dbPTM

RHG07_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHG07_HUMAN
UniProt AC	Q96QB1
Protein Name	Rho GTPase-activating protein 7
Gene Name	DLC1
Organism	Homo sapiens (Human).
Sequence Length	1528
Subcellular Localization	Cytoplasm. Cell junction, focal adhesion. Membrane Peripheral membrane protein. Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
Protein Description	Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality..
Protein Sequence	MSVAIRKRSWEEHVTHWMGQPFNSDDRNTACHHGLVADSLQASMEKDATLNVDRKEKCVSLPDCCHGSELRDFPGRPMGHLSKDVDENDSHEGEDQFLSLEASTETLVHVSDEDNNADLCLTDDKQVLNTQGQKTSGQHMIQGAGSLEKALPIIQSNQVSSNSWGIAGETELALVKESGERKVTDSISKSLELCNEISLSEIKDAPKVNAVDTLNVKDIAPEKQLLNSAVIAQQRRKPDPPKDENERSTCNVVQNEFLDTPCTNRGLPLLKTDFGSCLLQPPSCPNGMSAENGLEKSGFSQHQNKSPPKVKAEDGMQCLQLKETLATQEPTDNQVRLRKRKEIREDRDRARLDSMVLLIMKLDQLDQDIENALSTSSSPSGTPTNLRRHVPDLESGSESGADTISVNQTRVNLSSDTESTDLPSSTPVANSGTKPKTTAIQGISEKEKAEIEAKEACDWLRATGFPQYAQLYEDFLFPIDISLVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSDDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSHPKDGPSPGGTLMDLSERQEVSSVRSLSSTGSLPSHAPPSEDAATPRTNSVISVCSSSNLAGNDDSFGSLPSPKELSSFSFSMKGHEKTAKSKTRSLLKRMESLKLKSSHHSKHKAPSKLGLIISGPILQEGMDEEKLKQLNCVEISALNGNRINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSACNKRVGMYLEGFDPFNQSTFNNVVEQNFKNRESYPEDTVFYIPEDHKPGTFPKALTNGSFSPSGNNGSVNWRTGSFHGPGHISLRRENSSDSPKELKRRNSSSSMSSRLSIYDNVPGSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDNDRTTPSDLDSTGNSLNEPEEPSEIPERRDSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPLTLEALGHLGNDDSADYQHFLQDCVDGLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALLLTSVDHDRAPVVGVRVNVLLSRYLIEPCGPGKSKLTYMCRVDLRGHMPEWYTKSFGHLCAAEVVKIRDSFSNQNTETKDTKSR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 1)	Phosphorylation	-	36.83	24043423
12 (in isoform 1)	Phosphorylation	-	37.08	24043423
20 (in isoform 6)	Phosphorylation	-	24.25	25841592
22 (in isoform 6)	Phosphorylation	-	11.98	30266825
28 (in isoform 6)	Phosphorylation	-	38.74	24501219
306	Phosphorylation	FSQHQNKSPPKVKAE CCCCCCCCCCCCCHH	54.72	27732954
327	Phosphorylation	QLKETLATQEPTDNQ HHHHHHHCCCCCCCH	36.26	16338927
329	Phosphorylation	KETLATQEPTDNQVR HHHHHCCCCCCCHHH	45.90	16338927
354	Phosphorylation	RDRARLDSMVLLIMK HHHHHHHHHHHHHHH	18.51	28857561
374	Phosphorylation	QDIENALSTSSSPSG HHHHHHHHCCCCCCC	24.67	28857561
375	Phosphorylation	DIENALSTSSSPSGT HHHHHHHCCCCCCCC	33.21	28857561
376	Phosphorylation	IENALSTSSSPSGTP HHHHHHCCCCCCCCC	25.99	27732954
377	Phosphorylation	ENALSTSSSPSGTPT HHHHHCCCCCCCCCC	46.48	28857561
378	Phosphorylation	NALSTSSSPSGTPTN HHHHCCCCCCCCCCC	23.89	27732954
380	Phosphorylation	LSTSSSPSGTPTNLR HHCCCCCCCCCCCHH	58.19	27732954
382	Phosphorylation	TSSSPSGTPTNLRRH CCCCCCCCCCCHHHC	31.14	27732954
384	Phosphorylation	SSPSGTPTNLRRHVP CCCCCCCCCHHHCCC	46.88	27732954
395	Phosphorylation	RHVPDLESGSESGAD HCCCCCCCCCCCCCC	55.72	27251275
