KMT2C_HUMAN - dbPTM
KMT2C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KMT2C_HUMAN
UniProt AC Q8NEZ4
Protein Name Histone-lysine N-methyltransferase 2C
Gene Name KMT2C
Organism Homo sapiens (Human).
Sequence Length 4911
Subcellular Localization Nucleus .
Protein Description Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder..
Protein Sequence MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDGWSEQLPDTLVDESVSVTESTEKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQSKISLDNLSEDGAQLLYKTNMNTGFLDPSLDPLLSSSSAPTKSGTHGPADDPLADISEVLNTDDDILGIISDDLAKSVDHSDIGPVTDDPSSLPQPNVNQSSRPLSEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVLSPANTQPTPLPQPPPPTQLLPIHNQDAFSRMPLMNGLIGSSPHLPHNSLPPGSGLGTFSAIAQSSYPDARDKNSAFNPMASDPNNSWTSSAPTVEGENDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSELFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQFGSQHLLVQSGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPPPPAPSRIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFSRRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPRPVMTDQFPKSLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSGPGPFKTPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPIDNFSHNQSNDPYSQPPLTPHPAVNESFAHPSRAFSQPGTISRPTSQDPYSQPPGTPRPVVDSYSQSSGTARSNTDPYSQPPGTPRPTTVDPYSQQPQTPRPSTQTDLFVTPVTNQRHSDPYAHPPGTPRPGISVPYSQPPATPRPRISEGFTRSSMTRPVLMPNQDPFLQAAQNRGPALPGPLVRPPDTCSQTPRPPGPGLSDTFSRVSPSAARDPYDQSPMTPRSQSDSFGTSQTAHDVADQPRPGSEGSFCASSNSPMHSQGQQFSGVSQLPGPVPTSGVTDTQNTVNMAQADTEKLRQRQKLREIILQQQQQKKIAGRQEKGSQDSPAVPHPGPLQHWQPENVNQAFTRPPPPYPGNIRSPVAPPLGPRYAVFPKDQRGPYPPDVASMGMRPHGFRFGFPGGSHGTMPSQERFLVPPQQIQGSGVSPQLRRSVSVDMPRPLNNSQMNNPVGLPQHFSPQSLPVQQHNILGQAYIELRHRAPDGRQRLPFSAPPGSVVEASSNLRHGNFIPRPDFPGPRHTDPMRRPPQGLPNQLPVHPDLEQVPPSQQEQGHSVHSSSMVMRTLNHPLGGEFSEAPLSTSVPSETTSDNLQITTQPSDGLEEKLDSDDPSVKELDVKDLEGVEVKDLDDEDLENLNLDTEDGKVVELDTLDNLETNDPNLDDLLRSGEFDIIAYTDPELDMGDKKSMFNEELDLPIDDKLDNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTNEVKTEVLSPNSKVESKCETEKNDENKDNVDTPCSQASAHSDLNDGEKTSLHPCDPDLFEKRTNRETAGPSANVIQASTQLPAQDVINSCGITGSTPVLSSLLANEKSDNSDIRPSGSPPPPTLPASPSNHVSSLPPFIAPPGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIPGQSTVNHSLGTGKPATQTGPQTSQSGTSSMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGMPPMVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITHQISRPNPPNFGPGFVNDSQRKQYEEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMSQPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQESVEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKTDGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationEPGAPAPSPAAADKR
CCCCCCCCHHHCCCC
30576142
46PhosphorylationRPRKDGASPFQRARK
CCCCCCCCHHHHHCC
25159151
61PhosphorylationKPRSRGKTAVEDEDS
CCCCCCCCCCCCCCC
27732954
68PhosphorylationTAVEDEDSMDGLETT
CCCCCCCCCCCCCCC
27732954
74PhosphorylationDSMDGLETTETETIV
CCCCCCCCCCCEEEE
27732954
75PhosphorylationSMDGLETTETETIVE
CCCCCCCCCCEEEEE
27732954
77PhosphorylationDGLETTETETIVETE
