UniProt ID | ZFP91_HUMAN | |
---|---|---|
UniProt AC | Q96JP5 | |
Protein Name | E3 ubiquitin-protein ligase ZFP91 | |
Gene Name | ZFP91 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 570 | |
Subcellular Localization | Nucleus . | |
Protein Description | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.. | |
Protein Sequence | MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRRRRSSPSARPPDVPGQQPQAAKSPSPVQGKKSPRLLCIEKVTTDKDPKEEKEEEDDSALPQEVSIAASRPSRGWRSSRTSVSRHRDTENTRSSRSKTGSLQLICKSEPNTDQLDYDVGEEHQSPGGISSEEEEEEEEEMLISEEEIPFKDDPRDETYKPHLERETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGTNPESLTQPSDGQGLPLLPEPLGNSTSGECLLLEAEGMSKSYCSGTERVSLMADGKIFVGSGSSGGTEGLVMNSDILGATTEVLIEDSDSAGP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
5 | Phosphorylation | ---MPGETEEPRPPE ---CCCCCCCCCCHH | 52.11 | 27135362 | |
44 | Phosphorylation | VAAAPAGTTSSRVLR HHCCCCCCCCHHHHC | 26.13 | 22210691 | |
45 | Phosphorylation | AAAPAGTTSSRVLRG HCCCCCCCCHHHHCC | 24.64 | 22210691 | |
46 | Phosphorylation | AAPAGTTSSRVLRGG CCCCCCCCHHHHCCC | 18.91 | 22210691 | |
47 | Phosphorylation | APAGTTSSRVLRGGR CCCCCCCHHHHCCCC | 25.06 | 26434776 | |
51 | Methylation | TTSSRVLRGGRDRGR CCCHHHHCCCCHHHH | 42.54 | 115920357 | |
56 | Methylation | VLRGGRDRGRAAAAA HHCCCCHHHHHHHHH | 34.83 | 115920361 | |
58 | Methylation | RGGRDRGRAAAAAAA CCCCHHHHHHHHHHH | 23.19 | 115920365 | |
69 | Phosphorylation | AAAAAAVSRRRKAEY HHHHHHHHHHHHCCC | 18.49 | 26434776 | |
76 | Phosphorylation | SRRRKAEYPRRRRSS HHHHHCCCCCHHCCC | 13.60 | 26657352 | |
82 (in isoform 2) | Phosphorylation | - | 44.80 | - | |
82 | Phosphorylation | EYPRRRRSSPSARPP CCCCHHCCCCCCCCC | 44.80 | 29255136 | |
83 (in isoform 2) | Phosphorylation | - | 22.51 | - | |
83 | Phosphorylation | YPRRRRSSPSARPPD CCCHHCCCCCCCCCC | 22.51 | 29255136 | |
85 (in isoform 2) | Phosphorylation | - | 38.57 | - | |
85 | Phosphorylation | RRRRSSPSARPPDVP CHHCCCCCCCCCCCC | 38.57 | 29255136 | |
101 | Phosphorylation | QQPQAAKSPSPVQGK CCCCCCCCCCCCCCC | 26.36 | 30266825 | |
103 | Phosphorylation | PQAAKSPSPVQGKKS CCCCCCCCCCCCCCC | 44.81 | 25159151 | |
108 | Acetylation | SPSPVQGKKSPRLLC CCCCCCCCCCCCEEE | 32.74 | 25953088 | |
110 | Phosphorylation | SPVQGKKSPRLLCIE CCCCCCCCCCEEEEE | 20.81 | 30576142 | |
120 | Phosphorylation | LLCIEKVTTDKDPKE EEEEEEEECCCCHHH | 40.10 | 26074081 | |
121 | Phosphorylation | LCIEKVTTDKDPKEE EEEEEEECCCCHHHH | 44.00 | 26074081 | |
146 | Phosphorylation | QEVSIAASRPSRGWR HHHHHHHCCCCCCCC | 35.38 | 28555341 | |
149 | Phosphorylation | SIAASRPSRGWRSSR HHHHCCCCCCCCCCC | 42.17 | 25159151 | |
154 | Phosphorylation | RPSRGWRSSRTSVSR CCCCCCCCCCCCHHH | 20.05 | 26434776 | |
155 | Phosphorylation | PSRGWRSSRTSVSRH CCCCCCCCCCCHHHC | 30.88 | 26434776 | |
157 | Phosphorylation | RGWRSSRTSVSRHRD CCCCCCCCCHHHCCC | 35.11 | 26434776 | |
158 | Phosphorylation | GWRSSRTSVSRHRDT CCCCCCCCHHHCCCC | 19.58 | 26434776 | |
160 | Phosphorylation | RSSRTSVSRHRDTEN CCCCCCHHHCCCCCC | 23.33 | 26434776 | |
173 | Phosphorylation | ENTRSSRSKTGSLQL CCCCCCCCCCCCEEE | 36.20 | 23312004 | |
174 | Methylation | NTRSSRSKTGSLQLI CCCCCCCCCCCEEEE | 56.65 | 24129315 | |
175 | Phosphorylation | TRSSRSKTGSLQLIC CCCCCCCCCCEEEEE | 33.00 | 29449344 | |
177 | Phosphorylation | SSRSKTGSLQLICKS CCCCCCCCEEEEECC | 20.41 | 21815630 | |
