dbPTM

TNR1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNR1A_HUMAN
UniProt AC	P19438
Protein Name	Tumor necrosis factor receptor superfamily member 1A
Gene Name	TNFRSF1A
Organism	Homo sapiens (Human).
Sequence Length	455
Subcellular Localization	Cell membrane Single-pass type I membrane protein . Golgi apparatus membrane Single-pass type I membrane protein . Secreted . A secreted form is produced through proteolytic processing. Isoform 4: Secreted. Lacks a Golgi-retention motif, is
Protein Description	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase..
Protein Sequence	MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	DSVCPQGKYIHPQNN CCCCCCCCEECCCCC	35.47	-
54	N-linked_Glycosylation	GKYIHPQNNSICCTK CCEECCCCCEEECCC	48.98	UniProtKB CARBOHYD
61	Ubiquitination	NNSICCTKCHKGTYL CCEEECCCCCCCCEE	22.04	-
64	Ubiquitination	ICCTKCHKGTYLYND EECCCCCCCCEECCC	63.52	-
86	Phosphorylation	TDCRECESGSFTASE CCCCCCCCCCEECCH	51.93	-
90	Phosphorylation	ECESGSFTASENHLR CCCCCCEECCHHHHH	30.85	-
118	Phosphorylation	QVEISSCTVDRDTVC CEEEEEEEECCCCCC	27.65	-
145	N-linked_Glycosylation	ENLFQCFNCSLCLNG CCCHHHHCCCEECCC	23.30	UniProtKB CARBOHYD
147	Phosphorylation	LFQCFNCSLCLNGTV CHHHHCCCEECCCEE	24.19	26074081
151	N-linked_Glycosylation	FNCSLCLNGTVHLSC HCCCEECCCEEEEEE	42.99	UniProtKB CARBOHYD
234	Phosphorylation	LLFIGLMYRYQRWKS HHHHHHHHHHHHHHH	15.94	26657352
236	Phosphorylation	FIGLMYRYQRWKSKL HHHHHHHHHHHHHHH	5.73	26657352
242	Ubiquitination	RYQRWKSKLYSIVCG HHHHHHHHHEEECCC	47.95	-
245	Phosphorylation	RWKSKLYSIVCGKST HHHHHHEEECCCCCC	20.98	26657352
250	Ubiquitination	LYSIVCGKSTPEKEG HEEECCCCCCCCCCC	46.13	-
265	Ubiquitination	ELEGTTTKPLAPNPS CCCCCCCCCCCCCCC	35.62	-
274	Phosphorylation	LAPNPSFSPTPGFTP CCCCCCCCCCCCCCC	32.00	11606045
280	Phosphorylation	FSPTPGFTPTLGFSP CCCCCCCCCCCCCCC	22.68	11606045
318	Phosphorylation	RREVAPPYQGADPIL CCCCCCCCCCCCCHH	20.65	27259358
347	Ubiquitination	KWEDSAHKPQSLDTD HCCCCCCCCCCCCCC	44.46	-
353	Phosphorylation	HKPQSLDTDDPATLY CCCCCCCCCCCHHHH	47.82	-
360	Phosphorylation	TDDPATLYAVVENVP CCCCHHHHHHHHCCC	7.93	26356563
381	Phosphorylation	FVRRLGLSDHEIDRL HHHHHCCCHHHHHHH	34.81	21724995
401	Phosphorylation	RCLREAQYSMLATWR HHHHHHHHHHHHHHH	11.77	27259358
402	Phosphorylation	CLREAQYSMLATWRR HHHHHHHHHHHHHHH	8.67	26356563
406	Phosphorylation	AQYSMLATWRRRTPR HHHHHHHHHHHCCCC	18.62	27422710
411	Phosphorylation	LATWRRRTPRREATL HHHHHHCCCCHHHHH	21.24	-
417	Phosphorylation	RTPRREATLELLGRV CCCCHHHHHHHHHHH	18.93	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
360	Y	Phosphorylation	Kinase	SRC	P12931	GPS
381	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
411	T	Phosphorylation	Kinase	PKACA	P17612	PSP
