dbPTM

LATS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LATS2_HUMAN
UniProt AC	Q9NRM7
Protein Name	Serine/threonine-protein kinase LATS2
Gene Name	LATS2 {ECO:0000312\|EMBL:BAA92381.1}
Organism	Homo sapiens (Human).
Sequence Length	1088
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles
Protein Description	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ..
Protein Sequence	MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRPKTFPATTYS ---CCCCCCCCCCCC	37.22	-
9	Phosphorylation	RPKTFPATTYSGNSR CCCCCCCCCCCCCHH	26.89	-
10	Phosphorylation	PKTFPATTYSGNSRQ CCCCCCCCCCCCHHH	20.14	-
11	Phosphorylation	KTFPATTYSGNSRQR CCCCCCCCCCCHHHH	15.38	-
12	Phosphorylation	TFPATTYSGNSRQRL CCCCCCCCCCHHHHH	29.43	-
43	Phosphorylation	GLPAGPNSDTSLDAK CCCCCCCCCCCHHHH	45.45	27251275
45	Phosphorylation	PAGPNSDTSLDAKVL CCCCCCCCCHHHHHH	30.89	28555341
50	Ubiquitination	SDTSLDAKVLGSKDA CCCCHHHHHHCCCHH	37.34	-
55	Ubiquitination	DAKVLGSKDATRQQQ HHHHHCCCHHHHHHH	49.97	-
55	Acetylation	DAKVLGSKDATRQQQ HHHHHCCCHHHHHHH	49.97	20167786
58	Phosphorylation	VLGSKDATRQQQQMR HHCCCHHHHHHHHHH	38.86	26546556
67	Phosphorylation	QQQQMRATPKFGPYQ HHHHHHCCCCCCHHH	19.35	26657352
82	Phosphorylation	KALREIRYSLLPFAN HHHHHHHHHHHHCCC	14.88	22817900
83	Phosphorylation	ALREIRYSLLPFANE HHHHHHHHHHHCCCC	17.37	10673337
128	Phosphorylation	LKQTGSRSIEAALEY HHHHCCHHHHHHHHH	26.86	25002506
135	Phosphorylation	SIEAALEYISKMGYL HHHHHHHHHHHCCCC	16.02	25002506
154	Ubiquitination	EQIVRVIKQTSPGKG HHHEEHHHCCCCCCC	44.67	-
168	O-linked_Glycosylation	GLMPTPVTRRPSFEG CCCCCCCCCCCCCCC	23.36	30379171
172	Phosphorylation	TPVTRRPSFEGTGDS CCCCCCCCCCCCCCC	33.83	22817900
253	Phosphorylation	FPLQGAHYGRPHLLV CCCCCCCCCCCEEEC	17.81	27642862
272	Phosphorylation	LGYGVQRSPSFQSKT CCCCCCCCCCCCCCC	14.06	28555341
274	Phosphorylation	YGVQRSPSFQSKTPP CCCCCCCCCCCCCCC	36.84	30576142
277	Phosphorylation	QRSPSFQSKTPPETG CCCCCCCCCCCCCCC	36.16	26270265
277	O-linked_Glycosylation	QRSPSFQSKTPPETG CCCCCCCCCCCCCCC	36.16	30379171
278	Ubiquitination	RSPSFQSKTPPETGG CCCCCCCCCCCCCCC	55.02	-
279	Phosphorylation	SPSFQSKTPPETGGY CCCCCCCCCCCCCCC	49.69	18669648
283	Phosphorylation	QSKTPPETGGYASLP CCCCCCCCCCCCCCC	41.50	26270265
286	Phosphorylation	TPPETGGYASLPTKG CCCCCCCCCCCCCCC	8.38	25159151
288	Phosphorylation	PETGGYASLPTKGQG CCCCCCCCCCCCCCC	26.80	26270265
291	Phosphorylation	GGYASLPTKGQGGPP CCCCCCCCCCCCCCC	53.77	26270265
335	Phosphorylation	LHVLGSRSQVFASDS HHCCCCCCCEECCCC	32.18	24719451
340	O-linked_Glycosylation	SRSQVFASDSPPQSL CCCCEECCCCCCHHH	27.44	30379171
340	Phosphorylation	SRSQVFASDSPPQSL CCCCEECCCCCCHHH	27.44	25850435
342	O-linked_Glycosylation	SQVFASDSPPQSLLT CCEECCCCCCHHHCC	35.66	30379171
342	Phosphorylation	SQVFASDSPPQSLLT CCEECCCCCCHHHCC	35.66	25850435
346	O-linked_Glycosylation	ASDSPPQSLLTPSRN CCCCCCHHHCCCCCC	30.99	30379171
