dbPTM

WWC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WWC2_HUMAN
UniProt AC	Q6AWC2
Protein Name	Protein WWC2
Gene Name	WWC2
Organism	Homo sapiens (Human).
Sequence Length	1192
Subcellular Localization
Protein Description
Protein Sequence	MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MPRRAGSGQLP ----CCCCCCCCCCC	54.77	115920105
7	Phosphorylation	-MPRRAGSGQLPLPR -CCCCCCCCCCCCCC	23.52	25159151
28 (in isoform 6)	Phosphorylation	-	14.39	27642862
36	Phosphorylation	IDHNTRRTSWIDPRD EECCCCCCCCCCHHH	25.73	28348404
37	Phosphorylation	DHNTRRTSWIDPRDR ECCCCCCCCCCHHHC	21.88	27251275
115	Ubiquitination	QDALRTQKELYHVKE HHHHHHHHHHHHHHH	49.42	29967540
132	Phosphorylation	LALALDEYVRLNDAY HHHHHHHHHHHHHHH	7.19	22817900
132 (in isoform 6)	Phosphorylation	-	7.19	27642862
142	Ubiquitination	LNDAYKEKSSSHTSL HHHHHHHCCCCCCCC	52.03	29967540
145	Phosphorylation	AYKEKSSSHTSLFSG HHHHCCCCCCCCCCC	37.56	28857561
147	Phosphorylation	KEKSSSHTSLFSGSS HHCCCCCCCCCCCCC	29.13	28857561
153	Phosphorylation	HTSLFSGSSSSTKYD CCCCCCCCCCCCCCC	26.33	25627689
154	Phosphorylation	TSLFSGSSSSTKYDP CCCCCCCCCCCCCCH	31.65	25627689
155	Phosphorylation	SLFSGSSSSTKYDPD CCCCCCCCCCCCCHH	43.66	25627689
156	Phosphorylation	LFSGSSSSTKYDPDI CCCCCCCCCCCCHHH	30.76	28555341
183	Phosphorylation	KKLKRELSQMKQELL HHHHHHHHHHHHHHH	24.39	28102081
211	Phosphorylation	KKMSGGQSGYELSEA HHHCCCCCCCCHHHH	46.76	19664995
245	Phosphorylation	EKQDLMQSLAKLQER HHHHHHHHHHHHHHH	19.14	24719451
262	Phosphorylation	LDQNIGRSEPDLRCS CCCCCCCCCCCCCCC	48.55	23403867
269	Phosphorylation	SEPDLRCSPVNSHLC CCCCCCCCCCCCCEE	26.00	23403867
273	Phosphorylation	LRCSPVNSHLCLSRQ CCCCCCCCCEEECCC	20.33	27794612
278	Phosphorylation	VNSHLCLSRQTLDAG CCCCEEECCCEECCC	22.73	27794612
286	Phosphorylation	RQTLDAGSQTSISGD CCEECCCCCCCCCCC	31.82	-
288	Phosphorylation	TLDAGSQTSISGDIG EECCCCCCCCCCCCC	29.71	27251275
289	Phosphorylation	LDAGSQTSISGDIGV ECCCCCCCCCCCCCC	13.71	27251275
298	Phosphorylation	SGDIGVRSRSNLAEK CCCCCCCCCCCHHHH	37.34	24719451
300	Phosphorylation	DIGVRSRSNLAEKVR CCCCCCCCCHHHHHH	37.13	22798277
312	Phosphorylation	KVRLSLQYEEAKRSM HHHHHHHHHHHHHHH	22.49	23917254
328	Ubiquitination	NLKIELSKLDSEAWP HHEEEHHHCCCCCCC	69.78	29967540
331	Phosphorylation	IELSKLDSEAWPGAL EEHHHCCCCCCCCCC	39.38	22798277
342	Ubiquitination	PGALDIEKEKLMLIN CCCCCCHHHHEEEHH	61.56	29967540
