| UniProt ID | CRBN_HUMAN | |
|---|---|---|
| UniProt AC | Q96SW2 | |
| Protein Name | Protein cereblon | |
| Gene Name | CRBN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 442 | |
| Subcellular Localization |
Cytoplasm . Nucleus . Membrane Peripheral membrane protein. |
|
| Protein Description | Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.. | |
| Protein Sequence | MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 (in isoform 2) | Phosphorylation | - | 57.66 | 28348404 | |
| 24 | Phosphorylation | HLPLLPAESEEEDEM CCCCCCCCCCCCCCC | 57.66 | - | |
| 25 | Phosphorylation | LPLLPAESEEEDEME CCCCCCCCCCCCCCC | 53.03 | 23401153 | |
| 30 | Ubiquitination | AESEEEDEMEVEDQD CCCCCCCCCCCCCCC | 40.29 | 21890473 | |
| 30 | Ubiquitination | AESEEEDEMEVEDQD CCCCCCCCCCCCCCC | 40.29 | 21890473 | |
| 38 | Phosphorylation | MEVEDQDSKEAKKPN CCCCCCCCHHCCCCC | 27.11 | 26074081 | |
| 38 | Ubiquitination | MEVEDQDSKEAKKPN CCCCCCCCHHCCCCC | 27.11 | 22817900 | |
| 39 | Ubiquitination | EVEDQDSKEAKKPNI CCCCCCCHHCCCCCE | 70.72 | 21890473 | |
| 39 | Ubiquitination | EVEDQDSKEAKKPNI CCCCCCCHHCCCCCE | 70.72 | 22817900 | |
| 41 | Ubiquitination | EDQDSKEAKKPNIIN CCCCCHHCCCCCEEE | 28.98 | 22817900 | |
| 42 (in isoform 2) | Ubiquitination | - | 70.61 | 21890473 | |
| 42 | Ubiquitination | DQDSKEAKKPNIINF CCCCHHCCCCCEEEE | 70.61 | 21890473 | |
| 43 | Ubiquitination | QDSKEAKKPNIINFD CCCHHCCCCCEEEEC | 50.79 | 22817900 | |
| 43 (in isoform 1) | Ubiquitination | - | 50.79 | 21890473 | |
| 51 | Phosphorylation | PNIINFDTSLPTSHT CCEEEECCCCCCCCC | 28.20 | 28555341 | |
| 53 | Ubiquitination | IINFDTSLPTSHTYL EEEECCCCCCCCCCC | 6.11 | 27667366 | |
| 95 | Ubiquitination | MMILIPGQTLPLQLF EEEECCCCCCCEECC | 34.21 | 27667366 | |
| 103 | Ubiquitination | TLPLQLFHPQEVSMV CCCEECCCHHHHHHH | 31.55 | 21890473 | |
| 115 | Ubiquitination | SMVRNLIQKDRTFAV HHHHHHHHHCCEEEE | 44.77 | 27667366 | |
| 116 | Ubiquitination | MVRNLIQKDRTFAVL HHHHHHHHCCEEEEE | 42.03 | 27667366 | |
| 136 | Ubiquitination | QEREAQFGTTAEIYA HHHHHHHCCCEEEEE | 15.29 | 21890473 | |
| 153 | Ubiquitination | EEQDFGIEIVKVKAI HHCCCCEEEEEEEEE | 41.95 | 21890473 | |
| 153 | Ubiquitination | EEQDFGIEIVKVKAI HHCCCCEEEEEEEEE | 41.95 | 21890473 | |
| 157 | Ubiquitination | FGIEIVKVKAIGRQR CCEEEEEEEEECCCC | 3.33 | 27667366 | |
| 158 | Ubiquitination | GIEIVKVKAIGRQRF CEEEEEEEEECCCCE | 28.68 | 27667366 | |
| 162 | Ubiquitination | VKVKAIGRQRFKVLE EEEEEECCCCEEEEE | 20.56 | 21890473 | |
| 165 | Ubiquitination | KAIGRQRFKVLELRT EEECCCCEEEEEEEE | 4.93 | 21890473 | |
| 165 (in isoform 2) | Ubiquitination | - | 4.93 | 21890473 | |
| 166 (in isoform 1) | Ubiquitination | - | 48.36 | 21890473 | |
| 166 | Ubiquitination | AIGRQRFKVLELRTQ EECCCCEEEEEEEEC | 48.36 | 21890473 | |
| 172 | Phosphorylation | FKVLELRTQSDGIQQ EEEEEEEECCCCCCH | 45.08 | 23186163 | |
