TR10B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR10B_HUMAN
• UniProt AC: O14763
• Protein Name: Tumor necrosis factor receptor superfamily member 10B
• Gene Name: TNFRSF10B
• Organism: Homo sapiens (Human).
• Sequence Length: 440
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor for the cytotoxic ligand TNFSF10/TRAIL. [PubMed: 10549288 The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.]
• Protein Sequence: MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GQNAPAASGARKRHG CCCCCCCCCCCHHCC	34.78	20068231
37	Phosphorylation	PGPRVPKTLVLVVAA CCCCCCHHHHHHHHH	18.94	22468782
50	Phosphorylation	AAVLLLVSAESALIT HHHHHHHHHHHHHHC	26.70	22468782
216 (in isoform 2)	Ubiquitination	-	3.25	21890473
216	Ubiquitination	CSLSGIIIGVTVAAV CCCCHHHHHHHHHHH	3.25	21890473
245	Ubiquitination	KKVLPYLKGICSGGG HHHHHHHHHHCCCCC	40.15	21890473
245 (in isoform 1)	Ubiquitination	-	40.15	21890473
353	Phosphorylation	ADLVPFDSWEPLMRK HHCCCCCCHHHHHHH	33.45	22210691
360	Ubiquitination	SWEPLMRKLGLMDNE CHHHHHHHHCCCCCC	32.70	-
369	Ubiquitination	GLMDNEIKVAKAEAA CCCCCCHHHHHHHHH	29.93	-
369	Acetylation	GLMDNEIKVAKAEAA CCCCCCHHHHHHHHH	29.93	25038526
381	Phosphorylation	EAAGHRDTLYTMLIK HHHCCHHHHHHHHHH	22.94	-
383	Phosphorylation	AGHRDTLYTMLIKWV HCCHHHHHHHHHHHH	7.69	27642862
417	Ubiquitination	GERLAKQKIEDHLLS HHHHHHHHHHHHHHH	47.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF183	Q96D59	PMID:31889078

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR10B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR10B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIM50_HUMAN	TIMM50	physical	15044455
CASP8_HUMAN	CASP8	physical	9325248
CASPA_HUMAN	CASP10	physical	9325248
CFLAR_HUMAN	CFLAR	physical	9325248
TRADD_HUMAN	TRADD	physical	9430227
FADD_HUMAN	FADD	physical	9430227
RIPK1_HUMAN	RIPK1	physical	9430227
CASP8_HUMAN	CASP8	physical	11940602
CFLAR_HUMAN	CFLAR	physical	11940602
FADD_HUMAN	FADD	physical	11940602
CBL_HUMAN	CBL	physical	19932172
ITCH_HUMAN	ITCH	physical	19808964
CFLAR_HUMAN	CFLAR	physical	19343040
CASP8_HUMAN	CASP8	physical	19343040
CASP8_HUMAN	CASP8	physical	15388581
FADD_HUMAN	FADD	physical	15388581
TNAP3_HUMAN	TNFAIP3	physical	22585859
RIPK1_HUMAN	RIPK1	physical	22585859
TRAF2_HUMAN	TRAF2	physical	22585859
CASP8_HUMAN	CASP8	physical	23142077
CFLAR_HUMAN	CFLAR	physical	23142077
FADD_HUMAN	FADD	physical	23142077
TRAF2_HUMAN	TRAF2	physical	23142077
CUL3_HUMAN	CUL3	physical	23142077
LSR_HUMAN	LSR	physical	26186194
NFIP1_HUMAN	NDFIP1	physical	26186194
FLVC1_HUMAN	FLVCR1	physical	26186194
MFAP3_HUMAN	MFAP3	physical	26186194
TM214_HUMAN	TMEM214	physical	26186194
S15A4_HUMAN	SLC15A4	physical	26186194
PTH2_HUMAN	PTRH2	physical	26186194
SCAM1_HUMAN	SCAMP1	physical	26186194
REEP5_HUMAN	REEP5	physical	26186194
CASP8_HUMAN	CASP8	physical	26186194
CKAP4_HUMAN	CKAP4	physical	26186194
STX12_HUMAN	STX12	physical	26186194
FADD_HUMAN	FADD	physical	26186194
LAP4B_HUMAN	LAPTM4B	physical	26186194
RN149_HUMAN	RNF149	physical	26186194
FGFR1_HUMAN	FGFR1	physical	26186194
PRAF2_HUMAN	PRAF2	physical	26186194
CEGT_HUMAN	UGCG	physical	26186194
STX3_HUMAN	STX3	physical	26186194
INGR1_HUMAN	IFNGR1	physical	26186194
VAMP3_HUMAN	VAMP3	physical	26186194
CASP8_HUMAN	CASP8	physical	28514442
FADD_HUMAN	FADD	physical	28514442
SCAM1_HUMAN	SCAMP1	physical	28514442
STX3_HUMAN	STX3	physical	28514442
RN149_HUMAN	RNF149	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
S15A4_HUMAN	SLC15A4	physical	28514442
DDR1_HUMAN	DDR1	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
S20A1_HUMAN	SLC20A1	physical	28514442
LAP4B_HUMAN	LAPTM4B	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
PTH2_HUMAN	PTRH2	physical	28514442
INGR1_HUMAN	IFNGR1	physical	28514442
FGFR1_HUMAN	FGFR1	physical	28514442
CEGT_HUMAN	UGCG	physical	28514442
FLVC1_HUMAN	FLVCR1	physical	28514442
NFIP1_HUMAN	NDFIP1	physical	28514442
FADD_HUMAN	FADD	physical	28972304
CASP8_HUMAN	CASP8	physical	28972304

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 275355: Squamous cell carcinoma of the head and neck (HNSCC)
• Kegg Drug
• D06611: Lexatumumab (USAN/INN)
• D09329: Conatumumab (USAN/INN)
• D09888: Drozitumab (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.