WDR47_HUMAN - dbPTM
WDR47_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR47_HUMAN
UniProt AC O94967
Protein Name WD repeat-containing protein 47
Gene Name WDR47
Organism Homo sapiens (Human).
Sequence Length 919
Subcellular Localization Cytoplasm, cytoskeleton. Localization along microtubules is mediated by MAP1S..
Protein Description
Protein Sequence MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSLMLENTECHSIYEESPERDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYNG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
252-HydroxyisobutyrylationILDFLNSKKLHISML
HHHHHCCCCCEEEEH		59.28-
25UbiquitinationILDFLNSKKLHISML
HHHHHCCCCCEEEEH		59.28-
26UbiquitinationLDFLNSKKLHISMLA
HHHHCCCCCEEEEHH		45.15-
142PhosphorylationSKLCLLLTLPRLTNH
HHHHHHHHHHHCCCC		34.3824719451
183PhosphorylationIPADRKLSEAGFKAS
CCCCCHHHHCCCCCC		28.5625159151
188UbiquitinationKLSEAGFKASNNRLF
HHHHCCCCCCCCHHH		50.4132142685
195UbiquitinationKASNNRLFQLVMKGL
CCCCCHHHHHHHHHH		4.8232142685
274UbiquitinationIHVDKLLKPTKAAYA
CCHHHHCCCCHHHHH		62.1629967540
277UbiquitinationDKLLKPTKAAYADLL
HHHCCCCHHHHHHHH		39.2829967540
280PhosphorylationLKPTKAAYADLLTPL
CCCCHHHHHHHHHHH		12.90-
281UbiquitinationKPTKAAYADLLTPLI
CCCHHHHHHHHHHHH		9.0329967540
284UbiquitinationKAAYADLLTPLISKL
HHHHHHHHHHHHHHC		4.8229967540
285PhosphorylationAAYADLLTPLISKLS
HHHHHHHHHHHHHCC		24.2829255136
289PhosphorylationDLLTPLISKLSPYPS
HHHHHHHHHCCCCCC		34.9229255136
290UbiquitinationLLTPLISKLSPYPSS
HHHHHHHHCCCCCCC		46.09-
292PhosphorylationTPLISKLSPYPSSPM
HHHHHHCCCCCCCCC		26.5625159151
294PhosphorylationLISKLSPYPSSPMRR
HHHHCCCCCCCCCCC		16.6328450419
296PhosphorylationSKLSPYPSSPMRRPQ
HHCCCCCCCCCCCCC		41.0325159151
297PhosphorylationKLSPYPSSPMRRPQS
HCCCCCCCCCCCCCC		20.4328731282
299PhosphorylationSPYPSSPMRRPQSAD
CCCCCCCCCCCCCHH		6.4924719451
303PhosphorylationSSPMRRPQSADAYMT
CCCCCCCCCHHHHHH		49.8227251275
304PhosphorylationSPMRRPQSADAYMTR
CCCCCCCCHHHHHHC		30.6925159151
308PhosphorylationRPQSADAYMTRSLNP
CCCCHHHHHHCCCCH		10.2823927012
310PhosphorylationQSADAYMTRSLNPAL
CCHHHHHHCCCCHHH		12.3923927012
311PhosphorylationSADAYMTRSLNPALD
CHHHHHHCCCCHHHC		23.7124719451
312PhosphorylationADAYMTRSLNPALDG
HHHHHHCCCCHHHCC		24.2723401153
319PhosphorylationSLNPALDGLTCGLTS
CCCHHHCCCCCCCCC		24.6024719451
321PhosphorylationNPALDGLTCGLTSHD
CHHHCCCCCCCCCCC		15.2826552605
325PhosphorylationDGLTCGLTSHDKRIS
CCCCCCCCCCCCCHH		14.8625627689
326PhosphorylationGLTCGLTSHDKRISD
CCCCCCCCCCCCHHH		34.4325159151
329AcetylationCGLTSHDKRISDLGN
CCCCCCCCCHHHCCC		46.3225953088
332PhosphorylationTSHDKRISDLGNKTS
CCCCCCHHHCCCCCC		30.7127732954
338PhosphorylationISDLGNKTSPMSHSF
HHHCCCCCCCCCCCC		41.9018669648
339PhosphorylationSDLGNKTSPMSHSFA
HHCCCCCCCCCCCCC		21.8825159151
342PhosphorylationGNKTSPMSHSFANFH
CCCCCCCCCCCCCCC		21.2627174698
344PhosphorylationKTSPMSHSFANFHYP
CCCCCCCCCCCCCCC		20.8128555341
349PhosphorylationSHSFANFHYPGVQNL
CCCCCCCCCCCHHHH		27.9032142685
350PhosphorylationHSFANFHYPGVQNLS
CCCCCCCCCCHHHHC		9.5028122231
351PhosphorylationSFANFHYPGVQNLSR
CCCCCCCCCHHHHCH		28.1024719451
357PhosphorylationYPGVQNLSRSLMLEN
CCCHHHHCHHHHCCC		27.6325159151
359PhosphorylationGVQNLSRSLMLENTE
CHHHHCHHHHCCCCC		18.1125850435
365PhosphorylationRSLMLENTECHSIYE
HHHHCCCCCCCCCCC		30.5227732954
366PhosphorylationSLMLENTECHSIYEE
HHHCCCCCCCCCCCC		41.6427251275
369PhosphorylationLENTECHSIYEESPE
CCCCCCCCCCCCCCC		38.2327732954
371PhosphorylationNTECHSIYEESPERD
CCCCCCCCCCCCCCC		19.3627732954
372PhosphorylationTECHSIYEESPERDT
CCCCCCCCCCCCCCC		50.7827642862
374PhosphorylationCHSIYEESPERDTPV
CCCCCCCCCCCCCCC		21.8127732954