| 174 | Phosphorylation | VLELRTQSDGIQQAK EEEEEECCCCCCHHH | 36.87 | 23186163 | |
| 195 | Phosphorylation | CVLPSTMSAVQLESL HHCCCCCCHHHHHHC | 25.94 | 23025827 | |
| 201 | Phosphorylation | MSAVQLESLNKCQIF CCHHHHHHCCCCEEC | 45.92 | 23025827 | |
| 203 | Ubiquitination | AVQLESLNKCQIFPS HHHHHHCCCCEECCC | 52.95 | 29967540 | |
| 204 | Ubiquitination | VQLESLNKCQIFPSK HHHHHCCCCEECCCC | 32.58 | 29967540 | |
| 210 | Ubiquitination | NKCQIFPSKPVSRED CCCEECCCCCCCHHH | 38.55 | 29967540 | |
| 211 | Ubiquitination | KCQIFPSKPVSREDQ CCEECCCCCCCHHHC | 50.07 | 29967540 | |
| 211 | Acetylation | KCQIFPSKPVSREDQ CCEECCCCCCCHHHC | 50.07 | 25953088 | |
| 222 | Acetylation | REDQCSYKWWQKYQK HHHCCCHHHHHHHHH | 26.18 | 25953088 | |
| 222 | Ubiquitination | REDQCSYKWWQKYQK HHHCCCHHHHHHHHH | 26.18 | - | |
| 225 | Ubiquitination | QCSYKWWQKYQKRKF CCCHHHHHHHHHCCC | 33.20 | 29967540 | |
| 226 | Ubiquitination | CSYKWWQKYQKRKFH CCHHHHHHHHHCCCC | 35.61 | 29967540 | |
| 237 | Ubiquitination | RKFHCANLTSWPRWL CCCCCCCCCCHHHHH | 1.82 | 21890473 | |
| 239 | Phosphorylation | FHCANLTSWPRWLYS CCCCCCCCHHHHHHH | 37.94 | 24719451 | |
| 245 | Phosphorylation | TSWPRWLYSLYDAET CCHHHHHHHHHCHHH | 6.94 | 27732954 | |
| 246 | Phosphorylation | SWPRWLYSLYDAETL CHHHHHHHHHCHHHH | 20.48 | 27732954 | |
| 248 | Phosphorylation | PRWLYSLYDAETLMD HHHHHHHHCHHHHHH | 13.73 | 27732954 | |
| 268 | Ubiquitination | LREWDENLKDDSLPS HHHHHHHCCCCCCCC | 6.39 | 29967540 | |
| 269 | Ubiquitination | REWDENLKDDSLPSN HHHHHHCCCCCCCCC | 71.69 | 29967540 | |
| 287 | Ubiquitination | FSYRVAACLPIDDVL HHHHEEECCCHHHHH | 3.15 | 21890473 | |
| 287 | Ubiquitination | FSYRVAACLPIDDVL HHHHEEECCCHHHHH | 3.15 | 21890473 | |
| 299 (in isoform 2) | Ubiquitination | - | 1.86 | 21890473 | |
| 299 | Ubiquitination | DVLRIQLLKIGSAIQ HHHHHHHHHHHHHHH | 1.86 | 21890473 | |
| 300 (in isoform 1) | Ubiquitination | - | 54.32 | 21890473 | |
| 300 | Ubiquitination | VLRIQLLKIGSAIQR HHHHHHHHHHHHHHH | 54.32 | 23000965 | |
| 410 | Phosphorylation | TATKKDMSPQKFWGL EEECCCCCHHHHHCC | 34.02 | 21712546 | |
| 412 | Ubiquitination | TKKDMSPQKFWGLTR ECCCCCHHHHHCCCH | 46.39 | 29967540 | |
| 413 | Acetylation | KKDMSPQKFWGLTRS CCCCCHHHHHCCCHH | 46.60 | 25953088 | |
| 413 | Ubiquitination | KKDMSPQKFWGLTRS CCCCCHHHHHCCCHH | 46.60 | 29967540 | |
| 434 | Phosphorylation | PDTEDEISPDKVILC CCCCCCCCCCCEEEE | 25.62 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| - | K | Ubiquitination | E3 ubiquitin ligase | CRBN | Q96SW2 | PMID:30836149:31157769 |
| - | K | Ubiquitination | E3 ubiquitin ligase | FBXO7 | Q9Y3I1 | PMID:30026574 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CRBN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CRBN_HUMAN !! | ||||||
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