CLCN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLCN1_HUMAN
• UniProt AC: P35523
• Protein Name: Chloride channel protein 1
• Gene Name: CLCN1
• Organism: Homo sapiens (Human).
• Sequence Length: 988
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport..
• Protein Sequence: MEQSRSQQRGGEQSWWGSDPQYQYMPFEHCTSYGLPSENGGLQHRLRKDAGPRHNVHPTQIYGHHKEQFSDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDGIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESLGQSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDEDEDEDLSGKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSTRKSTGAPPSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELEELELVESPGLEEELADILQGPSLRSTDEEDEDELIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	PRHNVHPTQIYGHHK CCCCCCCCCCCCCCH	16.84	29038488
62	Phosphorylation	NVHPTQIYGHHKEQF CCCCCCCCCCCHHHC	10.69	29038488
70	Phosphorylation	GHHKEQFSDREQDIG CCCHHHCCCCCHHCC	35.14	29038488
195	Sumoylation	GSGIPEMKTILRGVV CCCCHHHHHHHHHHH	30.65	-
876	Phosphorylation	AIEGHTKSGVQLRPP HHCCCCCCCCCCCCC	45.40	26437602
886	Phosphorylation	QLRPPLASFRNTTST CCCCCCHHHCCCCCC	32.21	24719451
891	Phosphorylation	LASFRNTTSTRKSTG CHHHCCCCCCCCCCC	31.48	22817900
892	Phosphorylation	ASFRNTTSTRKSTGA HHHCCCCCCCCCCCC	24.95	22817900
893	Phosphorylation	SFRNTTSTRKSTGAP HHCCCCCCCCCCCCC	39.77	22817900
917	Phosphorylation	PEDRPGATGTGDVIA CCCCCCCCCCCCEEE	40.99	-
929	Phosphorylation	VIAASPETPVPSPSP EEEECCCCCCCCCCC	32.73	22817900
977	Phosphorylation	LQGPSLRSTDEEDED HCCCCCCCCCCCCCC	45.57	-
978	Phosphorylation	QGPSLRSTDEEDEDE CCCCCCCCCCCCCCC	40.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLCN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLCN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLCN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBP2_HUMAN	APPBP2	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
DDB1_HUMAN	DDB1	physical	26021757
STIP1_HUMAN	STIP1	physical	27580824
FKBP8_HUMAN	FKBP8	physical	27580824
AHSA1_HUMAN	AHSA1	physical	27580824

Drug and Disease Associations

• Kegg Disease
• H00705: Myotonia congenita, including: Autosomal dominant myotonia congenita (Thomsen disease); Autosomal re
• OMIM Disease
• 160800: Myotonia congenita, autosomal dominant (MCD)
• 255700: Myotonia congenita, autosomal recessive (MCR)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.