417	T	Phosphorylation	Kinase	PKACA	P17612	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNR1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNR1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSMD2_HUMAN	PSMD2	physical	7601280
PSMD2_HUMAN	PSMD2	physical	9126987
SUMO1_HUMAN	SUMO1	physical	10187798
FACD2_HUMAN	FANCD2	physical	14743216
TNFA_HUMAN	TNF	physical	14743216
TR10B_HUMAN	TNFRSF10B	physical	15659383
TP4AP_HUMAN	TRPC4AP	physical	14585990
BCL10_HUMAN	BCL10	physical	10400625
TRAP1_HUMAN	TRAP1	physical	7876093
CASPA_HUMAN	CASP10	physical	9045686
TNFB_HUMAN	LTA	physical	8387891
BAG4_HUMAN	BAG4	physical	9915703
TRADD_HUMAN	TRADD	physical	9915703
JAK1_HUMAN	JAK1	physical	9510175
JAK2_HUMAN	JAK2	physical	9510175
STAT1_HUMAN	STAT1	physical	10848577
DAPK1_HUMAN	DAPK1	physical	12911633
NEMO_HUMAN	IKBKG	physical	10755617
TRADD_HUMAN	TRADD	physical	10187805
TNR1A_HUMAN	TNFRSF1A	physical	8077196
TRADD_HUMAN	TRADD	physical	9082980
FAN_HUMAN	NSMAF	physical	8808629
IKKB_HUMAN	IKBKB	physical	11002417
NOL3_HUMAN	NOL3	genetic	9560245
RIPK1_HUMAN	RIPK1	physical	8985253
CRADD_HUMAN	CRADD	physical	8985253
CASP2_HUMAN	CASP2	physical	8985253
MADD_HUMAN	MADD	physical	9115275
TRADD_HUMAN	TRADD	physical	8612133
RIPK1_HUMAN	RIPK1	physical	8612133
TRAF2_HUMAN	TRAF2	physical	8612133
TRADD_HUMAN	TRADD	physical	8565075
TRAF1_HUMAN	TRAF1	physical	8565075
TRAF2_HUMAN	TRAF2	physical	8565075
FADD_HUMAN	FADD	physical	8565075
TNR1A_HUMAN	TNFRSF1A	physical	10875917
HSP7C_HUMAN	HSPA8	physical	11909948
PI42B_HUMAN	PIP4K2B	physical	9038203
TRADD_HUMAN	TRADD	physical	8943045
TRAF2_HUMAN	TRAF2	physical	8943045
BIRC2_HUMAN	BIRC2	physical	8943045
JAK1_HUMAN	JAK1	physical	11801527
RIPK1_HUMAN	RIPK1	physical	18939944
TRADD_HUMAN	TRADD	physical	18939944
BIRC3_HUMAN	BIRC3	physical	18939944
RIPK1_HUMAN	RIPK1	physical	18724939
RIPK1_HUMAN	RIPK1	physical	18621737
RIPK1_HUMAN	RIPK1	physical	16968706
BABA2_HUMAN	BRE	physical	15465831
FYN_HUMAN	FYN	physical	12753742
CAV1_HUMAN	CAV1	physical	12753742
BIRC3_HUMAN	BIRC3	physical	19815541
RIPK1_HUMAN	RIPK1	physical	19815541
TRAF2_HUMAN	TRAF2	physical	19815541
BIRC2_HUMAN	BIRC2	physical	19815541
RIPK1_HUMAN	RIPK1	physical	21113135
RIPK1_HUMAN	RIPK1	physical	20825417
RIPK1_HUMAN	RIPK1	physical	19773432
RIPK1_HUMAN	RIPK1	physical	21737329
RIPK1_HUMAN	RIPK1	physical	22179575
TRAF2_HUMAN	TRAF2	physical	22179575
UBP2_HUMAN	USP2	physical	22179575
RIPK1_HUMAN	RIPK1	physical	20448643
TRAF2_HUMAN	TRAF2	physical	20448643
TNAP3_HUMAN	TNFAIP3	physical	20448643
SRC_HUMAN	SRC	physical	15707590
CBL_HUMAN	CBL	physical	15707590
PK3CA_HUMAN	PIK3CA	physical	15707590
SH3K1_HUMAN	SH3KBP1	physical	15707590
MUC1_HUMAN	MUC1	physical	18037881
M3K7_HUMAN	MAP3K7	physical	18037881
TRADD_HUMAN	TRADD	physical	18776134
TRAF2_HUMAN	TRAF2	physical	18776134
RIPK1_HUMAN	RIPK1	physical	22733818
UBP4_HUMAN	USP4	physical	21331078
M3K7_HUMAN	MAP3K7	physical	21331078