351	Ubiquitination	KLMLINEKEELLKEL HEEEHHCHHHHHHHC	52.58	-
365	Ubiquitination	LQFVTPQKRTQDELE CCCCCCCCCCHHHHH	59.63	29967540
387	Phosphorylation	RLEEELLSVRGTPSR HHHHHHHHCCCCHHH	23.53	28555341
391	Phosphorylation	ELLSVRGTPSRALAE HHHHCCCCHHHHHHH	13.92	28555341
412	Ubiquitination	RRKELLQKLEETTKL HHHHHHHHHHHHHHH	58.81	29967540
422	Phosphorylation	ETTKLTTYLHSQLKS HHHHHHHHHHHHHHH	9.36	-
428	Ubiquitination	TYLHSQLKSLSASTL HHHHHHHHHCCCCCC	41.53	-
470	Phosphorylation	SLSSTELYYSSQSDQ CCCCCEEEECCCCCE	8.62	-
496 (in isoform 6)	Phosphorylation	-	19.42	27642862
513	Phosphorylation	HENEVVKSPSQPGQS ECCCEECCCCCCCCC	20.41	25627689
515	Phosphorylation	NEVVKSPSQPGQSGL CCEECCCCCCCCCCC	56.98	25627689
530	Phosphorylation	CGVAAAATGHTPPLA CHHHHHHCCCCCCHH	25.44	25159151
533	Phosphorylation	AAAATGHTPPLAEAP HHHHCCCCCCHHHCC	28.13	28978645
542	Phosphorylation	PLAEAPKSVASLSSR CHHHCCHHHHHCCCC	23.12	22210691
548	Phosphorylation	KSVASLSSRSSLSSL HHHHHCCCCCCHHCC	41.28	24945436
559	Phosphorylation	LSSLSPPGSPLVLEG HHCCCCCCCCEEEEE	45.33	15302935
608	Phosphorylation	ENQILLDSDSGGASQ ECCEEECCCCCCCCC	33.38	29759185
610	Phosphorylation	QILLDSDSGGASQSL CEEECCCCCCCCCCC	42.98	29759185
632 (in isoform 6)	Phosphorylation	-	24.03	27642862
632	Phosphorylation	ECAREPLYEGTADVE HHHCCCCCCCCCCHH	24.03	21945579
635	Phosphorylation	REPLYEGTADVEKSL CCCCCCCCCCHHHHC	14.03	21945579
663	Phosphorylation	TCVSAAVSDESVAGD EEEEEECCCCHHCCC	30.82	28985074
666	Phosphorylation	SAAVSDESVAGDSGV EEECCCCHHCCCCCC	23.43	-
674 (in isoform 6)	Phosphorylation	-	12.69	27642862
707	Methylation	AQVQIGLRYNAKSSS EEEEEECCCCCCCCC	19.90	30763467
707	Dimethylation	AQVQIGLRYNAKSSS EEEEEECCCCCCCCC	19.90	-
737	Phosphorylation	IPHTSKVYFRVAVLP CCCCCCEEEEEEECC	6.87	-
826	Phosphorylation	LWYNLLPSKQMPCKK HHHHHCCCCCCCCCC	35.17	24719451
840	Phosphorylation	KNEENEDSVFQPNQP CCCCCCCCCCCCCCC	20.74	28102081
851	Phosphorylation	PNQPLVDSIDLDAVS CCCCCCCCCCHHHHH	15.55	28102081
858	Phosphorylation	SIDLDAVSALLARTS CCCHHHHHHHHHHHH	18.21	28102081
864	Phosphorylation	VSALLARTSAELLAV HHHHHHHHHHHHHHH	27.04	30576142
865	Phosphorylation	SALLARTSAELLAVE HHHHHHHHHHHHHHH	17.75	30576142
883	Phosphorylation	AQEEEEESGQEEPRG HHHHHHHHCCCCCCC	49.40	27732954
903	Phosphorylation	LTMLREASDEIVAEK HHHHHHHCHHHHHHH	30.90	28674419
917	Ubiquitination	KEAEVKLPEDSSCTE HHEECCCCCCCCCCC	37.32	23000965
917 (in isoform 6)	Ubiquitination	-	37.32	-
