DP13B_HUMAN - dbPTM
DP13B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DP13B_HUMAN
UniProt AC Q8NEU8
Protein Name DCC-interacting protein 13-beta
Gene Name APPL2
Organism Homo sapiens (Human).
Sequence Length 664
Subcellular Localization Early endosome membrane
Peripheral membrane protein . Nucleus . Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Protein Description Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction..
Protein Sequence MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRKENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENENDKIVPKATASLPEAEELIAPGTPIQFDIVLPATEFLDQNRGSRRTNPFGETEDESFPEAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQSLRLIDPQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDGKYVLLNDQPDDDDGNPNEHRGAESEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MPAVDKLLLEEAL
--CCHHHHHHHHHHH		34.1430230243
16PhosphorylationLEEALQDSPQTRSLL
HHHHHCCCHHHHHHH		13.1221815630
19PhosphorylationALQDSPQTRSLLSVF
HHCCCHHHHHHHHHH		26.1329396449
48PhosphorylationLQAMQRVYGAQNEMC
HHHHHHHHHHHHHHH		14.6625072903
58PhosphorylationQNEMCLATQQLSKQL
HHHHHHHHHHHHHHH		12.1425072903
62PhosphorylationCLATQQLSKQLLAYE
HHHHHHHHHHHHHHH		17.6425072903
68PhosphorylationLSKQLLAYEKQNFAL
HHHHHHHHHHHHCCC		24.5125072903
78UbiquitinationQNFALGKGDEEVIST
HHCCCCCCCHHHHHH		45.8529967540
103UbiquitinationLNLLHTELAKQLADT
HHHHCHHHHHHHHHH		8.3029967540
121UbiquitinationPIIQFREKDLTEVST
EEEECCCCCCCHHHH		54.5029967540
124PhosphorylationQFREKDLTEVSTLKD
ECCCCCCCHHHHHHH		44.4628674151
144SulfoxidationSNEHDLSMAKYSRLP
CCHHHHHHHHHCCCC		4.9230846556
146UbiquitinationEHDLSMAKYSRLPKK
HHHHHHHHHCCCCCC		34.8129967540
177UbiquitinationARRKQHLSSLQYYCA
HHHHHHHHHHHHHHH		27.2032142685
220UbiquitinationKGAEMFSKRMDSFLS
HHHHHHHHHHHHHHH		40.2432142685
226UbiquitinationSKRMDSFLSSVADMV
HHHHHHHHHHHHHHH		4.2832142685
237UbiquitinationADMVQSIQVELEAEA
HHHHHHHHHHHHHHH		28.0727667366
243UbiquitinationIQVELEAEAEKMRVS
HHHHHHHHHHHHCCC		48.2427667366
267UbiquitinationSVYTPDSDVAAPQIN
CCCCCCCCCCHHHHC		41.2627667366
273UbiquitinationSDVAAPQINRNLIQK
CCCCHHHHCHHHHHH		5.2127667366
280UbiquitinationINRNLIQKAGYLNLR
HCHHHHHHHCCEECC		36.4627667366
283PhosphorylationNLIQKAGYLNLRNKT
HHHHHHCCEECCCCC		9.4022817900
286UbiquitinationQKAGYLNLRNKTGLV
HHHCCEECCCCCCCE		6.1927667366
318UbiquitinationCQPRGAVAGGLIQDL
EECCCCCCCCHHCCC		13.0529967540
331SulfoxidationDLDNCSVMAVDCEDR
CCCCCEEEEEECCCC		1.4030846556
345PhosphorylationRRYCFQITTPNGKSG
CEEEEEEECCCCCEE		25.9722199227
346PhosphorylationRYCFQITTPNGKSGI
EEEEEEECCCCCEEE		19.1822199227
351PhosphorylationITTPNGKSGIILQAE
EECCCCCEEEEEEEE		36.3027251275
359PhosphorylationGIILQAESRKENEEW
EEEEEEECCCCCCCE		52.23-
361UbiquitinationILQAESRKENEEWIC
EEEEECCCCCCCEEE		74.3329967540
367UbiquitinationRKENEEWICAINNIS
CCCCCCEEEEECCCC		0.9729967540
378PhosphorylationNNISRQIYLTDNPEA
CCCCCEEEECCCHHH		8.6629978859
393PhosphorylationVAIKLNQTALQAVTP
HEHHCCHHHHHHHCC		28.4128555341
399PhosphorylationQTALQAVTPITSFGK
HHHHHHHCCCCCCCC		16.4022199227
402PhosphorylationLQAVTPITSFGKKQE
HHHHCCCCCCCCCCC		21.1429514088
405PhosphorylationVTPITSFGKKQESSC
HCCCCCCCCCCCCCC		35.7027251275
406AcetylationTPITSFGKKQESSCP
CCCCCCCCCCCCCCC		49.6325953088
434PhosphorylationDKIVPKATASLPEAE
CCCCCCCCCCCCCHH		23.9428348404
436PhosphorylationIVPKATASLPEAEEL
CCCCCCCCCCCHHHH		39.8528348404
540PhosphorylationTESHLMVTSQSLRLI
CCHHHEEECCCEEEC		13.6924275569
555MethylationDPQTQVSRANFELTS
CCCCCHHHHCEEEEE		34.39-
640PhosphorylationPLTNDGKYVLLNDQP
EECCCCCEEEECCCC		11.2328796482
646PhosphorylationKYVLLNDQPDDDDGN
CEEEECCCCCCCCCC		42.1027642862
662PhosphorylationNEHRGAESEA-----
CCCCCCCCCC-----		37.9929514088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DP13B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DP13B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DP13B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RB22A_HUMANRAB22Aphysical
16189514
RUVB2_HUMANRUVBL2physical
19433865
RBBP7_HUMANRBBP7physical
15016378
MTA2_HUMANMTA2physical
15016378
DP13A_HUMANAPPL1physical
17030088
SUV92_HUMANSUV39H2physical
23455924
RB22A_HUMANRAB22Aphysical
25416956
SUV92_HUMANSUV39H2physical
25416956
LST8_HUMANMLST8physical
25814554
LEG9C_HUMANLGALS9Cphysical
25814554
LIX1_HUMANLIX1physical
25814554
KMT2C_HUMANKMT2Cphysical
25814554
MARE3_HUMANMAPRE3physical
25814554
CQ082_HUMANC17orf82physical
25814554
DOK3_HUMANDOK3physical
25814554
LDH6B_HUMANLDHAL6Bphysical
25814554
PINK1_HUMANPINK1physical
25814554
RET7_HUMANRBP7physical
25814554
ATF3_HUMANATF3physical
25814554
CRBN_HUMANCRBNphysical
25814554
CRLF3_HUMANCRLF3physical
25814554
CNMD_HUMANLECT1physical
25814554
RAI2_HUMANRAI2physical
25814554
TSC1_HUMANTSC1physical
25814554
DP13A_HUMANAPPL1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DP13B_HUMAN

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Related Literatures of Post-Translational Modification

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