374 (in isoform 3)Phosphorylation-21.8128985074
376PhosphorylationSIYEESPERDTPVDA
CCCCCCCCCCCCCCC		72.9027642862
378PhosphorylationYEESPERDTPVDAQR
CCCCCCCCCCCCCCC		54.4227642862
378 (in isoform 3)Phosphorylation-54.4227732954
380 (in isoform 3)Phosphorylation-26.7027732954
381 (in isoform 4)Phosphorylation-11.7728985074
385 (in isoform 4)Phosphorylation-26.9027732954
387 (in isoform 4)Phosphorylation-11.7527732954
395PhosphorylationGSEILGQSSVSEKEP
CCHHHCCCCCCCCCC		30.8025850435
396PhosphorylationSEILGQSSVSEKEPA
CHHHCCCCCCCCCCC		23.0625850435
398PhosphorylationILGQSSVSEKEPANG
HHCCCCCCCCCCCCC		44.9225850435
422PhosphorylationEKNELRDSTEQFQEY
HHHHHHHHHHHHHHH		27.6623401153
423PhosphorylationKNELRDSTEQFQEYY
HHHHHHHHHHHHHHH		37.7923401153
429PhosphorylationSTEQFQEYYRQRLRY
HHHHHHHHHHHHHHH		7.9923403867
430PhosphorylationTEQFQEYYRQRLRYQ
HHHHHHHHHHHHHHH		10.2624719451
507PhosphorylationLNQQCNGSKGNGSNG
HHHHCCCCCCCCCCC		24.3322199227
518PhosphorylationGSNGSSVTSFTTPPQ
CCCCCCCEEECCCCC		21.77-
521PhosphorylationGSSVTSFTTPPQDSS
CCCCEEECCCCCCCC		37.85-
522PhosphorylationSSVTSFTTPPQDSSQ
CCCEEECCCCCCCCC		30.8428985074
528PhosphorylationTTPPQDSSQRLTHDA
CCCCCCCCCCCCCCH		27.84-
532PhosphorylationQDSSQRLTHDASNIH
CCCCCCCCCCHHHCC		21.6527732954
536PhosphorylationQRLTHDASNIHTSTP
CCCCCCHHHCCCCCC		42.2326055452
540PhosphorylationHDASNIHTSTPRNPG
CCHHHCCCCCCCCCC		30.4225159151
541PhosphorylationDASNIHTSTPRNPGS
CHHHCCCCCCCCCCC		23.4225159151
542PhosphorylationASNIHTSTPRNPGST
HHHCCCCCCCCCCCC		27.6725159151
548PhosphorylationSTPRNPGSTNHIPFL
CCCCCCCCCCCCCCC		27.5623312004
549PhosphorylationTPRNPGSTNHIPFLE
CCCCCCCCCCCCCCC		36.4123312004
558PhosphorylationHIPFLEESPCGSQIS
CCCCCCCCCCCCCCC		19.0020068231
562PhosphorylationLEESPCGSQISSEHS
CCCCCCCCCCCCCCC		30.9323663014
565PhosphorylationSPCGSQISSEHSVIK
CCCCCCCCCCCCCCC		23.2623663014
566PhosphorylationPCGSQISSEHSVIKP
CCCCCCCCCCCCCCC		40.7423663014
569PhosphorylationSQISSEHSVIKPPLG
CCCCCCCCCCCCCCC		22.8323663014
578PhosphorylationIKPPLGDSPGSLSRS
CCCCCCCCCCCCCCC		29.3928348404
581PhosphorylationPLGDSPGSLSRSKGE
CCCCCCCCCCCCCCC		26.9323663014
583PhosphorylationGDSPGSLSRSKGEED
CCCCCCCCCCCCCCC		35.8823663014
585PhosphorylationSPGSLSRSKGEEDDK
CCCCCCCCCCCCCCC		41.4528985074
586PhosphorylationPGSLSRSKGEEDDKS
CCCCCCCCCCCCCCC		70.0524719451
629PhosphorylationAVGSNSKTLRVCAYP
EEECCCCEEEEECCC		21.4428857561
646PhosphorylationIDPSAHETPKQPVVR
CCCCCCCCCCCCEEE		26.3925159151
648UbiquitinationPSAHETPKQPVVRFK
CCCCCCCCCCEEEEE		74.7329967540
649UbiquitinationSAHETPKQPVVRFKR
CCCCCCCCCEEEEEC		36.9029967540
656UbiquitinationQPVVRFKRNKHHKGS
CCEEEEECCCCCCCC		55.5129967540
801PhosphorylationTTFHGTGSAVASVAV
EEECCCCCCEEEEEE		21.2922210691
822PhosphorylationLATGQEDSSCMLYDI
EEECCCCCCCEEEEE		25.3722210691
827PhosphorylationEDSSCMLYDIRGGRM
CCCCCEEEEECCCEE		5.1722210691
867UbiquitinationGSYDMKIKVTDLQGD
EECEEEEEEEECCCC		33.3029967540
868UbiquitinationSYDMKIKVTDLQGDL
ECEEEEEEEECCCCH		6.0029967540
875UbiquitinationVTDLQGDLTKQLPIM
EEECCCCHHCCCCEE		9.1329967540
898PhosphorylationVIQCRWHTQDLSFLS
EEEEEEECCCHHHHC		19.47-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR47_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR47_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR47_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of WDR47_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR47_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-285; SER-292; SER-296AND SER-297, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-542, AND MASSSPECTROMETRY.

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