Phosphorylation	ARRLTVSSLQESGLK HHEEEHHHHHHCCCC	29.72	30266825
2343	Phosphorylation	TVSSLQESGLKVNQP EHHHHHHCCCCCCCC	36.14	25159151
2346	Malonylation	SLQESGLKVNQPASF HHHHCCCCCCCCCEE	42.54	26320211
2352	Phosphorylation	LKVNQPASFAVSLNG CCCCCCCEEEEECCC	22.03	28857561
2356	Phosphorylation	QPASFAVSLNGAKGA CCCEEEEECCCCCCE	16.82	25849741
2361	2-Hydroxyisobutyrylation	AVSLNGAKGAIDAKV EEECCCCCCEEEEEE	50.72	-
2361	Ubiquitination	AVSLNGAKGAIDAKV EEECCCCCCEEEEEE	50.72	-
2367	2-Hydroxyisobutyrylation	AKGAIDAKVHSPSGA CCCEEEEEEECCCCC	36.41	-
2367	Acetylation	AKGAIDAKVHSPSGA CCCEEEEEEECCCCC	36.41	26051181
2367	Malonylation	AKGAIDAKVHSPSGA CCCEEEEEEECCCCC	36.41	26320211
2367	Ubiquitination	AKGAIDAKVHSPSGA CCCEEEEEEECCCCC	36.41	-
2370	Phosphorylation	AIDAKVHSPSGALEE EEEEEEECCCCCCEE	24.61	21712546
2372	Phosphorylation	DAKVHSPSGALEECY EEEEECCCCCCEEEE	39.45	25849741
2379	Phosphorylation	SGALEECYVTEIDQD CCCCEEEEEEEECCC	17.43	26657352
2381	Phosphorylation	ALEECYVTEIDQDKY CCEEEEEEEECCCCE	10.76	26356563
2387	Acetylation	VTEIDQDKYAVRFIP EEEECCCCEEEEEEE	29.49	25825284
2387	Malonylation	VTEIDQDKYAVRFIP EEEECCCCEEEEEEE	29.49	26320211
2387	Ubiquitination	VTEIDQDKYAVRFIP EEEECCCCEEEEEEE	29.49	-
2388	Phosphorylation	TEIDQDKYAVRFIPR EEECCCCEEEEEEEC	20.72	21253578
2400	Phosphorylation	IPRENGVYLIDVKFN EECCCCEEEEEEEEC	10.19	28152594
2409	Phosphorylation	IDVKFNGTHIPGSPF EEEEECCEECCCCCC	20.10	24732914
2409 (in isoform 2)	Ubiquitination	-	20.10	21890473
2409	Ubiquitination	IDVKFNGTHIPGSPF EEEEECCEECCCCCC	20.10	21890473
2414	Phosphorylation	NGTHIPGSPFKIRVG CCEECCCCCCEEECC	23.08	25159151
2417	Acetylation	HIPGSPFKIRVGEPG ECCCCCCEEECCCCC	32.74	25953088
2417	Ubiquitination	HIPGSPFKIRVGEPG ECCCCCCEEECCCCC	32.74	21890473
2417 (in isoform 1)	Ubiquitination	-	32.74	21890473
2417	Ubiquitination	HIPGSPFKIRVGEPG ECCCCCCEEECCCCC	32.74	21890473
2473	2-Hydroxyisobutyrylation	IDGPSKVKMDCQECP EECCCCEEEECCCCC	32.53	-
2473	Acetylation	IDGPSKVKMDCQECP EECCCCEEEECCCCC	32.53	25953088
2473	Malonylation	IDGPSKVKMDCQECP EECCCCEEEECCCCC	32.53	26320211
2473	Ubiquitination	IDGPSKVKMDCQECP EECCCCEEEECCCCC	32.53	-
2474	Sulfoxidation	DGPSKVKMDCQECPE ECCCCEEEECCCCCC	7.54	30846556
2476	S-nitrosylation	PSKVKMDCQECPEGY CCCEEEECCCCCCCE	3.08	22126794
2479	S-nitrosylation	VKMDCQECPEGYRVT EEEECCCCCCCEEEE	1.21	2212679
2483	Phosphorylation	CQECPEGYRVTYTPM CCCCCCCEEEEEECC	10.55	-