346	Phosphorylation	ASDSPPQSLLTPSRN CCCCCCHHHCCCCCC	30.99	25850435
349	Phosphorylation	SPPQSLLTPSRNSLN CCCHHHCCCCCCCCC	25.22	27251275
351	Phosphorylation	PQSLLTPSRNSLNVD CHHHCCCCCCCCCEE	38.57	27251275
380	Phosphorylation	ATLARRDSLQKPGLE HHHHHHHHCCCCCCC	30.78	23401153
406	Phosphorylation	DCPVPSRTNSFNSHQ CCCCCCCCCCCCCCC	39.28	23312004
408	Phosphorylation	PVPSRTNSFNSHQPR CCCCCCCCCCCCCCC	25.78	25159151
411	Phosphorylation	SRTNSFNSHQPRPGP CCCCCCCCCCCCCCC	22.84	23312004
431	O-linked_Glycosylation	PSLPAPNTVTAVTAA CCCCCCCCEEEEEHH	20.41	30379171
433	O-linked_Glycosylation	LPAPNTVTAVTAAHI CCCCCCEEEEEHHHH	17.24	30379171
436	O-linked_Glycosylation	PNTVTAVTAAHILHP CCCEEEEEHHHHHCC	18.70	30379171
446	Phosphorylation	HILHPVKSVRVLRPE HHHCCCCEEEEECCC	18.52	22817900
526	Phosphorylation	PKHLLLRSKSEQYDL CCCEECCCCCCCCCH	40.27	30576142
528	Phosphorylation	HLLLRSKSEQYDLDS CEECCCCCCCCCHHH	31.04	25849741
531	Phosphorylation	LRSKSEQYDLDSLCA CCCCCCCCCHHHHHH	17.89	22115753
535	Phosphorylation	SEQYDLDSLCAGMEQ CCCCCHHHHHHHHHH	32.42	22115753
543	Phosphorylation	LCAGMEQSLRAGPNE HHHHHHHHHHCCCCC	13.40	28102081
565	Acetylation	RKSAKGDKGGKDKKQ CCCCCCCCCCCCHHH	77.54	7709875
570	Acetylation	GDKGGKDKKQIQTSP CCCCCCCHHHCCCCC	50.49	20167786
571	Acetylation	DKGGKDKKQIQTSPV CCCCCCHHHCCCCCC	63.87	20167786
575	Phosphorylation	KDKKQIQTSPVPVRK CCHHHCCCCCCCCCC	36.31	30266825
576	Phosphorylation	DKKQIQTSPVPVRKN CHHHCCCCCCCCCCC	13.92	30266825
598	Phosphorylation	ESRIKSYSPYAFKFF HHHHHHHCHHHHHHH	20.65	21815630
616	Phosphorylation	HVENVIKTYQQKVNR HHHHHHHHHHHHHHH	18.55	26074081
617	Phosphorylation	VENVIKTYQQKVNRR HHHHHHHHHHHHHHH	12.16	26074081
620	Ubiquitination	VIKTYQQKVNRRLQL HHHHHHHHHHHHHHH	26.42	-
651	Ubiquitination	MRKILYQKESNYNRL HHHHHHHHHHCHHHH	49.94	-
690	Phosphorylation	CLACKVDTHALYAMK HHHCCCCHHHHHHHH	16.43	-
697	Ubiquitination	THALYAMKTLRKKDV HHHHHHHHHHHHHHC	35.91	-
793	Ubiquitination	GFIHRDIKPDNILID CCCCCCCCCCCEEEE	51.08	-
827	Ubiquitination	HNSKYYQKGSHVRQD CCCCCCCCCCCCCCC	46.38	-
829	Phosphorylation	SKYYQKGSHVRQDSM CCCCCCCCCCCCCCC	26.33	12853976
835	Phosphorylation	GSHVRQDSMEPSDLW CCCCCCCCCCHHHHH	19.39	27251275
839	Phosphorylation	RQDSMEPSDLWDDVS CCCCCCHHHHHHHHH	31.84	29449344
872	Phosphorylation	HQRCLAHSLVGTPNY HHHHHHHHCCCCCCC	21.10	25850435
876	Phosphorylation	LAHSLVGTPNYIAPE HHHHCCCCCCCCCHH	10.81	25850435
939	Ubiquitination	LHIPAQVKLSPEARD EECCCEEECCHHHHH	31.03	-
950	Ubiquitination	EARDLITKLCCSADH HHHHHHHHHHHCCCC	32.31	-
968	Ubiquitination	RNGADDLKAHPFFSA CCCHHHHHHCCCCCC	52.20	-
984	Ubiquitination	DFSSDIRKQPAPYVP CCCCCHHHCCCCCCC	62.05	-
1024	Phosphorylation	GSTKAWDTLTSPNNK CCCCHHHCCCCCCCC	22.64	18669648
1026	Phosphorylation	TKAWDTLTSPNNKHP CCHHHCCCCCCCCCC	44.20	18669648
1027	Phosphorylation	KAWDTLTSPNNKHPE CHHHCCCCCCCCCCC	28.83	20363803