920	Phosphorylation	EVKLPEDSSCTEDLS ECCCCCCCCCCCCHH	26.17	28674151
921	Phosphorylation	VKLPEDSSCTEDLSS CCCCCCCCCCCCHHH	37.06	28674151
952	Phosphorylation	NCAKDLRSQPPTRIP CHHHHHHHCCCCCCC	55.10	22985185
984	Phosphorylation	AVRPKERSSLSSRQH CCCHHHHCCCHHCCC	36.40	29691806
985	Phosphorylation	VRPKERSSLSSRQHP CCHHHHCCCHHCCCC	38.19	20363803
987	Phosphorylation	PKERSSLSSRQHPFV HHHHCCCHHCCCCCC	25.98	29691806
988	Phosphorylation	KERSSLSSRQHPFVR HHHCCCHHCCCCCCC	41.05	21406692
1002	Phosphorylation	RSSVIVRSQTFSPGE CEEEEEECCCCCCCC	23.76	23403867
1004	Phosphorylation	SVIVRSQTFSPGERN EEEEECCCCCCCCCC	27.59	23401153
1006	Phosphorylation	IVRSQTFSPGERNQY EEECCCCCCCCCCEE	35.07	21815630
1009 (in isoform 6)	Phosphorylation	-	52.41	21406692
1011 (in isoform 6)	Phosphorylation	-	34.40	21406692
1020	Phosphorylation	YICRLNRSDSDSSTL EEEECCCCCCCCCCH	40.15	29255136
1022	Phosphorylation	CRLNRSDSDSSTLAK EECCCCCCCCCCHHH	40.41	29255136
1024	Phosphorylation	LNRSDSDSSTLAKKS CCCCCCCCCCHHHHH	29.22	23403867
1025	Phosphorylation	NRSDSDSSTLAKKSL CCCCCCCCCHHHHHH	32.22	23403867
1026	Phosphorylation	RSDSDSSTLAKKSLF CCCCCCCCHHHHHHC	34.39	23403867
1044 (in isoform 6)	Phosphorylation	-	32.91	21406692
1046 (in isoform 6)	Phosphorylation	-	35.60	21406692
1065	Phosphorylation	TQECPVRTSLDLELD CCCCCCCCCCCEEEH	33.60	26356563
1066	Phosphorylation	QECPVRTSLDLELDL CCCCCCCCCCEEEHH	14.88	26356563
1076	Phosphorylation	LELDLQASLTRQSRL EEEHHHHHHHHHHHH	19.81	24719451
1078	Phosphorylation	LDLQASLTRQSRLND EHHHHHHHHHHHHHH	24.94	26356563
1081	Phosphorylation	QASLTRQSRLNDELQ HHHHHHHHHHHHHHH	35.13	26356563
1096	Ubiquitination	ALRDLRQKLEELKAQ HHHHHHHHHHHHHHC	51.97	-
1183	Phosphorylation	YFTRAKISIPSLPAD HHHCCCCCCCCCCCC	27.95	27251275
1186	Phosphorylation	RAKISIPSLPADDV- CCCCCCCCCCCCCC-	45.36	22985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WWC2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WWC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WWC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWC2_HUMAN	WWC2	physical	24682284
WWC3_HUMAN	WWC3	physical	24682284
KPCA_HUMAN	PRKCA	physical	24682284
LATS2_HUMAN	LATS2	physical	24682284
LATS1_HUMAN	LATS1	physical	24682284

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WWC2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1022, AND MASSSPECTROMETRY.	15302935 [Abstract]