COBL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COBL_HUMAN
• UniProt AC: O75128
• Protein Name: Protein cordon-bleu
• Gene Name: COBL
• Organism: Homo sapiens (Human).
• Sequence Length: 1261
• Subcellular Localization: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the n
• Protein Description: Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles..
• Protein Sequence: MDAPRASAAKPPTGRKMKARAPPPPGKAATLHVHSDQKPPHDGALGSQQNLVRMKEALRASTMDVTVVLPSGLEKRSVLNGSHAMMDLLVELCLQNHLNPSHHALEIRSSETQQPLSFKPNTLIGTLNVHTVFLKEKVPEEKVKPGPPKVPEKSVRLVVNYLRTQKAVVRVSPEVPLQNILPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRRETFRKSSLGNDETDKEKKKFLGFFKVNKRSNSKGCLTTPNSPSMHSRSLTLGPSLSLGSISGVSVKSEMKKRRAPPPPGSGPPVQDKASEKVSLGSQIDLQKKKRRAPAPPPPQPPPPSPLIPNRTEDKEENRKSTMVSLPLGSGSHCSPDGAPQVLSEAEETVSVGSCFASEDTTEDSGVMSSPSDIVSLDSQQDSMKYKDKWATDQEDCSDQDLAGTPDLGPQKSPLWEKNGSENSHLRTEKAVTASNDEEDLLIAGEFRKTLAELDEDLEEMEDSYETDTSSLTSSIHGASNHCPQDAMIPHGDTDAIPVTFIGEVSDDPVDSGLFSNRNNNAGSFDSEGVASRRDSLAPLQAEHSQPHEKAREEVPALHPASHDVGKGIRVALSNISKDGNLMETAPRVTSFASNLHTDNLNAKVKDKVYGCADGERTQATERVNSQPVNEKDSNDKNAALAPTSWHQRGQNPGKSYRLKHGLTTYKIIPPKSEMRCYDRDVSLSTGAIKIDELGNLVSPHATGIRIISLSSSVPEAESQPIGKVREFWRCNSVEKHLGRPSESSARGPPSTPVPTQTQNPESRLQADPKPISPQQKSAHHEGRNPLGEGRNQPPTMGMGHVRVPAAHTTEVTFLKPQRRTSSQYVASAIAKRIGAPKVHADVVRPHGYAEKGYAGKAPVLAAPPVTVKDDRTSSPHSETQGWKDGAQWPCVTPPNNHGEDLAVGAPPRGEVIGPHRKLSTQDRPAAIHRSSCFSLVQSSQRDRVSVGQSCGFSGKQSTSSQEASSASEPRRAPDGTDPPPPHTSDTQACSRELVNGSVRAPGHGEPSHPPGGSGTESHILLEREEKPSVFSTDGNETDSIWPPSIFGPKKKFKPVVQRPVPKDTSLHSALMEAIHSAGGKDRLRKTAEHTGEGRPAKLSYTEAEGERSALLAAIRGHSGTCSLRKVASSASEELQSFRDAALSAQGSESPLLEDLGLLSPPAIPPPPPPPSQALSAPRTASRFSTGTLSNTADARQALMDAIRSGTGAARLRKVPLLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MDAPRASAAKPPTG -CCCCCCCCCCCCCC	30.00	26437602
35	Phosphorylation	AATLHVHSDQKPPHD CEEEEECCCCCCCCC	40.42	26437602
47	Phosphorylation	PHDGALGSQQNLVRM CCCCCCCCHHHHHHH	29.46	23312004
61	Phosphorylation	MKEALRASTMDVTVV HHHHHHHHCCEEEEE	20.17	26437602
62	Phosphorylation	KEALRASTMDVTVVL HHHHHHHCCEEEEEC	19.19	24719451
117	Phosphorylation	SETQQPLSFKPNTLI CCCCCCCCCCCCCEE	37.60	24719451
211	Ubiquitination	GEELELSKSLNELGI CCHHHHHHHHHHHCC	72.14	29967540
212	Phosphorylation	EELELSKSLNELGIK CHHHHHHHHHHHCCC	32.81	26437602
234	Phosphorylation	RRETFRKSSLGNDET HHHHHHHHHCCCCCC	26.92	22167270
235	Phosphorylation	RETFRKSSLGNDETD HHHHHHHHCCCCCCH	43.24	28355574
241	Phosphorylation	SSLGNDETDKEKKKF HHCCCCCCHHHHHHH	56.06	22167270
258	Phosphorylation	FFKVNKRSNSKGCLT EEECCCCCCCCCCCC	47.25	20873877
260	Phosphorylation	KVNKRSNSKGCLTTP ECCCCCCCCCCCCCC	31.50	25849741
260 (in isoform 2)	Phosphorylation	-	31.50	26657352
265	Phosphorylation	SNSKGCLTTPNSPSM CCCCCCCCCCCCCCC	44.26	22167270
266	Phosphorylation	NSKGCLTTPNSPSMH CCCCCCCCCCCCCCC	13.92	30266825