1038	Phosphorylation	KHPEHAFYEFTFRRF CCCCCCEEEEEEHHH	15.77	23917254
1041	Phosphorylation	EHAFYEFTFRRFFDD CCCEEEEEEHHHCCC	12.32	10871863
1051	Phosphorylation	RFFDDNGYPFRCPKP HHCCCCCCCCCCCCC	12.88	-
1064	Phosphorylation	KPSGAEASQAESSDL CCCCCCHHHCCCCCC	22.79	22210691
1080	Phosphorylation	SSDLVDQTEGCQPVY CCCCCCCCCCCEECC	29.86	22210691
1087	Phosphorylation	TEGCQPVYV------ CCCCEECCC------	13.71	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
83	S	Phosphorylation	Kinase	AURA	O14965	PSP
172	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
380	S	Phosphorylation	Kinase	AURKA	O14965	GPS
380	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
408	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
408	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
446	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
835	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
835	S	Phosphorylation	Kinase	LATS2	Q9NRM7	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:25438054
-	K	Ubiquitination	E3 ubiquitin ligase	DCAF1	Q9Y4B6	PMID:25026211

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LATS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LATS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIBRA_HUMAN	WWC1	physical	21233212
LATS1_HUMAN	LATS1	physical	21233212
YAP1_HUMAN	YAP1	physical	19797269
YAP1_HUMAN	YAP1	physical	18413746
ANDR_HUMAN	AR	physical	15131260
AURKB_HUMAN	AURKB	physical	21822051
ASPP1_HUMAN	PPP1R13B	physical	21041411
YAP1_HUMAN	YAP1	physical	21041411
1433G_HUMAN	YWHAG	physical	21118956
MOB1B_HUMAN	MOB1B	physical	19919647
YAP1_HUMAN	YAP1	physical	19919647
STK3_HUMAN	STK3	physical	19919647
MDM2_HUMAN	MDM2	physical	17015431
SNAI1_HUMAN	SNAI1	physical	21952048
AMOL2_HUMAN	AMOTL2	physical	21832154
YAP1_HUMAN	YAP1	physical	21832154
ASPP1_HUMAN	PPP1R13B	physical	21041410
YAP1_HUMAN	YAP1	physical	21041410
AJUBA_HUMAN	AJUBA	physical	16413547
DYR1A_HUMAN	DYRK1A	physical	21498571
AURKA_HUMAN	AURKA	physical	15147269
MOB1A_HUMAN	MOB1A	physical	20624913
YAP1_HUMAN	YAP1	physical	18640976
YAP1_HUMAN	YAP1	physical	22863277
P5CS_HUMAN	ALDH18A1	physical	24255178
ALMS1_HUMAN	ALMS1	physical	24255178
AMOT_HUMAN	AMOT	physical	24255178
AMOL1_HUMAN	AMOTL1	physical	24255178
AMOL2_HUMAN	AMOTL2	physical	24255178
APC1_HUMAN	ANAPC1	physical	24255178
APC5_HUMAN	ANAPC5	physical	24255178
APC_HUMAN	APC	physical	24255178
CP131_HUMAN	CEP131	physical	24255178
BAG2_HUMAN	BAG2	physical	24255178
BAG5_HUMAN	BAG5	physical	24255178
CCD77_HUMAN	CCDC77	physical	24255178
CC85C_HUMAN	CCDC85C	physical	24255178
DAPLE_HUMAN	CCDC88C	physical	24255178
CP110_HUMAN	CCP110	physical	24255178
CENPJ_HUMAN	CENPJ	physical	24255178
CEP72_HUMAN	CEP72	physical	24255178
CEP85_HUMAN	CEP85	physical	24255178
CEP89_HUMAN	CEP89	physical	24255178
CING_HUMAN	CGN	physical	24255178