CCCCCCCCEEEEEHH
27732954
79PhosphorylationLETTETETIVETEIK
CCCCCCEEEEEHHHH
27732954
89PhosphorylationETEIKEQSAEEDAEA
EHHHHHCCHHHHHHH
29255136
101PhosphorylationAEAEVDNSKQLIPTL
HHHHCCCHHHHHHHH
27794612
111PhosphorylationLIPTLQRSVSEESAN
HHHHHHHHCCHHHHH
30266825
113PhosphorylationPTLQRSVSEESANSL
HHHHHHCCHHHHHHH
23401153
116PhosphorylationQRSVSEESANSLVSV
HHHCCHHHHHHHHCC
30266825
119PhosphorylationVSEESANSLVSVGVE
CCHHHHHHHHCCCCC
30266825
122PhosphorylationESANSLVSVGVEAKI
HHHHHHHCCCCCEEC
30108239
143PhosphorylationFCYCGEKSSLGQGDL
HHCCCCCCCCCCCCH
27251275
144PhosphorylationCYCGEKSSLGQGDLK
HCCCCCCCCCCCCHH
24719451
177PhosphorylationKKDIDDNSNGTYEKM
CCCCCCCCCCHHHHH
25262027
180PhosphorylationIDDNSNGTYEKMQNS
CCCCCCCHHHHHHHC
25262027
181PhosphorylationDDNSNGTYEKMQNSA
CCCCCCHHHHHHHCC
27251275
200PhosphorylationRGQRKERSPQQNIVS
HCCCCCCCCCCCEEE
29255136
207PhosphorylationSPQQNIVSCVSVSTQ
CCCCCEEEEEEEEEC
23312004
210PhosphorylationQNIVSCVSVSTQTAS
CCEEEEEEEEECCCC
23312004
212PhosphorylationIVSCVSVSTQTASDD
EEEEEEEEECCCCHH
27251275
213PhosphorylationVSCVSVSTQTASDDQ
EEEEEEEECCCCHHH
27251275
215PhosphorylationCVSVSTQTASDDQAG
EEEEEECCCCHHHHH
27251275
217PhosphorylationSVSTQTASDDQAGKL
EEEECCCCHHHHHHH
23312004
512PhosphorylationDTQLKEEYICMYCKH
HHHCCHHHHHHHHHH
23663014
516PhosphorylationKEEYICMYCKHLGAE
CHHHHHHHHHHHCCC
23663014
572PhosphorylationDVNGQESTPGIVPDA
CCCCCCCCCCCCCCC
28555341
620PhosphorylationTELEKQISNEVDSED
HHHHHHHCCCCCHHH
24719451
625PhosphorylationQISNEVDSEDLKMSS
HHCCCCCHHHHHCCH
18491316
631PhosphorylationDSEDLKMSSEVKHIC
CHHHHHCCHHHHHHH
18491316
701PhosphorylationLPLETLVSPHEESIS
ECHHHHCCCCHHHCC
22468782
708PhosphorylationSPHEESISLCPEEQL
CCCHHHCCCCCHHHH
30278072
739PhosphorylationLSTGLMDSEMTPTIE
CCCCCCCCCCCCCCC
27251275
742PhosphorylationGLMDSEMTPTIEGCV
CCCCCCCCCCCCCEE
27251275
753PhosphorylationEGCVKDVSYQGGKSI
CCEEEECEECCCEEE
-
754PhosphorylationGCVKDVSYQGGKSIK
CEEEECEECCCEEEE
-
758AcetylationDVSYQGGKSIKLSSE
ECEECCCEEEECCCC
19608861
782PhosphorylationDISKADVSSSPTPSS
CHHHCCCCCCCCCCC
27080861
783PhosphorylationISKADVSSSPTPSSD
HHHCCCCCCCCCCCC
27080861
784PhosphorylationSKADVSSSPTPSSDL
HHCCCCCCCCCCCCC
27080861
786PhosphorylationADVSSSPTPSSDLPS
CCCCCCCCCCCCCCC
27080861
788PhosphorylationVSSSPTPSSDLPSHD
CCCCCCCCCCCCCCH
27080861
789PhosphorylationSSSPTPSSDLPSHDM
CCCCCCCCCCCCCHH
27080861
793PhosphorylationTPSSDLPSHDMLHNY
CCCCCCCCCHHHHCC
27080861
818PhosphorylationIMPTTYISVTPKIGM
CCCCEEEEEECCCCC
24719451
827AcetylationTPKIGMGKPAITKRK
ECCCCCCCCCCCCCC
23954790
836PhosphorylationAITKRKFSPGRPRSK
CCCCCCCCCCCCCCC
23312004
843MethylationSPGRPRSKQGAWSTH
CCCCCCCCCCCCCCC
115973151
848PhosphorylationRSKQGAWSTHNTVSP
CCCCCCCCCCCCCCC
27251275
849PhosphorylationSKQGAWSTHNTVSPP
CCCCCCCCCCCCCCC
27251275
852PhosphorylationGAWSTHNTVSPPSWS
CCCCCCCCCCCCCCC
27251275
854PhosphorylationWSTHNTVSPPSWSPD
CCCCCCCCCCCCCCC
23186163
857PhosphorylationHNTVSPPSWSPDISE
CCCCCCCCCCCCCCC
27251275
