HNRC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNRC1_HUMAN
• UniProt AC: O60812
• Protein Name: Heterogeneous nuclear ribonucleoprotein C-like 1
• Gene Name: HNRNPCL1
• Organism: Homo sapiens (Human).
• Sequence Length: 293
• Subcellular Localization: Nucleus. Component of ribonucleosomes..
• Protein Description: May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs..
• Protein Sequence: MASNVTNKMDPHSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIAGCSVHKGFAFVQYDKEKNARAAVAGEDGRMIASQVVDINLAAEPKVNRGNAGVKRSAAEMYGSSFDLDYGFQRDYYDGMYSFPARVPPPPPIALAVVPSKRQRLSGNTSRRGKSGFNSKSGKRGSSKSGKLKGDDLQAIKQELTQIKQKVDSLLENLEKIEKEQSKQEVEVKNAKSEEEQSSSSMKKDETHVKMESEGGAEDSAEEGDPLDDDVNEDQGDDQLELIKDDEKEAEEGEDDRDSTNGQDDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASNVTNKM ------CCCCCCCCC		-
3	Phosphorylation	-----MASNVTNKMD -----CCCCCCCCCC		-
25	Phosphorylation	VFIGNLNTLVVKKSD EEEEECCEEEEEHHH		30576142
29	Ubiquitination	NLNTLVVKKSDVEAI ECCEEEEEHHHHHHH		21890473
29	Acetylation	NLNTLVVKKSDVEAI ECCEEEEEHHHHHHH		25953088
29	Ubiquitination	NLNTLVVKKSDVEAI ECCEEEEEHHHHHHH		23000965
30	Acetylation	LNTLVVKKSDVEAIF CCEEEEEHHHHHHHH		26051181
30	Ubiquitination	LNTLVVKKSDVEAIF CCEEEEEHHHHHHHH		23000965
30	Malonylation	LNTLVVKKSDVEAIF CCEEEEEHHHHHHHH		26320211
31	Phosphorylation	NTLVVKKSDVEAIFS CEEEEEHHHHHHHHH		30266825
38	Phosphorylation	SDVEAIFSKYGKIAG HHHHHHHHHHCCCCC		21712546
39	Sumoylation	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		-
39	Ubiquitination	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		32015554
39	Methylation	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		88743
39	Malonylation	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		26320211
39	Acetylation	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		25825284
42	Ubiquitination	AIFSKYGKIAGCSVH HHHHHHCCCCCCEEE		-
50	Ubiquitination	IAGCSVHKGFAFVQY CCCCEEECCEEEEEE		22817900
89	Ubiquitination	INLAAEPKVNRGNAG EEECCCCCCCCCCCC		29967540
100	Phosphorylation	GNAGVKRSAAEMYGS CCCCCCHHHHHHHCC		24043423
105	Phosphorylation	KRSAAEMYGSSFDLD CHHHHHHHCCCCCCC		18669648
107	Phosphorylation	SAAEMYGSSFDLDYG HHHHHHCCCCCCCCC		22496350
108	Phosphorylation	AAEMYGSSFDLDYGF HHHHHCCCCCCCCCC		24043423
113	Phosphorylation	GSSFDLDYGFQRDYY CCCCCCCCCCCCCCC		24043423
120	Phosphorylation	YGFQRDYYDGMYSFP CCCCCCCCCCCEECC		30576142
124	Phosphorylation	RDYYDGMYSFPARVP CCCCCCCEECCCCCC		30576142
125	Phosphorylation	DYYDGMYSFPARVPP CCCCCCEECCCCCCC		30576142
143	Phosphorylation	IALAVVPSKRQRLSG EEEEECCCCCCCCCC		30266825
144	Acetylation	ALAVVPSKRQRLSGN EEEECCCCCCCCCCC		25953088
144	Ubiquitination	ALAVVPSKRQRLSGN EEEECCCCCCCCCCC		24816145
149	Phosphorylation	PSKRQRLSGNTSRRG CCCCCCCCCCCCCCC		22817900
152	Phosphorylation	RQRLSGNTSRRGKSG CCCCCCCCCCCCCCC		22817900
157	Ubiquitination	GNTSRRGKSGFNSKS CCCCCCCCCCCCCCC		27667366
157	Acetylation	GNTSRRGKSGFNSKS CCCCCCCCCCCCCCC		26051181
158	Phosphorylation	NTSRRGKSGFNSKSG CCCCCCCCCCCCCCC		28985074
163	Acetylation	GKSGFNSKSGKRGSS CCCCCCCCCCCCCCC		90171
164	Phosphorylation	KSGFNSKSGKRGSSK CCCCCCCCCCCCCCC		22817900
166	Acetylation	GFNSKSGKRGSSKSG CCCCCCCCCCCCCCC		61177
169	Phosphorylation	SKSGKRGSSKSGKLK CCCCCCCCCCCCCCC		24260401
171	Acetylation	SGKRGSSKSGKLKGD CCCCCCCCCCCCCHH		90173
171	Ubiquitination	SGKRGSSKSGKLKGD CCCCCCCCCCCCCHH		23000965
172	Phosphorylation	GKRGSSKSGKLKGDD CCCCCCCCCCCCHHH		26546556
174	Acetylation	RGSSKSGKLKGDDLQ CCCCCCCCCCHHHHH		23749302
174	Ubiquitination	RGSSKSGKLKGDDLQ CCCCCCCCCCHHHHH		23000965
176	Acetylation	SSKSGKLKGDDLQAI CCCCCCCCHHHHHHH		26051181
176	Sumoylation	SSKSGKLKGDDLQAI CCCCCCCCHHHHHHH		-
176	Ubiquitination	SSKSGKLKGDDLQAI CCCCCCCCHHHHHHH		23000965
176	Methylation	SSKSGKLKGDDLQAI CCCCCCCCHHHHHHH		-
191	Acetylation	KQELTQIKQKVDSLL HHHHHHHHHHHHHHH		25953088
191	Ubiquitination	KQELTQIKQKVDSLL HHHHHHHHHHHHHHH		23000965
193	Ubiquitination	ELTQIKQKVDSLLEN HHHHHHHHHHHHHHH		23000965
193	Ubiquitination	ELTQIKQKVDSLLEN HHHHHHHHHHHHHHH		21890473
193	Acetylation	ELTQIKQKVDSLLEN HHHHHHHHHHHHHHH		26051181
193	Malonylation	ELTQIKQKVDSLLEN HHHHHHHHHHHHHHH		26320211
196	Phosphorylation	QIKQKVDSLLENLEK HHHHHHHHHHHHHHH		30266825
203	Ubiquitination	SLLENLEKIEKEQSK HHHHHHHHHHHHHHH		21890473
203	Acetylation	SLLENLEKIEKEQSK HHHHHHHHHHHHHHH		23749302
206	Ubiquitination	ENLEKIEKEQSKQEV HHHHHHHHHHHHHHH		22817900
210	Ubiquitination	KIEKEQSKQEVEVKN HHHHHHHHHHHHHHH		22817900
216	Acetylation	SKQEVEVKNAKSEEE HHHHHHHHHCCCHHH		7987643
219	Acetylation	EVEVKNAKSEEEQSS HHHHHHCCCHHHHCC		7987651
220	Phosphorylation	VEVKNAKSEEEQSSS HHHHHCCCHHHHCCC		28102081
225	Phosphorylation	AKSEEEQSSSSMKKD CCCHHHHCCCCCCCC		28102081
226	Phosphorylation	KSEEEQSSSSMKKDE CCHHHHCCCCCCCCC		28102081
227	Phosphorylation	SEEEQSSSSMKKDET CHHHHCCCCCCCCCC		28102081
228	Phosphorylation	EEEQSSSSMKKDETH HHHHCCCCCCCCCCC		28102081
234	Phosphorylation	SSMKKDETHVKMESE CCCCCCCCCEEEECC		-
237	Sumoylation	KKDETHVKMESEGGA CCCCCCEEEECCCCC		-
240	Phosphorylation	ETHVKMESEGGAEDS CCCEEEECCCCCCCC		26657352
247	Phosphorylation	SEGGAEDSAEEGDPL CCCCCCCCCCCCCCC		24173317
271	Ubiquitination	DDQLELIKDDEKEAE CCHHEEEECCHHHHH		32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNRC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNRC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNRC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRL2_HUMAN	HNRNPUL2	physical	22939629
HNRPC_HUMAN	HNRNPC	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.