RIPK1_HUMAN	RIPK1	physical	21331078
IKKB_HUMAN	IKBKB	physical	21331078
RIPK1_HUMAN	RIPK1	physical	16115877
M3K7_HUMAN	MAP3K7	physical	16115877
RIPK1_HUMAN	RIPK1	physical	22848449
CLIP3_HUMAN	CLIP3	physical	22297296
TRADD_HUMAN	TRADD	physical	22297296
TRAF3_HUMAN	TRAF3	physical	7859281
TRAF1_HUMAN	TRAF1	physical	7859281
TRAF2_HUMAN	TRAF2	physical	11821416
TRADD_HUMAN	TRADD	physical	11821416
IKKB_HUMAN	IKBKB	physical	11821416
TRPC1_HUMAN	TRPC1	physical	20458742
TRPC4_HUMAN	TRPC4	physical	20458742
TRPC5_HUMAN	TRPC5	physical	20458742
TRAF2_HUMAN	TRAF2	physical	20333651
TRADD_HUMAN	TRADD	physical	21724995
IKKA_HUMAN	CHUK	physical	21724995
IKKB_HUMAN	IKBKB	physical	21724995
GRB2_HUMAN	GRB2	physical	19289468
SOS1_HUMAN	SOS1	physical	19289468
TRADD_HUMAN	TRADD	physical	7758105
TRAF2_HUMAN	TRAF2	physical	15743837
TRADD_HUMAN	TRADD	physical	11035039
FADD_HUMAN	FADD	physical	11035039
TRAF1_MOUSE	Traf1	physical	11035039
DAB2P_HUMAN	DAB2IP	physical	15310755
DAXX_HUMAN	DAXX	physical	9215629
M3K7_HUMAN	MAP3K7	physical	16260783
KPCB_HUMAN	PRKCB	physical	11078718
KPCD_HUMAN	PRKCD	physical	11078718
RIPK1_HUMAN	RIPK1	physical	16611992
TRADD_HUMAN	TRADD	physical	16611992
TRAF2_HUMAN	TRAF2	physical	16611992
FADD_HUMAN	FADD	physical	16611992
BIRC2_HUMAN	BIRC2	physical	18022363
RIPK1_HUMAN	RIPK1	physical	18022363
TRAF2_HUMAN	TRAF2	physical	18022363
JAK2_HUMAN	JAK2	physical	18606683
SRC_HUMAN	SRC	physical	18606683
P85A_HUMAN	PIK3R1	physical	18606683
KHDR1_HUMAN	KHDRBS1	physical	18606683
M3K7_HUMAN	MAP3K7	physical	18949366
IKKB_HUMAN	IKBKB	physical	18949366
IKKA_HUMAN	CHUK	physical	18949366
PP1A_HUMAN	PPP1CA	physical	18949366
RIPK1_HUMAN	RIPK1	physical	18949366
TNFA_HUMAN	TNF	physical	2170559
TNFA_HUMAN	TNF	physical	8288897
TNFB_HUMAN	LTA	physical	8288897
TNR1A_HUMAN	TNFRSF1A	physical	21988832
UBQL1_HUMAN	UBQLN1	physical	21988832
TRADD_HUMAN	TRADD	physical	24130170
RIPK1_HUMAN	RIPK1	physical	24130170
TRAF2_HUMAN	TRAF2	physical	24735611
RNF8_HUMAN	RNF8	physical	24980434
RIPK1_HUMAN	RIPK1	physical	15258597
RIPK1_HUMAN	RIPK1	physical	18450452
FAN_HUMAN	NSMAF	physical	10187805
BIRC2_HUMAN	BIRC2	physical	25681446
RIPK1_HUMAN	RIPK1	physical	25681446
TRADD_HUMAN	TRADD	physical	15310755
TNFA_HUMAN	TNF	physical	25241761
TRAF2_HUMAN	TRAF2	physical	25241761
IKKB_HUMAN	IKBKB	physical	25241761
TRAF6_HUMAN	TRAF6	physical	24758719
TRADD_HUMAN	TRADD	physical	24758719
RIPK1_HUMAN	RIPK1	physical	24758719
KSYK_HUMAN	SYK	physical	26212014
TRAF2_HUMAN	TRAF2	physical	26212014
TNAP3_HUMAN	TNFAIP3	physical	26802121
RIPK1_HUMAN	RIPK1	physical	26802121
RIPK1_HUMAN	RIPK1	physical	25388546
RIPK1_HUMAN	RIPK1	physical	24098568
TNAP3_HUMAN	TNFAIP3	physical	24098568
CYLD_HUMAN	CYLD	physical	24098568
MK01_HUMAN	MAPK1	physical	19850087
RIPK1_HUMAN	RIPK1	physical	27552911