2486	Phosphorylation	CPEGYRVTYTPMAPG CCCCEEEEEECCCCC	16.81	20068231
2487	Phosphorylation	PEGYRVTYTPMAPGS CCCEEEEEECCCCCC	13.14	27251275
2488	Phosphorylation	EGYRVTYTPMAPGSY CCEEEEEECCCCCCE	9.38	26657352
2494	Phosphorylation	YTPMAPGSYLISIKY EECCCCCCEEEEEEE	18.73	26657352
2495	Phosphorylation	TPMAPGSYLISIKYG ECCCCCCEEEEEEEC	17.61	28857561
2501	Phosphorylation	SYLISIKYGGPYHIG CEEEEEEECCCCEEC	26.16	28152594
2505	Acetylation	SIKYGGPYHIGGSPF EEEECCCCEECCCCC	14.89	19608861
2505	Phosphorylation	SIKYGGPYHIGGSPF EEEECCCCEECCCCC	14.89	28152594
2510	Phosphorylation	GPYHIGGSPFKAKVT CCCEECCCCCCCEEC	23.19	22167270
2513	Acetylation	HIGGSPFKAKVTGPR EECCCCCCCEECCCE	51.16	26051181
2513	Malonylation	HIGGSPFKAKVTGPR EECCCCCCCEECCCE	51.16	26320211
2513	Ubiquitination	HIGGSPFKAKVTGPR EECCCCCCCEECCCE	51.16	-
2517	Phosphorylation	SPFKAKVTGPRLVSN CCCCCEECCCEEECC	40.54	26437602
2523	Phosphorylation	VTGPRLVSNHSLHET ECCCEEECCCCCCCC	33.16	21712546
2526	Phosphorylation	PRLVSNHSLHETSSV CEEECCCCCCCCCEE	35.35	22617229
2530	Phosphorylation	SNHSLHETSSVFVDS CCCCCCCCCEEEHHH	18.63	28450419
2531	Phosphorylation	NHSLHETSSVFVDSL CCCCCCCCEEEHHHC	22.86	28450419
2532	Phosphorylation	HSLHETSSVFVDSLT CCCCCCCEEEHHHCC	27.30	28450419
2537	Phosphorylation	TSSVFVDSLTKATCA CCEEEHHHCCCCCCC	32.41	28060719
2539	Phosphorylation	SVFVDSLTKATCAPQ EEEHHHCCCCCCCCC	23.68	28060719
2540	Acetylation	VFVDSLTKATCAPQH EEHHHCCCCCCCCCC	47.17	26051181
2540	Malonylation	VFVDSLTKATCAPQH EEHHHCCCCCCCCCC	47.17	26320211
2540	Ubiquitination	VFVDSLTKATCAPQH EEHHHCCCCCCCCCC	47.17	-
2542	Phosphorylation	VDSLTKATCAPQHGA HHHCCCCCCCCCCCC	15.68	-
2543	S-nitrosocysteine	DSLTKATCAPQHGAP HHCCCCCCCCCCCCC	6.59	-
2543	Glutathionylation	DSLTKATCAPQHGAP HHCCCCCCCCCCCCC	6.59	22555962
2543	S-nitrosylation	DSLTKATCAPQHGAP HHCCCCCCCCCCCCC	6.59	20140087
2543	S-palmitoylation	DSLTKATCAPQHGAP HHCCCCCCCCCCCCC	6.59	29575903
2559	2-Hydroxyisobutyrylation	PGPADASKVVAKGLG CCCCCHHHHHHHHCC	42.31	-
2559	Acetylation	PGPADASKVVAKGLG CCCCCHHHHHHHHCC	42.31	25953088
2559	Malonylation	PGPADASKVVAKGLG CCCCCHHHHHHHHCC	42.31	26320211
2563	2-Hydroxyisobutyrylation	DASKVVAKGLGLSKA CHHHHHHHHCCCCCC	42.96	-
2563	Malonylation	DASKVVAKGLGLSKA CHHHHHHHHCCCCCC	42.96	26320211
2563	Ubiquitination	DASKVVAKGLGLSKA CHHHHHHHHCCCCCC	42.96	-
2569	2-Hydroxyisobutyrylation	AKGLGLSKAYVGQKS HHHCCCCCCCCCCCC	49.10	-
2569	Acetylation	AKGLGLSKAYVGQKS HHHCCCCCCCCCCCC	49.10	23954790
2569	Malonylation	AKGLGLSKAYVGQKS HHHCCCCCCCCCCCC	49.10	26320211
2569	Succinylation	AKGLGLSKAYVGQKS HHHCCCCCCCCCCCC	49.10	-
2569	Succinylation	AKGLGLSKAYVGQKS HHHCCCCCCCCCCCC	49.10	-
2569	Ubiquitination	AKGLGLSKAYVGQKS HHHCCCCCCCCCCCC	49.10	-
2571	Phosphorylation	GLGLSKAYVGQKSSF HCCCCCCCCCCCCEE	14.62	24719451
2575	2-Hydroxyisobutyrylation	SKAYVGQKSSFTVDC CCCCCCCCCEEEEEC	41.98	-
2575	Acetylation	SKAYVGQKSSFTVDC CCCCCCCCCEEEEEC	41.98	26051181
2575	Malonylation	SKAYVGQKSSFTVDC CCCCCCCCCEEEEEC	41.98	26320211
2575	Ubiquitination	SKAYVGQKSSFTVDC CCCCCCCCCEEEEEC	41.98	-
2576	Phosphorylation	KAYVGQKSSFTVDCS CCCCCCCCEEEEECH	23.85	21815630
2577	Phosphorylation	AYVGQKSSFTVDCSK CCCCCCCEEEEECHH	31.78	24670416
2579	Phosphorylation	VGQKSSFTVDCSKAG CCCCCEEEEECHHCC	19.86	28060719
2584	2-Hydroxyisobutyrylation	SFTVDCSKAGNNMLL EEEEECHHCCCCEEE	67.65	-
2584	Acetylation	SFTVDCSKAGNNMLL EEEEECHHCCCCEEE	67.65	26051181
2584	Malonylation	SFTVDCSKAGNNMLL EEEEECHHCCCCEEE	67.65	32601280
2584	Ubiquitination	SFTVDCSKAGNNMLL EEEEECHHCCCCEEE	67.65	-
2589	Sulfoxidation	CSKAGNNMLLVGVHG CHHCCCCEEEEEEEC	3.38	30846556
2599	Acetylation	VGVHGPRTPCEEILV EEEECCCCCHHHHHH	35.11	19608861
2599	Phosphorylation	VGVHGPRTPCEEILV EEEECCCCCHHHHHH	35.11	30266825
2601	Glutathionylation	VHGPRTPCEEILVKH EECCCCCHHHHHHHH	7.87	22555962
2601	S-nitrosylation	VHGPRTPCEEILVKH EECCCCCHHHHHHHH	7.87	2212679
2601	S-palmitoylation	VHGPRTPCEEILVKH EECCCCCHHHHHHHH	7.87	29575903
2607	2-Hydroxyisobutyrylation	PCEEILVKHVGSRLY CHHHHHHHHHHHCEE	29.18	-
2607	Acetylation	PCEEILVKHVGSRLY CHHHHHHHHHHHCEE	29.18	19608861
2607	Malonylation	PCEEILVKHVGSRLY CHHHHHHHHHHHCEE	29.18	26320211
2611	Phosphorylation	ILVKHVGSRLYSVSY HHHHHHHHCEEEEEE	20.30	23898821
2613	Acetylation	VKHVGSRLYSVSYLL HHHHHHCEEEEEEEE	3.91	19608861
2613 (in isoform 2)	Ubiquitination	-	3.91	21890473
2613	Ubiquitination	VKHVGSRLYSVSYLL HHHHHHCEEEEEEEE	3.91	21890473
2614	Phosphorylation	KHVGSRLYSVSYLLK HHHHHCEEEEEEEEC	13.10	28152594
2615	Phosphorylation	HVGSRLYSVSYLLKD HHHHCEEEEEEEECC	14.80	28152594
2617	O-linked_Glycosylation	GSRLYSVSYLLKDKG HHCEEEEEEEECCCC	12.24	23301498
2617	Phosphorylation	GSRLYSVSYLLKDKG HHCEEEEEEEECCCC	12.24	28152594
2618	Phosphorylation	SRLYSVSYLLKDKGE HCEEEEEEEECCCCE	17.56	28152594
2621	Acetylation	YSVSYLLKDKGEYTL EEEEEEECCCCEEEE	55.59	19608861
2621	Malonylation	YSVSYLLKDKGEYTL EEEEEEECCCCEEEE	55.59	26320211
2621	Ubiquitination	YSVSYLLKDKGEYTL EEEEEEECCCCEEEE	55.59	21890473
2621 (in isoform 1)	Ubiquitination	-	55.59	21890473
2621	Ubiquitination	YSVSYLLKDKGEYTL EEEEEEECCCCEEEE	55.59	21890473
2623	Acetylation	VSYLLKDKGEYTLVV EEEEECCCCEEEEEE	52.64	23954790
2623	Malonylation	VSYLLKDKGEYTLVV EEEEECCCCEEEEEE	52.64	26320211
2623	Ubiquitination	VSYLLKDKGEYTLVV EEEEECCCCEEEEEE	52.64	-
2626	Phosphorylation	LLKDKGEYTLVVKWG EECCCCEEEEEEEEC	17.65	28060719
2627	Phosphorylation	LKDKGEYTLVVKWGD ECCCCEEEEEEEECC	14.58	28060719
2631	Ubiquitination	GEYTLVVKWGDEHIP CEEEEEEEECCCCCC	37.67	-
2640	Phosphorylation	GDEHIPGSPYRVVVP CCCCCCCCCEEEECC	17.26	25159151
2642	Phosphorylation	EHIPGSPYRVVVP-- CCCCCCCEEEECC--	20.10	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1084	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1286	T	Phosphorylation	Kinase	MAP3K7	O43318	GPS
1436	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1459	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1459	S	Phosphorylation	Kinase	CDK4	P11802	PSP
1459	S	Phosphorylation	Kinase	CDK6	Q00534	PSP
1533	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1630	S	Phosphorylation	Kinase	CDK1	P06493	PSP
2152	S	Phosphorylation	Kinase	RSK_GROUP	-	PhosphoELM
2152	S	Phosphorylation	Kinase	AKT1	P31749	PSP
2152	S	Phosphorylation	Kinase	RSK-SUBFAMILY	-	GPS
2152	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
2152	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
2152	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
2152	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
2152	S	Phosphorylation	Kinase	PKACA	P17612	PSP
2152	S	Phosphorylation	Kinase	PKACA	P00517	PSP
2152	S	Phosphorylation	Kinase	CDK6	Q00534	PSP
2152	S	Phosphorylation	Kinase	CDK4	P11802	PSP
2292	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
2370	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
2523	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
2523	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
2523	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	ASB2	Q96Q27	PMID:18799729

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
2152	S	Phosphorylation	17081983
Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA.
