TPRN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPRN_HUMAN
• UniProt AC: Q4KMQ1
• Protein Name: Taperin
• Gene Name: TPRN
• Organism: Homo sapiens (Human).
• Sequence Length: 711
• Subcellular Localization: Cell projection, stereocilium. Localized prominently at the taper regions of hair cell stereocilia..
• Protein Sequence: MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENPFMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRAAEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAPGPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAGSPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIRPAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGPASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPPPFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPARPLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Ubiquitination	RAAVPAWKREILERK HHCCCHHHHHHHHHH	42.11	29967540
29	Ubiquitination	ILERKRAKLAALGGG HHHHHHHHHHHHCCC	42.57	-
52	Phosphorylation	EQRVLAESLGPLREN HHHHHHHHHCCCCCC	32.78	28857561
126	Phosphorylation	RAAEVLVYGAPPGRV EEEEEEEECCCCCHH	11.92	28152594
151	Phosphorylation	AAPRRRGSPERARPP CCCCCCCCCHHCCCC	23.06	24300666
175	Phosphorylation	RPPPAAPSPPAAPGP CCCCCCCCCCCCCCC	38.50	29496963
188	Phosphorylation	GPRGGGASPGARRSD CCCCCCCCCCCCHHH	27.43	26329039
192	Methylation	GGASPGARRSDFLQK CCCCCCCCHHHHHHH	44.55	115386803
202	Phosphorylation	DFLQKTGSNSFTVHP HHHHHHCCCCEEECC	34.24	27251275
204	Phosphorylation	LQKTGSNSFTVHPRG HHHHCCCCEEECCCC	24.80	27251275
206	Phosphorylation	KTGSNSFTVHPRGLH HHCCCCEEECCCCCC	20.09	-
222	Phosphorylation	GAGARLLSNGHSAPE CCCCHHCCCCCCCCC	45.41	28450419
226	Phosphorylation	RLLSNGHSAPEPRAG HHCCCCCCCCCCCCC	47.09	-
241	Phosphorylation	PANRLAGSPPGSGQW CCHHHCCCCCCCCCC	23.47	30266825
245	Phosphorylation	LAGSPPGSGQWKPKV HCCCCCCCCCCCCCC	33.32	30266825
254	Phosphorylation	QWKPKVESGDPSLHP CCCCCCCCCCCCCCC	52.03	28450419
258	Phosphorylation	KVESGDPSLHPPPSP CCCCCCCCCCCCCCC	44.01	28450419
264	Phosphorylation	PSLHPPPSPGTPSAT CCCCCCCCCCCCCCC	41.56	28355574
267	Phosphorylation	HPPPSPGTPSATPAS CCCCCCCCCCCCCCC	19.90	21712546
269	Phosphorylation	PPSPGTPSATPASPP CCCCCCCCCCCCCCC	44.61	26657352
271	Phosphorylation	SPGTPSATPASPPAS CCCCCCCCCCCCCCC	24.59	29496963
274	Phosphorylation	TPSATPASPPASATP CCCCCCCCCCCCCCC	32.40	23401153
278	Phosphorylation	TPASPPASATPSQRQ CCCCCCCCCCCCHHH	38.15	21712546
280	Phosphorylation	ASPPASATPSQRQCV CCCCCCCCCCHHHHH	22.45	30108239
282	Phosphorylation	PPASATPSQRQCVSA CCCCCCCCHHHHHHC	33.37	30108239
296	Phosphorylation	AATSTNDSFEIRPAP CCCCCCCCCEECCCC	27.18	25159151
322	Phosphorylation	LQARALASLRANSRN HHHHHHHHHHCCCCC	21.16	24719451
330	Phosphorylation	LRANSRNSFMVIPKS HHCCCCCCEEEEEHH	17.38	28555341
350	Phosphorylation	PPPEGRQSVELPKGD CCCCCCCCCCCCCCC	19.05	28450419
362	Phosphorylation	KGDLGPASPSQELGS CCCCCCCCCCHHHCC	28.37	29255136
364	Phosphorylation	DLGPASPSQELGSQP CCCCCCCCHHHCCCC	33.52	29255136
369	Phosphorylation	SPSQELGSQPVPGGD CCCHHHCCCCCCCCC	43.89	29255136
417	Phosphorylation	AIRWQRPSSPPPFLP HHHCCCCCCCCCCCC	58.63	23401153
418	Phosphorylation	IRWQRPSSPPPFLPA HHCCCCCCCCCCCCC	44.07	29255136
427	Phosphorylation	PPFLPAASEEAEPAE CCCCCCCCCCCCCCC	37.77	24732914
448	Phosphorylation	LAKNSREYVRPGLPV CCCCCCHHCCCCCCE	10.72	27642862
463	Phosphorylation	TFIDEVDSEEAPQAA EEEEECCCCCCCCHH	42.38	21082442
498	Phosphorylation	AELQPRGSNTFTVVP EECCCCCCCEEEEEE	33.70	28555341
543	Ubiquitination	CLLGPTLKKRYPTVH HHHCHHHHHHCCCCE	37.37	29967540
564	Phosphorylation	GYLALQKSCLTKAGS HHHHHHHHHHCCCCC	11.03	29083192
567	Phosphorylation	ALQKSCLTKAGSSRK HHHHHHHCCCCCCCC	24.15	29083192
571	Phosphorylation	SCLTKAGSSRKKMKI HHHCCCCCCCCCEEE	31.65	29083192
572	Phosphorylation	CLTKAGSSRKKMKIS HHCCCCCCCCCEEEE	47.39	29083192
579	Phosphorylation	SRKKMKISFNDKSLQ CCCCEEEEECCCCCC	16.69	25159151
623	Phosphorylation	EEEEEEGSGSEEKPF HHHHHCCCCCCCCCE	42.29	26074081
625	Phosphorylation	EEEEGSGSEEKPFAL HHHCCCCCCCCCEEE	44.26	26074081
638	Phosphorylation	ALFLPRATFVSSVRP EEEECCCEEECCCCC	26.33	26074081
641	Phosphorylation	LPRATFVSSVRPESS ECCCEEECCCCCHHH	20.94	26074081
642	Phosphorylation	PRATFVSSVRPESSR CCCEEECCCCCHHHC	19.49	26074081
647	Phosphorylation	VSSVRPESSRLPEGS ECCCCCHHHCCCCCC	24.36	26074081
648	Phosphorylation	SSVRPESSRLPEGSS CCCCCHHHCCCCCCC	35.85	26074081
654	O-linked_Glycosylation	SSRLPEGSSGLSSYT HHCCCCCCCCCCCCC	21.41	28657654
661	Phosphorylation	SSGLSSYTPKHSVAF CCCCCCCCCCHHCCC	28.01	28555341
710	Phosphorylation	FRSEPALYF------ HHCCCCCCC------	14.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPRN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPRN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPRN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EPS8_HUMAN	EPS8	physical	21988832
PP1B_HUMAN	PPP1CB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613307: Deafness, autosomal recessive, 79 (DFNB79)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.