CYLD_HUMAN	CYLD	physical	27552911
TRADD_HUMAN	TRADD	physical	27552911
NEMO_HUMAN	IKBKG	physical	27552911
RNF31_HUMAN	RNF31	physical	27552911
HOIL1_HUMAN	RBCK1	physical	27552911
SHRPN_HUMAN	SHARPIN	physical	27552911
UBC_HUMAN	UBC	physical	27552911
RIPK1_HUMAN	RIPK1	physical	27321185
TRAF2_HUMAN	TRAF2	physical	27321185
TRADD_HUMAN	TRADD	physical	28514442
SCAI_HUMAN	SCAI	physical	28514442
FGOP2_HUMAN	FGFR1OP2	physical	28514442
UBB_HUMAN	UBB	physical	28514442
TNFA_HUMAN	TNF	physical	28514442
SLMAP_HUMAN	SLMAP	physical	28514442
FOXK2_HUMAN	FOXK2	physical	28514442
TPC1_HUMAN	TPCN1	physical	28514442
ATR_HUMAN	ATR	physical	28514442
GPC5B_HUMAN	GPRC5B	physical	28514442
RIPK1_HUMAN	RIPK1	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
UTP20_HUMAN	UTP20	physical	28514442
STRP1_HUMAN	STRIP1	physical	28514442
STRN_HUMAN	STRN	physical	28514442
THADA_HUMAN	THADA	physical	28514442
DOLK_HUMAN	DOLK	physical	28514442
RABX5_HUMAN	RABGEF1	physical	28514442
GRK6_HUMAN	GRK6	physical	28514442
KHNYN_HUMAN	KHNYN	physical	28514442
SIKE1_HUMAN	SIKE1	physical	28514442
PHOCN_HUMAN	MOB4	physical	28514442
MFSD5_HUMAN	MFSD5	physical	28514442
VANG1_HUMAN	VANGL1	physical	28514442
S39A1_HUMAN	SLC39A1	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
CDC6_HUMAN	CDC6	physical	28514442
STRN3_HUMAN	STRN3	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
IKBL1_HUMAN	NFKBIL1	physical	28514442
MCRS1_HUMAN	MCRS1	physical	28514442
DPH1_HUMAN	DPH1	physical	28514442
UTP6_HUMAN	UTP6	physical	28514442
VANG2_HUMAN	VANGL2	physical	28514442
KIF2C_HUMAN	KIF2C	physical	28514442
KC1E_HUMAN	CSNK1E	physical	28514442
XPR1_HUMAN	XPR1	physical	28514442
STRN4_HUMAN	STRN4	physical	28514442
ZN101_HUMAN	ZNF101	physical	28514442
DHRS7_HUMAN	DHRS7	physical	28514442
KDIS_HUMAN	KIDINS220	physical	28514442
MTR1L_HUMAN	GPR50	physical	28514442
KIF14_HUMAN	KIF14	physical	28514442
UTP15_HUMAN	UTP15	physical	28514442
ZN865_HUMAN	ZNF865	physical	28514442
GPC5C_HUMAN	GPRC5C	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442
PRLD1_HUMAN	PRELID1	physical	28514442
CA112_HUMAN	C1orf112	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
TTYH3_HUMAN	TTYH3	physical	28514442
TBC15_HUMAN	TBC1D15	physical	28514442
RN138_HUMAN	RNF138	physical	28514442
RNF31_HUMAN	RNF31	physical	27591049
CYLD_HUMAN	CYLD	physical	27591049
RIPK1_HUMAN	RIPK1	physical	27591049
TNFA_HUMAN	TNF	physical	15173183
TNFA_HUMAN	TNF	physical	11448951

Drug and Disease Associations

Kegg Disease
H00912	Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
OMIM Disease
142680	Familial hibernian fever (FHF)
614810	Multiple sclerosis 5 (MS5)
Kegg Drug
D05263	Onercept (USAN/INN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNR1A_HUMAN

Related Literatures of Post-Translational Modification