ADAP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADAP2_HUMAN
• UniProt AC: Q9NPF8
• Protein Name: Arf-GAP with dual PH domain-containing protein 2
• Gene Name: ADAP2
• Organism: Homo sapiens (Human).
• Sequence Length: 381
• Subcellular Localization: Cytoplasm . Cell membrane . Constitutively associated with the plasma membrane. Excluded from the nucleus.
• Protein Description: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity..
• Protein Sequence: MGDRERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISRVKSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDLNATFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAFPELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVFLGNKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVLSSPLTPLNRLTASTESGRSSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	Phosphorylation	WKRGRDNSQFLRRKF EECCCCCHHHHHHHH	26.97	28857561
179	Phosphorylation	KSPKAVISIKDLNAT CCCCEEEEEEEHHCE	19.58	24719451
246	Phosphorylation	AFPELPESELVPFLT HCCCCCHHHHHHHHC	34.00	-
256	Phosphorylation	VPFLTRNYLKQGFME HHHHCHHHHHHCHHH	16.40	-
264	Acetylation	LKQGFMEKTGPKQKE HHHCHHHCCCCCCCC	47.17	7962797
331	Phosphorylation	NRWKAGLTIVTPERR CCEECCEEEECCCCE	16.69	29116813
334	Phosphorylation	KAGLTIVTPERRFVL ECCEEEECCCCEEEE	18.64	29116813
342	Phosphorylation	PERRFVLTCPSEKEQ CCCEEEEECCCHHHH	19.64	29116813
345	Phosphorylation	RFVLTCPSEKEQQEW EEEEECCCHHHHHHH	64.54	-
373	Phosphorylation	PLNRLTASTESGRSS CHHHHHCCCCCCCCC	27.72	29449344
374	Phosphorylation	LNRLTASTESGRSSR HHHHHCCCCCCCCCC	31.54	29449344
376	Phosphorylation	RLTASTESGRSSR-- HHHCCCCCCCCCC--	39.33	29449344
379	Phosphorylation	ASTESGRSSR----- CCCCCCCCCC-----	33.71	28857561
380	Phosphorylation	STESGRSSR------ CCCCCCCCC------	40.42	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADAP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADAP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADAP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1G_HUMAN	EEF1G	physical	16169070
A4_HUMAN	APP	physical	21832049
RANB9_HUMAN	RANBP9	physical	18298663
NUCL_HUMAN	NCL	physical	18298663
BACD3_HUMAN	KCTD10	physical	26186194
BACD3_HUMAN	KCTD10	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.