2152	S	Phosphorylation	17081983
Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FLNA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DRD3_HUMAN	DRD3	physical	11911837
ITB1_HUMAN	ITGB1	physical	11807098
CMIP_HUMAN	CMIP	physical	15128042
TRIO_HUMAN	TRIO	physical	11146652
CASR_HUMAN	CASR	physical	11390380
FLNB_HUMAN	FLNB	physical	12393796
ITB3_HUMAN	ITGB3	physical	11807098
ITB6_HUMAN	ITGB6	physical	11807098
TF_HUMAN	F3	physical	9490735
ITB7_HUMAN	ITGB7	physical	11781567
RALA_HUMAN	RALA	physical	10051605
CASR_HUMAN	CASR	physical	11390379
SH2B3_HUMAN	SH2B3	physical	11163396
FLIP1_HUMAN	FILIP1	physical	12055638
ASB2_HUMAN	ASB2	physical	21750192
LMNA_HUMAN	LMNA	physical	16248985
KCND2_HUMAN	KCND2	physical	20498229
KCNE4_HUMAN	KCNE4	physical	20498229
FLNB_HUMAN	FLNB	physical	22939629
MYH9_HUMAN	MYH9	physical	22939629
LEG1_HUMAN	LGALS1	physical	22939629
ILF2_HUMAN	ILF2	physical	22939629
RBP2_HUMAN	RANBP2	physical	22939629
SRRM2_HUMAN	SRRM2	physical	22939629
SRS11_HUMAN	SRSF11	physical	22939629
RBM39_HUMAN	RBM39	physical	22939629
IKIP_HUMAN	IKBIP	physical	22939629
TRA2B_HUMAN	TRA2B	physical	22939629
IGSF8_HUMAN	IGSF8	physical	23463506
CD81_HUMAN	CD81	physical	23463506
ICAM1_HUMAN	ICAM1	physical	23463506
BASI_HUMAN	BSG	physical	23463506
ASB2_HUMAN	ASB2	physical	24052262
AKA12_HUMAN	AKAP12	physical	22863883
DYHC1_HUMAN	DYNC1H1	physical	22863883
DC1L1_HUMAN	DYNC1LI1	physical	22863883
DC1L2_HUMAN	DYNC1LI2	physical	22863883
RS23_HUMAN	RPS23	physical	22863883
SYNP2_HUMAN	SYNPO2	physical	20554076
REL_HUMAN	REL	physical	25416956
ITF2_HUMAN	TCF4	physical	25416956
HSPB7_HUMAN	HSPB7	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	25416956
PPL13_HUMAN	LGALS14	physical	25416956
KLH12_HUMAN	KLHL12	physical	25416956
RFLA_HUMAN	FAM101A	physical	25416956
ACTB_HUMAN	ACTB	physical	26496610
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
AP2A1_HUMAN	AP2A1	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
ANXA2_HUMAN	ANXA2	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
CD44_HUMAN	CD44	physical	26496610
CD59_HUMAN	CD59	physical	26496610
COF1_HUMAN	CFL1	physical	26496610
COF2_HUMAN	CFL2	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DAPK3_HUMAN	DAPK3	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
SRC8_HUMAN	CTTN	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
FLII_HUMAN	FLII	physical	26496610
FLNB_HUMAN	FLNB	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
GNAI1_HUMAN	GNAI1	physical	26496610
GNAS3_HUMAN	GNAS	physical	26496610
GNAS2_HUMAN	GNAS	physical	26496610
ALEX_HUMAN	GNAS	physical	26496610
GNAS1_HUMAN	GNAS	physical	26496610
GBB2_HUMAN	GNB2	physical	26496610
GELS_HUMAN	GSN	physical	26496610
HMGB2_HUMAN	HMGB2	physical	26496610
HS90B_HUMAN	HSP90AB1	physical	26496610
ITPR3_HUMAN	ITPR3	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO1E_HUMAN	MYO1E	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
PALM_HUMAN	PALM	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
PP1G_HUMAN	PPP1CC	physical	26496610
TWF1_HUMAN	TWF1	physical	26496610
S10AA_HUMAN	S100A10	physical	26496610
SEC13_HUMAN	SEC13	physical	26496610
FSCN1_HUMAN	FSCN1	physical	26496610
UAP1_HUMAN	UAP1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SPTN2_HUMAN	SPTBN2	physical	26496610
SSFA2_HUMAN	SSFA2	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
TPM2_HUMAN	TPM2	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
