TNPO3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNPO3_HUMAN
• UniProt AC: Q9Y5L0
• Protein Name: Transportin-3
• Gene Name: TNPO3
• Organism: Homo sapiens (Human).
• Sequence Length: 923
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains..
• Protein Sequence: MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGAKPTL -------CCCCCCHH	10.93	19413330
5	Acetylation	---MEGAKPTLQLVY ---CCCCCCHHHHHH	49.76	21339330
19	Phosphorylation	YQAVQALYHDPDPSG HHHHHHHHCCCCCCC	13.75	20068231
59	Phosphorylation	QIRQDVESCYFAAQT HHHHHHHHHHHHHHH	17.61	27067055
61	Phosphorylation	RQDVESCYFAAQTMK HHHHHHHHHHHHHHH	12.92	27067055
66	Phosphorylation	SCYFAAQTMKMKIQT HHHHHHHHHHHHHEE	17.65	27067055
68	Ubiquitination	YFAAQTMKMKIQTSF HHHHHHHHHHHEECE	40.19	-
73	Phosphorylation	TMKMKIQTSFYELPT HHHHHHEECEECCCC	25.03	20873877
74	Phosphorylation	MKMKIQTSFYELPTD HHHHHEECEECCCCC	14.95	20873877
76	Phosphorylation	MKIQTSFYELPTDSH HHHEECEECCCCCCC	19.14	20873877
80	Phosphorylation	TSFYELPTDSHASLR ECEECCCCCCCHHHH	63.86	20873877
82	Phosphorylation	FYELPTDSHASLRDS EECCCCCCCHHHHHH	24.35	20873877
85	Phosphorylation	LPTDSHASLRDSLLT CCCCCCHHHHHHHHH	20.65	20068231
89	Phosphorylation	SHASLRDSLLTHIQN CCHHHHHHHHHHHHH	20.88	20873877
92	Phosphorylation	SLRDSLLTHIQNLKD HHHHHHHHHHHHHHC	23.40	20873877
190	Ubiquitination	LLMTCVEKAGTDEKM HHHHHHHHHCCCHHH	31.55	-
291	2-Hydroxyisobutyrylation	VAREDLDKVLNYCRI HHHHHHHHHHHHHHH	56.79	-
355	Ubiquitination	RLGEHLYKTNDEVIH HHCCHHHHCCHHHHH	47.41	-
501 (in isoform 5)	Phosphorylation	-	25.94	28348404
513	Ubiquitination	LMKGLCEKPLASAAA HHHCCCCCHHHHHHH	44.31	-
513	Acetylation	LMKGLCEKPLASAAA HHHCCCCCHHHHHHH	44.31	25953088
521	Ubiquitination	PLASAAAKAIHNICS HHHHHHHHHHHHHHH	43.05	-
530	Ubiquitination	IHNICSVCRDHMAQH HHHHHHHHHHHHHHH	2.13	21890473
554	Phosphorylation	SLDSFLLSPEAAVGL HHHHHHCCHHHHHHH	23.88	-
594 (in isoform 3)	Ubiquitination	-	56.35	21890473
594	Acetylation	VQVMALKKLLSQEPS HHHHHHHHHHCCCCC	56.35	25953088
594 (in isoform 2)	Ubiquitination	-	56.35	21890473
594	Ubiquitination	VQVMALKKLLSQEPS HHHHHHHHHHCCCCC	56.35	2189047
628 (in isoform 1)	Ubiquitination	-	36.66	21890473
646	Phosphorylation	QEIWPVLSETLNKHR HHHHHHHHHHHHHHC	28.86	20873877
648	Phosphorylation	IWPVLSETLNKHRAD HHHHHHHHHHHHCCC	32.05	20873877
877	Acetylation	RWLENSLKGLPKETT HHHHHHCCCCCCCCC	59.22	25953088
883	Phosphorylation	LKGLPKETTVGAVTV CCCCCCCCCCCEEEE	32.67	19690332
891	Phosphorylation	TVGAVTVTHKQLTDF CCCEEEEEHHHHHHH	17.62	19690332
896 (in isoform 3)	Phosphorylation	-	33.84	25599653
896	Phosphorylation	TVTHKQLTDFHKQVT EEEHHHHHHHHHHCC	33.84	10366588
900	Acetylation	KQLTDFHKQVTSAEE HHHHHHHHHCCCHHH	46.59	23749302
909	Acetylation	VTSAEECKQVCWALR CCCHHHHHHHHHHHH	49.39	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNPO3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNPO3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNPO3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE3A_HUMAN	UBE3A	physical	22939629
ARP3_HUMAN	ACTR3	physical	22863883
ARPC2_HUMAN	ARPC2	physical	22863883
FEN1_HUMAN	FEN1	physical	22863883
HNRH1_HUMAN	HNRNPH1	physical	22863883
IPO9_HUMAN	IPO9	physical	22863883
PFD6_HUMAN	PFDN6	physical	22863883
PP2AA_HUMAN	PPP2CA	physical	22863883
PP2BA_HUMAN	PPP3CA	physical	22863883
TTL12_HUMAN	TTLL12	physical	22863883
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608423: Limb-girdle muscular dystrophy 1F (LGMD1F)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-896, AND MASSSPECTROMETRY.
PubMed: 19690332