CNTRB_HUMAN	CNTROB	physical	24255178
CPVL_HUMAN	CPVL	physical	24255178
CSPP1_HUMAN	CSPP1	physical	24255178
CTNB1_HUMAN	CTNNB1	physical	24255178
CUL7_HUMAN	CUL7	physical	24255178
CYLD_HUMAN	CYLD	physical	24255178
DCAF7_HUMAN	DCAF7	physical	24255178
DNJA3_HUMAN	DNAJA3	physical	24255178
4ET_HUMAN	EIF4ENIF1	physical	24255178
RB6I2_HUMAN	ERC1	physical	24255178
AMER1_HUMAN	AMER1	physical	24255178
FXL16_HUMAN	FBXL16	physical	24255178
FUBP3_HUMAN	FUBP3	physical	24255178
GGYF1_HUMAN	GIGYF1	physical	24255178
GRIP1_HUMAN	GRIP1	physical	24255178
IFFO1_HUMAN	IFFO1	physical	24255178
INADL_HUMAN	INADL	physical	24255178
ECM29_HUMAN	KIAA0368	physical	24255178
JCAD_HUMAN	KIAA1462	physical	24255178
K1549_HUMAN	KIAA1549	physical	24255178
K1671_HUMAN	KIAA1671	physical	24255178
CE295_HUMAN	CEP295	physical	24255178
LATS2_HUMAN	LATS2	physical	24255178
LETM1_HUMAN	LETM1	physical	24255178
LIMD1_HUMAN	LIMD1	physical	24255178
LIN7C_HUMAN	LIN7C	physical	24255178
LNX2_HUMAN	LNX2	physical	24255178
LONM_HUMAN	LONP1	physical	24255178
LZTS2_HUMAN	LZTS2	physical	24255178
MAGI1_HUMAN	MAGI1	physical	24255178
TGO1_HUMAN	MIA3	physical	24255178
MIPO1_HUMAN	MIPOL1	physical	24255178
AFAD_HUMAN	MLLT4	physical	24255178
MOB1A_HUMAN	MOB1A	physical	24255178
MPDZ_HUMAN	MPDZ	physical	24255178
MPP9_HUMAN	MPHOSPH9	physical	24255178
MPP5_HUMAN	MPP5	physical	24255178
NCK5L_HUMAN	NCKAP5L	physical	24255178
NIN_HUMAN	NIN	physical	24255178
NINL_HUMAN	NINL	physical	24255178
NDK7_HUMAN	NME7	physical	24255178
NOTC1_HUMAN	NOTCH1	physical	24255178
NOTC2_HUMAN	NOTCH2	physical	24255178
NU160_HUMAN	NUP160	physical	24255178
OFD1_HUMAN	OFD1	physical	24255178
PAK4_HUMAN	PAK4	physical	24255178
PARD3_HUMAN	PARD3	physical	24255178
PCM1_HUMAN	PCM1	physical	24255178
PDZ11_HUMAN	PDZD11	physical	24255178
PHLB2_HUMAN	PHLDB2	physical	24255178
PKP4_HUMAN	PKP4	physical	24255178
PKHA1_HUMAN	PLEKHA1	physical	24255178
PKHA5_HUMAN	PLEKHA5	physical	24255178
PKHA7_HUMAN	PLEKHA7	physical	24255178
PKHG1_HUMAN	PLEKHG1	physical	24255178
PLOD1_HUMAN	PLOD1	physical	24255178
PNMA2_HUMAN	PNMA2	physical	24255178
LIPA1_HUMAN	PPFIA1	physical	24255178
LIPB1_HUMAN	PPFIBP1	physical	24255178
ASPP1_HUMAN	PPP1R13B	physical	24255178
2AAA_HUMAN	PPP2R1A	physical	24255178
2ABA_HUMAN	PPP2R2A	physical	24255178
PTN13_HUMAN	PTPN13	physical	24255178
PTN14_HUMAN	PTPN14	physical	24255178
RADIL_HUMAN	RADIL	physical	24255178
NGAP_HUMAN	RASAL2	physical	24255178
RBM15_HUMAN	RBM15	physical	24255178
RCN2_HUMAN	RCN2	physical	24255178
SDCG3_HUMAN	SDCCAG3	physical	24255178
SC16A_HUMAN	SEC16A	physical	24255178
SI1L1_HUMAN	SIPA1L1	physical	24255178
SI1L2_HUMAN	SIPA1L2	physical	24255178
SI1L3_HUMAN	SIPA1L3	physical	24255178
SKP1_HUMAN	SKP1	physical	24255178
SKP2_HUMAN	SKP2	physical	24255178
SRBS1_HUMAN	SORBS1	physical	24255178
SPICE_HUMAN	SPICE1	physical	24255178
