dbPTM

TRPV6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRPV6_HUMAN
UniProt AC	Q9H1D0
Protein Name	Transient receptor potential cation channel subfamily V member 6
Gene Name	TRPV6
Organism	Homo sapiens (Human).
Sequence Length	765
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. [PubMed: 11097838]
Protein Sequence	MGPLQGDGGPALGGADVAPRLSPVRVWPRPQAPKEPALHPMGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLPMPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGESWEYQI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
107	Phosphorylation	ALNKLLKYEDCKVHQ HHHHHHCCCCCCCCC	15.86	-
144	Phosphorylation	VLMEAAPELVFEPMT HHHHHCHHHHEECCC	15.00	-
182	Phosphorylation	ALLARRASVSARATG HHHHHHHHHHHHHCC	2.79	-
184	Phosphorylation	LARRASVSARATGTA HHHHHHHHHHHCCCC	35.92	-
188	Phosphorylation	ASVSARATGTAFRRS HHHHHHHCCCCCCCC	35.18	22210691
190	Phosphorylation	VSARATGTAFRRSPC HHHHHCCCCCCCCCC	27.09	22210691
201	Phosphorylation	RSPCNLIYFGEHPLS CCCCEEEEEECCCCC	14.42	-
208	N-linked_Glycosylation	YFGEHPLSFAACVNS EEECCCCCEEECCCH	42.93	-
248	N-linked_Glycosylation	HILILQPNKTFACQM EEEEECCCCCCHHHH	28.57	12765696
318	Phosphorylation	GPLTSTLYDLTEIDS CCCHHCEEECCCCCC	36.53	-
358	N-linked_Glycosylation	TPVKELVSLKWKRYG CCHHHHHHHCCHHHC	48.25	-
396	Phosphorylation	YRPLKPRTNNRTSPR HCCCCCCCCCCCCCC	4.43	29052541
398	N-linked_Glycosylation	PLKPRTNNRTSPRDN CCCCCCCCCCCCCCC	1.47	12765696
398	N-linked_Glycosylation	PLKPRTNNRTSPRDN CCCCCCCCCCCCCCC	1.47	UniProtKB CARBOHYD
400	Phosphorylation	KPRTNNRTSPRDNTL CCCCCCCCCCCCCHH	2.86	23090842
401	Phosphorylation	PRTNNRTSPRDNTLL CCCCCCCCCCCCHHH	1.86	23090842
406	Phosphorylation	RTSPRDNTLLQQKLL CCCCCCCHHHHHHHH	58.81	23090842
417	Phosphorylation	QKLLQEAYMTPKDDI HHHHHHHHCCCHHHH	22.47	23090842
419	Phosphorylation	LLQEAYMTPKDDIRL HHHHHHCCCHHHHHH	20.67	23090842
601	Phosphorylation	MYSITYAAFAIIATL HHHHHHHHHHHHHHH	8.32	18669648
641	Phosphorylation	RAQIVATTVMLERKL HHHHHHHHHHHHCCC	34.16	18669648
688	Phosphorylation	RQRIQRYAQAFHTRG HHHHHHHHHHHHHCC	27.35	-
696	Phosphorylation	QAFHTRGSEDLDKDS HHHHHCCCCCCCHHH	41.46	28102081
702	Phosphorylation	GSEDLDKDSVEKLEL CCCCCCHHHHHHHCC	14.57	11248124
703	Phosphorylation	SEDLDKDSVEKLELG CCCCCHHHHHHHCCC	5.59	28102081
714	Phosphorylation	LELGCPFSPHLSLPM HCCCCCCCCCCCCCC	29.00	28270605
718	Phosphorylation	CPFSPHLSLPMPSVS CCCCCCCCCCCCCCC	22.82	28270605
723	Phosphorylation	HLSLPMPSVSRSTSR CCCCCCCCCCCCCCC	12.78	28270605
727	Phosphorylation	PMPSVSRSTSRSSAN CCCCCCCCCCCCCCC		-
728	Phosphorylation	MPSVSRSTSRSSANW CCCCCCCCCCCCCCH		22817900
731	Phosphorylation	VSRSTSRSSANWERL CCCCCCCCCCCHHHH		-
732	Phosphorylation	SRSTSRSSANWERLR CCCCCCCCCCHHHHH		-
742	Phosphorylation	WERLRQGTLRRDLRG HHHHHHCCHHHHHHH		11278579
760	Phosphorylation	RGLEDGESWEYQI-- CCCCCCCCCCCCC--		25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
184	S	Phosphorylation	Kinase	PRKCB	P05771-2	GPS
201	Y	Phosphorylation	Kinase	SRC	P12931	Uniprot
702	T	Phosphorylation	Kinase	KPCA	P17252	PhosphoELM
728	T	Phosphorylation	Kinase	PRKCB	P05771-2	GPS
742	T	Phosphorylation	Kinase	PKCA	P17252	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:20843805

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRPV6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRPV6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_HUMAN	NEDD4	physical	20843805
K1C40_HUMAN	KRT40	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRPV6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Competitive regulation of CaT-like-mediated Ca2+ entry by proteinkinase C and calmodulin."; Niemeyer B.A., Bergs C., Wissenbach U., Flockerzi V., Trost C.; Proc. Natl. Acad. Sci. U.S.A. 98:3600-3605(2001). Cited for: FUNCTION, INTERACTION WITH CALMODULIN, PHOSPHORYLATION AT THR-702, ANDMUTAGENESIS OF THR-702.	11248124 [Abstract]