S10AA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S10AA_HUMAN
• UniProt AC: P60903
• Protein Name: Protein S100-A10
• Gene Name: S100A10
• Organism: Homo sapiens (Human).
• Sequence Length: 97
• Protein Description: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase..
• Protein Sequence: MPSQMEHAMETMMFTFHKFAGDKGYLTKEDLRVLMEKEFPGFLENQKDPLAVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSQMEHAME -----CCHHHHHHHH	40.64	20068231
5	Sulfoxidation	---MPSQMEHAMETM ---CCHHHHHHHHHH	4.84	30846556
9	Sulfoxidation	PSQMEHAMETMMFTF CHHHHHHHHHHHHHH	4.80	30846556
11	Phosphorylation	QMEHAMETMMFTFHK HHHHHHHHHHHHHHH	10.80	20068231
12	Sulfoxidation	MEHAMETMMFTFHKF HHHHHHHHHHHHHHH	1.01	28465586
13	Sulfoxidation	EHAMETMMFTFHKFA HHHHHHHHHHHHHHH	3.60	30846556
15	Phosphorylation	AMETMMFTFHKFAGD HHHHHHHHHHHHHCC	13.61	24043423
18	Ubiquitination	TMMFTFHKFAGDKGY HHHHHHHHHHCCCCC	32.49	23000965
23	Ubiquitination	FHKFAGDKGYLTKED HHHHHCCCCCCCHHH	48.84	23000965
23	2-Hydroxyisobutyrylation	FHKFAGDKGYLTKED HHHHHCCCCCCCHHH	48.84	-
23	Acetylation	FHKFAGDKGYLTKED HHHHHCCCCCCCHHH	48.84	19608861
25	Phosphorylation	KFAGDKGYLTKEDLR HHHCCCCCCCHHHHH	19.55	21082442
27	Phosphorylation	AGDKGYLTKEDLRVL HCCCCCCCHHHHHHH	24.73	28152594
28	Malonylation	GDKGYLTKEDLRVLM CCCCCCCHHHHHHHH	46.78	26320211
28	Ubiquitination	GDKGYLTKEDLRVLM CCCCCCCHHHHHHHH	46.78	23000965
28	Acetylation	GDKGYLTKEDLRVLM CCCCCCCHHHHHHHH	46.78	19608861
28	2-Hydroxyisobutyrylation	GDKGYLTKEDLRVLM CCCCCCCHHHHHHHH	46.78	-
37	Sumoylation	DLRVLMEKEFPGFLE HHHHHHHCCCCCHHH	51.17	28112733
37	Malonylation	DLRVLMEKEFPGFLE HHHHHHHCCCCCHHH	51.17	26320211
37	Ubiquitination	DLRVLMEKEFPGFLE HHHHHHHCCCCCHHH	51.17	23000965
37	Acetylation	DLRVLMEKEFPGFLE HHHHHHHCCCCCHHH	51.17	19608861
37	2-Hydroxyisobutyrylation	DLRVLMEKEFPGFLE HHHHHHHCCCCCHHH	51.17	-
47	Acetylation	PGFLENQKDPLAVDK CCHHHCCCCHHHHHH	73.27	26051181
47	Ubiquitination	PGFLENQKDPLAVDK CCHHHCCCCHHHHHH	73.27	23000965
47	2-Hydroxyisobutyrylation	PGFLENQKDPLAVDK CCHHHCCCCHHHHHH	73.27	-
54	2-Hydroxyisobutyrylation	KDPLAVDKIMKDLDQ CCHHHHHHHHHHHHH	37.79	-
54	Ubiquitination	KDPLAVDKIMKDLDQ CCHHHHHHHHHHHHH	37.79	23000965
54	Acetylation	KDPLAVDKIMKDLDQ CCHHHHHHHHHHHHH	37.79	19608861
57	2-Hydroxyisobutyrylation	LAVDKIMKDLDQCRD HHHHHHHHHHHHHCC	59.62	-
57	Ubiquitination	LAVDKIMKDLDQCRD HHHHHHHHHHHHHCC	59.62	23000965
57	Acetylation	LAVDKIMKDLDQCRD HHHHHHHHHHHHHCC	59.62	19608861
57	Malonylation	LAVDKIMKDLDQCRD HHHHHHHHHHHHHCC	59.62	26320211
86	Phosphorylation	LTIACNDYFVVHMKQ HHHHCCCEEEEECCC	5.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S10AA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S10AA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S10AA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRPV5_HUMAN	TRPV5	physical	12660155
TRPV6_HUMAN	TRPV6	physical	12660155
CSN6_HUMAN	COPS6	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
CATB_HUMAN	CTSB	physical	10777578
KCNK3_HUMAN	KCNK3	physical	12198146
S10AA_HUMAN	S100A10	physical	9886297
ANXA2_HUMAN	ANXA2	physical	9886297
ANXA2_HUMAN	ANXA2	physical	18434302
RHG07_HUMAN	DLC1	physical	21372205
ANXA2_HUMAN	ANXA2	physical	21372205
SIN3A_HUMAN	SIN3A	physical	22939629
ZFR_HUMAN	ZFR	physical	22939629
TMM65_HUMAN	TMEM65	physical	22939629
SRPRB_HUMAN	SRPRB	physical	22939629
VATE1_HUMAN	ATP6V1E1	physical	22939629
VIGLN_HUMAN	HDLBP	physical	22939629
SRP09_HUMAN	SRP9	physical	22939629
WDR92_HUMAN	WDR92	physical	22939629
UBAP2_HUMAN	UBAP2	physical	22939629
PA24A_HUMAN	PLA2G4A	physical	14599294
ANXA2_HUMAN	ANXA2	physical	14599294
ANXA2_HUMAN	ANXA2	physical	23415230
HLTF_HUMAN	HLTF	physical	23415230
SPT6H_HUMAN	SUPT6H	physical	23415230
AHNK_HUMAN	AHNAK	physical	23415230
S10AA_HUMAN	S100A10	physical	23415230
PA24A_HUMAN	PLA2G4A	physical	18065419
ANXA2_HUMAN	ANXA2	physical	18065419

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23; LYS-28; LYS-37; LYS-54AND LYS-57, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-25, AND MASSSPECTROMETRY.
PubMed: 19534553

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-25, AND MASSSPECTROMETRY.
PubMed: 18083107