LAP4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAP4B_HUMAN
• UniProt AC: Q86VI4
• Protein Name: Lysosomal-associated transmembrane protein 4B {ECO:0000305}
• Gene Name: LAPTM4B {ECO:0000312|HGNC:HGNC:13646}
• Organism: Homo sapiens (Human).
• Sequence Length: 370
• Subcellular Localization: Endomembrane system ; Multi-pass membrane protein . Late endosome membrane . Cell membrane . Cell projection . Lysosome membrane . Endosome membrane. Endosome, multivesicular body membrane . Endosome, multivesicular body lumen .
• Protein Description: Required for optimal lysosomal function. [PubMed: 21224396 Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation]
• Protein Sequence: MELHERPDERRKARTSTQGRLGDWRRVHADGFTHRVLGAPAAAWSSSSWLEPAMTSRTRVTWPSPPRPLPVPAAAAVAFGAKGTDPAEARSSRGIEEAGPRAHGRAGREPERRRSRQQRRGGLQARRSTLLKTCARARATAPGAMKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLIINAVVLLILLSALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPYVSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Ubiquitination	-	59.85	-
15	Phosphorylation	DERRKARTSTQGRLG HHHHHCCCCCCCCCC	40.77	24425749
16	Phosphorylation	ERRKARTSTQGRLGD HHHHCCCCCCCCCCC	17.12	23532336
17	Phosphorylation	RRKARTSTQGRLGDW HHHCCCCCCCCCCCC	34.14	23532336
64	Phosphorylation	RTRVTWPSPPRPLPV CCEEECCCCCCCCCC	38.81	17081983
93	Ubiquitination	PAEARSSRGIEEAGP HHHHHHHCCCHHHCC	51.89	27667366
146	Ubiquitination	ATAPGAMKMVAPWTR CCCCCHHHHHCCCHH	29.68	-
159	S-palmitoylation	TRFYSNSCCLCCHVR HHHCCCCEEHHHCCC	2.10	29575903
160	S-palmitoylation	RFYSNSCCLCCHVRT HHCCCCEEHHHCCCC	3.06	29575903
162	S-palmitoylation	YSNSCCLCCHVRTGT CCCCEEHHHCCCCCC	0.66	29575903
163	S-palmitoylation	SNSCCLCCHVRTGTI CCCEEHHHCCCCCCH	1.83	29575903
286	Phosphorylation	QLPPNFPYRDDVMSV CCCCCCCCCCCCCCC	23.65	-
367	Phosphorylation	AKEPPPPYVSA---- CCCCCCCCCCC----	16.89	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAP4B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAP4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAP4B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFR1_HUMAN	TFRC	physical	22096579
NADL2_HUMAN	NAALADL2	physical	25416956
PI51C_HUMAN	PIP5K1C	physical	25588945
HGS_HUMAN	HGS	physical	25588945
NEDD4_HUMAN	NEDD4	physical	25588945
SNX5_HUMAN	SNX5	physical	25588945

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-367, AND MASSSPECTROMETRY.
PubMed: 18083107