FRAS1_HUMAN - dbPTM
FRAS1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRAS1_HUMAN
UniProt AC Q86XX4
Protein Name Extracellular matrix protein FRAS1
Gene Name FRAS1
Organism Homo sapiens (Human).
Sequence Length 4008
Subcellular Localization Cell membrane
Single-pass type I membrane protein
Extracellular side .
Protein Description
Protein Sequence MGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYLDDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKNCDSYCLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVYNCVPGFSVHTSNETCSGKIHTPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHSKEKLRKGYLFLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNPQDVVIEIIDPPLHGQLLQTLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSDVAVLQANDGHSFHNILFQVKTVPQNDRGLQLVANSMVWVPEGGMLQITNRILQAEAPGASAEEIIYKITQDYPQFGEVVLLVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVSSASNAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGLQVVVRDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISISEDKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVPKSAMGSLFYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALADASDNARIGRVATAKVLISGPNDASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYLGLPLGNHWSGARIGKNNMATITISNDEDAPTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEEVTKEGVKKSPSPGYPLVCVTPCDPHFPRYAVMKERCSEAGINQTSVQFSWEVAAPTDGNGARSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNIVTIGTDSAICHTPVVAGTSRGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLISTMPLHNLHFLLSESIYRHQHVCSNLVTTYDLRGLAEAGFLDDVVYDSTALGPGYDRPFQFDPSVREPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLYVSYIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIEFKTHAKFRGQFVMEHHTLPEVKSFVLTPDHLGGIEFDLQLLWSAQTFDSPHQLWRATSSYNRKDYSGEYTIYLIPCTVQPTQPWVDPGEKPLACTAHAPERFLIPIAFQQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNPEQNLNSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRNQPEVTDKYFHDVPFEAHFASELPDFHVVSNMPGVDGFTLKVDALYKVEAGHQWYLQVIYIIGPDTISGPRVQRSLTAPLRRNRRDLVEPDGQLILDDSLIYDNEGDQVKNGTNMKSLNLEMQELAVAASLSQTGASIGSALAAIMLLLLVFLVACFINRKCQKQRKKKPAEDILEEYPLNTKVEVPKRHPDRVEKNVNRHYCTVRNVNILSEPEAAYTFKGAKVKRLNLEVRVHNNLQDGTEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
344PhosphorylationKCCPECISRNGYCVY
CCCHHHHHCCCEEEE		31.2124260401
361N-linked_GlycosylationTGEFMSSNASEVKRI
CCCCCCCCHHHCEEC		39.93UniProtKB CARBOHYD
549UbiquitinationGCESSCGKGFYNRQG
CCCCCCCCCCCCCCC		50.6129967540
571PhosphorylationSCDSCGPSSPRCLTC
CCCCCCCCCCCCEEE		37.9526853621
572PhosphorylationCDSCGPSSPRCLTCT
CCCCCCCCCCCEEEC		21.3526853621
627PhosphorylationPSHCTACSPPKALRQ
CCCCCCCCCCHHHHC		41.60-
728N-linked_GlycosylationCAGKSPHNCTDCGPS
CCCCCCCCCCCCCCC		33.49UniProtKB CARBOHYD
1093N-linked_GlycosylationGFSVHTSNETCSGKI
CCEEECCCCCCCCEE		51.46UniProtKB CARBOHYD
1108N-linked_GlycosylationHTPSLHVNGSLILPI
CCCCEEECCEEEEEE		23.81UniProtKB CARBOHYD
1154PhosphorylationTNGQLVLSRNGKEVQ
CCCCEEECCCCEEEE		52.3224719451