397	Phosphorylation	VPDLESGSESGADTI CCCCCCCCCCCCCEE	37.56	27251275
399	Phosphorylation	DLESGSESGADTISV CCCCCCCCCCCEEEE	40.76	27251275
403	Phosphorylation	GSESGADTISVNQTR CCCCCCCEEEEECCE	18.02	22798277
482	Phosphorylation	FLFPIDISLVKREHD HHCEEEHHHHCCCCC	24.30	24719451
513	Sumoylation	LNKCAVMKLEISPHR HCCEEEEEEEECCCC	36.05	-
517	Phosphorylation	AVMKLEISPHRKRSD EEEEEEECCCCCCCC	12.79	30266825
523	Phosphorylation	ISPHRKRSDDSDEDE ECCCCCCCCCCCCCC	49.13	23927012
526	Phosphorylation	HRKRSDDSDEDEPCA CCCCCCCCCCCCCCC	48.14	23401153
535	Phosphorylation	EDEPCAISGKWTFQR CCCCCCCCCCEEEEC	18.78	26091039
539	Phosphorylation	CAISGKWTFQRDSKR CCCCCCEEEECCCCC	17.24	28348404
544	Phosphorylation	KWTFQRDSKRWSRLE CEEEECCCCCHHHHH	26.72	29514088
548	O-linked_Glycosylation	QRDSKRWSRLEEFDV ECCCCCHHHHHHCCC	30.90	30379171
548	Phosphorylation	QRDSKRWSRLEEFDV ECCCCCHHHHHHCCC	30.90	27422710
549	Phosphorylation	RDSKRWSRLEEFDVF CCCCCHHHHHHCCCC	38.88	19664995
557	Phosphorylation	LEEFDVFSPKQDLVP HHHCCCCCCCHHCCC	30.91	22199227
566	Phosphorylation	KQDLVPGSPDDSHPK CHHCCCCCCCCCCCC	21.05	29255136
567	Phosphorylation	QDLVPGSPDDSHPKD HHCCCCCCCCCCCCC	56.17	16338927
570	Phosphorylation	VPGSPDDSHPKDGPS CCCCCCCCCCCCCCC	49.41	29255136
577	Phosphorylation	SHPKDGPSPGGTLMD CCCCCCCCCCCCCCC	41.53	29255136
581	Phosphorylation	DGPSPGGTLMDLSER CCCCCCCCCCCHHHH	25.48	29255136
596	Phosphorylation	QEVSSVRSLSSTGSL HHHHHCCCCCCCCCC	30.37	29255136
598	Phosphorylation	VSSVRSLSSTGSLPS HHHCCCCCCCCCCCC	27.40	29255136
599	Phosphorylation	SSVRSLSSTGSLPSH HHCCCCCCCCCCCCC	41.92	29255136
600	Phosphorylation	SVRSLSSTGSLPSHA HCCCCCCCCCCCCCC	27.67	23312004
602	Phosphorylation	RSLSSTGSLPSHAPP CCCCCCCCCCCCCCC	36.88	23312004
605	Phosphorylation	SSTGSLPSHAPPSED CCCCCCCCCCCCCCC	37.26	23312004
610	Phosphorylation	LPSHAPPSEDAATPR CCCCCCCCCCCCCCC	47.23	23312004
615	Phosphorylation	PPSEDAATPRTNSVI CCCCCCCCCCCCCEE	18.28	23312004
618	Phosphorylation	EDAATPRTNSVISVC CCCCCCCCCCEEEEC	32.80	22210691
620	Phosphorylation	AATPRTNSVISVCSS CCCCCCCCEEEECCC	21.88	30576142
623	Phosphorylation	PRTNSVISVCSSSNL CCCCCEEEECCCCCC	18.21	22210691
628	Phosphorylation	VISVCSSSNLAGNDD EEEECCCCCCCCCCC	21.40	30576142
636	Phosphorylation	NLAGNDDSFGSLPSP CCCCCCCCCCCCCCH	34.08	22210691
639	Phosphorylation	GNDDSFGSLPSPKEL CCCCCCCCCCCHHHH	34.79	22199227
642	Phosphorylation	DSFGSLPSPKELSSF CCCCCCCCHHHHHCC	54.63	27422710
652	Phosphorylation	ELSSFSFSMKGHEKT HHHCCEEECCCCHHH	20.56	24719451
666	Phosphorylation	TAKSKTRSLLKRMES HHHHHHHHHHHHHHH	43.20	24719451
673	Phosphorylation	SLLKRMESLKLKSSH HHHHHHHHHCCCCCC	22.82	28857561
707	Ubiquitination	QEGMDEEKLKQLNCV HCCCCHHHHHHCCCE	59.96	-
733	Phosphorylation	VPMVRKRSVSNSTQT CCEEEEECCCCCCCC	32.69	27422710
735	Phosphorylation	MVRKRSVSNSTQTSS EEEEECCCCCCCCCC	26.72	30576142
737	Phosphorylation	RKRSVSNSTQTSSSS EEECCCCCCCCCCCC	17.87	30576142
738	Phosphorylation	KRSVSNSTQTSSSSS EECCCCCCCCCCCCC	39.87	27732954
740	Phosphorylation	SVSNSTQTSSSSSQS CCCCCCCCCCCCCCC	30.57	27732954
