MICA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MICA_HUMAN
• UniProt AC: Q29983
• Protein Name: MHC class I polypeptide-related sequence A
• Gene Name: MICA {ECO:0000312|EMBL:CAI41907.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 383
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses
• Protein Description: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis..
• Protein Sequence: MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	N-linked_Glycosylation	EPHSLRYNLTVLSWD CCCCCEEEEEEEEEC	23.85	UniProtKB CARBOHYD
79	N-linked_Glycosylation	WAEDVLGNKTWDRET CHHHHHCCCCCCCCC	34.13	UniProtKB CARBOHYD
94	Ubiquitination	RDLTGNGKDLRMTLA CCCCCCCCCHHHHHH	58.55	-
104	Ubiquitination	RMTLAHIKDQKEGLH HHHHHHHHCHHCCHH	44.21	-
194	Phosphorylation	CLQELRRYLKSGVVL HHHHHHHHHHHCCEE	16.43	20068231
197	Phosphorylation	ELRRYLKSGVVLRRT HHHHHHHHCCEEEEC	33.94	20068231
204	Phosphorylation	SGVVLRRTVPPMVNV HCCEEEECCCCEEEE	30.81	22210691
210	N-linked_Glycosylation	RTVPPMVNVTRSEAS ECCCCEEEEECCCCC	24.16	UniProtKB CARBOHYD
212	Phosphorylation	VPPMVNVTRSEASEG CCCEEEEECCCCCCC	24.23	22210691
220	N-linked_Glycosylation	RSEASEGNITVTCRA CCCCCCCCEEEEEEC	23.78	UniProtKB CARBOHYD
238	Phosphorylation	YPWNITLSWRQDGVS ECEEEEEEEECCCEE	16.15	24719451
261	N-linked_Glycosylation	GDVLPDGNGTYQTWV CCCCCCCCCCEEEEE	47.19	UniProtKB CARBOHYD
330	S-palmitoylation	IIIFYVRCCKKKTSA HHHHHHHHHCCCCCC	2.59	21928280
331	S-palmitoylation	IIFYVRCCKKKTSAA HHHHHHHHCCCCCCC	5.19	21928280
335	Phosphorylation	VRCCKKKTSAAEGPE HHHHCCCCCCCCCCC	32.26	23312004
336	Phosphorylation	RCCKKKTSAAEGPEL HHHCCCCCCCCCCCE	34.07	23312004
345	Phosphorylation	AEGPELVSLQVLDQH CCCCCEEEEEEECCC	26.21	23312004
356	Phosphorylation	LDQHPVGTSDHRDAT ECCCCCCCCCCCHHH	31.08	23312004
357	Phosphorylation	DQHPVGTSDHRDATQ CCCCCCCCCCCHHHH	26.03	23312004
372	Phosphorylation	LGFQPLMSDLGSTGS HCCCCCHHHCCCCCC	37.05	29485707
376	Phosphorylation	PLMSDLGSTGSTEGA CCHHHCCCCCCCCCC	36.57	29485707

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MICA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MICA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MICA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAC14_HUMAN	VAC14	physical	26186194
FLVC1_HUMAN	FLVCR1	physical	26186194
TNPO2_HUMAN	TNPO2	physical	26186194
SCAM1_HUMAN	SCAMP1	physical	26186194
RYK_HUMAN	RYK	physical	26186194
ADAP2_HUMAN	ADAP2	physical	26186194
TNPO3_HUMAN	TNPO3	physical	26186194
NR3L1_HUMAN	NCR3LG1	physical	26186194
ERLEC_HUMAN	ERLEC1	physical	26186194
VAMP3_HUMAN	VAMP3	physical	26186194
PGRC2_HUMAN	PGRMC2	physical	26186194
TR10B_HUMAN	TNFRSF10B	physical	26186194
TNFL9_HUMAN	TNFSF9	physical	26186194
ADAP2_HUMAN	ADAP2	physical	28514442
SCAM1_HUMAN	SCAMP1	physical	28514442
FLVC1_HUMAN	FLVCR1	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
RYK_HUMAN	RYK	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
ERLEC_HUMAN	ERLEC1	physical	28514442
TNFL9_HUMAN	TNFSF9	physical	28514442
TR10B_HUMAN	TNFRSF10B	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00288: Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
• OMIM Disease
• : Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.
• 177900:
• 607507: Psoriatic arthritis (PSORAS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.