1171UbiquitinationKAGRFSWKDVNEKKV
CCCCCCCCCCCCCEE		42.0629967540
1361PhosphorylationQAEAPGASAEEIIYK
HCCCCCCCHHHHHHH		20.2228857561
1504N-linked_GlycosylationPSGKIVYNITLPLHP
CCCEEEEEEEEECCC		1.98UniProtKB CARBOHYD
1541PhosphorylationINQGKVMYRPPPAAP
HCCCCCEECCCCCCH		21.10-
1689PhosphorylationDSMEISVTDGLTVTM
CCCEEEEECCEEEEE		48.2028985074
1706PhosphorylationVRVEVSLSEDRGPRL
EEEEEECCCCCCCCC		57.9528985074
1722PhosphorylationAGSSLSITVASKSTA
CCCEEEEEEECCCEE		5.5819413330
1777N-linked_GlycosylationEELSEVSNFTMEDIN
HHHHHHCCCCHHHHC		5.54UniProtKB CARBOHYD
1942PhosphorylationVSDGTSRSEIHSINI
ECCCCCHHHEEEEEE		43.5430631047
1946PhosphorylationTSRSEIHSINITIER
CCHHHEEEEEEEEEE		2.4030631047
1948N-linked_GlycosylationRSEIHSINITIERKN
HHHEEEEEEEEEECC		3.80UniProtKB CARBOHYD
1962PhosphorylationNDEPPRMTLQPLRVQ
CCCCCCCEEEEEEEE		3.4524719451
1977PhosphorylationLSSGVVISNSSLSLQ
ECCCEEEECCCCCCC		25.2122210691
1978N-linked_GlycosylationSSGVVISNSSLSLQD
CCCEEEECCCCCCCC		26.35UniProtKB CARBOHYD
2076O-linked_GlycosylationIYTELPASDTPHLAI
EEEECCCCCCCCEEE		67.38OGP
2093O-linked_GlycosylationGLQLSAGSVARITEQ
CCCCCCCHHHHHCEE		3.9829351928
2188 (in isoform 2)Phosphorylation-10.4129083192
2190 (in isoform 2)Phosphorylation-3.9029083192
2192 (in isoform 2)Phosphorylation-5.0829083192
2198 (in isoform 2)Phosphorylation-32.6829083192
2203 (in isoform 2)Phosphorylation-24.6529083192
2204PhosphorylationKSPPVITTNKGLVLD
CCCCEEECCCCEEEC		27.96-
2204 (in isoform 2)Phosphorylation-27.9629083192
2219PhosphorylationENSVKKITTLQLSAT
CCCCEEEEEEEEEEE		18.91-
2331O-linked_GlycosylationEGMRKTITEFELKAV
HHHHCEECEEEEEEC		33.02OGP
2386PhosphorylationDIYQNRVSYSHDGSN
HHHHCCCEECCCCCC		13.7328509920
2387PhosphorylationIYQNRVSYSHDGSNS
HHHCCCEECCCCCCC		13.9528509920
2388PhosphorylationYQNRVSYSHDGSNSL
HHCCCEECCCCCCCC		34.9128509920
2469PhosphorylationITKKELLTMDPDTED
EEHHHHHCCCCCCCC		7.7027135362
2474PhosphorylationLLTMDPDTEDAQLVY
HHCCCCCCCCCEEEE		59.7427135362
2530PhosphorylationKIREMMDSFQFLVKD
HHHHHHHHHCHHCCC		5.3330631047
2538PhosphorylationFQFLVKDSKPNVVSD
HCHHCCCCCCCEEEC		51.2330631047
2556PhosphorylationHIQWSLISFKYTSYN
EEEEEEEEEEEEEEE		5.7824719451
2559PhosphorylationWSLISFKYTSYNVSE
EEEEEEEEEEEECCC		25.89-
2560PhosphorylationSLISFKYTSYNVSEK
EEEEEEEEEEECCCC		16.18-
2563N-linked_GlycosylationSFKYTSYNVSEKAGS
EEEEEEEECCCCCCE		6.25UniProtKB CARBOHYD
2565PhosphorylationKYTSYNVSEKAGSVS
EEEEEECCCCCCEEE		42.51-
2664N-linked_GlycosylationTQAKVIINDTEDEPT
CCCEEEEECCCCCCC		40.85UniProtKB CARBOHYD
2682N-linked_GlycosylationDKKIYWVNESAGFLF
CCEEEEEECCCCEEE		32.14UniProtKB CARBOHYD
2699PhosphorylationIERKGDASSIVSAIC
CEECCCHHHHEEHHE		28.8229083192
2700PhosphorylationERKGDASSIVSAICY
EECCCHHHHEEHHEE		2.3529083192
2703PhosphorylationGDASSIVSAICYTVP
CCHHHHEEHHEEECC		5.7429083192
2707PhosphorylationSIVSAICYTVPKSAM
HHEEHHEEECCHHHH		26.3929083192
2708PhosphorylationIVSAICYTVPKSAMG
HEEHHEEECCHHHHH		1.9629083192
2908N-linked_GlycosylationFQAVIAINDTFQDVP
EEEEEEECCCCCCCC		42.67UniProtKB CARBOHYD
