CRADD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRADD_HUMAN
• UniProt AC: P78560
• Protein Name: Death domain-containing protein CRADD
• Gene Name: CRADD
• Organism: Homo sapiens (Human).
• Sequence Length: 199
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex..
• Protein Sequence: MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQINQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSLHNGLRAVEVDPSLLLHMLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RDKQVLRSLRLELGA HHHHHHHHHHHHHCH	17.43	21712546
48	Phosphorylation	IQEINAQTTGLRKTM HHHHHHCCCCHHHHH	22.03	-
53	Ubiquitination	AQTTGLRKTMLLLDI HCCCCHHHHHHHHHC	43.24	-
53	Ubiquitination	AQTTGLRKTMLLLDI HCCCCHHHHHHHHHC	43.24	-
94	Sulfoxidation	KKAREEAMTDLPAGD HHHHHHHHHCCCCCC	3.20	21406390
113	Phosphorylation	IPSHILNSSPSDRQI CCHHHHCCCHHHHHH	39.93	25159151
114	Phosphorylation	PSHILNSSPSDRQIN CHHHHCCCHHHHHHH	27.61	25159151
116	Phosphorylation	HILNSSPSDRQINQL HHHCCCHHHHHHHHH	47.58	21712546
137	Phosphorylation	EWEPMVLSLGLSQTD CCCCHHHHCCCCHHH	14.69	28348404
141	Phosphorylation	MVLSLGLSQTDIYRC HHHHCCCCHHHHHHH	29.27	28348404
173	Ubiquitination	RWRQRFGKQATFQSL HHHHHHCCHHHHHHH	33.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRADD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRADD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRADD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERG28_HUMAN	C14orf1	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
CCSE2_HUMAN	CCSER2	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
CASP2_HUMAN	CASP2	physical	8985253
RIPK1_HUMAN	RIPK1	physical	8985253
CASP2_HUMAN	CASP2	genetic	8985253
A4_HUMAN	APP	physical	21832049
IL9R_HUMAN	IL9R	physical	21988832
IMA5_HUMAN	KPNA1	physical	21988832
VTNC_HUMAN	VTN	physical	21988832
S35A3_HUMAN	SLC35A3	physical	21988832
DCXR_HUMAN	DCXR	physical	21988832
CRYAB_HUMAN	CRYAB	physical	23049853
KCTD9_HUMAN	KCTD9	physical	25416956
DP13B_HUMAN	APPL2	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
BBS5_HUMAN	BBS5	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.