268 (in isoform 2)	Phosphorylation	-	65.54	30266825
269	Phosphorylation	GCLTTPNSPSMHSRS CCCCCCCCCCCCCCC	21.39	30266825
271	Phosphorylation	LTTPNSPSMHSRSLT CCCCCCCCCCCCCEE	29.02	30266825
272 (in isoform 2)	Phosphorylation	-	3.65	30266825
274	Phosphorylation	PNSPSMHSRSLTLGP CCCCCCCCCCEEECC	18.21	22167270
276	Phosphorylation	SPSMHSRSLTLGPSL CCCCCCCCEEECCCC	28.81	22210691
276 (in isoform 2)	Phosphorylation	-	28.81	23663014
277 (in isoform 2)	Phosphorylation	-	4.44	23663014
278	Phosphorylation	SMHSRSLTLGPSLSL CCCCCCEEECCCCCC	30.80	24719451
282	Phosphorylation	RSLTLGPSLSLGSIS CCEEECCCCCCCCCC	28.88	26270265
284	Phosphorylation	LTLGPSLSLGSISGV EEECCCCCCCCCCCC	34.71	26657352
287	Phosphorylation	GPSLSLGSISGVSVK CCCCCCCCCCCCCHH	20.90	29083192
289	Phosphorylation	SLSLGSISGVSVKSE CCCCCCCCCCCHHHH	34.54	29083192
290 (in isoform 2)	Phosphorylation	-	17.66	23898821
291 (in isoform 2)	Phosphorylation	-	4.79	22210691
292	Phosphorylation	LGSISGVSVKSEMKK CCCCCCCCHHHHHHH	27.61	24719451
294 (in isoform 2)	Phosphorylation	-	32.94	25849741
295	Phosphorylation	ISGVSVKSEMKKRRA CCCCCHHHHHHHCCC	40.54	-
308	Phosphorylation	RAPPPPGSGPPVQDK CCCCCCCCCCCCCCC	54.63	21406692
317	Phosphorylation	PPVQDKASEKVSLGS CCCCCCHHCCCCCCC	43.63	26437602
321	Phosphorylation	DKASEKVSLGSQIDL CCHHCCCCCCCHHHH	37.77	25159151
324	Phosphorylation	SEKVSLGSQIDLQKK HCCCCCCCHHHHHHH	29.29	30266825
347	Phosphorylation	PPQPPPPSPLIPNRT CCCCCCCCCCCCCCC	37.80	29255136
354	Phosphorylation	SPLIPNRTEDKEENR CCCCCCCCCCCHHHH	56.00	27251275
363 (in isoform 4)	Phosphorylation	-	20.64	22210691
363 (in isoform 5)	Phosphorylation	-	20.64	26437602
364 (in isoform 4)	Phosphorylation	-	25.32	22210691
367 (in isoform 4)	Phosphorylation	-	17.28	22210691
393 (in isoform 4)	Phosphorylation	-	28.34	29052541
397 (in isoform 4)	Phosphorylation	-	2.44	29052541
401 (in isoform 4)	Phosphorylation	-	56.82	29052541
402 (in isoform 4)	Phosphorylation	-	57.33	29052541
434	Phosphorylation	KYKDKWATDQEDCSD CCCHHCCCCHHHCCC	36.78	30576142
440	Phosphorylation	ATDQEDCSDQDLAGT CCCHHHCCCCCCCCC	51.10	30278072
447	Phosphorylation	SDQDLAGTPDLGPQK CCCCCCCCCCCCCCC	14.18	21815630
455	Phosphorylation	PDLGPQKSPLWEKNG CCCCCCCCCHHHCCC	21.70	20363803
463	Phosphorylation	PLWEKNGSENSHLRT CHHHCCCCCCCCCCE	42.89	20068231
466	Phosphorylation	EKNGSENSHLRTEKA HCCCCCCCCCCEEEE	21.61	20068231
566	Phosphorylation	NRNNNAGSFDSEGVA CCCCCCCCCCCCCHH	24.38	25159151
569	Phosphorylation	NNAGSFDSEGVASRR CCCCCCCCCCHHHCC	33.95	22167270
574	Phosphorylation	FDSEGVASRRDSLAP CCCCCHHHCCHHCCC	25.99	22167270
578	Phosphorylation	GVASRRDSLAPLQAE CHHHCCHHCCCCCCC	25.31	28348404
587	Phosphorylation	APLQAEHSQPHEKAR CCCCCCCCCCCHHHH	36.59	-
619	Phosphorylation	RVALSNISKDGNLME HHHHHCCCCCCCHHH	29.01	28348404
652	Phosphorylation	AKVKDKVYGCADGER HHEECCEECCCCCCC	16.54	20007894
668	Phosphorylation	QATERVNSQPVNEKD CCHHHHHCCCCCCCC	32.76	28348404
687	Phosphorylation	NAALAPTSWHQRGQN CCCCCCCCHHHCCCC	22.85	28555341
698	Phosphorylation	RGQNPGKSYRLKHGL CCCCCCCCCCCCCCC	22.77	28857561
708	Phosphorylation	LKHGLTTYKIIPPKS CCCCCEEEEEECCHH	8.58	-
720	Phosphorylation	PKSEMRCYDRDVSLS CHHHCCEECCCCCCC	12.03	24732914
725	Phosphorylation	RCYDRDVSLSTGAIK CEECCCCCCCCCCEE	22.38	24732914
728	Phosphorylation	DRDVSLSTGAIKIDE CCCCCCCCCCEEHHH	35.61	20068231
741	Phosphorylation	DELGNLVSPHATGIR HHHCCCCCCCCCCEE	17.71	25159151
745	Phosphorylation	NLVSPHATGIRIISL CCCCCCCCCEEEEEE	30.06	24732914
751	Phosphorylation	ATGIRIISLSSSVPE CCCEEEEEECCCCCH	21.59	15345747
753	Phosphorylation	GIRIISLSSSVPEAE CEEEEEECCCCCHHH	17.49	25159151
754	Phosphorylation	IRIISLSSSVPEAES EEEEEECCCCCHHHC	40.42	25159151
755	Phosphorylation	RIISLSSSVPEAESQ EEEEECCCCCHHHCC	38.01	25159151
766	Ubiquitination	AESQPIGKVREFWRC HHCCCCCHHHHHHCC	38.55	29967540
775	Phosphorylation	REFWRCNSVEKHLGR HHHHCCCCHHHHCCC	34.97	24719451
784	Phosphorylation	EKHLGRPSESSARGP HHHCCCCCCCCCCCC	49.07	28555341
787	Phosphorylation	LGRPSESSARGPPST CCCCCCCCCCCCCCC	20.24	22210691
793	Phosphorylation	SSARGPPSTPVPTQT CCCCCCCCCCCCCCC	48.77	25159151
794	Phosphorylation	SARGPPSTPVPTQTQ CCCCCCCCCCCCCCC	33.79	25159151
798	Phosphorylation	PPSTPVPTQTQNPES CCCCCCCCCCCCHHH	44.47	23312004
800	Phosphorylation	STPVPTQTQNPESRL CCCCCCCCCCHHHHC	32.56	23312004
805	Phosphorylation	TQTQNPESRLQADPK CCCCCHHHHCCCCCC	39.28	22210691
815	Phosphorylation	QADPKPISPQQKSAH CCCCCCCCHHHHHCC	25.78	25159151
823	Ubiquitination	PQQKSAHHEGRNPLG HHHHHCCCCCCCCCC	38.63	29967540
863	Phosphorylation	FLKPQRRTSSQYVAS EECCCCCCCHHHHHH	34.61	21945579
864	Phosphorylation	LKPQRRTSSQYVASA ECCCCCCCHHHHHHH	17.40	21945579
865	Phosphorylation	KPQRRTSSQYVASAI CCCCCCCHHHHHHHH	25.56	21945579
867	Phosphorylation	QRRTSSQYVASAIAK CCCCCHHHHHHHHHH	10.42	21945579
870	Phosphorylation	TSSQYVASAIAKRIG CCHHHHHHHHHHHHC	15.34	21945579
894	Ubiquitination	RPHGYAEKGYAGKAP CCCCCCCCCCCCCCC	49.39	29967540
896	Phosphorylation	HGYAEKGYAGKAPVL CCCCCCCCCCCCCEE	24.21	20068231
915	Phosphorylation	VTVKDDRTSSPHSET CEECCCCCCCCCCCC	40.32	28985074
916	Phosphorylation	TVKDDRTSSPHSETQ EECCCCCCCCCCCCC	42.65	25159151
917	Phosphorylation	VKDDRTSSPHSETQG ECCCCCCCCCCCCCC	26.47	25849741
920	Phosphorylation	DRTSSPHSETQGWKD CCCCCCCCCCCCCCC	45.80	27251275
935	Phosphorylation	GAQWPCVTPPNNHGE CCCCCCCCCCCCCCC	39.48	25159151
951	Ubiquitination	LAVGAPPRGEVIGPH CCCCCCCCCCCCCCC	53.50	29967540
962	Phosphorylation	IGPHRKLSTQDRPAA CCCCCCCCCCCCCHH	27.36	23927012
963	Phosphorylation	GPHRKLSTQDRPAAI CCCCCCCCCCCCHHH	44.95	30576142
973	Phosphorylation	RPAAIHRSSCFSLVQ CCHHHHHHHHHHHHH	19.80	24719451
974	Phosphorylation	PAAIHRSSCFSLVQS CHHHHHHHHHHHHHC	21.09	28857561