ADIP_HUMAN	SSX2IP	physical	24255178
STK3_HUMAN	STK3	physical	24255178
STK4_HUMAN	STK4	physical	24255178
STXB4_HUMAN	STXBP4	physical	24255178
TANC2_HUMAN	TANC2	physical	24255178
TBK1_HUMAN	TBK1	physical	24255178
TBKB1_HUMAN	TBKBP1	physical	24255178
TCHP_HUMAN	TCHP	physical	24255178
ZO1_HUMAN	TJP1	physical	24255178
ZO2_HUMAN	TJP2	physical	24255178
TNR6B_HUMAN	TNRC6B	physical	24255178
ASPP2_HUMAN	TP53BP2	physical	24255178
TRI27_HUMAN	TRIM27	physical	24255178
TRI37_HUMAN	TRIM37	physical	24255178
TBB2A_HUMAN	TUBB2A	physical	24255178
TBB6_HUMAN	TUBB6	physical	24255178
UBP54_HUMAN	USP54	physical	24255178
USP9X_HUMAN	USP9X	physical	24255178
UTRO_HUMAN	UTRN	physical	24255178
1433F_HUMAN	YWHAH	physical	24255178
AMOT_HUMAN	AMOT	physical	24101513
HS90B_HUMAN	HSP90AB1	physical	20841485
TAZ_HUMAN	TAZ	physical	20858893
AMOT_HUMAN	AMOT	physical	24225952
AMOT_HUMAN	AMOT	physical	24106267
ABL1_HUMAN	ABL1	physical	23852372
CTNB1_HUMAN	CTNNB1	physical	24360964
CDN1A_HUMAN	CDKN1A	physical	23886938
LIMD1_HUMAN	LIMD1	physical	20303269
AJUBA_HUMAN	AJUBA	physical	20303269
WTIP_HUMAN	WTIP	physical	20303269
STK4_HUMAN	STK4	physical	26578655
YAP1_HUMAN	YAP1	physical	26578655
RASF1_HUMAN	RASSF1	physical	26578655
LATS2_HUMAN	LATS2	physical	26578655
SIAH1_HUMAN	SIAH1	physical	25587023
WWTR1_HUMAN	WWTR1	physical	25670202
YAP1_HUMAN	YAP1	physical	25670202
LATS2_HUMAN	LATS2	physical	25670202
KIF23_HUMAN	KIF23	physical	25658096
IKKB_HUMAN	IKBKB	physical	25946971
YAP1_HUMAN	YAP1	physical	26598551
AMOL2_HUMAN	AMOTL2	physical	26598551
ZYX_HUMAN	ZYX	physical	27030211
SIAH2_HUMAN	SIAH2	physical	27030211
KIF23_MOUSE	Kif23	physical	25786116
MOB1A_HUMAN	MOB1A	physical	26898830
EZH2_HUMAN	EZH2	physical	27434182
SUZ12_HUMAN	SUZ12	physical	27434182
USP9X_HUMAN	USP9X	physical	28720576
SRC_HUMAN	SRC	physical	28754671
YAP1_HUMAN	YAP1	physical	28754671

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LATS2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-279 AND SER-380, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"The centrosomal protein Lats2 is a phosphorylation target of Aurora-Akinase."; Toji S., Yabuta N., Hosomi T., Nishihara S., Kobayashi T., Suzuki S.,Tamai K., Nojima H.; Genes Cells 9:383-397(2004). Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AURKA, MUTAGENESIS OF SER-83,AND PHOSPHORYLATION AT SER-83.	15147269 [Abstract]
"Structure, expression, and chromosome mapping of LATS2, a mammalianhomologue of the Drosophila tumor suppressor gene lats/warts."; Yabuta N., Fujii T., Copeland N.G., Gilbert D.J., Jenkins N.A.,Nishiguchi H., Endo Y., Toji S., Tanaka H., Nishimune Y., Nojima H.; Genomics 63:263-270(2000). Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-1088, TISSUE SPECIFICITY, AND VARIANTVAL-324.	10673337 [Abstract]