WWC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WWC3_HUMAN
• UniProt AC: Q9ULE0
• Protein Name: Protein WWC3
• Gene Name: WWC3
• Organism: Homo sapiens (Human).
• Sequence Length: 1092
• Protein Sequence: MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCEDDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLADSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPFVRSGTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQSCRSSLAELMARTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQLRGQTDLPPWVLRDERLRGLLREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEPIQVQTFREKIAFFTRPRINIPPLPADDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MDHINKLTQIEDPRE CCCHHHHHCCCCHHH	29.16	22210691
46	Ubiquitination	KKEIYQIKQQRFELA HHHHHHHHHHHHHHH	25.50	29967540
57	Phosphorylation	FELAQEEYQQLHKMC HHHHHHHHHHHHHHC	10.78	27251275
74	Phosphorylation	DSRSYASSFSGYSTN CCCHHHHHCCCCCCC	18.43	28857561
170	Phosphorylation	ERRDLMHSLAKLTDS HHHHHHHHHHHHHHH	18.96	26091039
275	Ubiquitination	RDRLQLIKEKEALLQ HHHHHHHHHHHHHHH	71.91	29967540
293	Phosphorylation	LIIAQRRSAGDVARL HHHHHHCCHHHHHHH	38.50	-
316	Phosphorylation	EELRRARATSAQGAT HHHHHHHHHHHCCHH	12.62	18669648
351	Phosphorylation	RLTSYLQSQLKSLCA HHHHHHHHHHHHHHH	34.58	-
355	Phosphorylation	YLQSQLKSLCASTLT HHHHHHHHHHHCEEE	36.95	25137130
359	Phosphorylation	QLKSLCASTLTVSSG HHHHHHHCEEEECCC	23.97	28348404
360	Phosphorylation	LKSLCASTLTVSSGS HHHHHHCEEEECCCC	14.13	25137130
362	Phosphorylation	SLCASTLTVSSGSSR HHHHCEEEECCCCCC	20.59	22777824
364	Phosphorylation	CASTLTVSSGSSRGS HHCEEEECCCCCCCC	24.60	27251275
365	Phosphorylation	ASTLTVSSGSSRGSL HCEEEECCCCCCCCC	38.06	27251275
367	Phosphorylation	TLTVSSGSSRGSLAS EEEECCCCCCCCCCC	20.86	25137130
369	Methylation	TVSSGSSRGSLASSR EECCCCCCCCCCCCC	40.18	115389293
371	Phosphorylation	SSGSSRGSLASSRGS CCCCCCCCCCCCCCC	21.47	18669648
375	Phosphorylation	SRGSLASSRGSLASS CCCCCCCCCCCCCCC	34.74	25137130
376	Methylation	RGSLASSRGSLASSR CCCCCCCCCCCCCCC	35.90	115389299
378	Phosphorylation	SLASSRGSLASSRGS CCCCCCCCCCCCCCC	21.47	18669648
385	Phosphorylation	SLASSRGSLSSVSFT CCCCCCCCCCCCEEE	24.78	26657352
387	Phosphorylation	ASSRGSLSSVSFTDI CCCCCCCCCCEEEEC	30.32	29209046
388	Phosphorylation	SSRGSLSSVSFTDIY CCCCCCCCCEEEECC	27.37	29209046
390	Phosphorylation	RGSLSSVSFTDIYGL CCCCCCCEEEECCCC	25.11	28102081
392	Phosphorylation	SLSSVSFTDIYGLPQ CCCCCEEEECCCCCC	17.62	29209046
395	Phosphorylation	SVSFTDIYGLPQYEK CCEEEECCCCCCCCC	18.54	28102081
400	Phosphorylation	DIYGLPQYEKPDAEG ECCCCCCCCCCCCCC	24.79	29209046
420	Phosphorylation	FDLIPFDSLGRDAPF EEEECCCCCCCCCCC	32.86	27251275
442	Phosphorylation	GFHKQRRSLDTPQSL CCCCCCCCCCCHHHH	32.55	25849741
445	Phosphorylation	KQRRSLDTPQSLASL CCCCCCCCHHHHHHH	28.64	23403867
453	Phosphorylation	PQSLASLSSRSSLSS HHHHHHHHCCHHHHC	22.62	24114839
456	Phosphorylation	LASLSSRSSLSSLSP HHHHHCCHHHHCCCC	37.26	23403867
457	Phosphorylation	ASLSSRSSLSSLSPP HHHHCCHHHHCCCCC	31.03	23403867
459	Phosphorylation	LSSRSSLSSLSPPSS HHCCHHHHCCCCCCC	31.05	23403867
460	Phosphorylation	SSRSSLSSLSPPSSP HCCHHHHCCCCCCCC	37.85	23403867
462	Phosphorylation	RSSLSSLSPPSSPLD CHHHHCCCCCCCCCC	36.39	23403867
465	Phosphorylation	LSSLSPPSSPLDTPF HHCCCCCCCCCCCCC	48.23	23403867
466	Phosphorylation	SSLSPPSSPLDTPFL HCCCCCCCCCCCCCC	34.94	23403867
476	Phosphorylation	DTPFLPASRDSPLAQ CCCCCCCCCCCHHHH	34.38	27251275
479	Phosphorylation	FLPASRDSPLAQLAD CCCCCCCCHHHHHHH	22.24	26657352
487	Phosphorylation	PLAQLADSCEGPGLG HHHHHHHHCCCCCCH	14.41	27794612
504	Phosphorylation	DRLRAHASAMGDEDL HHHHHHHHHCCCCCC	14.66	28555341
538	Phosphorylation	ERGPPPASAPVGGTV CCCCCCCCCCCCCEE	38.59	24961811
544	Phosphorylation	ASAPVGGTVTLREDS CCCCCCCEEEECHHH	12.37	28555341
551	Phosphorylation	TVTLREDSAKRLERR EEEECHHHHHHHHHH	30.82	28555341
563	Phosphorylation	ERRARRISACLSDYS HHHHHHHHHHHCCCC	15.89	27794612
567	Phosphorylation	RRISACLSDYSLASD HHHHHHHCCCCCCCC	34.09	28450419
569	Phosphorylation	ISACLSDYSLASDSG HHHHHCCCCCCCCCC	11.38	28450419
570	Phosphorylation	SACLSDYSLASDSGV HHHHCCCCCCCCCCC	23.58	28450419
573	Phosphorylation	LSDYSLASDSGVFEP HCCCCCCCCCCCCCC	37.29	28857561
575	Phosphorylation	DYSLASDSGVFEPLT CCCCCCCCCCCCCCC	34.07	23090842
582	Phosphorylation	SGVFEPLTKRNEDAE CCCCCCCCCCCCCCC	38.38	23090842
643	Phosphorylation	CKVHIRVYLPPLDSG CEEEEEEECCCCCCC	12.02	22817900
649	Phosphorylation	VYLPPLDSGTPNTYC EECCCCCCCCCCCCC	52.85	24719451
651	Phosphorylation	LPPLDSGTPNTYCSK CCCCCCCCCCCCCCC	19.81	28348404
655	Phosphorylation	DSGTPNTYCSKALEF CCCCCCCCCCCCHHC	11.02	22817900
657	Phosphorylation	GTPNTYCSKALEFQV CCCCCCCCCCHHCCC	15.56	-
736	Phosphorylation	TSSEPSRTREAGCAG ECCCCCCCCCCCCCC	36.88	-
746	Phosphorylation	AGCAGESSARDPAHT CCCCCCCCCCCCCCE	24.03	-
753	Phosphorylation	SARDPAHTISISGKT CCCCCCCEEEECCCC	20.65	27251275
755	Phosphorylation	RDPAHTISISGKTDA CCCCCEEEECCCCHH	16.32	23312004
757	Phosphorylation	PAHTISISGKTDAVT CCCEEEECCCCHHHH	27.70	30576142
764	Phosphorylation	SGKTDAVTVLLARTT CCCCHHHHHHHHHHH	13.73	30576142
790	Phosphorylation	EERAKLEYTEEEVLE HHHHCCCCCHHHHHH	29.86	23401153
791	Phosphorylation	ERAKLEYTEEEVLEM HHHCCCCCHHHHHHH	27.78	23401153
809	Phosphorylation	EEQAEAISERSWQAD HHHHHHHHHCCCHHC	33.72	21815630
826	Phosphorylation	DSGCSNCTQTSPPYP CCCCCCCCCCCCCCC	38.85	30576142
828	Phosphorylation	GCSNCTQTSPPYPEP CCCCCCCCCCCCCCC	25.66	17081983
842	Phosphorylation	PCCMGIDSILGHPFA CCCCCHHHHHCCCCH	20.14	28348404
856	Phosphorylation	AAQAGPYSPEKFQPS HHHCCCCCCCCCCCC	29.71	30576142
863	Phosphorylation	SPEKFQPSPLKVDKE CCCCCCCCCCCCCCC	31.89	23312004
883	Phosphorylation	LFLEEAASLVKERPS HHHHHHHHHHHHCCC	40.52	22199227
890	Phosphorylation	SLVKERPSRRARGSP HHHHHCCCHHCCCCC	40.39	22817900
896	Phosphorylation	PSRRARGSPFVRSGT CCHHCCCCCCCCCCE	15.04	28674419
907	Phosphorylation	RSGTIVRSQTFSPGA CCCEEEEEEECCCCC	23.76	23403867
909	Phosphorylation	GTIVRSQTFSPGARS CEEEEEEECCCCCCH	27.59	27273156
911	Phosphorylation	IVRSQTFSPGARSQY EEEEEECCCCCCHHE	26.30	30278072
923	Phosphorylation	SQYVCRLYRSDSDSS HHEEEEHCCCCCCCC	6.68	23403867
925	Phosphorylation	YVCRLYRSDSDSSTL EEEEHCCCCCCCCCC	28.10	22617229
927	Phosphorylation	CRLYRSDSDSSTLPR EEHCCCCCCCCCCCC	40.41	23401153
929	Phosphorylation	LYRSDSDSSTLPRKS HCCCCCCCCCCCCCC	29.22	30278072
930	Phosphorylation	YRSDSDSSTLPRKSP CCCCCCCCCCCCCCH	38.67	30278072
931	Phosphorylation	RSDSDSSTLPRKSPF CCCCCCCCCCCCCHH	44.74	23403867
936	Phosphorylation	SSTLPRKSPFVRNTL CCCCCCCCHHHHHHH	25.50	29214152
953	Phosphorylation	RTLRYKQSCRSSLAE HHHHHHHHHHHHHHH	13.82	24501219
956	Phosphorylation	RYKQSCRSSLAELMA HHHHHHHHHHHHHHH	33.75	25850435
957	Phosphorylation	YKQSCRSSLAELMAR HHHHHHHHHHHHHHH	16.55	23403867
1044	Acetylation	RHEQAAEKMLKKASK HHHHHHHHHHHHHHH	44.82	30593441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WWC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WWC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WWC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
WWC3_HUMAN	WWC3	physical	24682284
KPCA_HUMAN	PRKCA	physical	24682284
LATS2_HUMAN	LATS2	physical	24682284
LATS1_HUMAN	LATS1	physical	24682284
WWC2_HUMAN	WWC2	physical	24682284

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.