RHGBA_HUMAN	ARHGAP11A	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
ARPC4_HUMAN	ARPC4	physical	26496610
ARPC3_HUMAN	ARPC3	physical	26496610
ARC1B_HUMAN	ARPC1B	physical	26496610
ARP3_HUMAN	ACTR3	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
FLOT1_HUMAN	FLOT1	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
PALLD_HUMAN	PALLD	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
COBL_HUMAN	COBL	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
TES_HUMAN	TES	physical	26496610
ZBT20_HUMAN	ZBTB20	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
MYO5C_HUMAN	MYO5C	physical	26496610
GBG12_HUMAN	GNG12	physical	26496610
COR1B_HUMAN	CORO1B	physical	26496610
K1211_HUMAN	KIAA1211	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
BACD3_HUMAN	KCTD10	physical	26496610
ANTR1_HUMAN	ANTXR1	physical	26496610
NEB2_HUMAN	PPP1R9B	physical	26496610
STON2_HUMAN	STON2	physical	26496610
DIXC1_HUMAN	DIXDC1	physical	26496610
SSH2_HUMAN	SSH2	physical	26496610
PHLB2_HUMAN	PHLDB2	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
MISP_HUMAN	MISP	physical	26496610
CHM4B_HUMAN	CHMP4B	physical	26496610
PPR18_HUMAN	PPP1R18	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
MY18A_HUMAN	MYO18A	physical	26496610
BIG2_HUMAN	ARFGEF2	physical	24089482

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300049	Periventricular nodular heterotopia 1 (PVNH1)
300537	Periventricular nodular heterotopia 4 (PVNH4)
311300	Otopalatodigital syndrome 1 (OPD1)
304120	Otopalatodigital syndrome 2 (OPD2)
305620	Frontometaphyseal dysplasia (FMD)
309350	Melnick-Needles syndrome (MNS)
300048	Intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked (IPOX)
300321	FG syndrome 2 (FGS2)
300244	Terminal osseous dysplasia (TOD)
314400	Cardiac valvular dysplasia X-linked (CVDX)
	Note=Defects in FLNA may be a cause of macrothrombocytopenia, a disorder characterized by subnormal levels of blood platelets. Blood platelets are abnormally enlarged.
300048
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FLNA_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-504; LYS-508; LYS-700;LYS-781; LYS-837; LYS-891; LYS-994; LYS-1538; LYS-2607 AND LYS-2621,AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084 AND SER-2152, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084; SER-1338;SER-1459; SER-1533; SER-1630; SER-2053; SER-2152; SER-2327; SER-2414AND SER-2510, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1081; SER-1084 ANDSER-1459, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1459, AND MASSSPECTROMETRY.	19367720 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084; SER-1459; SER-2152AND SER-2158, AND MASS SPECTROMETRY.	18088087 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084; SER-1459 ANDSER-2152, AND MASS SPECTROMETRY.	18187866 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084, AND MASSSPECTROMETRY.	16565220 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084 AND SER-1459, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1089; SER-1459;SER-1533; SER-2152; SER-2284 AND SER-2327, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084 AND SER-1459, ANDMASS SPECTROMETRY.	15302935 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-373; TYR-1604 ANDTYR-2388, AND MASS SPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1047, AND MASSSPECTROMETRY.	15592455 [Abstract]

show

show