| UniProt ID | TRADD_HUMAN | |
|---|---|---|
| UniProt AC | Q15628 | |
| Protein Name | Tumor necrosis factor receptor type 1-associated DEATH domain protein | |
| Gene Name | TRADD | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 312 | |
| Subcellular Localization | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton . Shuttles between the cytoplasm and the nucleus.. | |
| Protein Description | The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.. | |
| Protein Sequence | MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 32 | Phosphorylation | KVVLSDAYAHPQQKV EEHHHCCCCCHHHHH | 15.50 | 27642862 | |
| 38 | Ubiquitination | AYAHPQQKVAVYRAL CCCCHHHHHHHHHHH | 27.24 | 29967540 | |
| 42 | Phosphorylation | PQQKVAVYRALQAAL HHHHHHHHHHHHHHH | 4.76 | - | |
| 102 | Phosphorylation | LRAALQRSLAAALAQ HHHHHHHHHHHHHHH | 14.92 | 20068231 | |
| 103 | Ubiquitination | RAALQRSLAAALAQH HHHHHHHHHHHHHHC | 4.02 | 22817900 | |
| 103 | Ubiquitination | RAALQRSLAAALAQH HHHHHHHHHHHHHHC | 4.02 | - | |
| 111 | Phosphorylation | AAALAQHSVPLQLEL HHHHHHCCCCEEEEH | 17.22 | 20068231 | |
| 137 | Phosphorylation | ADEERCLSCILAQQP CCHHHHHHHHHHCCC | 11.61 | 28857561 | |
| 163 | Ubiquitination | EDALRNLKCGSGARG HHHHHHCCCCCCCCC | 39.85 | 22817900 | |
| 169 | Ubiquitination | LKCGSGARGGDGEVA CCCCCCCCCCCCCCC | 53.83 | - | |
| 215 | Phosphorylation | PVVNRPLSLKDQQTF ECCCCCCCHHCHHHH | 35.74 | 21724995 | |
| 229 | Ubiquitination | FARSVGLKWRKVGRS HHHHHCCHHHHHHHH | 38.74 | - | |
| 254 | Phosphorylation | PALDSLAYEYEREGL HHHHHHHHHHHHCCH | 25.08 | 28796482 | |
| 256 | Phosphorylation | LDSLAYEYEREGLYE HHHHHHHHHHCCHHH | 13.96 | 28796482 | |
| 296 | Phosphorylation | LEENELTSLAEDLLG HHHCCCHHHHHHHHC | 37.90 | 21724995 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRADD_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRADD_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRADD_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRAF2_HUMAN | TRAF2 | physical | 14743216 | |
| STAT1_HUMAN | STAT1 | physical | 10848577 | |
| TRAF2_HUMAN | TRAF2 | physical | 10892748 | |
| TRAF2_HUMAN | TRAF2 | physical | 10911999 | |
| NOL3_HUMAN | NOL3 | genetic | 9560245 | |
| RIPK1_HUMAN | RIPK1 | physical | 8612133 | |
| TNR1A_HUMAN | TNFRSF1A | physical | 8565075 | |
| TRAF2_HUMAN | TRAF2 | physical | 8565075 | |
| FADD_HUMAN | FADD | physical | 8565075 | |
| TRADD_HUMAN | TRADD | physical | 8943045 | |
| TRAF2_HUMAN | TRAF2 | physical | 9020361 | |
| K1C18_HUMAN | KRT18 | physical | 11684708 | |
| RIPK1_HUMAN | RIPK1 | physical | 16603398 | |
| SH3K1_HUMAN | SH3KBP1 | physical | 15707590 | |
| TRIPC_HUMAN | TRIP12 | physical | 22561347 | |
| FADD_HUMAN | FADD | physical | 21724995 | |
| RIPK1_HUMAN | RIPK1 | physical | 21724995 | |
| TRADD_HUMAN | TRADD | physical | 7758105 | |
| TRAF2_HUMAN | TRAF2 | physical | 12796506 | |
| DAB2P_HUMAN | DAB2IP | physical | 15310755 | |
| ZMY11_HUMAN | ZMYND11 | physical | 19379743 | |
| RIPK1_HUMAN | RIPK1 | physical | 24735611 | |
| IFIT3_HUMAN | IFIT3 | physical | 21813773 | |
| TRAF6_HUMAN | TRAF6 | physical | 24758719 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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