ASCL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASCL2_HUMAN
• UniProt AC: Q99929
• Protein Name: Achaete-scute homolog 2
• Gene Name: ASCL2
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Nucleus .
• Protein Description: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system..
• Protein Sequence: MDGGTLPRSAPPAPPVPVGCAARRRPASPELLRCSRRRRPATAETGGGAAAVARRNERERNRVKLVNLGFQALRQHVPHGGASKKLSKVETLRSAVEYIRALQRLLAEHDAVRNALAGGLRPQAVRPSAPRGPPGTTPVAASPSRASSSPGRGGSSEPGSPRSAYSSDDSGCEGALSPAERELLDFSSWLGGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	AARRRPASPELLRCS CCCCCCCCHHHHHCC	22.91	25849741
42	Phosphorylation	SRRRRPATAETGGGA CCCCCCCCCCCCCHH	27.92	-
45	Phosphorylation	RRPATAETGGGAAAV CCCCCCCCCCHHHHH	38.37	-
87	Phosphorylation	GGASKKLSKVETLRS CCCCCCHHHHHHHHH	43.46	29083192
91	Phosphorylation	KKLSKVETLRSAVEY CCHHHHHHHHHHHHH	30.38	27174698
94	Phosphorylation	SKVETLRSAVEYIRA HHHHHHHHHHHHHHH	39.52	27174698
98	Phosphorylation	TLRSAVEYIRALQRL HHHHHHHHHHHHHHH	6.79	27174698
136	Phosphorylation	APRGPPGTTPVAASP CCCCCCCCCCCCCCC	33.43	25841592
137	Phosphorylation	PRGPPGTTPVAASPS CCCCCCCCCCCCCCC	22.98	25841592
142	Phosphorylation	GTTPVAASPSRASSS CCCCCCCCCCCCCCC	17.42	25849741
144	Phosphorylation	TPVAASPSRASSSPG CCCCCCCCCCCCCCC	37.67	25841592
147	Phosphorylation	AASPSRASSSPGRGG CCCCCCCCCCCCCCC	30.18	23312004
148	Phosphorylation	ASPSRASSSPGRGGS CCCCCCCCCCCCCCC	39.30	23312004
149	Phosphorylation	SPSRASSSPGRGGSS CCCCCCCCCCCCCCC	28.95	22210691
155	Phosphorylation	SSPGRGGSSEPGSPR CCCCCCCCCCCCCCC	34.06	24719451
156	Phosphorylation	SPGRGGSSEPGSPRS CCCCCCCCCCCCCCC	51.60	24719451
160	Phosphorylation	GGSSEPGSPRSAYSS CCCCCCCCCCCCCCC	28.05	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASCL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASCL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASCL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA6_HUMAN	NCOA6	physical	12482968
RBBP5_HUMAN	RBBP5	physical	12482968
TBA1A_HUMAN	TUBA1A	physical	12482968

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.