859PhosphorylationTVSPPSWSPDISEGR
CCCCCCCCCCCCCCC
27251275
870AcetylationSEGREIFKPRQLPGS
CCCCCCCCCCCCCCC
26051181
870UbiquitinationSEGREIFKPRQLPGS
CCCCCCCCCCCCCCC
-
870 (in isoform 3)Ubiquitination--
877PhosphorylationKPRQLPGSAIWSIKV
CCCCCCCCEEEEEEE
22210691
893AcetylationRGSGFPGKRRPRGAG
CCCCCCCCCCCCCCC
25953088
914PhosphorylationRGRSKLKSGIGAVVL
CCHHHCCCCCCEEEE
23312004
925PhosphorylationAVVLPGVSTADISSN
EEEECCCCHHHHCCC
23312004
926PhosphorylationVVLPGVSTADISSNK
EEECCCCHHHHCCCC
23312004
930PhosphorylationGVSTADISSNKDDEE
CCCHHHHCCCCCCCC
23312004
931PhosphorylationVSTADISSNKDDEEN
CCHHHHCCCCCCCCC
23312004
948PhosphorylationHNTVVLFSSSDKFTL
CCEEEEECCCCCCCC
-
1043PhosphorylationCLDPPLQTVPKGGWK
ECCCCCCCCCCCCCE
-
1193PhosphorylationQLQSLTVTVPRRKRS
EEEEEEEECCCCCCC
24719451
1213PhosphorylationLKIINQNSVAVLQTP
EEEECCCCEEEEECC
23663014
1219PhosphorylationNSVAVLQTPPDIQSE
CCEEEEECCCCCCCC
29255136
1225PhosphorylationQTPPDIQSEHSRDGE
ECCCCCCCCCCCCCC
25849741
1228PhosphorylationPDIQSEHSRDGEMDD
CCCCCCCCCCCCCCC
23663014
1236PhosphorylationRDGEMDDSREGELMD
CCCCCCCCCCCCEEC
30576142
1248PhosphorylationLMDCDGKSESSPERE
EECCCCCCCCCCCHH
20363803
1250PhosphorylationDCDGKSESSPEREAV
CCCCCCCCCCCHHHC
20363803
1251PhosphorylationCDGKSESSPEREAVD
CCCCCCCCCCHHHCC
20363803
1261PhosphorylationREAVDDETKGVEGTD
HHHCCCCCCCCCCCC
29449344
1267PhosphorylationETKGVEGTDGVKKRK
CCCCCCCCCHHHCCC
23403867
1278PhosphorylationKKRKRKPYRPGIGGF
HCCCCCCCCCCCCCE
-
1298PhosphorylationSRTGQGKTKRSVIRK
CCCCCCCCCCEEEEC
21406692
1301PhosphorylationGQGKTKRSVIRKDSS
CCCCCCCEEEECCCC
21406692
1307PhosphorylationRSVIRKDSSGSISEQ
CEEEECCCCCCHHHC
23663014
1308PhosphorylationSVIRKDSSGSISEQL
EEEECCCCCCHHHCC
23663014
1310PhosphorylationIRKDSSGSISEQLPC
EECCCCCCHHHCCCC
23663014
1312PhosphorylationKDSSGSISEQLPCRD
CCCCCCHHHCCCCCC
23663014
1323PhosphorylationPCRDDGWSEQLPDTL
CCCCCCHHHCCCCCH
30108239
1329PhosphorylationWSEQLPDTLVDESVS
HHHCCCCCHHCCCCC
30108239
1375O-linked_GlycosylationFGKDLLDTSRQSKIS
CCCCHHCCCCCCCCC
30059200
1379PhosphorylationLLDTSRQSKISLDNL
HHCCCCCCCCCHHCC
-
1380UbiquitinationLDTSRQSKISLDNLS
HCCCCCCCCCHHCCC
29967540
1387PhosphorylationKISLDNLSEDGAQLL
CCCHHCCCHHHHHHH
25159151
1395PhosphorylationEDGAQLLYKTNMNTG
HHHHHHHHHCCCCCC
20068231
1435PhosphorylationDDPLADISEVLNTDD
CCCCCHHHHHHCCCC
25159151
1479PhosphorylationPQPNVNQSSRPLSEE
CCCCCCCCCCCCCHH
27251275
1480PhosphorylationQPNVNQSSRPLSEEQ
CCCCCCCCCCCCHHH
27251275
1484PhosphorylationNQSSRPLSEEQLDGI
CCCCCCCCHHHCCCC
27251275
1493PhosphorylationEQLDGILSPELDKMV
HHCCCCCCHHHHHHC
29255136
1508AcetylationTDGAILGKLYKIPEL
CCCCHHHHHHCCHHH
19608861
1510PhosphorylationGAILGKLYKIPELGG
CCHHHHHHCCHHHCC
20068231
1529PhosphorylationDLFTAVLSPANTQPT
HHHHHHCCCCCCCCC
28348404
1533PhosphorylationAVLSPANTQPTPLPQ
HHCCCCCCCCCCCCC
28348404
1602PhosphorylationPDARDKNSAFNPMAS
CCCCCCCCCCCCCCC
-
1686PhosphorylationAKLWRKASSQERAPY
HHHHHHHCCCCCCHH
28102081
1687PhosphorylationKLWRKASSQERAPYV
HHHHHHCCCCCCHHH
25627689
1717AcetylationQMSNDSMKRQQQQDS
CCCCHHHHHHHHHHC
25953088
1724O-linked_GlycosylationKRQQQQDSIDPSSRI
HHHHHHHCCCHHHHH
30059200
1733PhosphorylationDPSSRIDSELFKDPL
CHHHHHCHHHHCCHH
20873877
1752AcetylationSEHEQEWKFRQQMRQ
CHHHHHHHHHHHHHH
25953088
1766AcetylationQKSKQQAKIEATQKL
HHHHHHHHHHHHHHH
23749302
1772AcetylationAKIEATQKLEQVKNE
HHHHHHHHHHHHHHH
19608861
1836PhosphorylationLFTKQPPSTPTSTSS
HHCCCCCCCCCCCCC
27251275
1837PhosphorylationFTKQPPSTPTSTSSD
HCCCCCCCCCCCCCC
27251275
1839PhosphorylationKQPPSTPTSTSSDDV
CCCCCCCCCCCCCCC
27251275
1840PhosphorylationQPPSTPTSTSSDDVF
CCCCCCCCCCCCCCE
27251275
1841PhosphorylationPPSTPTSTSSDDVFV
CCCCCCCCCCCCCEE
27251275
1842PhosphorylationPSTPTSTSSDDVFVK
CCCCCCCCCCCCEEC
27251275
1843PhosphorylationSTPTSTSSDDVFVKP
CCCCCCCCCCCEECC
27251275
1849AcetylationSSDDVFVKPQAPPPP
CCCCCEECCCCCCCC
26051181
1867PhosphorylationSRIPIQDSLSQAQTS
CCCCCCCCCCCCCCC
26074081
1869PhosphorylationIPIQDSLSQAQTSQP
CCCCCCCCCCCCCCC
26074081
1873PhosphorylationDSLSQAQTSQPPSPQ
CCCCCCCCCCCCCCC
26074081
1874PhosphorylationSLSQAQTSQPPSPQV
CCCCCCCCCCCCCCC
26074081
1878PhosphorylationAQTSQPPSPQVFSPG
CCCCCCCCCCCCCCC
28450419
1883PhosphorylationPPSPQVFSPGSSNSR
CCCCCCCCCCCCCCC
28450419
1886PhosphorylationPQVFSPGSSNSRPPS
CCCCCCCCCCCCCCC
28450419
1887PhosphorylationQVFSPGSSNSRPPSP
CCCCCCCCCCCCCCC
26657352
1889PhosphorylationFSPGSSNSRPPSPMD
CCCCCCCCCCCCCCC
28450419
1893PhosphorylationSSNSRPPSPMDPYAK
CCCCCCCCCCCCHHH
28450419
1898PhosphorylationPPSPMDPYAKMVGTP
CCCCCCCHHHCCCCC
28450419
1904PhosphorylationPYAKMVGTPRPPPVG
CHHHCCCCCCCCCCC
28348404
1915PhosphorylationPPVGHSFSRRNSAAP
CCCCCCCCCCCCCCC
26074081
1919PhosphorylationHSFSRRNSAAPVENC
CCCCCCCCCCCCCCC
26657352
1942PhosphorylationPLQMNETTANRPSPV
CCCCCCCCCCCCCCH
27732954
1947PhosphorylationETTANRPSPVRDLCS
CCCCCCCCCHHHHCC
25849741
1965AcetylationTNNDPYAKPPDTPRP
CCCCCCCCCCCCCCC
25953088
1981PhosphorylationMTDQFPKSLGLSRSP
CCCCCCHHHCCCCCC
28176443
1985PhosphorylationFPKSLGLSRSPVVSE
CCHHHCCCCCCCCCC
22199227
1987PhosphorylationKSLGLSRSPVVSEQT
HHHCCCCCCCCCCCC
25159151
1991PhosphorylationLSRSPVVSEQTAKGP
CCCCCCCCCCCCCCC
18669648
1994PhosphorylationSPVVSEQTAKGPIAA
CCCCCCCCCCCCCCC
28176443
1996AcetylationVVSEQTAKGPIAAGT
CCCCCCCCCCCCCCC
25953088
1996UbiquitinationVVSEQTAKGPIAAGT
CCCCCCCCCCCCCCC
-
2003PhosphorylationKGPIAAGTSDHFTKP
CCCCCCCCCCCCCCC
18669648
2008PhosphorylationAGTSDHFTKPSPRAD
CCCCCCCCCCCCCCC
25159151
2009AcetylationGTSDHFTKPSPRADV
CCCCCCCCCCCCCCH
19608861
2011O-linked_GlycosylationSDHFTKPSPRADVFQ
CCCCCCCCCCCCHHH
30059200
2011PhosphorylationSDHFTKPSPRADVFQ
CCCCCCCCCCCCHHH
25159151
2045PhosphorylationSGPGPFKTPMQPPPS
CCCCCCCCCCCCCCC
25072903
2052PhosphorylationTPMQPPPSSQDPYGS
CCCCCCCCCCCCCCC
25072903
2053PhosphorylationPMQPPPSSQDPYGSV
CCCCCCCCCCCCCCH
25072903
2057PhosphorylationPPSSQDPYGSVSQAS
CCCCCCCCCCHHHHH
25072903
2059PhosphorylationSSQDPYGSVSQASRR
CCCCCCCCHHHHHHC
25072903
2061PhosphorylationQDPYGSVSQASRRLS
CCCCCCHHHHHHCCC
25072903
2064PhosphorylationYGSVSQASRRLSVDP
CCCHHHHHHCCCCCC
25072903
2068PhosphorylationSQASRRLSVDPYERP
HHHHHCCCCCCCCCC
27732954
2072PhosphorylationRRLSVDPYERPALTP
HCCCCCCCCCCCCCC
29449344
2078PhosphorylationPYERPALTPRPIDNF
CCCCCCCCCCCCCCC
29449344
2117PhosphorylationAHPSRAFSQPGTISR
CCCCCCCCCCCCCCC
-
2132PhosphorylationPTSQDPYSQPPGTPR
CCCCCCCCCCCCCCC
-
2137PhosphorylationPYSQPPGTPRPVVDS
CCCCCCCCCCCCCCC
-
2156PhosphorylationSGTARSNTDPYSQPP
CCCCCCCCCCCCCCC
30576142
2159PhosphorylationARSNTDPYSQPPGTP
CCCCCCCCCCCCCCC
30576142
2169PhosphorylationPPGTPRPTTVDPYSQ
CCCCCCCCCCCCCCC
30576142
2211MethylationAHPPGTPRPGISVPY
CCCCCCCCCCCCCCC
115483429
2224PhosphorylationPYSQPPATPRPRISE
CCCCCCCCCCCCCCC
-
2226MethylationSQPPATPRPRISEGF
CCCCCCCCCCCCCCC
115483437
2228MethylationPPATPRPRISEGFTR
CCCCCCCCCCCCCCC
115483445
2230O-linked_GlycosylationATPRPRISEGFTRSS
CCCCCCCCCCCCCCC
30059200
2235MethylationRISEGFTRSSMTRPV
CCCCCCCCCCCCCCE
97812429
2239PhosphorylationGFTRSSMTRPVLMPN
CCCCCCCCCCEECCC
24719451
2267MethylationALPGPLVRPPDTCSQ
CCCCCCCCCCCCCCC
115483373
2277MethylationDTCSQTPRPPGPGLS
CCCCCCCCCCCCCCC
115483381
2289MethylationGLSDTFSRVSPSAAR
CCCCCCCCCCHHHCC
115483389
2291PhosphorylationSDTFSRVSPSAARDP
CCCCCCCCHHHCCCC
26657352
2293PhosphorylationTFSRVSPSAARDPYD
CCCCCCHHHCCCCCC
27794612
2302PhosphorylationARDPYDQSPMTPRSQ
CCCCCCCCCCCCCHH
21815630
2305PhosphorylationPYDQSPMTPRSQSDS
CCCCCCCCCCHHCCC
21815630
2308O-linked_GlycosylationQSPMTPRSQSDSFGT
CCCCCCCHHCCCCCC
30059200
2398AcetylationILQQQQQKKIAGRQE
HHHHHHHHHHCCCCC
25953088
2454Asymmetric dimethylarginineVAPPLGPRYAVFPKD
CCCCCCCCCEECCCC
-
2454MethylationVAPPLGPRYAVFPKD
CCCCCCCCCEECCCC
-
2508PhosphorylationPPQQIQGSGVSPQLR
CHHHCCCCCCCHHHH
29083192
2511PhosphorylationQIQGSGVSPQLRRSV
HCCCCCCCHHHHCCE
29083192
2571Asymmetric dimethylarginineRAPDGRQRLPFSAPP
CCCCCCCCCCCCCCC
-
2571MethylationRAPDGRQRLPFSAPP
CCCCCCCCCCCCCCC
115483453
2596MethylationRHGNFIPRPDFPGPR
CCCCCCCCCCCCCCC
115483405
2603MethylationRPDFPGPRHTDPMRR
CCCCCCCCCCCCCCC
115483413
2609MethylationPRHTDPMRRPPQGLP
CCCCCCCCCCCCCCC
115483421
2691PhosphorylationGLEEKLDSDDPSVKE
CHHHHCCCCCCCCEE
27499020
2695PhosphorylationKLDSDDPSVKELDVK
HCCCCCCCCEECCHH
18785766
2697AcetylationDSDDPSVKELDVKDL
CCCCCCCEECCHHHC
27452117
2751PhosphorylationNLDDLLRSGEFDIIA
CHHHHHHHCCCCEEE
24719451
2769AcetylationPELDMGDKKSMFNEE
CCCCCCCCHHHCCCC
26051181
2770AcetylationELDMGDKKSMFNEEL
CCCCCCCHHHCCCCC
26051181
2784AcetylationLDLPIDDKLDNQCVS
CCCCCCCCCCCCCCC
25953088
2795AcetylationQCVSVEPKKKEQENK
CCCCCCCCCCHHCCC
20167786
2802AcetylationKKKEQENKTLVLSDK
CCCHHCCCEEEECCC
19608861
2807PhosphorylationENKTLVLSDKHSPQK
CCCEEEECCCCCCCC
23927012
2809AcetylationKTLVLSDKHSPQKKS
CEEEECCCCCCCCCC
19608861
2811PhosphorylationLVLSDKHSPQKKSTV
EEECCCCCCCCCCCC
23401153
2814AcetylationSDKHSPQKKSTVTNE
CCCCCCCCCCCCCHH
21466224
2815AcetylationDKHSPQKKSTVTNEV
CCCCCCCCCCCCHHH
21466224
2816PhosphorylationKHSPQKKSTVTNEVK
CCCCCCCCCCCHHHH
23312004
2817PhosphorylationHSPQKKSTVTNEVKT
CCCCCCCCCCHHHHE
23312004
2819PhosphorylationPQKKSTVTNEVKTEV
CCCCCCCCHHHHEEE
23312004
2823AcetylationSTVTNEVKTEVLSPN
CCCCHHHHEEECCCC
25953088
2824PhosphorylationTVTNEVKTEVLSPNS
CCCHHHHEEECCCCC
20068231
2828PhosphorylationEVKTEVLSPNSKVES
HHHEEECCCCCCCCH
23401153
2831O-linked_GlycosylationTEVLSPNSKVESKCE
EEECCCCCCCCHHHC
30059200
2831PhosphorylationTEVLSPNSKVESKCE
EEECCCCCCCCHHHC
28102081
2832AcetylationEVLSPNSKVESKCET
EECCCCCCCCHHHCC
19608861
2835PhosphorylationSPNSKVESKCETEKN
CCCCCCCHHHCCCCC
23186163
2836AcetylationPNSKVESKCETEKND
CCCCCCHHHCCCCCC
26051181
2841AcetylationESKCETEKNDENKDN
CHHHCCCCCCCCCCC
25953088
2851PhosphorylationENKDNVDTPCSQASA
CCCCCCCCCCHHHHC
29978859
2854PhosphorylationDNVDTPCSQASAHSD
CCCCCCCHHHHCCCC
29978859
2857PhosphorylationDTPCSQASAHSDLND
CCCCHHHHCCCCCCC
29978859
2860PhosphorylationCSQASAHSDLNDGEK
CHHHHCCCCCCCCCC
22777824
2867AcetylationSDLNDGEKTSLHPCD
CCCCCCCCCCCCCCC
-
2880AcetylationCDPDLFEKRTNRETA
CCHHHHHHHCCCCCC
26051181
2927PhosphorylationSLLANEKSDNSDIRP
HHHCCCCCCCCCCCC
30175587
2930PhosphorylationANEKSDNSDIRPSGS
CCCCCCCCCCCCCCC
30175587
2935PhosphorylationDNSDIRPSGSPPPPT
CCCCCCCCCCCCCCC
23401153
2937PhosphorylationSDIRPSGSPPPPTLP
CCCCCCCCCCCCCCC
23401153
2942PhosphorylationSGSPPPPTLPASPSN
CCCCCCCCCCCCCCC
22115753
2946PhosphorylationPPPTLPASPSNHVSS
CCCCCCCCCCCCCCC
23401153
2948PhosphorylationPTLPASPSNHVSSLP
CCCCCCCCCCCCCCC
22115753
2952PhosphorylationASPSNHVSSLPPFIA
CCCCCCCCCCCCCCC
22115753
2953PhosphorylationSPSNHVSSLPPFIAP
CCCCCCCCCCCCCCC
30175587
3080PhosphorylationQAMIRQRSEPFFPNI
HHHHHHHCCCCCCCC
24247654
3105AcetylationKAKMVALKGINKVMA
HHHHHHHHHHHHHHH
25953088
3124PhosphorylationGMPPMVMSRFPFMGQ
CCCCCHHHCCCCCCE
20068231
3136PhosphorylationMGQVVTGTQNSEGQN
CCEEEECCCCCCCCC
22210691
3139PhosphorylationVVTGTQNSEGQNLGP
EEECCCCCCCCCCCC
22210691
3210AcetylationGAHRKSKKALSAKQR
HHHHHHHHHHHHHHH
19819143
3215AcetylationSKKALSAKQRTAKKA
HHHHHHHHHHHHHHH
25953088
3238PhosphorylationAEQLKHVTEQQSMVQ
HHHHHHHHHHHHHHH
20873877
3242PhosphorylationKHVTEQQSMVQKQLE
HHHHHHHHHHHHHHH
20873877
3339PhosphorylationLPGWQPNSAPAHLPL
CCCCCCCCCCCCCCC
-
3362PhosphorylationIAQLPIKTCTPAPGT
CCCCCCCCCCCCCCC
-
3371PhosphorylationTPAPGTVSNANPQSG
CCCCCCCCCCCCCCC
-
3442PhosphorylationGMVGSEISSSRTSVS
CCCCCHHCCCCCCHH
24905233
3443PhosphorylationMVGSEISSSRTSVSQ
CCCCHHCCCCCCHHH
24905233
3444PhosphorylationVGSEISSSRTSVSQI
CCCHHCCCCCCHHHC
24905233
3514PhosphorylationRRQVGPPSFVPDSPS
CCCCCCCCCCCCCCC
24117733
3519PhosphorylationPPSFVPDSPSIPVGS
CCCCCCCCCCCCCCC
26657352
3521PhosphorylationSFVPDSPSIPVGSPN
CCCCCCCCCCCCCCC
30576142
3526PhosphorylationSPSIPVGSPNFSSVK
CCCCCCCCCCCCCCC
30576142
3530PhosphorylationPVGSPNFSSVKQGHG
CCCCCCCCCCCCCCC
22199227
3531PhosphorylationVGSPNFSSVKQGHGN
CCCCCCCCCCCCCCC
22199227
3693PhosphorylationNSDFSQATPNQQTYA
CCCCCCCCCCCCHHC
25159151
3706AcetylationYANSEVDKLSMETPA
HCCCHHHHHHCCCCC
26051181
3711PhosphorylationVDKLSMETPAKTEEI
HHHHHCCCCCCCCEE
23401153
3714AcetylationLSMETPAKTEEIKLE
HHCCCCCCCCEEEHH
19608861
3715PhosphorylationSMETPAKTEEIKLEK
HCCCCCCCCEEEHHH
23401153
3727PhosphorylationLEKAETESCPGQEEP
HHHCCCCCCCCCCCC
28348404
3754PhosphorylationNAVACPVSSAQSPPH
CEEEEECCCCCCCCC
23663014
3755PhosphorylationAVACPVSSAQSPPHS
EEEEECCCCCCCCCC
29255136
3758PhosphorylationCPVSSAQSPPHSAGA
EECCCCCCCCCCCCC
29255136
3762PhosphorylationSAQSPPHSAGAPAAK
CCCCCCCCCCCCCCC
29255136
3772PhosphorylationAPAAKGDSGNELLKH
CCCCCCCCHHHHHHH
26074081
3778AcetylationDSGNELLKHLLKNKK
CCHHHHHHHHHHCCC
25953088
3786PhosphorylationHLLKNKKSSSLLNQK
HHHHCCCCHHHCCCC
28450419
3787PhosphorylationLLKNKKSSSLLNQKP
HHHCCCCHHHCCCCC
28450419
3788PhosphorylationLKNKKSSSLLNQKPE
HHCCCCHHHCCCCCC
28450419
3793AcetylationSSSLLNQKPEGSICS
CHHHCCCCCCCCCCC
26051181
3797PhosphorylationLNQKPEGSICSEDDC
CCCCCCCCCCCCCCC
27732954
3800PhosphorylationKPEGSICSEDDCTKD
CCCCCCCCCCCCCCC
30108239
3805PhosphorylationICSEDDCTKDNKLVE
CCCCCCCCCCCCHHH
27732954
3860AcetylationRTQRTGEKAAPRSKK
HHHHHCCCCCCCCHH
25953088
3929AcetylationTTEELAGKAGVLVSH
CHHHHCHHCCEEEEE
25953088
3945AcetylationVTKTLGPKPFQLPFR
HHHCCCCCCCCCCCC
23954790
3968PhosphorylationALAQGPKTVDVPASL
HHHCCCCEEECCCCC
28450419
3974PhosphorylationKTVDVPASLPTPPHN
CEEECCCCCCCCCCC
30266825
3977PhosphorylationDVPASLPTPPHNNQE
ECCCCCCCCCCCCHH
30266825
3997PhosphorylationDHCGDRDTPDSFVPS
CCCCCCCCCCCCCCC
30177828
4000PhosphorylationGDRDTPDSFVPSSSP
CCCCCCCCCCCCCCC
30177828
4004PhosphorylationTPDSFVPSSSPESVV
CCCCCCCCCCCHHEE
30177828
4005PhosphorylationPDSFVPSSSPESVVG
CCCCCCCCCCHHEEE
24247654
4006PhosphorylationDSFVPSSSPESVVGV
CCCCCCCCCHHEEEE
27135362
4009PhosphorylationVPSSSPESVVGVEVS
CCCCCCHHEEEEEEE
30177828
4016PhosphorylationSVVGVEVSRYPDLSL
HEEEEEEECCCCCCC
30177828
4018PhosphorylationVGVEVSRYPDLSLVK
EEEEEECCCCCCCCC
22817900
4022PhosphorylationVSRYPDLSLVKEEPP
EECCCCCCCCCCCCC
26074081
4025SumoylationYPDLSLVKEEPPEPV
CCCCCCCCCCCCCCC
-
4034PhosphorylationEPPEPVPSPIIPILP
CCCCCCCCCCCCCCC
29255136
4042PhosphorylationPIIPILPSTAGKSSE
CCCCCCCCCCCCCCH
30108239
4043PhosphorylationIIPILPSTAGKSSES
CCCCCCCCCCCCCHH
30108239
4047PhosphorylationLPSTAGKSSESRRND
CCCCCCCCCHHHHHC
26074081
4048PhosphorylationPSTAGKSSESRRNDI
CCCCCCCCHHHHHCC
26074081
4050PhosphorylationTAGKSSESRRNDIKT
CCCCCCHHHHHCCCC
22817900
4066PhosphorylationPGTLYFASPFGPSPN
CCEEEEECCCCCCCC
28348404
4071PhosphorylationFASPFGPSPNGPRSG
EECCCCCCCCCCCCC
28348404
4112PhosphorylationLHVRIPNSYEVSSAP
CCEECCCCCCCCCCC
24275569
4113PhosphorylationHVRIPNSYEVSSAPD
CEECCCCCCCCCCCC
24275569
4139Asymmetric dimethylarginineINPGLEYRQHLLLRG
CCCCCCEEEEEHHCC
-
4139MethylationINPGLEYRQHLLLRG
CCCCCCEEEEEHHCC
-
4156MethylationPGSANPPRLVSSYRL
CCCCCCCCEEEEEEC
115483397
4162MethylationPRLVSSYRLKQPNVP
CCEEEEEECCCCCCC
80702399
4208PhosphorylationCKVVILGSGVRKSFK
CEEEEECCCHHHHHH
28555341
4213PhosphorylationLGSGVRKSFKDLTLL
ECCCHHHHHHHHHHC
-
4215UbiquitinationSGVRKSFKDLTLLNK
CCHHHHHHHHHHCCC
29967540
4218PhosphorylationRKSFKDLTLLNKDSR
HHHHHHHHHCCCCCH
20068231
4222UbiquitinationKDLTLLNKDSRESTK
HHHHHCCCCCHHHHC
29967540
4224PhosphorylationLTLLNKDSRESTKRV
HHHCCCCCHHHHCCH
20068231
4227PhosphorylationLNKDSRESTKRVEKD
CCCCCHHHHCCHHCC
20068231
4228PhosphorylationNKDSRESTKRVEKDI
CCCCHHHHCCHHCCE
20068231
4260PhosphorylationKNSENKESIPSLPQS
CCCCCCCCCCCCCCC
23403867
4263PhosphorylationENKESIPSLPQSPMR
CCCCCCCCCCCCCCC
30631047
4267PhosphorylationSIPSLPQSPMRETPS
CCCCCCCCCCCCCCC
23401153
4272PhosphorylationPQSPMRETPSKAFHQ
CCCCCCCCCCHHHHH
25159151
4274PhosphorylationSPMRETPSKAFHQYS
CCCCCCCCHHHHHHC
23403867
4300PhosphorylationPQLPEKASPPASPPI
CCCCCCCCCCCCCCC
29255136
4304PhosphorylationEKASPPASPPIAFPP
CCCCCCCCCCCCCCC
29255136
4361PhosphorylationGMKWKKWSIHIVIPK
CCCCCCEEEEEEEEC
28450419
4370PhosphorylationHIVIPKGTFKPPCED
EEEEECCCCCCCCHH
-
4372UbiquitinationVIPKGTFKPPCEDEI
EEECCCCCCCCHHHH
29967540
4388PhosphorylationEFLKKLGTSLKPDPV
HHHHHHCCCCCCCCC
20068231
4389PhosphorylationFLKKLGTSLKPDPVP
HHHHHCCCCCCCCCC
24719451
4399PhosphorylationPDPVPKDYRKCCFCH
CCCCCCCHHHCCCCC
24719451
4526PhosphorylationFAVFRRVYVQRDEVR
HHHEEEEEECHHHHH
-
4537PhosphorylationDEVRQIASIVQRGER
HHHHHHHHHHHCCCC
-
4586PhosphorylationGYEASRLYWSTRYAN
CHHHHHHHHHHHHHH
24719451
4588PhosphorylationEASRLYWSTRYANRR
HHHHHHHHHHHHHCC
24719451
4737PhosphorylationNSTSTSKSFQSTVTG
CCCCCCCCCCCCCCC
30576142
4741PhosphorylationTSKSFQSTVTGELNA
CCCCCCCCCCCCCCC
30576142
4757PhosphorylationYSKQFVHSKSSQYRK
CHHHHHCCCCHHHHH
24719451
4871PhosphorylationRGHKIIISSSRRIQK
CCCEEEECCCCCCCC
24905233
4872PhosphorylationGHKIIISSSRRIQKG
CCEEEECCCCCCCCC
24905233
4873PhosphorylationHKIIISSSRRIQKGE
CEEEECCCCCCCCCC
24905233

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KMT2C_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KMT2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KMT2C_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NCOA6_HUMANNCOA6physical
12482968
H32_HUMANHIST2H3Cphysical
12482968
ASCL2_HUMANASCL2physical
12482968
RBBP5_HUMANRBBP5physical
12482968
NCOA6_HUMANNCOA6physical
17021013
PAXI1_HUMANPAXIP1physical
17500065
RBBP5_HUMANRBBP5physical
17500065
ASH2L_HUMANASH2Lphysical
17500065
WDR5_HUMANWDR5physical
22665483
H32_HUMANHIST2H3Cphysical
22266653
H31_HUMANHIST1H3Aphysical
23870121
H31T_HUMANHIST3H3physical
26324722
WDR5_HUMANWDR5physical
26324722
RBBP5_HUMANRBBP5physical
26324722
ASH2L_HUMANASH2Lphysical
26324722
DPY30_HUMANDPY30physical
26324722
FOXA1_HUMANFOXA1physical
27926873
WDR5_HUMANWDR5physical
27563068
RBBP5_HUMANRBBP5physical
27563068
ASH2L_HUMANASH2Lphysical
27563068

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KMT2C_HUMAN

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Related Literatures of Post-Translational Modification

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