741	Phosphorylation	VSNSTQTSSSSSQSE CCCCCCCCCCCCCCC	20.57	27732954
742	Phosphorylation	SNSTQTSSSSSQSET CCCCCCCCCCCCCCC	37.31	27732954
743	Phosphorylation	NSTQTSSSSSQSETS CCCCCCCCCCCCCCC	33.50	27732954
744	Phosphorylation	STQTSSSSSQSETSS CCCCCCCCCCCCCCC	34.05	27732954
745	Phosphorylation	TQTSSSSSQSETSSA CCCCCCCCCCCCCCC	39.41	27732954
747	Phosphorylation	TSSSSSQSETSSAVS CCCCCCCCCCCCCCC	44.80	30576142
749	Phosphorylation	SSSSQSETSSAVSTP CCCCCCCCCCCCCCC	32.98	30576142
750	Phosphorylation	SSSQSETSSAVSTPS CCCCCCCCCCCCCCC	16.55	-
755	Phosphorylation	ETSSAVSTPSPVTRT CCCCCCCCCCCCCCC	22.61	-
757	Phosphorylation	SSAVSTPSPVTRTRS CCCCCCCCCCCCCCC	31.90	10649492
762	Phosphorylation	TPSPVTRTRSLSACN CCCCCCCCCCHHHHH	18.42	27251275
764	Phosphorylation	SPVTRTRSLSACNKR CCCCCCCCHHHHHHH	26.51	16338927
766	Phosphorylation	VTRTRSLSACNKRVG CCCCCCHHHHHHHHC	31.83	30576142
823	Phosphorylation	GTFPKALTNGSFSPS CCCCCCCCCCCCCCC	42.25	30576142
826	Phosphorylation	PKALTNGSFSPSGNN CCCCCCCCCCCCCCC	25.31	22199227
828	Phosphorylation	ALTNGSFSPSGNNGS CCCCCCCCCCCCCCC	21.61	30576142
830	Phosphorylation	TNGSFSPSGNNGSVN CCCCCCCCCCCCCCE	53.61	22199227
840	Phosphorylation	NGSVNWRTGSFHGPG CCCCEEECCCCCCCC	28.88	29255136
842	Phosphorylation	SVNWRTGSFHGPGHI CCEEECCCCCCCCEE	17.29	23401153
850	Phosphorylation	FHGPGHISLRRENSS CCCCCEEEEECCCCC	15.34	23403867
856	Phosphorylation	ISLRRENSSDSPKEL EEEECCCCCCCHHHH	30.67	26699800
857	Phosphorylation	SLRRENSSDSPKELK EEECCCCCCCHHHHH	54.40	26699800
859	Phosphorylation	RRENSSDSPKELKRR ECCCCCCCHHHHHHH	39.56	26699800
868	Phosphorylation	KELKRRNSSSSMSSR HHHHHHCCCCCHHHC	29.77	28102081
869	Phosphorylation	ELKRRNSSSSMSSRL HHHHHCCCCCHHHCC	29.95	28102081
870	Phosphorylation	LKRRNSSSSMSSRLS HHHHCCCCCHHHCCE	29.85	28102081
871	Phosphorylation	KRRNSSSSMSSRLSI HHHCCCCCHHHCCEE	25.32	28102081
873	Phosphorylation	RNSSSSMSSRLSIYD HCCCCCHHHCCEEEC	17.79	28102081
874	Phosphorylation	NSSSSMSSRLSIYDN CCCCCHHHCCEEECC	28.71	28102081
928	Phosphorylation	NQWSEKFSDEGDSDS HHHHHHHCCCCCCCC	45.91	22617229
933	Phosphorylation	KFSDEGDSDSALDSV HHCCCCCCCCCCCCC	44.30	22617229
935	Phosphorylation	SDEGDSDSALDSVSP CCCCCCCCCCCCCCC	34.38	28857561
939	Phosphorylation	DSDSALDSVSPCPSS CCCCCCCCCCCCCCC	25.91	27732954
941	Phosphorylation	DSALDSVSPCPSSPK CCCCCCCCCCCCCCC	25.41	25850435
945	Phosphorylation	DSVSPCPSSPKQIHL CCCCCCCCCCCEEEE	67.02	22199227
946	Phosphorylation	SVSPCPSSPKQIHLD CCCCCCCCCCEEEEE	22.66	29507054
959	Phosphorylation	LDVDNDRTTPSDLDS EECCCCCCCHHHHHC	46.02	22210691
978	Phosphorylation	LNEPEEPSEIPERRD CCCCCCCCCCCCCCC	51.98	22210691
986	Phosphorylation	EIPERRDSGVGASLT CCCCCCCCCCCCCCC	33.30	30266825
991	Phosphorylation	RDSGVGASLTRSNRH CCCCCCCCCCCCCCH	25.09	29255136
993	Phosphorylation	SGVGASLTRSNRHRL CCCCCCCCCCCCHHH	29.56	29255136
995	Phosphorylation	VGASLTRSNRHRLRW CCCCCCCCCCHHHEE	32.74	-
1004	Phosphorylation	RHRLRWHSFQSSHRP CHHHEEEECCCCCCC	20.30	16338927