2944PhosphorylationITRSGDLSYESSVRC
ECCCCCCCCCEEEEE		27.42-
2947PhosphorylationSGDLSYESSVRCYTQ
CCCCCCCEEEEEECC		11.1428857561
2952PhosphorylationYESSVRCYTQSHSAQ
CCEEEEEECCCCCCH		27.50-
2953PhosphorylationESSVRCYTQSHSAQV
CEEEEEECCCCCCHH		16.81-
2955PhosphorylationSVRCYTQSHSAQVME
EEEEECCCCCCHHHH		19.82-
2957PhosphorylationRCYTQSHSAQVMEDF
EEECCCCCCHHHHHH		10.68-
2985N-linked_GlycosylationLKGDKVKNCTVYIHD
EECCEECCEEEEECC		1.95UniProtKB CARBOHYD
3045PhosphorylationIEFEEAAYQVREPAG
EEEEHHHHHCCCCCC		24.06-
3070N-linked_GlycosylationVIRRGDQNRTSKVRC
EEECCCCCCCCEEEE		34.44UniProtKB CARBOHYD
3090PhosphorylationSAQSGVDYYPKSRVL
CCCCCCCCCCCCCEE		10.34-
3091PhosphorylationAQSGVDYYPKSRVLK
CCCCCCCCCCCCEEE		23.16-
3097UbiquitinationYYPKSRVLKFSPGVD
CCCCCCEEECCCCCC		40.7229967540
3218N-linked_GlycosylationRCSEAGINQTSVQFS
HHCCCCCCCCCEEEE		32.98UniProtKB CARBOHYD
3540PhosphorylationRLVIEFKTHAKFRGQ
EEEEEEEECCEECCE		27.7524670416
3543GlycationIEFKTHAKFRGQFVM
EEEEECCEECCEEHH		12.61-
3559AcetylationHHTLPEVKSFVLTPD
CCCCCCCEEEEECHH		26.267977263
3676N-linked_GlycosylationKVFLMDPNTSDMSLA
EEEEECCCCCCCCHH		31.34UniProtKB CARBOHYD
3841PhosphorylationPRVQRSLTAPLRRNR
HHHHHHCCCCCCCCC		13.3630631047
3863PhosphorylationGQLILDDSLIYDNEG
CCEEECCCCEECCCC		5.6022798277
3875N-linked_GlycosylationNEGDQVKNGTNMKSL
CCCCCCCCCCCCCCC		16.85UniProtKB CARBOHYD
3875UbiquitinationNEGDQVKNGTNMKSL
CCCCCCCCCCCCCCC		16.8523503661
3877PhosphorylationGDQVKNGTNMKSLNL
CCCCCCCCCCCCCCH		36.9622798277
3880UbiquitinationVKNGTNMKSLNLEMQ
CCCCCCCCCCCHHHH		16.2423503661
3913UbiquitinationLAAIMLLLLVFLVAC
HHHHHHHHHHHHHHH		2.3023503661
3916UbiquitinationIMLLLLVFLVACFIN
HHHHHHHHHHHHHHH		1.5423503661
3918UbiquitinationLLLLVFLVACFINRK
HHHHHHHHHHHHHHH		5.6623503661
3951 (in isoform 2)Ubiquitination-69.39-
3951UbiquitinationLNTKVEVPKRHPDRV
CCCCCCCCCCCCCHH		69.3923503661
3956UbiquitinationEVPKRHPDRVEKNVN
CCCCCCCCHHHHHHC		42.8423503661
3966PhosphorylationEKNVNRHYCTVRNVN
HHHHCCCEEEEEECE		2.0125884760
3982PhosphorylationLSEPEAAYTFKGAKV
CCCCCCEEECCCCEE		17.7221945579
3983PhosphorylationSEPEAAYTFKGAKVK
CCCCCEEECCCCEEE		4.4721945579
3985AcetylationPEAAYTFKGAKVKRL
CCCEEECCCCEEEEE		26.8319824983
3989 (in isoform 2)Ubiquitination-50.92-
3989UbiquitinationYTFKGAKVKRLNLEV
EECCCCEEEEECCEE		50.9223503661
3992UbiquitinationKGAKVKRLNLEVRVH
CCCEEEEECCEEEEE		37.8823503661
3994UbiquitinationAKVKRLNLEVRVHNN
CEEEEECCEEEEECC		27.4923503661
4006PhosphorylationHNNLQDGTEV-----
ECCCCCCCCC-----		52.3223312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRAS1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRAS1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRAS1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FRAS1_HUMAN !!
Drug and Disease Associations
Kegg Disease
H00687 Fraser syndrome
OMIM Disease
219000Fraser syndrome (FRASS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRAS1_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory