dbPTM

CMBL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CMBL_HUMAN
UniProt AC	Q96DG6
Protein Name	Carboxymethylenebutenolidase homolog
Gene Name	CMBL
Organism	Homo sapiens (Human).
Sequence Length	245
Subcellular Localization	Cytoplasm, cytosol .
Protein Description	Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin..
Protein Sequence	MANEAYPCPCDIGHRLEYGGLGREVQVEHIKAYVTKSPVDAGKAVIVIQDIFGWQLPNTRYIADMISGNGYTTIVPDFFVGQEPWDPSGDWSIFPEWLKTRNAQKIDREISAILKYLKQQCHAQKIGIVGFCWGGTAVHHLMMKYSEFRAGVSVYGIVKDSEDIYNLKNPTLFIFAENDVVIPLKDVSLLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREDCSPADKPYIDEARRNLIEWLNKYM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANEAYPCP ------CCCCCCCCC	23.67	-
6	Phosphorylation	--MANEAYPCPCDIG --CCCCCCCCCCCCC	10.13	25159151
18	Phosphorylation	DIGHRLEYGGLGREV CCCCCCCCCCCCCEE	22.53	29496907
31	Ubiquitination	EVQVEHIKAYVTKSP EEEEEEEEEEEECCC	35.26	22817900
31	Acetylation	EVQVEHIKAYVTKSP EEEEEEEEEEEECCC	35.26	26051181
33	Phosphorylation	QVEHIKAYVTKSPVD EEEEEEEEEECCCCC	12.03	29496907
35	Phosphorylation	EHIKAYVTKSPVDAG EEEEEEEECCCCCCC	17.09	26270265
36	Acetylation	HIKAYVTKSPVDAGK EEEEEEECCCCCCCC	42.59	19608861
36	Ubiquitination	HIKAYVTKSPVDAGK EEEEEEECCCCCCCC	42.59	27667366
37	Phosphorylation	IKAYVTKSPVDAGKA EEEEEECCCCCCCCE	22.31	26270265
111	Phosphorylation	QKIDREISAILKYLK HHHHHHHHHHHHHHH	12.42	26437602
115	Acetylation	REISAILKYLKQQCH HHHHHHHHHHHHHHH	42.28	26051181
115	Ubiquitination	REISAILKYLKQQCH HHHHHHHHHHHHHHH	42.28	29967540
116	Phosphorylation	EISAILKYLKQQCHA HHHHHHHHHHHHHHH	18.71	-
118	Acetylation	SAILKYLKQQCHAQK HHHHHHHHHHHHHCC	34.92	26051181
118	Ubiquitination	SAILKYLKQQCHAQK HHHHHHHHHHHHHCC	34.92	29967540
146	Phosphorylation	HHLMMKYSEFRAGVS HHHHHHHHHHCCCEE	25.41	27642862
155	Phosphorylation	FRAGVSVYGIVKDSE HCCCEEEEEEECCHH	8.14	27642862
165	Phosphorylation	VKDSEDIYNLKNPTL ECCHHHHHCCCCCEE	27.11	25159151
188	Phosphorylation	VIPLKDVSLLTQKLK EEEHHHHHHHHHHHH	28.00	26437602
191	Phosphorylation	LKDVSLLTQKLKEHC HHHHHHHHHHHHHHC	29.02	20860994
193	Ubiquitination	DVSLLTQKLKEHCKV HHHHHHHHHHHHCCE	57.18	27667366
193	Acetylation	DVSLLTQKLKEHCKV HHHHHHHHHHHHCCE	57.18	27452117
195	Ubiquitination	SLLTQKLKEHCKVEY HHHHHHHHHHCCEEE	53.07	27667366
199	Ubiquitination	QKLKEHCKVEYQIKT HHHHHHCCEEEEEEE	39.75	29967540
199	Methylation	QKLKEHCKVEYQIKT HHHHHHCCEEEEEEE	39.75	-
199	Acetylation	QKLKEHCKVEYQIKT HHHHHHCCEEEEEEE	39.75	26051181
202	Phosphorylation	KEHCKVEYQIKTFSG HHHCCEEEEEEECCC	20.65	26437602
206	Phosphorylation	KVEYQIKTFSGQTHG CEEEEEEECCCCCCE	25.35	28857561
208	Phosphorylation	EYQIKTFSGQTHGFV EEEEEECCCCCCEEE	34.91	25159151
211	Phosphorylation	IKTFSGQTHGFVHRK EEECCCCCCEEEEEC	27.73	23186163
218	Ubiquitination	THGFVHRKREDCSPA CCEEEEECCCCCCCC	45.31	29967540
223	Phosphorylation	HRKREDCSPADKPYI EECCCCCCCCCCCCH	35.13	26657352
227	Ubiquitination	EDCSPADKPYIDEAR CCCCCCCCCCHHHHH	41.65	29967540
227	Acetylation	EDCSPADKPYIDEAR CCCCCCCCCCHHHHH	41.65	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CMBL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CMBL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CMBL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CMBL_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CMBL_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36, AND MASS SPECTROMETRY.	19608861 [Abstract]