1007	Phosphorylation	LRWHSFQSSHRPSLN HEEEECCCCCCCCCC	26.54	24719451
1008	Phosphorylation	RWHSFQSSHRPSLNS EEEECCCCCCCCCCE	16.84	26853621
1015	Phosphorylation	SHRPSLNSVSLQINC CCCCCCCEEEEEEHH	20.55	19053533
1017	Phosphorylation	RPSLNSVSLQINCQS CCCCCEEEEEEHHHH	17.87	19053533
1034	Phosphorylation	QMNLLQKYSLLKLTA HHHHHHHHHHHHHHH	7.50	24719451
1035	Phosphorylation	MNLLQKYSLLKLTAL HHHHHHHHHHHHHHH	33.97	24719451
1055	Phosphorylation	PSNKHGFSWAVPKFM CCCCCCCCCHHHHHH	20.79	27251275
1153	Phosphorylation	VADMLKQYFRDLPEP HHHHHHHHHHCCCCC	10.05	29978859
1163	Phosphorylation	DLPEPLMTNKLSETF CCCCCHHCCCCCHHH	36.56	29978859
1167	Phosphorylation	PLMTNKLSETFLQIY CHHCCCCCHHHHHHH	35.88	29978859
1169	Phosphorylation	MTNKLSETFLQIYQY HCCCCCHHHHHHHHH	26.69	29978859
1174	Phosphorylation	SETFLQIYQYVPKDQ CHHHHHHHHHCCHHH	4.84	29978859
1176	Phosphorylation	TFLQIYQYVPKDQRL HHHHHHHHCCHHHHH	11.18	29978859
1209	Phosphorylation	QTLLYFLSDVTAAVK HHHHHHHHHHHHHHH	21.82	-
1238	Phosphorylation	PSLFHLNTLKRENSS HHHHHHHHHCCCCCC	39.76	-
1244	Phosphorylation	NTLKRENSSPRVMQR HHHCCCCCCHHHHHH	36.65	21087603
1254	Phosphorylation	RVMQRKQSLGKPDQK HHHHHHHHCCCCCHH	41.97	26657352
1291	Phosphorylation	FQVPEEMSRCRNSYT HCCCHHHHHHCCCCC	31.35	26074081
1296	Phosphorylation	EMSRCRNSYTEQELK HHHHHCCCCCHHHHH	17.68	27422710
1297	Phosphorylation	MSRCRNSYTEQELKP HHHHCCCCCHHHHHH	20.18	26074081
1298	Phosphorylation	SRCRNSYTEQELKPL HHHCCCCCHHHHHHH	30.89	26074081
1355	Phosphorylation	TSEQAELSYKKVSEG CHHCEEHHEEEHHCC	26.81	-
1435	Phosphorylation	VVLRTWRTNLPKGAC EEEEEECCCCCCCCE	32.44	23312004
1516	Phosphorylation	VKIRDSFSNQNTETK EEHHHHCCCCCCCCC	41.27	28509920
1520	Phosphorylation	DSFSNQNTETKDTKS HHCCCCCCCCCCCCC	34.96	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
557	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
642	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
735	S	Phosphorylation	Kinase	AKT1	P31749	PSP
766	S	Phosphorylation	Kinase	AKT1	P31749	PSP
859	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
946	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
1004	S	Phosphorylation	Kinase	AKT1	P31749	PSP
1244	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHG07_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHG07_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIBRA_HUMAN	WWC1	physical	16684779
S10AA_HUMAN	S100A10	physical	21372205
TNS2_HUMAN	TENC1	physical	16951145
CUL4A_HUMAN	CUL4A	physical	24082123
DDB1_HUMAN	DDB1	physical	24082123
FBXW5_HUMAN	FBXW5	physical	24082123
WWC2_HUMAN	WWC2	physical	24682284
WWC3_HUMAN	WWC3	physical	24682284
KIBRA_HUMAN	WWC1	physical	24682284
CAV1_HUMAN	CAV1	physical	22693251
LACC1_HUMAN	LACC1	physical	28514442
FEM1B_HUMAN	FEM1B	physical	28514442
NJMU_HUMAN	C17orf75	physical	28514442
PTEN_HUMAN	PTEN	physical	19482022

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHG07_HUMAN

Related Literatures of Post-Translational Modification