981	Phosphorylation	SCFSLVQSSQRDRVS HHHHHHHCCCCCCCE	22.43	28555341
988	Phosphorylation	SSQRDRVSVGQSCGF CCCCCCCEECCCCCC	22.79	28674419
1000	Phosphorylation	CGFSGKQSTSSQEAS CCCCCCCCCCCCCCC	33.47	24043423
1001	Phosphorylation	GFSGKQSTSSQEASS CCCCCCCCCCCCCCC	29.88	24043423
1002	Phosphorylation	FSGKQSTSSQEASSA CCCCCCCCCCCCCCC	34.96	24043423
1003	Phosphorylation	SGKQSTSSQEASSAS CCCCCCCCCCCCCCC	31.93	24043423
1007	Phosphorylation	STSSQEASSASEPRR CCCCCCCCCCCCCCC	26.19	24043423
1008	Phosphorylation	TSSQEASSASEPRRA CCCCCCCCCCCCCCC	42.75	24043423
1010	Phosphorylation	SQEASSASEPRRAPD CCCCCCCCCCCCCCC	50.51	24043423
1026	Phosphorylation	TDPPPPHTSDTQACS CCCCCCCCCCCCHHC	33.79	-
1027	Phosphorylation	DPPPPHTSDTQACSR CCCCCCCCCCCHHCH	35.31	28985074
1029	Phosphorylation	PPPHTSDTQACSREL CCCCCCCCCHHCHHH	20.17	28985074
1033	Phosphorylation	TSDTQACSRELVNGS CCCCCHHCHHHHCCC	31.63	28985074
1108	Phosphorylation	RPVPKDTSLHSALME CCCCCCCCHHHHHHH	33.93	28555341
1119	Phosphorylation	ALMEAIHSAGGKDRL HHHHHHHHCCCHHHH	23.61	28555341
1129	Phosphorylation	GKDRLRKTAEHTGEG CHHHHHHHHHHHCCC	30.74	23186163
1133	Phosphorylation	LRKTAEHTGEGRPAK HHHHHHHHCCCCCCC	28.56	23312004
1142	Phosphorylation	EGRPAKLSYTEAEGE CCCCCCCEEEECCHH	29.33	21815630
1143	Phosphorylation	GRPAKLSYTEAEGER CCCCCCEEEECCHHH	21.02	23312004
1144	Phosphorylation	RPAKLSYTEAEGERS CCCCCEEEECCHHHH	25.91	23312004
1163	Phosphorylation	AIRGHSGTCSLRKVA HHHCCCCCCCHHHHH	11.26	28348404
1165	Phosphorylation	RGHSGTCSLRKVASS HCCCCCCCHHHHHCC	30.92	28348404
1171	Phosphorylation	CSLRKVASSASEELQ CCHHHHHCCHHHHHH	29.44	23312004
1172	Phosphorylation	SLRKVASSASEELQS CHHHHHCCHHHHHHH	26.52	23312004
1174	Phosphorylation	RKVASSASEELQSFR HHHHCCHHHHHHHHH	33.29	23312004
1190	Phosphorylation	AALSAQGSESPLLED HHHHCCCCCCCHHHH	23.87	28348404
1192	Phosphorylation	LSAQGSESPLLEDLG HHCCCCCCCHHHHCC	23.65	28348404
1202	Phosphorylation	LEDLGLLSPPAIPPP HHHCCCCCCCCCCCC	33.60	28348404
1218	Phosphorylation	PPPSQALSAPRTASR CCHHHHCCCCCCCCC	38.96	24719451
1222	Phosphorylation	QALSAPRTASRFSTG HHCCCCCCCCCCCCC	28.11	22210691
1224	Phosphorylation	LSAPRTASRFSTGTL CCCCCCCCCCCCCCC	32.99	22210691
1227	Phosphorylation	PRTASRFSTGTLSNT CCCCCCCCCCCCCCC	25.47	28387310
1228	Phosphorylation	RTASRFSTGTLSNTA CCCCCCCCCCCCCCH	31.32	28387310

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COBL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COBL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COBL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTBL_HUMAN	ACTBL2	physical	28514442
WDR47_HUMAN	WDR47	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442
ACTC_HUMAN	ACTC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347 AND SER-815, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-741, AND MASSSPECTROMETRY.
PubMed: 18220336