220 | Phosphorylation | EEEEMLISEEEIPFK HHHHHCCCCCCCCCC | 34.69 | 26074081 | |
234 | Phosphorylation | KDDPRDETYKPHLER CCCCCCCCCHHHHCC | 40.93 | 26074081 | |
235 | Phosphorylation | DDPRDETYKPHLERE CCCCCCCCHHHHCCC | 22.07 | 26074081 | |
243 | Phosphorylation | KPHLERETPKPRRKS HHHHCCCCCCCCCCC | 42.72 | 25159151 | |
250 | Phosphorylation | TPKPRRKSGKVKEEK CCCCCCCCCCCCCHH | 41.87 | 26074081 | |
296 (in isoform 2) | Phosphorylation | - | 23.42 | - | |
296 | Phosphorylation | RRRKDDKSPRLPKRR CCCCCCCCCCCCCCC | 23.42 | 30576142 | |
305 | Ubiquitination | RLPKRRKKPPIQYVR CCCCCCCCCCCCEEE | 54.97 | - | |
333 (in isoform 2) | Ubiquitination | - | 34.20 | 21890473 | |
333 | Ubiquitination | RYLQHHIKYQHLLKK HHHHHHHHHHHHHCC | 34.20 | 21890473 | |
333 (in isoform 1) | Ubiquitination | - | 34.20 | 21890473 | |
333 | Ubiquitination | RYLQHHIKYQHLLKK HHHHHHHHHHHHHCC | 34.20 | 21890473 | |
339 | Ubiquitination | IKYQHLLKKKYVCPH HHHHHHHCCCCCCCC | 54.29 | - | |
342 | Phosphorylation | QHLLKKKYVCPHPSC HHHHCCCCCCCCCCH | 19.03 | 28152594 | |
348 | Phosphorylation | KYVCPHPSCGRLFRL CCCCCCCCHHHHHHH | 26.60 | - | |
357 | Ubiquitination | GRLFRLQKQLLRHAK HHHHHHHHHHHHHHH | 47.72 | - | |
367 (in isoform 2) | Phosphorylation | - | 33.28 | - | |
367 | Phosphorylation | LRHAKHHTDQRDYIC HHHHHCCCCCHHHHH | 33.28 | 20068231 | |
382 | Ubiquitination | EYCARAFKSSHNLAV HHHHHHHHHCCCEEE | 50.49 | - | |
395 | Phosphorylation | AVHRMIHTGEKPLQC EEEEEECCCCCCEEE | 35.79 | 21712546 | |
395 (in isoform 2) | Phosphorylation | - | 35.79 | - | |
398 | Ubiquitination | RMIHTGEKPLQCEIC EEECCCCCCEEEEEC | 52.99 | - | |
414 | Phosphorylation | FTCRQKASLNWHMKK CEECEECEECEEECC | 29.30 | 25159151 | |
426 | Phosphorylation | MKKHDADSFYQFSCN ECCCCCCCCEEEEEC | 27.81 | 26434776 | |
428 | Phosphorylation | KHDADSFYQFSCNIC CCCCCCCEEEEECCC | 16.76 | 26434776 | |
438 | Acetylation | SCNICGKKFEKKDSV EECCCCCCCCCCCCC | 44.00 | 30593537 | |
441 | Acetylation | ICGKKFEKKDSVVAH CCCCCCCCCCCCHHH | 66.08 | 30593543 | |
442 | Acetylation | CGKKFEKKDSVVAHK CCCCCCCCCCCHHHC | 48.30 | 30593549 | |
449 | Acetylation | KDSVVAHKAKSHPEV CCCCHHHCCCCCHHH | 48.01 | 30593555 | |
521 | Phosphorylation | GMSKSYCSGTERVSL CCCCHHCCCCCEEEE | 40.28 | 28102081 | |
523 | Phosphorylation | SKSYCSGTERVSLMA CCHHCCCCCEEEEEE | 12.34 | 22210691 | |
527 | Phosphorylation | CSGTERVSLMADGKI CCCCCEEEEEECCEE | 20.74 | 22210691 | |
551 | Phosphorylation | TEGLVMNSDILGATT CCCEEECCCCCCCEE | 14.13 | 22210691 | |
558 | Phosphorylation | SDILGATTEVLIEDS CCCCCCEEEEEECCC | 24.46 | 22210691 | |
565 | Phosphorylation | TEVLIEDSDSAGP-- EEEEECCCCCCCC-- | 22.22 | 22210691 | |
567 | Phosphorylation | VLIEDSDSAGP---- EEECCCCCCCC---- | 38.79 | 22210691 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZFP91_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZFP91_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZFP91_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
M3K14_HUMAN | MAP3K14 | physical | 20682767 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82 AND SER-83, AND MASSSPECTROMETRY. | |
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103, AND MASSSPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-395, AND MASSSPECTROMETRY. |