TAZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAZ_HUMAN
• UniProt AC: Q16635
• Protein Name: Tafazzin
• Gene Name: TAZ
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Isoform 1: Membrane; Single-pass membrane protein.; Isoform 2: Cytoplasm .; Isoform 3: Membrane; Single-pass membrane protein.; Isoform 4: Membrane; Single-pass membrane protein.; Isoform 5: Membrane; Single-pass membrane protein.; Isoform 6: Cytoplasm .
• Protein Description: Some isoforms may be involved in cardiolipin (CL) metabolism..
• Protein Sequence: MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQPGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Ubiquitination	VLYELIEKRGPATPL HHHHHHHHHCCCCCE	56.51	-
135	Ubiquitination	FQAENEGKGVLDTGR EECCCCCCCCCCCCC	39.40	-
149	Acetylation	RHMPGAGKRREKGDG CCCCCCCCCCCCCCC	47.99	30592807
160	Ubiquitination	KGDGVYQKGMDFILE CCCCCCCCCHHHHHH	38.22	-
264	Ubiquitination	KSAVEMRKALTDFIQ CCHHHHHHHHHHHHH	46.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAZ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCG1_HUMAN	CHGB	physical	16169070
FBW1A_HUMAN	BTRC	physical	20858893
KC1E_HUMAN	CSNK1E	physical	20858893
GSK3B_HUMAN	GSK3B	physical	22692215
FBW1A_HUMAN	BTRC	physical	22692215
STK3_HUMAN	STK3	physical	22078877
LATS1_HUMAN	LATS1	physical	22078877
FBW1A_HUMAN	BTRC	physical	22078877
CH60_HUMAN	HSPD1	physical	26186194
CA2D2_HUMAN	CACNA2D2	physical	26186194
KDEL1_HUMAN	KDELC1	physical	26186194
T132A_HUMAN	TMEM132A	physical	26186194
LRP5_HUMAN	LRP5	physical	26186194
LRP6_HUMAN	LRP6	physical	26186194
LRP1B_HUMAN	LRP1B	physical	26186194
AMD_HUMAN	PAM	physical	26186194
HLAF_HUMAN	HLA-F	physical	26186194
FREM2_HUMAN	FREM2	physical	26186194
MBTP1_HUMAN	MBTPS1	physical	26186194
ITAV_HUMAN	ITGAV	physical	26186194
GALNS_HUMAN	GALNS	physical	26186194
ADA10_HUMAN	ADAM10	physical	26186194
TXD16_HUMAN	TXNDC16	physical	26186194
FAT1_HUMAN	FAT1	physical	26186194
CA2D1_HUMAN	CACNA2D1	physical	26186194
GALT7_HUMAN	GALNT7	physical	26186194
NDST2_HUMAN	NDST2	physical	26186194
NDST1_HUMAN	NDST1	physical	26186194
B3GLT_HUMAN	B3GALTL	physical	26186194
PGLT1_HUMAN	POGLUT1	physical	26186194
PLXA2_HUMAN	PLXNA2	physical	26186194
PLXA1_HUMAN	PLXNA1	physical	26186194
ARSK_HUMAN	ARSK	physical	26186194
MEGF8_HUMAN	MEGF8	physical	26186194
SC65_HUMAN	P3H4	physical	26186194
CNTP3_HUMAN	CNTNAP3	physical	26186194
LOXL2_HUMAN	LOXL2	physical	26186194
XYLT2_HUMAN	XYLT2	physical	26186194
LRIG3_HUMAN	LRIG3	physical	26186194
TBC9B_HUMAN	TBC1D9B	physical	26186194
TM131_HUMAN	TMEM131	physical	26186194
CD109_HUMAN	CD109	physical	26186194
ITA7_HUMAN	ITGA7	physical	26186194
MICA_HUMAN	MICA	physical	26186194
GLT18_HUMAN	GALNT18	physical	26186194
MOXD1_HUMAN	MOXD1	physical	26186194
ANAG_HUMAN	NAGLU	physical	26186194
BGLR_HUMAN	GUSB	physical	26186194
FRAS1_HUMAN	FRAS1	physical	26186194
NID2_HUMAN	NID2	physical	26186194
MANBA_HUMAN	MANBA	physical	26186194
ITA8_HUMAN	ITGA8	physical	26186194
VWDE_HUMAN	VWDE	physical	26186194
TRFM_HUMAN	MFI2	physical	26186194
MGRN1_HUMAN	MGRN1	physical	26186194
NHLC3_HUMAN	NHLRC3	physical	26186194
NAGAB_HUMAN	NAGA	physical	26186194
FUT11_HUMAN	FUT11	physical	26186194
ANR46_HUMAN	ANKRD46	physical	26186194
GPR98_HUMAN	GPR98	physical	26186194
LMF1_HUMAN	LMF1	physical	26186194
GT253_HUMAN	CERCAM	physical	26186194
HPLN3_HUMAN	HAPLN3	physical	26186194
COIA1_HUMAN	COL18A1	physical	26186194
LARG2_HUMAN	GYLTL1B	physical	26186194
CO6A2_HUMAN	COL6A2	physical	26186194
GPC3_HUMAN	GPC3	physical	26186194
TXD15_HUMAN	TXNDC15	physical	26186194
GNPTG_HUMAN	GNPTG	physical	26186194
BTD_HUMAN	BTD	physical	26186194
NRP2_HUMAN	NRP2	physical	26186194
SELN_HUMAN	SEPN1	physical	26186194
BMP8B_HUMAN	BMP8B	physical	26186194
TOR3A_HUMAN	TOR3A	physical	26186194
LAMA3_HUMAN	LAMA3	physical	26186194
SUMF1_HUMAN	SUMF1	physical	26186194
EDEM2_HUMAN	EDEM2	physical	26186194
BMP7_HUMAN	BMP7	physical	26186194
SMOC1_HUMAN	SMOC1	physical	26186194
G6PE_HUMAN	H6PD	physical	26186194
ADA11_HUMAN	ADAM11	physical	26186194
CAH11_HUMAN	CA11	physical	26186194
ATS2_HUMAN	ADAMTS2	physical	26186194
HYAL2_HUMAN	HYAL2	physical	26186194
CH60_HUMAN	HSPD1	physical	28514442
VWDE_HUMAN	VWDE	physical	28514442
FUT11_HUMAN	FUT11	physical	28514442
GLT18_HUMAN	GALNT18	physical	28514442
CNTP3_HUMAN	CNTNAP3	physical	28514442
ADA11_HUMAN	ADAM11	physical	28514442
ITA8_HUMAN	ITGA8	physical	28514442
G6PE_HUMAN	H6PD	physical	28514442
GALNS_HUMAN	GALNS	physical	28514442
HYAL2_HUMAN	HYAL2	physical	28514442
ITA7_HUMAN	ITGA7	physical	28514442
FRAS1_HUMAN	FRAS1	physical	28514442
PGLT1_HUMAN	POGLUT1	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
LRP1B_HUMAN	LRP1B	physical	28514442
ANAG_HUMAN	NAGLU	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442
NDST1_HUMAN	NDST1	physical	28514442
LAMA3_HUMAN	LAMA3	physical	28514442
CD109_HUMAN	CD109	physical	28514442
LRP5_HUMAN	LRP5	physical	28514442
HPLN3_HUMAN	HAPLN3	physical	28514442
NID2_HUMAN	NID2	physical	28514442
MICA_HUMAN	MICA	physical	28514442
TOR3A_HUMAN	TOR3A	physical	28514442
GT253_HUMAN	CERCAM	physical	28514442
LARG2_HUMAN	GYLTL1B	physical	28514442
XYLT2_HUMAN	XYLT2	physical	28514442
MANBA_HUMAN	MANBA	physical	28514442
CA2D1_HUMAN	CACNA2D1	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
SMOC1_HUMAN	SMOC1	physical	28514442
ANR46_HUMAN	ANKRD46	physical	28514442
TXD15_HUMAN	TXNDC15	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
ITAV_HUMAN	ITGAV	physical	28514442
KDEL1_HUMAN	KDELC1	physical	28514442
GPC3_HUMAN	GPC3	physical	28514442
NRP2_HUMAN	NRP2	physical	28514442
COIA1_HUMAN	COL18A1	physical	28514442
BMP7_HUMAN	BMP7	physical	28514442
CAH11_HUMAN	CA11	physical	28514442
TXD16_HUMAN	TXNDC16	physical	28514442
LMLN_HUMAN	LMLN	physical	28514442
BMP8B_HUMAN	BMP8B	physical	28514442
MA2A2_HUMAN	MAN2A2	physical	28514442
AMD_HUMAN	PAM	physical	28514442
TM131_HUMAN	TMEM131	physical	28514442
LAMP2_HUMAN	LAMP2	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
MBTP1_HUMAN	MBTPS1	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442
TBC9B_HUMAN	TBC1D9B	physical	28514442
EDEM2_HUMAN	EDEM2	physical	28514442
NID1_HUMAN	NID1	physical	28514442
SUMF1_HUMAN	SUMF1	physical	28514442
NAGAB_HUMAN	NAGA	physical	28514442
PLTP_HUMAN	PLTP	physical	28514442
B3GL2_HUMAN	B3GALNT2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.